Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Upstream Bio, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 148
- +9 vs. Q1 2026
- Shares held
- 50.6M
- +5.69M (+12.7%) vs. Q1 2026
- Total value
- $350.1M
- −$54.4M (−13.4%) vs. Q1 2026
- New holders
- 37
- 65 more added
- Sold out
- 28
- 28 more reduced
1 institution that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting UPB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 148 | $350.1M |
| Q1 2026 | 140 | $404.5M |
| Q4 2025 | 133 | $1.39B |
| Q3 2025 | 95 | $836.3M |
| Q2 2025 | 83 | $530.9M |
| Q1 2025 | 79 | $266.9M |
| Q4 2024 | 70 | $690.1M |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Upstream Bio, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Legal & General Group Plc | 12,561 | $86.9K | 0.00% | +2,952+30.7% | Added |
| Engineers Gate Manager LP | 12,491 | $86.4K | 0.00% | +12,491 | New |
| STRS Ohio | 12,000 | $83.0K | 0.00% | +2,200+22.4% | Added |
| Canada Pension Plan Investment Board | 11,500 | $79.6K | 0.00% | +11,500 | New |
| HSBC Holdings PLC | 10,793 | $77.6K | 0.00% | −629,533−98.3% | Reduced |
| Wealth Enhancement Advisory Services, LLC | 10,017 | $75.4K | 0.00% | +10,017 | New |
| Prelude Capital Management, LLC | 10,550 | $73.0K | 0.01% | +10,550 | New |
| Ameriprise Financial Inc | 10,487 | $72.6K | 0.00% | +10,487 | New |
| Police & Firemen's Retirement System of New Jersey | 9,456 | $65.4K | 0.00% | 00.0% | Unchanged |
| China Universal Asset Management Co., Ltd. | 8,661 | $59.9K | 0.00% | −929−9.7% | Reduced |
| KLP Kapitalforvaltning AS | 5,900 | $40.8K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 5,200 | $36.0K | 0.00% | +5,100+5,100.0% | Added |
| Persistent Asset Partners Ltd | 4,855 | $33.6K | 0.01% | −640−11.6% | Reduced |
| Tower Research Capital LLC (TRC) | 4,788 | $33.1K | 0.00% | +3,363+236.0% | Added |
| Public Employees Retirement System of Ohio | 4,700 | $32.5K | 0.00% | +4,700 | New |
| Nisa Investment Advisors, LLC | 4,278 | $29.6K | 0.00% | −15,280−78.1% | Reduced |
| Vanguard Investments Australia, Ltd. | 4,096 | $28.3K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 2,741 | $19.0K | 0.00% | 00.0% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. | 2,434 | $16.8K | 0.00% | −385−13.7% | Reduced |
| Global Retirement Partners, LLC | 1,870 | $12.9K | 0.00% | +1,870 | New |
| SRS Capital Advisors, Inc. | 1,771 | $12.3K | 0.00% | +1,694+2,200.0% | Added |
| GAMMA Investing LLC | 1,164 | $8.05K | 0.00% | +449+62.8% | Added |
| GF Fund Management Co. Ltd. | 1,145 | $7.92K | 0.00% | −58−4.8% | Reduced |
| Royal Bank of Canada | 1,091 | $7.00K | 0.00% | +1,091 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 965 | $6.68K | 0.00% | +488+102.3% | Added |
| Quarry LP | 893 | $6.18K | 0.00% | +893 | New |
| Allworth Financial LP | 778 | $5.38K | 0.00% | +515+195.8% | Added |
| Rockefeller Capital Management L.P. | 738 | $5.11K | 0.00% | 00.0% | Unchanged |
| Sterling Capital Management LLC | 710 | $4.91K | 0.00% | −384−35.1% | Reduced |
| UBS Asset Management Americas Inc | 588 | $4.07K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 387 | $2.68K | 0.00% | +387 | New |
