Upstream Bio, Inc.
UPB- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
近 90 天，Upstream Bio, Inc. 內部人申報 0 筆公開市場買進、5 筆賣出；2026 年第 2 季末有 148 家機構在 13F 申報持有，市值合計 $3.50 億；沒有大師持有。
2026 年第 2 季 13F 持有人
Upstream Bio, Inc. 在 2026/6/30 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 148
- 較 2026 年第 1 季 +9 家
- 持有股數
- 5,057 萬
- 較 2026 年第 1 季 +568.9 萬 (+12.7%)
- 總市值
- $3.50 億
- 較 2026 年第 1 季 −$5,435 萬 (−13.4%)
- 新進機構
- 37
- 另有 65 家加碼
- 清倉機構
- 28
- 另有 28 家減碼
另有 1 家機構在 2026 年第 1 季持有、還沒有申報 2026 年第 2 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 UPB 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 148 | $3.50 億 |
| 2026 年第 1 季 | 140 | $4.04 億 |
| 2025 年第 4 季 | 133 | $13.9 億 |
| 2025 年第 3 季 | 95 | $8.37 億 |
| 2025 年第 2 季 | 83 | $5.31 億 |
| 2025 年第 1 季 | 79 | $2.67 億 |
| 2024 年第 4 季 | 70 | $6.90 億 |
| 2024 年第 3 季 | 0 | $0 |
| 2024 年第 2 季 | 0 | $0 |
| 2024 年第 1 季 | 0 | $0 |
| 2023 年第 4 季 | 0 | $0 |
| 2023 年第 3 季 | 0 | $0 |
| 2023 年第 2 季 | 0 | $0 |
| 2023 年第 1 季 | 0 | $0 |
| 2022 年第 4 季 | 0 | $0 |
| 2022 年第 3 季 | 0 | $0 |
| 2022 年第 2 季 | 0 | $0 |
| 2022 年第 1 季 | 0 | $0 |
| 2021 年第 4 季 | 0 | $0 |
| 2021 年第 3 季 | 0 | $0 |
| 2021 年第 2 季 | 0 | $0 |
| 2021 年第 1 季 | 0 | $0 |
2026 年第 2 季持有機構
每家機構持有 Upstream Bio, Inc. 的股數、市值與佔組合比重；股數變化跟 2026 年第 1 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 8,162,897 | $5,649 萬 | 0.00% | +61,334+0.8% | 加碼 |
| OrbiMed Advisors LLC | 5,693,589 | $3,940 萬 | 0.75% | 00.0% | 不變 |
| Norges Bank | 3,768,619 | $2,608 萬 | 0.00% | +3,768,619 | 新進 |
| BlackRock, Inc. | 3,753,358 | $2,597 萬 | 0.00% | +382,669+11.4% | 加碼 |
| Decheng Capital LLC | 2,724,868 | $1,886 萬 | 2.58% | 00.0% | 不變 |
| Enavate Sciences GP, LLC | 2,459,703 | $1,702 萬 | 4.93% | 00.0% | 不變 |
| Vanguard Capital Management LLC | 1,876,734 | $1,299 萬 | 0.00% | +3,160+0.2% | 加碼 |
| Millennium Management LLC | 1,143,775 | $791.5 萬 | 0.01% | +206,452+22.0% | 加碼 |
| D. E. Shaw & Co., Inc. | 1,036,044 | $716.9 萬 | 0.00% | +215,564+26.3% | 加碼 |
| JPMorgan Chase & Co | 1,012,044 | $701.3 萬 | 0.00% | +549,043+118.6% | 加碼 |
| Qube Research & Technologies Ltd | 978,500 | $677.1 萬 | 0.01% | +359,179+58.0% | 加碼 |
| Parkman Healthcare Partners LLC | 935,247 | $647.2 萬 | 0.66% | +148,464+18.9% | 加碼 |
| Geode Capital Management, LLC | 931,261 | $644.6 萬 | 0.00% | −19,356−2.0% | 減碼 |
| SEB Asset Management AB | 878,473 | $607.9 萬 | 0.02% | 00.0% | 不變 |
| Woodline Partners LP | 831,481 | $575.4 萬 | 0.02% | 00.0% | 不變 |
| State Street Corp | 766,323 | $530.3 萬 | 0.00% | +60,973+8.6% | 加碼 |
| Vanguard Portfolio Management LLC | 712,667 | $493.2 萬 | 0.00% | −15,044−2.1% | 減碼 |
| Y-Intercept (Hong Kong) Ltd | 693,555 | $479.9 萬 | 0.09% | −307,076−30.7% | 減碼 |
| Bain Capital Life Sciences Investors, LLC | 600,949 | $415.9 萬 | 0.25% | −266,262−30.7% | 減碼 |
| AQR Capital Management LLC | 544,869 | $377.0 萬 | 0.00% | +472,698+655.0% | 加碼 |
| Morgan Stanley | 524,632 | $363.0 萬 | 0.00% | −27,977−5.1% | 減碼 |
| BNP Paribas Arbitrage, SA | 511,546 | $354.0 萬 | 0.00% | +385,546+306.0% | 加碼 |
