Upstream Bio, Inc.
UPB- 交易所
- Nasdaq
- 產業
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
近 90 天，Upstream Bio, Inc. 內部人申報 0 筆公開市場買進、5 筆賣出；2026 年第 2 季末有 148 家機構在 13F 申報持有，市值合計 $3.50 億；沒有大師持有。
2026 年第 1 季 13F 持有人
Upstream Bio, Inc. 在 2026/3/31 季末的機構持股。管理 1 億美元以上美股的機構，每季結束後 45 天內要用 13F 申報多頭部位。13F 是什麼
- 持有機構
- 140
- 較 2025 年第 4 季 +10 家
- 持有股數
- 4,489 萬
- 較 2025 年第 4 季 −101.8 萬 (−2.2%)
- 總市值
- $4.04 億
- 較 2025 年第 4 季 −$8.42 億 (−67.5%)
- 新進機構
- 47
- 另有 47 家加碼
- 清倉機構
- 37
- 另有 35 家減碼
另有 3 家機構在 2025 年第 4 季持有、還沒有申報 2026 年第 1 季 13F：沒申報不算清倉，也不計入上面的變化。
歷季持有家數與市值
2021 年第 1 季起，每季在 13F 申報持有 UPB 的機構家數與合計市值。市值是各季季末的申報市值，也會跟著股價漲跌。
| 季度 | 家數 | 市值 |
|---|---|---|
| 2026 年第 2 季 | 148 | $3.50 億 |
| 2026 年第 1 季 | 140 | $4.04 億 |
| 2025 年第 4 季 | 133 | $13.9 億 |
| 2025 年第 3 季 | 95 | $8.36 億 |
| 2025 年第 2 季 | 83 | $5.31 億 |
| 2025 年第 1 季 | 79 | $2.67 億 |
| 2024 年第 4 季 | 70 | $6.90 億 |
| 2024 年第 3 季 | 0 | $0 |
| 2024 年第 2 季 | 0 | $0 |
| 2024 年第 1 季 | 0 | $0 |
| 2023 年第 4 季 | 0 | $0 |
| 2023 年第 3 季 | 0 | $0 |
| 2023 年第 2 季 | 0 | $0 |
| 2023 年第 1 季 | 0 | $0 |
| 2022 年第 4 季 | 0 | $0 |
| 2022 年第 3 季 | 0 | $0 |
| 2022 年第 2 季 | 0 | $0 |
| 2022 年第 1 季 | 0 | $0 |
| 2021 年第 4 季 | 0 | $0 |
| 2021 年第 3 季 | 0 | $0 |
| 2021 年第 2 季 | 0 | $0 |
| 2021 年第 1 季 | 0 | $0 |
2026 年第 1 季持有機構
每家機構持有 Upstream Bio, Inc. 的股數、市值與佔組合比重；股數變化跟 2025 年第 4 季比。
| 機構 | 股數 | 市值 | 佔組合 % | 股數變化 | 動作 |
|---|---|---|---|---|---|
| FMR LLC | 8,101,563 | $7,291 萬 | 0.00% | +583,361+7.8% | 加碼 |
| OrbiMed Advisors LLC | 5,693,589 | $5,124 萬 | 1.16% | 00.0% | 不變 |
| BlackRock, Inc. | 3,370,689 | $3,034 萬 | 0.00% | +26,185+0.8% | 加碼 |
| Decheng Capital LLC | 2,724,868 | $2,452 萬 | 3.71% | −418,210−13.3% | 減碼 |
| Enavate Sciences GP, LLC | 2,459,703 | $2,214 萬 | 6.30% | 00.0% | 不變 |
| Vanguard Capital Management LLC | 1,873,574 | $1,686 萬 | 0.00% | +1,873,574 | 新進 |
| Y-Intercept (Hong Kong) Ltd | 1,000,631 | $900.6 萬 | 0.17% | +954,072+2,049.2% | 加碼 |
| Federated Hermes, Inc. | 979,758 | $881.8 萬 | 0.01% | +979,276+203,169.3% | 加碼 |
| Geode Capital Management, LLC | 950,617 | $855.7 萬 | 0.00% | +98,709+11.6% | 加碼 |
| Millennium Management LLC | 937,323 | $843.6 萬 | 0.01% | +420,059+81.2% | 加碼 |
| SEB Asset Management AB | 878,473 | $790.6 萬 | 0.03% | +878,473 | 新進 |