| Farther Finance Advisors, LLC | 353 | $2.44K | 0.00% | +272+335.8% | Added |
| Rothschild Investment LLC | 287 | $1.99K | 0.00% | +226+370.5% | Added |
| EverSource Wealth Advisors, LLC | 272 | $1.88K | 0.00% | +50+22.5% | Added |
| US Bancorp | 264 | $1.83K | 0.00% | −326−55.3% | Reduced |
| IFP Advisors, Inc | 242 | $1.68K | 0.00% | +241+24,100.0% | Added |
| UMA Financial Services, Inc. | 160 | $1.11K | 0.00% | +160 | New |
| Essential Partners LLC | 146 | $1.01K | 0.00% | −256−63.7% | Reduced |
| N.E.W. Advisory Services LLC | 120 | $830 | 0.00% | 00.0% | Unchanged |
| SJS Investment Consulting Inc. | 76 | $526 | 0.00% | +74+3,700.0% | Added |
| Silver Grove Financial Group, Inc. | 28 | $194 | 0.00% | +28 | New |
| Simplex Trading, LLC | 20 | $138 | 0.00% | +20 | New |
| Advisor Group Holdings, Inc. | 19 | $131 | 0.00% | −370−95.1% | Reduced |
| Clearstead Advisors, LLC | 15 | $105 | 0.00% | +15 | New |
| JPL Wealth Management, LLC | 14 | $97 | 0.00% | +14 | New |
| Freestone Grove Partners LP | 1 | $7 | 0.00% | 00.0% | Unchanged |
| National Bank of Canada | 1 | $7 | 0.00% | +1 | New |
| Covestor Ltd | 39 | $0 | 0.00% | +35+875.0% | Added |
| Federated Hermes, Inc. | 0 | $0 | 0.00% | −979,758−100.0% | Sold out |
| Pictet Asset Management Holding SA | 0 | $0 | 0.00% | −733,431−100.0% | Sold out |
| Nantahala Capital Management, LLC | 0 | $0 | 0.00% | −400,000−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −298,329−100.0% | Sold out |
| Prosight Management, LP | 0 | $0 | 0.00% | −241,123−100.0% | Sold out |
| TCG Crossover Management, LLC | 0 | $0 | 0.00% | −181,063−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −66,770−100.0% | Sold out |
| ADAR1 Capital Management, LLC | 0 | $0 | 0.00% | −35,000−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −31,484−100.0% | Sold out |
| Bleakley Financial Group, LLC | 0 | $0 | 0.00% | −28,864−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −26,412−100.0% | Sold out |
| Martingale Asset Management L P | 0 | $0 | 0.00% | −26,223−100.0% | Sold out |
| Victory Capital Management Inc | 0 | $0 | 0.00% | −25,866−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −15,961−100.0% | Sold out |
| Franklin Resources Inc | 0 | $0 | 0.00% | −14,589−100.0% | Sold out |
| CI Private Wealth, LLC | 0 | $0 | 0.00% | −12,157−100.0% | Sold out |
| Wellington Grp LLC | 0 | $0 | 0.00% | −3,000−100.0% | Sold out |
| Larson Financial Group LLC | 0 | $0 | 0.00% | −1,107−100.0% | Sold out |
| Versant Capital Management, Inc | 0 | $0 | 0.00% | −762−100.0% | Sold out |
| MAI Capital Management | 0 | $0 | 0.00% | −171−100.0% | Sold out |
| Torren Management, LLC | 0 | $0 | 0.00% | −162−100.0% | Sold out |
| Natixis | 0 | $0 | 0.00% | −120−100.0% | Sold out |
| Wealth Preservation Advisors, LLC | 0 | $0 | 0.00% | −86−100.0% | Sold out |
| Signaturefd, LLC | 0 | $0 | 0.00% | −66−100.0% | Sold out |
| Ameritas Advisory Services, LLC | 0 | $0 | 0.00% | −31−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −23−100.0% | Sold out |
| Root Financial Partners, LLC | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| Parallel Advisors, LLC | 0 | $0 | 0.00% | −2−100.0% | Sold out |
| CWM, LLC | – | – | – | – | Not filed |