Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Upstream Bio, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 95
- +13 vs. Q2 2025
- Shares held
- 44.5M
- −2.92M (−6.2%) vs. Q2 2025
- Total value
- $836.3M
- +$316.1M (+60.7%) vs. Q2 2025
- New holders
- 22
- 38 more added
- Sold out
- 9
- 22 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting UPB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 148 | $350.1M |
| Q1 2026 | 140 | $404.5M |
| Q4 2025 | 133 | $1.39B |
| Q3 2025 | 95 | $836.3M |
| Q2 2025 | 83 | $530.9M |
| Q1 2025 | 79 | $266.9M |
| Q4 2024 | 70 | $690.1M |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Upstream Bio, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| FMR LLC | 8,086,413 | $152.1M | 0.01% | +149,533+1.9% | Added |
| OrbiMed Advisors LLC | 5,693,589 | $107.1M | 2.57% | 00.0% | Unchanged |
| Decheng Capital LLC | 3,285,293 | $61.8M | 10.78% | 00.0% | Unchanged |
| BlackRock, Inc. | 2,603,706 | $49.0M | 0.00% | +507,200+24.2% | Added |
| Enavate Sciences GP, LLC | 2,459,703 | $46.3M | 14.13% | 00.0% | Unchanged |
| Vanguard Group Inc | 2,442,551 | $45.9M | 0.00% | +271,718+12.5% | Added |
| Bain Capital Life Sciences Investors, LLC | 2,439,538 | $45.9M | 3.05% | 00.0% | Unchanged |
| TCG Crossover Management, LLC | 2,117,103 | $39.8M | 1.96% | −684,660−24.4% | Reduced |
| Altshuler Shaham Ltd | 1,416,822 | $26.7M | 0.44% | −1,977,619−58.3% | Reduced |
| Omega Fund Management, LLC | 1,356,293 | $25.5M | 11.47% | −680,000−33.4% | Reduced |
| VR Adviser, LLC | 1,169,298 | $22.0M | 1.24% | −1,126,021−49.1% | Reduced |
| Wellington Management Group LLP | 1,125,395 | $21.2M | 0.00% | −99,900−8.2% | Reduced |
| State Street Corp | 1,114,581 | $21.0M | 0.00% | +633,206+131.5% | Added |
| Samsara BioCapital, LLC | 962,154 | $18.1M | 2.36% | −481,077−33.3% | Reduced |
| Marshall Wace, LLP | 867,999 | $16.3M | 0.02% | +577,473+198.8% | Added |
| Parkman Healthcare Partners LLC | 843,502 | $15.9M | 1.74% | +127,998+17.9% | Added |
| Geode Capital Management, LLC | 817,109 | $15.4M | 0.00% | +170,474+26.4% | Added |
| Siren, L.L.C. | 788,450 | $14.8M | 0.58% | 00.0% | Unchanged |
| Woodline Partners LP | 602,252 | $11.3M | 0.05% | +44,000+7.9% | Added |
| Nantahala Capital Management, LLC | 594,971 | $11.2M | 0.69% | 00.0% | Unchanged |
| Integral Health Asset Management, LLC | 575,000 | $10.8M | 0.79% | +575,000 | New |
| Great Point Partners LLC | 300,000 | $5.64M | 2.36% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 284,828 | $5.36M | 0.00% | +106,575+59.8% | Added |
| UBS Group AG | 272,271 | $5.12M | 0.00% | +39,384+16.9% | Added |
| Northern Trust Corp | 254,719 | $4.79M | 0.00% | +25,416+11.1% | Added |
| Goldman Sachs Group Inc | 223,214 | $4.20M | 0.00% | +223,214 | New |
| Schonfeld Strategic Advisors LLC | 190,244 | $3.58M | 0.02% | −175,546−48.0% | Reduced |
| Ikarian Capital, LLC | 161,113 | $3.03M | 0.69% | +161,113 | New |
| SummitTX Capital, L.P. | 112,404 | $2.11M | 0.09% | +112,404 | New |
| Bank of New York Mellon Corp | 91,521 | $1.72M | 0.00% | +11,755+14.7% | Added |
| Morgan Stanley | 87,535 | $1.65M | 0.00% | −11,773−11.9% | Reduced |
| Barclays PLC | 85,315 | $1.60M | 0.00% | −11,675−12.0% | Reduced |
| Balyasny Asset Management LLC | 73,131 | $1.38M | 0.00% | +73,131 | New |
| American Century Companies Inc | 71,540 | $1.35M | 0.00% | +49,178+219.9% | Added |
| Nuveen, LLC | 69,882 | $1.31M | 0.00% | −4,054−5.5% | Reduced |
| Boothbay Fund Management, LLC | 61,299 | $1.15M | 0.03% | +61,299 | New |
| Bank of America Corp | 55,473 | $1.04M | 0.00% | +37,442+207.7% | Added |
| Exome Asset Management LLC | 51,960 | $977.4K | 0.65% | +51,960 | New |
| Rhumbline Advisers | 49,406 | $929.3K | 0.00% | +1,340+2.8% | Added |
| Verition Fund Management LLC | 47,001 | $884.1K | 0.01% | +13,496+40.3% | Added |
| Citigroup Inc | 42,037 | $790.7K | 0.00% | +30,342+259.4% | Added |
| Millennium Management LLC | 40,113 | $754.5K | 0.00% | +40,113 | New |
| Rafferty Asset Management, LLC | 34,521 | $649.3K | 0.00% | +34,521 | New |
| AQR Capital Management LLC | 29,954 | $563.4K | 0.00% | +202+0.7% | Added |