| Bain Capital Life Sciences Investors, LLC | 867,211 | $780.5 萬 | 0.70% | −462,333−34.8% | 減碼 |
| Woodline Partners LP | 831,481 | $748.3 萬 | 0.03% | +71,229+9.4% | 加碼 |
| D. E. Shaw & Co., Inc. | 820,480 | $738.4 萬 | 0.01% | +793,389+2,928.6% | 加碼 |
| Parkman Healthcare Partners LLC | 786,783 | $708.1 萬 | 0.73% | −47,776−5.7% | 減碼 |
| Samsara BioCapital, LLC | 736,047 | $662.4 萬 | 0.64% | 00.0% | 不變 |
| Pictet Asset Management Holding SA | 733,431 | $660.1 萬 | 0.01% | −39,717−5.1% | 減碼 |
| Vanguard Portfolio Management LLC | 727,711 | $654.9 萬 | 0.00% | +727,711 | 新進 |
| State Street Corp | 705,350 | $634.8 萬 | 0.00% | −613,876−46.5% | 減碼 |
| HSBC Holdings PLC | 640,326 | $576.3 萬 | 0.00% | +640,326 | 新進 |
| Qube Research & Technologies Ltd | 619,321 | $557.4 萬 | 0.01% | +619,321 | 新進 |
| Morgan Stanley | 552,609 | $497.3 萬 | 0.00% | +430,541+352.7% | 加碼 |
| JPMorgan Chase & Co | 463,001 | $406.5 萬 | 0.00% | +352,721+319.8% | 加碼 |
| Nantahala Capital Management, LLC | 400,000 | $360.0 萬 | 0.22% | −94,971−19.2% | 減碼 |
| Altshuler Shaham Ltd | 380,061 | $342.1 萬 | 0.06% | −961,479−71.7% | 減碼 |
| Sphera Funds Management Ltd. | 358,000 | $322.2 萬 | 0.55% | +358,000 | 新進 |
| Propel Bio Management, LLC | 341,779 | $310.0 萬 | 1.95% | +341,779 | 新進 |
| Wellington Management Group LLP | 342,353 | $308.1 萬 | 0.00% | −552,380−61.7% | 減碼 |
| Jump Financial, LLC | 319,400 | $287.5 萬 | 0.04% | +319,400 | 新進 |
| Goldman Sachs Group Inc | 316,587 | $284.9 萬 | 0.00% | −16,894−5.1% | 減碼 |
| Alyeska Investment Group, L.P. | 298,329 | $268.5 萬 | 0.01% | 00.0% | 不變 |
| Northern Trust Corp | 260,992 | $234.9 萬 | 0.00% | +24,193+10.2% | 加碼 |
| Charles Schwab Investment Management Inc | 257,729 | $232.0 萬 | 0.00% | −27,202−9.5% | 減碼 |
| Prosight Management, LP | 241,123 | $217.0 萬 | 0.36% | +241,123 | 新進 |
| UBS Group AG | 231,254 | $208.1 萬 | 0.00% | −1,574,989−87.2% | 減碼 |
| Vanguard Fiduciary Trust Co | 224,157 | $201.7 萬 | 0.00% | +224,157 | 新進 |
| XTX Topco Ltd | 209,277 | $188.3 萬 | 0.03% | +194,186+1,286.8% | 加碼 |
| Arrowstreet Capital, Limited Partnership | 185,087 | $166.6 萬 | 0.00% | +185,087 | 新進 |
| TCG Crossover Management, LLC | 181,063 | $163.0 萬 | 0.05% | −562,823−75.7% | 減碼 |
| Deutsche Bank AG | 180,889 | $162.8 萬 | 0.00% | +53,074+41.5% | 加碼 |
