Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Upstream Bio, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 148
- +9 vs. Q1 2026
- Shares held
- 50.6M
- +5.69M (+12.7%) vs. Q1 2026
- Total value
- $350.1M
- −$54.4M (−13.4%) vs. Q1 2026
- New holders
- 37
- 65 more added
- Sold out
- 28
- 28 more reduced
1 institution that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting UPB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 148 | $350.1M |
| Q1 2026 | 140 | $404.5M |
| Q4 2025 | 133 | $1.39B |
| Q3 2025 | 95 | $836.9M |
| Q2 2025 | 83 | $531.0M |
| Q1 2025 | 79 | $266.9M |
| Q4 2024 | 70 | $690.1M |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Upstream Bio, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 8,162,897 | $56.5M | 0.00% | +61,334+0.8% | Added |
| OrbiMed Advisors LLC | 5,693,589 | $39.4M | 0.75% | 00.0% | Unchanged |
| Norges Bank | 3,768,619 | $26.1M | 0.00% | +3,768,619 | New |
| BlackRock, Inc. | 3,753,358 | $26.0M | 0.00% | +382,669+11.4% | Added |
| Decheng Capital LLC | 2,724,868 | $18.9M | 2.58% | 00.0% | Unchanged |
| Enavate Sciences GP, LLC | 2,459,703 | $17.0M | 4.93% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 1,876,734 | $13.0M | 0.00% | +3,160+0.2% | Added |
| Millennium Management LLC | 1,143,775 | $7.91M | 0.01% | +206,452+22.0% | Added |
| D. E. Shaw & Co., Inc. | 1,036,044 | $7.17M | 0.00% | +215,564+26.3% | Added |
| JPMorgan Chase & Co | 1,012,044 | $7.01M | 0.00% | +549,043+118.6% | Added |
| Qube Research & Technologies Ltd | 978,500 | $6.77M | 0.01% | +359,179+58.0% | Added |
| Parkman Healthcare Partners LLC | 935,247 | $6.47M | 0.66% | +148,464+18.9% | Added |
| Geode Capital Management, LLC | 931,261 | $6.45M | 0.00% | −19,356−2.0% | Reduced |
| SEB Asset Management AB | 878,473 | $6.08M | 0.02% | 00.0% | Unchanged |
| Woodline Partners LP | 831,481 | $5.75M | 0.02% | 00.0% | Unchanged |
| State Street Corp | 766,323 | $5.30M | 0.00% | +60,973+8.6% | Added |
| Vanguard Portfolio Management LLC | 712,667 | $4.93M | 0.00% | −15,044−2.1% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 693,555 | $4.80M | 0.09% | −307,076−30.7% | Reduced |
| Bain Capital Life Sciences Investors, LLC | 600,949 | $4.16M | 0.25% | −266,262−30.7% | Reduced |
| AQR Capital Management LLC | 544,869 | $3.77M | 0.00% | +472,698+655.0% | Added |
| Morgan Stanley | 524,632 | $3.63M | 0.00% | −27,977−5.1% | Reduced |
| BNP Paribas Arbitrage, SA | 511,546 | $3.54M | 0.00% | +385,546+306.0% | Added |
| Walleye Capital LLC | 498,490 | $3.45M | 0.02% | +498,490 | New |
| Trexquant Investment LP | 466,430 | $3.23M | 0.02% | +289,773+164.0% | Added |
| Point72 Asset Management, L.P. | 453,011 | $3.13M | 0.00% | +274,843+154.3% | Added |
| Bank of America Corp | 391,762 | $2.71M | 0.00% | +343,302+708.4% | Added |
| Dimensional Fund Advisors LP | 381,613 | $2.64M | 0.00% | +301,611+377.0% | Added |