| JPMorgan Chase & Co | 29,947 | $563.3K | 0.00% | +13,478+81.8% | Added |
| Nomura Holdings Inc | 28,290 | $532.1K | 0.00% | +28,290 | New |
| Deutsche Bank AG | 26,737 | $502.9K | 0.00% | +3,334+14.2% | Added |
| Alps Advisors Inc | 25,962 | $488.3K | 0.00% | −3,014−10.4% | Reduced |
| Wells Fargo & Company | 25,160 | $473.3K | 0.00% | +2,796+12.5% | Added |
| MetLife Investment Management | 21,691 | $408.0K | 0.00% | 00.0% | Unchanged |
| Alliancebernstein L.P. | 19,850 | $373.4K | 0.00% | −4,710−19.2% | Reduced |
| Price T Rowe Associates Inc | 18,501 | $349.0K | 0.00% | +1,053+6.0% | Added |
| Caption Management, LLC | 18,196 | $342.3K | 0.02% | +18,196 | New |
| Invesco Ltd. | 17,190 | $323.3K | 0.00% | +890+5.5% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 16,863 | $314.6K | 0.00% | −2,221−11.6% | Reduced |
| Prelude Capital Management, LLC | 15,735 | $296.0K | 0.02% | +15,735 | New |
| Commonwealth Equity Services, LLC | 15,503 | $292.0K | 0.00% | −23−0.1% | Reduced |
| Quantinno Capital Management LP | 14,889 | $280.1K | 0.00% | +4,275+40.3% | Added |
| Creative Planning | 14,266 | $268.3K | 0.00% | +236+1.7% | Added |
| Manufacturers Life Insurance Company, The | 12,092 | $227.5K | 0.00% | −1,098−8.3% | Reduced |
| Mariner, LLC | 10,933 | $205.7K | 0.00% | +10,933 | New |
| Two Sigma Investments, LP | 10,500 | $197.5K | 0.00% | +10,500 | New |
| Intech Investment Management LLC | 10,396 | $195.5K | 0.00% | −10,894−51.2% | Reduced |
| Virtus Investment Advisers, Inc. | 9,843 | $185.1K | 0.05% | +1,709+21.0% | Added |
| Police & Firemen's Retirement System of New Jersey | 9,447 | $177.7K | 0.00% | +1,614+20.6% | Added |
| BNP Paribas Arbitrage, SA | 6,527 | $122.8K | 0.00% | +3,430+110.8% | Added |
| New York State Common Retirement Fund | 6,300 | $118.5K | 0.00% | +1,600+34.0% | Added |
| CWM, LLC | 3,341 | $63.0K | 0.00% | +29+0.9% | Added |
| Russell Investments Group, Ltd. | 3,034 | $57.1K | 0.00% | +2,887+1,963.9% | Added |
| Legal & General Group Plc | 2,924 | $55.0K | 0.00% | −250−7.9% | Reduced |
| Ameritas Investment Partners, Inc. | 2,741 | $51.6K | 0.00% | −817−23.0% | Reduced |
| Sterling Capital Management LLC | 2,264 | $42.6K | 0.00% | +1,323+140.6% | Added |
| California State Teachers Retirement System | 2,176 | $40.9K | 0.00% | +2+0.1% | Added |
| Tower Research Capital LLC (TRC) | 1,868 | $35.1K | 0.00% | −1,183−38.8% | Reduced |
| Group One Trading, L.P. | 1,305 | $24.5K | 0.00% | +1,305 | New |
| Aster Capital Management (DIFC) Ltd | 1,141 | $21.5K | 0.01% | +1,141 | New |
| GAMMA Investing LLC | 890 | $16.7K | 0.00% | +197+28.4% | Added |
| Royal Bank of Canada | 832 | $16.0K | 0.00% | −2,258−73.1% | Reduced |
| Amalgamated Bank | 594 | $11.0K | 0.00% | 00.0% | Unchanged |
| Versant Capital Management, Inc | 548 | $10.3K | 0.00% | −10−1.8% | Reduced |
| US Bancorp | 531 | $9.99K | 0.00% | −128−19.4% | Reduced |
| Global Retirement Partners, LLC | 332 | $6.25K | 0.00% | +332 | New |
| EverSource Wealth Advisors, LLC | 310 | $5.83K | 0.00% | +1+0.3% | Added |
| Clearstead Advisors, LLC | 163 | $3.07K | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 149 | $2.80K | 0.00% | +149 | New |
| The PNC Financial Services Group, Inc. | 130 | $2.45K | 0.00% | +130 | New |
| J.Safra Asset Management Corp | 128 | $2.41K | 0.00% | +128 | New |
| Essential Partners LLC | 97 | $1.82K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 96 | $1.81K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 67 | $1.26K | 0.00% | +1+1.5% | Added |
| N.E.W. Advisory Services LLC | 60 | $1.13K | 0.00% | +60 | New |
| Signaturefd, LLC | 51 | $959 | 0.00% | +2+4.1% | Added |
| Sunbelt Securities, Inc. | 19 | $357 | 0.00% | +19 | New |
| Parallel Advisors, LLC | 2 | $38 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 2 | $38 | 0.00% | +1+100.0% | Added |
| Deep Track Capital, LP | 0 | $0 | 0.00% | −1,442,767−100.0% | Sold out |
| Lynx1 Capital Management LP | 0 | $0 | 0.00% | −219,247−100.0% | Sold out |
| Velan Capital Investment Management LP | 0 | $0 | 0.00% | −107,000−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −85,000−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −42,263−100.0% | Sold out |