| Walleye Capital LLC | 498,490 | $345.0 萬 | 0.02% | +498,490 | 新進 |
| Trexquant Investment LP | 466,430 | $322.8 萬 | 0.02% | +289,773+164.0% | 加碼 |
| Point72 Asset Management, L.P. | 453,011 | $313.5 萬 | 0.00% | +274,843+154.3% | 加碼 |
| Bank of America Corp | 391,762 | $271.1 萬 | 0.00% | +343,302+708.4% | 加碼 |
| Dimensional Fund Advisors LP | 381,613 | $264.1 萬 | 0.00% | +301,611+377.0% | 加碼 |
| Altshuler Shaham Ltd | 380,061 | $263.0 萬 | 0.03% | 00.0% | 不變 |
| Arrowstreet Capital, Limited Partnership | 357,756 | $247.6 萬 | 0.00% | +172,669+93.3% | 加碼 |
| Samsara BioCapital, LLC | 353,717 | $244.8 萬 | 0.20% | −382,330−51.9% | 減碼 |
| Propel Bio Management, LLC | 350,389 | $242.5 萬 | 1.27% | +8,610+2.5% | 加碼 |
| Wellington Management Group LLP | 342,353 | $236.9 萬 | 0.00% | 00.0% | 不變 |
| Northern Trust Corp | 297,346 | $205.8 萬 | 0.00% | +36,354+13.9% | 加碼 |
| Squarepoint Ops LLC | 290,904 | $201.3 萬 | 0.00% | +246,278+551.9% | 加碼 |
| Voleon Capital Management LP | 285,234 | $197.4 萬 | 0.04% | +285,234 | 新進 |
| Charles Schwab Investment Management Inc | 262,456 | $181.6 萬 | 0.00% | +4,727+1.8% | 加碼 |
| Jacobs Levy Equity Management, Inc | 253,092 | $175.1 萬 | 0.01% | +253,092 | 新進 |
| Goldman Sachs Group Inc | 246,917 | $170.9 萬 | 0.00% | −69,670−22.0% | 減碼 |
| XTX Topco Ltd | 242,346 | $167.7 萬 | 0.02% | +33,069+15.8% | 加碼 |
| Deutsche Bank AG | 241,447 | $167.1 萬 | 0.00% | +60,558+33.5% | 加碼 |
| Vanguard Fiduciary Trust Co | 239,616 | $165.8 萬 | 0.00% | +15,459+6.9% | 加碼 |
| UBS Group AG | 234,714 | $162.4 萬 | 0.00% | +3,460+1.5% | 加碼 |
| Schonfeld Strategic Advisors LLC | 225,760 | $156.2 萬 | 0.01% | +64,411+39.9% | 加碼 |
| Jump Financial, LLC | 223,223 | $154.5 萬 | 0.01% | −96,177−30.1% | 減碼 |
| Sphera Funds Management Ltd. | 219,700 | $152.0 萬 | 0.22% | −138,300−38.6% | 減碼 |
| Acadian Asset Management LLC | 175,110 | $120.8 萬 | 0.00% | +175,110 | 新進 |
| HRT Financial LP | 170,590 | $118.0 萬 | 0.00% | +170,590 | 新進 |
| Boxer Capital Management, LLC | 150,000 | $103.8 萬 | 0.08% | 00.0% | 不變 |
| Renaissance Technologies LLC | 131,300 | $90.9 萬 | 0.00% | +69,200+111.4% | 加碼 |
| EntryPoint Capital, LLC | 129,446 | $89.6 萬 | 0.22% | +55,878+76.0% | 加碼 |
| Algert Global LLC | 118,630 | $82.1 萬 | 0.01% | +118,630 | 新進 |
| Bank of New York Mellon Corp | 85,747 | $59.3 萬 | 0.00% | +4,364+5.4% | 加碼 |
| Nuveen, LLC | 84,770 | $58.7 萬 | 0.00% | +9,234+12.2% | 加碼 |
| American Century Companies Inc | 78,194 | $54.1 萬 | 0.00% | −9,430−10.8% | 減碼 |
| Man Group plc | 73,823 | $51.1 萬 | 0.00% | +52,669+249.0% | 加碼 |
| Gsa Capital Partners LLP | 69,348 | $48.0 萬 | 0.03% | +30,116+76.8% | 加碼 |
| Alliancebernstein L.P. | 51,680 | $46.5 萬 | 0.00% | +20,670+66.7% | 加碼 |
| Simplify Asset Management Inc. | 62,113 | $43.0 萬 | 0.01% | −15,680−20.2% | 減碼 |
| Alps Advisors Inc | 55,228 | $38.2 萬 | 0.00% | +11,236+25.5% | 加碼 |
| Quantinno Capital Management LP | 54,838 | $37.9 萬 | 0.00% | +5,449+11.0% | 加碼 |