| Point72 Asset Management, L.P. | 178,168 | $160.4 萬 | 0.00% | +178,168 | 新進 |
| Trexquant Investment LP | 176,657 | $159.0 萬 | 0.01% | +145,608+469.0% | 加碼 |
| Schonfeld Strategic Advisors LLC | 161,349 | $145.2 萬 | 0.01% | +45,542+39.3% | 加碼 |
| Boxer Capital Management, LLC | 150,000 | $135.0 萬 | 0.18% | 00.0% | 不變 |
| BNP Paribas Arbitrage, SA | 126,000 | $113.4 萬 | 0.00% | +121,024+2,432.2% | 加碼 |
| Alliancebernstein L.P. | 31,010 | $84.2 萬 | 0.00% | 00.0% | 不變 |
| ExodusPoint Capital Management, LP | 91,431 | $82.3 萬 | 0.01% | +16,029+21.3% | 加碼 |
| American Century Companies Inc | 87,624 | $78.9 萬 | 0.00% | −132−0.2% | 減碼 |
| Bank of New York Mellon Corp | 81,383 | $73.2 萬 | 0.00% | −3,470−4.1% | 減碼 |
| Dimensional Fund Advisors LP | 80,002 | $71.9 萬 | 0.00% | +80,002 | 新進 |
| Simplify Asset Management Inc. | 77,793 | $70.0 萬 | 0.01% | +77,793 | 新進 |
| Nuveen, LLC | 75,536 | $68.0 萬 | 0.00% | −3,032−3.9% | 減碼 |
| EntryPoint Capital, LLC | 73,568 | $66.2 萬 | 0.19% | +73,568 | 新進 |
| AQR Capital Management LLC | 72,171 | $65.0 萬 | 0.00% | +41,668+136.6% | 加碼 |
| Marshall Wace, LLP | 66,770 | $60.1 萬 | 0.00% | −277,021−80.6% | 減碼 |
| Renaissance Technologies LLC | 62,100 | $55.9 萬 | 0.00% | +45,700+278.7% | 加碼 |
| Quantinno Capital Management LP | 49,389 | $44.5 萬 | 0.00% | +33,974+220.4% | 加碼 |
| Bank of America Corp | 48,460 | $43.6 萬 | 0.00% | −37,924−43.9% | 減碼 |
| Swiss National Bank | 48,100 | $43.3 萬 | 0.00% | +21,500+80.8% | 加碼 |
| Squarepoint Ops LLC | 44,626 | $40.2 萬 | 0.00% | +44,626 | 新進 |
| Alps Advisors Inc | 43,992 | $39.6 萬 | 0.00% | −384−0.9% | 減碼 |
| State of Wisconsin Investment Board | 41,671 | $37.5 萬 | 0.00% | +41,671 | 新進 |
| Rhumbline Advisers | 41,203 | $37.1 萬 | 0.00% | −320−0.8% | 減碼 |
| Invesco Ltd. | 40,510 | $36.5 萬 | 0.00% | −122,676−75.2% | 減碼 |
| California State Teachers Retirement System | 39,661 | $35.7 萬 | 0.00% | +25,009+170.7% | 加碼 |
| Gsa Capital Partners LLP | 39,232 | $35.3 萬 | 0.02% | +39,232 | 新進 |
| Stonepine Capital Management, LLC | 35,000 | $31.5 萬 | 0.28% | +35,000 | 新進 |
| ADAR1 Capital Management, LLC | 35,000 | $31.5 萬 | 0.02% | +35,000 | 新進 |
| Aquatic Capital Management LLC | 31,484 | $28.3 萬 | 0.01% | +31,484 | 新進 |
| Bleakley Financial Group, LLC | 28,864 | $26.0 萬 | 0.00% | +28,864 | 新進 |