| Altshuler Shaham Ltd | 380,061 | $2.63M | 0.03% | 00.0% | Unchanged |
| Arrowstreet Capital, Limited Partnership | 357,756 | $2.48M | 0.00% | +172,669+93.3% | Added |
| Samsara BioCapital, LLC | 353,717 | $2.45M | 0.20% | −382,330−51.9% | Reduced |
| Propel Bio Management, LLC | 350,389 | $2.42M | 1.27% | +8,610+2.5% | Added |
| Wellington Management Group LLP | 342,353 | $2.37M | 0.00% | 00.0% | Unchanged |
| Northern Trust Corp | 297,346 | $2.06M | 0.00% | +36,354+13.9% | Added |
| Squarepoint Ops LLC | 290,904 | $2.01M | 0.00% | +246,278+551.9% | Added |
| Voleon Capital Management LP | 285,234 | $1.97M | 0.04% | +285,234 | New |
| Charles Schwab Investment Management Inc | 262,456 | $1.82M | 0.00% | +4,727+1.8% | Added |
| Jacobs Levy Equity Management, Inc | 253,092 | $1.75M | 0.01% | +253,092 | New |
| Goldman Sachs Group Inc | 246,917 | $1.71M | 0.00% | −69,670−22.0% | Reduced |
| XTX Topco Ltd | 242,346 | $1.68M | 0.02% | +33,069+15.8% | Added |
| Deutsche Bank AG | 241,447 | $1.67M | 0.00% | +60,558+33.5% | Added |
| Vanguard Fiduciary Trust Co | 239,616 | $1.66M | 0.00% | +15,459+6.9% | Added |
| UBS Group AG | 234,714 | $1.62M | 0.00% | +3,460+1.5% | Added |
| Schonfeld Strategic Advisors LLC | 225,760 | $1.56M | 0.01% | +64,411+39.9% | Added |
| Jump Financial, LLC | 223,223 | $1.54M | 0.01% | −96,177−30.1% | Reduced |
| Sphera Funds Management Ltd. | 219,700 | $1.52M | 0.22% | −138,300−38.6% | Reduced |
| Acadian Asset Management LLC | 175,110 | $1.21M | 0.00% | +175,110 | New |
| HRT Financial LP | 170,590 | $1.18M | 0.00% | +170,590 | New |
| Boxer Capital Management, LLC | 150,000 | $1.04M | 0.08% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 131,300 | $908.6K | 0.00% | +69,200+111.4% | Added |
| EntryPoint Capital, LLC | 129,446 | $895.8K | 0.22% | +55,878+76.0% | Added |
| Algert Global LLC | 118,630 | $820.9K | 0.01% | +118,630 | New |
| Bank of New York Mellon Corp | 85,747 | $593.4K | 0.00% | +4,364+5.4% | Added |
| Nuveen, LLC | 84,770 | $586.6K | 0.00% | +9,234+12.2% | Added |
| American Century Companies Inc | 78,194 | $541.1K | 0.00% | −9,430−10.8% | Reduced |
| Man Group plc | 73,823 | $510.9K | 0.00% | +52,669+249.0% | Added |
| Gsa Capital Partners LLP | 69,348 | $480.0K | 0.03% | +30,116+76.8% | Added |
| Alliancebernstein L.P. | 51,680 | $465.1K | 0.00% | +20,670+66.7% | Added |
| Simplify Asset Management Inc. | 62,113 | $429.8K | 0.01% | −15,680−20.2% | Reduced |
| Alps Advisors Inc | 55,228 | $382.2K | 0.00% | +11,236+25.5% | Added |
| Quantinno Capital Management LP | 54,838 | $379.5K | 0.00% | +5,449+11.0% | Added |
| Virtus Investment Advisers, Inc. | 53,638 | $371.2K | 0.09% | +43,592+433.9% | Added |
| Invesco Ltd. | 53,397 | $369.5K | 0.00% | +12,887+31.8% | Added |
| Brevan Howard Capital Management LP | 50,369 | $348.6K | 0.00% | +50,369 | New |