| Virtus Investment Advisers, Inc. | 53,638 | $37.1 萬 | 0.09% | +43,592+433.9% | 加碼 |
| Invesco Ltd. | 53,397 | $37.0 萬 | 0.00% | +12,887+31.8% | 加碼 |
| Brevan Howard Capital Management LP | 50,369 | $34.9 萬 | 0.00% | +50,369 | 新進 |
| Swiss National Bank | 48,100 | $33.3 萬 | 0.00% | 00.0% | 不變 |
| Russell Investments Group, Ltd. | 47,543 | $32.9 萬 | 0.00% | +43,896+1,203.6% | 加碼 |
| Allspring Global Investments Holdings, LLC | 43,182 | $29.9 萬 | 0.00% | +43,182 | 新進 |
| Rhumbline Advisers | 42,384 | $29.3 萬 | 0.00% | +1,181+2.9% | 加碼 |
| Two Sigma Investments, LP | 42,325 | $29.3 萬 | 0.00% | +42,325 | 新進 |
| ExodusPoint Capital Management, LP | 41,045 | $28.4 萬 | 0.00% | −50,386−55.1% | 減碼 |
| Citigroup Inc | 40,339 | $27.9 萬 | 0.00% | +35,284+698.0% | 加碼 |
| California State Teachers Retirement System | 38,634 | $26.7 萬 | 0.00% | −1,027−2.6% | 減碼 |
| Stonepine Capital Management, LLC | 33,432 | $23.1 萬 | 0.18% | −1,568−4.5% | 減碼 |
| Mariner, LLC | 33,141 | $22.9 萬 | 0.00% | +5,827+21.3% | 加碼 |
| Wells Fargo & Company | 29,497 | $20.4 萬 | 0.00% | +11,095+60.3% | 加碼 |
| Barclays PLC | 29,208 | $20.2 萬 | 0.00% | +4,488+18.2% | 加碼 |
| Creative Planning | 28,483 | $19.7 萬 | 0.00% | +17,633+162.5% | 加碼 |
| Price T Rowe Associates Inc | 28,058 | $19.5 萬 | 0.00% | +1,624+6.1% | 加碼 |
| Quantbot Technologies LP | 28,178 | $19.5 萬 | 0.01% | +27,515+4,150.1% | 加碼 |
| Axq Capital, LP | 27,068 | $18.7 萬 | 0.02% | −435−1.6% | 減碼 |
| nVerses Capital, LLC | 24,029 | $16.6 萬 | 0.26% | +24,029 | 新進 |
| DnB Asset Management AS | 23,600 | $16.3 萬 | 0.00% | +85+0.4% | 加碼 |
| Vanguard Asset Management, Ltd | 22,724 | $15.7 萬 | 0.00% | +13,474+145.7% | 加碼 |
| Graham Capital Management, L.P. | 22,508 | $15.6 萬 | 0.00% | +22,508 | 新進 |
| Los Angeles Capital Management LLC | 22,385 | $15.5 萬 | 0.00% | +22,385 | 新進 |
| Verdad Advisers, LP | 21,810 | $15.1 萬 | 0.14% | +21,810 | 新進 |
| MetLife Investment Management | 20,852 | $14.4 萬 | 0.00% | +1,472+7.6% | 加碼 |
| SG Americas Securities, LLC | 20,338 | $14.1 萬 | 0.00% | +20,338 | 新進 |
| SEI Investments Co | 20,026 | $13.9 萬 | 0.00% | +20,026 | 新進 |
| Winton Group Ltd | 19,800 | $13.7 萬 | 0.00% | +19,800 | 新進 |
| Ieq Capital, LLC | 19,535 | $13.5 萬 | 0.00% | +19,535 | 新進 |
| Diadema Partners LP | 19,093 | $13.2 萬 | 0.05% | −2,516−11.6% | 減碼 |
| Shay Capital LLC | 18,000 | $12.5 萬 | 0.01% | +8,000+80.0% | 加碼 |
| Quadrature Capital Ltd | 17,988 | $12.4 萬 | 0.00% | +17,988 | 新進 |
| Entropy Technologies, LP | 17,542 | $12.1 萬 | 0.00% | −5,794−24.8% | 減碼 |
| State of Wisconsin Investment Board | 17,065 | $11.8 萬 | 0.00% | −24,606−59.0% | 減碼 |
| Mirae Asset Global ETFs Holdings Ltd. | 16,217 | $11.2 萬 | 0.00% | +609+3.9% | 加碼 |
| Manufacturers Life Insurance Company, The | 15,735 | $10.9 萬 | 0.00% | +397+2.6% | 加碼 |
| Jane Street Group, LLC | 15,594 | $10.8 萬 | 0.00% | +15,594 | 新進 |
| Mercer Global Advisors Inc | 13,352 | $9.24 萬 | 0.00% | +13,352 | 新進 |
| Vanguard Global Advisers, LLC | 13,059 | $9.04 萬 | 0.00% | 00.0% | 不變 |