| Axq Capital, LP | 27,503 | $24.8 萬 | 0.03% | +27,503 | 新進 |
| Mariner, LLC | 27,314 | $24.6 萬 | 0.00% | +15,484+130.9% | 加碼 |
| Price T Rowe Associates Inc | 26,434 | $23.8 萬 | 0.00% | +6,798+34.6% | 加碼 |
| Tudor Investment Corp Et Al | 26,412 | $23.8 萬 | 0.00% | +26,412 | 新進 |
| Martingale Asset Management L P | 26,223 | $23.6 萬 | 0.01% | +26,223 | 新進 |
| Victory Capital Management Inc | 25,866 | $23.3 萬 | 0.00% | +25,866 | 新進 |
| Barclays PLC | 24,720 | $22.2 萬 | 0.00% | −499,779−95.3% | 減碼 |
| DnB Asset Management AS | 23,515 | $21.2 萬 | 0.00% | +10,722+83.8% | 加碼 |
| Entropy Technologies, LP | 23,336 | $21.0 萬 | 0.01% | +23,336 | 新進 |
| Diadema Partners LP | 21,609 | $19.4 萬 | 0.08% | +1,109+5.4% | 加碼 |
| Man Group plc | 21,154 | $19.0 萬 | 0.00% | +21,154 | 新進 |
| Nisa Investment Advisors, LLC | 19,558 | $17.6 萬 | 0.00% | +19,158+4,789.5% | 加碼 |
| MetLife Investment Management | 19,380 | $17.4 萬 | 0.00% | −298−1.5% | 減碼 |
| Wells Fargo & Company | 18,402 | $16.6 萬 | 0.00% | −18,392−50.0% | 減碼 |
| Susquehanna International Group, LLP | 15,961 | $14.4 萬 | 0.00% | −39,880−71.4% | 減碼 |
| Mirae Asset Global ETFs Holdings Ltd. | 15,608 | $14.0 萬 | 0.00% | −1,883−10.8% | 減碼 |
| Manufacturers Life Insurance Company, The | 15,338 | $13.8 萬 | 0.00% | +5,191+51.2% | 加碼 |
| Franklin Resources Inc | 14,589 | $13.1 萬 | 0.00% | +14,589 | 新進 |
| Vanguard Global Advisers, LLC | 13,059 | $11.8 萬 | 0.00% | +13,059 | 新進 |
| CI Private Wealth, LLC | 12,157 | $10.9 萬 | 0.00% | +12,157 | 新進 |
| Creative Planning | 10,850 | $9.77 萬 | 0.00% | −899−7.7% | 減碼 |
| Virtus Investment Advisers, Inc. | 10,046 | $9.04 萬 | 0.02% | +245+2.5% | 加碼 |
| Shay Capital LLC | 10,000 | $9.00 萬 | 0.01% | +10,000 | 新進 |
| STRS Ohio | 9,800 | $8.82 萬 | 0.00% | 00.0% | 不變 |
| Legal & General Group Plc | 9,609 | $8.65 萬 | 0.00% | −4,100−29.9% | 減碼 |
| China Universal Asset Management Co., Ltd. | 9,590 | $8.63 萬 | 0.01% | +784+8.9% | 加碼 |
| Police & Firemen's Retirement System of New Jersey | 9,456 | $8.51 萬 | 0.00% | 00.0% | 不變 |
| Vanguard Asset Management, Ltd | 9,250 | $8.32 萬 | 0.00% | +9,250 | 新進 |
| KLP Kapitalforvaltning AS | 5,900 | $5.31 萬 | 0.00% | +3,000+103.4% | 加碼 |
| Persistent Asset Partners Ltd | 5,495 | $4.95 萬 | 0.02% | −3,412−38.3% | 減碼 |