| Swiss National Bank | 48,100 | $332.9K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 47,543 | $329.0K | 0.00% | +43,896+1,203.6% | Added |
| Allspring Global Investments Holdings, LLC | 43,182 | $298.8K | 0.00% | +43,182 | New |
| Rhumbline Advisers | 42,384 | $293.3K | 0.00% | +1,181+2.9% | Added |
| Two Sigma Investments, LP | 42,325 | $292.9K | 0.00% | +42,325 | New |
| ExodusPoint Capital Management, LP | 41,045 | $284.0K | 0.00% | −50,386−55.1% | Reduced |
| Citigroup Inc | 40,339 | $279.1K | 0.00% | +35,284+698.0% | Added |
| California State Teachers Retirement System | 38,634 | $267.3K | 0.00% | −1,027−2.6% | Reduced |
| Stonepine Capital Management, LLC | 33,432 | $231.3K | 0.18% | −1,568−4.5% | Reduced |
| Mariner, LLC | 33,141 | $229.3K | 0.00% | +5,827+21.3% | Added |
| Wells Fargo & Company | 29,497 | $204.1K | 0.00% | +11,095+60.3% | Added |
| Barclays PLC | 29,208 | $202.1K | 0.00% | +4,488+18.2% | Added |
| Creative Planning | 28,483 | $197.1K | 0.00% | +17,633+162.5% | Added |
| Price T Rowe Associates Inc | 28,058 | $195.0K | 0.00% | +1,624+6.1% | Added |
| Quantbot Technologies LP | 28,178 | $195.0K | 0.01% | +27,515+4,150.1% | Added |
| Axq Capital, LP | 27,068 | $187.3K | 0.02% | −435−1.6% | Reduced |
| nVerses Capital, LLC | 24,029 | $166.3K | 0.26% | +24,029 | New |
| DnB Asset Management AS | 23,600 | $163.3K | 0.00% | +85+0.4% | Added |
| Vanguard Asset Management, Ltd | 22,724 | $157.3K | 0.00% | +13,474+145.7% | Added |
| Graham Capital Management, L.P. | 22,508 | $155.8K | 0.00% | +22,508 | New |
| Los Angeles Capital Management LLC | 22,385 | $154.9K | 0.00% | +22,385 | New |
| Verdad Advisers, LP | 21,810 | $150.9K | 0.14% | +21,810 | New |
| MetLife Investment Management | 20,852 | $144.3K | 0.00% | +1,472+7.6% | Added |
| SG Americas Securities, LLC | 20,338 | $141.0K | 0.00% | +20,338 | New |
| SEI Investments Co | 20,026 | $138.6K | 0.00% | +20,026 | New |
| Winton Group Ltd | 19,800 | $137.0K | 0.00% | +19,800 | New |
| Ieq Capital, LLC | 19,535 | $135.2K | 0.00% | +19,535 | New |
| Diadema Partners LP | 19,093 | $132.1K | 0.05% | −2,516−11.6% | Reduced |
| Shay Capital LLC | 18,000 | $124.6K | 0.01% | +8,000+80.0% | Added |
| Quadrature Capital Ltd | 17,988 | $124.5K | 0.00% | +17,988 | New |
| Entropy Technologies, LP | 17,542 | $121.4K | 0.00% | −5,794−24.8% | Reduced |
| State of Wisconsin Investment Board | 17,065 | $118.1K | 0.00% | −24,606−59.0% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 16,217 | $112.2K | 0.00% | +609+3.9% | Added |
| Manufacturers Life Insurance Company, The | 15,735 | $108.9K | 0.00% | +397+2.6% | Added |
| Jane Street Group, LLC | 15,594 | $107.9K | 0.00% | +15,594 | New |
| Mercer Global Advisors Inc | 13,352 | $92.4K | 0.00% | +13,352 | New |
| Vanguard Global Advisers, LLC | 13,059 | $90.4K | 0.00% | 00.0% | Unchanged |