Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Upstream Bio, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 95
- +13 vs. Q2 2025
- Shares held
- 44.5M
- −2.92M (−6.2%) vs. Q2 2025
- Total value
- $836.3M
- +$316.1M (+60.7%) vs. Q2 2025
- New holders
- 22
- 38 more added
- Sold out
- 9
- 22 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting UPB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 148 | $350.1M |
| Q1 2026 | 140 | $404.5M |
| Q4 2025 | 133 | $1.39B |
| Q3 2025 | 95 | $836.3M |
| Q2 2025 | 83 | $530.9M |
| Q1 2025 | 79 | $266.9M |
| Q4 2024 | 70 | $690.1M |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Upstream Bio, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Parallel Advisors, LLC | 2 | $38 | 0.00% | 00.0% | Unchanged |
| IFP Advisors, Inc | 2 | $38 | 0.00% | +1+100.0% | Added |
| Sunbelt Securities, Inc. | 19 | $357 | 0.00% | +19 | New |
| Signaturefd, LLC | 51 | $959 | 0.00% | +2+4.1% | Added |
| N.E.W. Advisory Services LLC | 60 | $1.13K | 0.00% | +60 | New |
| Allworth Financial LP | 67 | $1.26K | 0.00% | +1+1.5% | Added |
| Nisa Investment Advisors, LLC | 96 | $1.81K | 0.00% | 00.0% | Unchanged |
| Essential Partners LLC | 97 | $1.82K | 0.00% | 00.0% | Unchanged |
| J.Safra Asset Management Corp | 128 | $2.41K | 0.00% | +128 | New |
| The PNC Financial Services Group, Inc. | 130 | $2.45K | 0.00% | +130 | New |
| SRS Capital Advisors, Inc. | 149 | $2.80K | 0.00% | +149 | New |
| Clearstead Advisors, LLC | 163 | $3.07K | 0.00% | 00.0% | Unchanged |
| EverSource Wealth Advisors, LLC | 310 | $5.83K | 0.00% | +1+0.3% | Added |
| Global Retirement Partners, LLC | 332 | $6.25K | 0.00% | +332 | New |
| US Bancorp | 531 | $9.99K | 0.00% | −128−19.4% | Reduced |
| Versant Capital Management, Inc | 548 | $10.3K | 0.00% | −10−1.8% | Reduced |
| Amalgamated Bank | 594 | $11.0K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 832 | $16.0K | 0.00% | −2,258−73.1% | Reduced |
| GAMMA Investing LLC | 890 | $16.7K | 0.00% | +197+28.4% | Added |
| Aster Capital Management (DIFC) Ltd | 1,141 | $21.5K | 0.01% | +1,141 | New |
| Group One Trading, L.P. | 1,305 | $24.5K | 0.00% | +1,305 | New |
| Tower Research Capital LLC (TRC) | 1,868 | $35.1K | 0.00% | −1,183−38.8% | Reduced |
| California State Teachers Retirement System | 2,176 | $40.9K | 0.00% | +2+0.1% | Added |
| Sterling Capital Management LLC | 2,264 | $42.6K | 0.00% | +1,323+140.6% | Added |
| Ameritas Investment Partners, Inc. | 2,741 | $51.6K | 0.00% | −817−23.0% | Reduced |
| Legal & General Group Plc | 2,924 | $55.0K | 0.00% | −250−7.9% | Reduced |
| Russell Investments Group, Ltd. | 3,034 | $57.1K | 0.00% | +2,887+1,963.9% | Added |
| CWM, LLC | 3,341 | $63.0K | 0.00% | +29+0.9% | Added |
| New York State Common Retirement Fund | 6,300 | $118.5K | 0.00% | +1,600+34.0% | Added |
| BNP Paribas Arbitrage, SA | 6,527 | $122.8K | 0.00% | +3,430+110.8% | Added |
| Police & Firemen's Retirement System of New Jersey | 9,447 | $177.7K | 0.00% | +1,614+20.6% | Added |
| Virtus Investment Advisers, Inc. | 9,843 | $185.1K | 0.05% | +1,709+21.0% | Added |
| Intech Investment Management LLC | 10,396 | $195.5K | 0.00% | −10,894−51.2% | Reduced |
| Two Sigma Investments, LP | 10,500 | $197.5K | 0.00% | +10,500 | New |
| Mariner, LLC | 10,933 | $205.7K | 0.00% | +10,933 | New |
| Manufacturers Life Insurance Company, The | 12,092 | $227.5K | 0.00% | −1,098−8.3% | Reduced |
| Creative Planning | 14,266 | $268.3K | 0.00% | +236+1.7% | Added |
| Quantinno Capital Management LP | 14,889 | $280.1K | 0.00% | +4,275+40.3% | Added |
| Commonwealth Equity Services, LLC | 15,503 | $292.0K | 0.00% | −23−0.1% | Reduced |
| Prelude Capital Management, LLC | 15,735 | $296.0K | 0.02% | +15,735 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 16,863 | $314.6K | 0.00% | −2,221−11.6% | Reduced |
| Invesco Ltd. | 17,190 | $323.3K | 0.00% | +890+5.5% | Added |
| Caption Management, LLC | 18,196 | $342.3K | 0.02% | +18,196 | New |
| Price T Rowe Associates Inc | 18,501 | $349.0K | 0.00% | +1,053+6.0% | Added |
| Alliancebernstein L.P. | 19,850 | $373.4K | 0.00% | −4,710−19.2% | Reduced |
| MetLife Investment Management | 21,691 | $408.0K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 25,160 | $473.3K | 0.00% | +2,796+12.5% | Added |
| Alps Advisors Inc | 25,962 | $488.3K | 0.00% | −3,014−10.4% | Reduced |
| Deutsche Bank AG | 26,737 | $502.9K | 0.00% | +3,334+14.2% | Added |
| Nomura Holdings Inc | 28,290 | $532.1K | 0.00% | +28,290 | New |
| JPMorgan Chase & Co | 29,947 | $563.3K | 0.00% | +13,478+81.8% | Added |
| AQR Capital Management LLC | 29,954 | $563.4K | 0.00% | +202+0.7% | Added |
| Rafferty Asset Management, LLC | 34,521 | $649.3K | 0.00% | +34,521 | New |
| Millennium Management LLC | 40,113 | $754.5K | 0.00% | +40,113 | New |
| Citigroup Inc | 42,037 | $790.7K | 0.00% | +30,342+259.4% | Added |
| Verition Fund Management LLC | 47,001 | $884.1K | 0.01% | +13,496+40.3% | Added |
| Rhumbline Advisers | 49,406 | $929.3K | 0.00% | +1,340+2.8% | Added |
| Exome Asset Management LLC | 51,960 | $977.4K | 0.65% | +51,960 | New |
| Bank of America Corp | 55,473 | $1.04M | 0.00% | +37,442+207.7% | Added |
| Boothbay Fund Management, LLC | 61,299 | $1.15M | 0.03% | +61,299 | New |
| Nuveen, LLC | 69,882 | $1.31M | 0.00% | −4,054−5.5% | Reduced |
| American Century Companies Inc | 71,540 | $1.35M | 0.00% | +49,178+219.9% | Added |
| Balyasny Asset Management LLC | 73,131 | $1.38M | 0.00% | +73,131 | New |
| Barclays PLC | 85,315 | $1.60M | 0.00% | −11,675−12.0% | Reduced |
| Morgan Stanley | 87,535 | $1.65M | 0.00% | −11,773−11.9% | Reduced |
| Bank of New York Mellon Corp | 91,521 | $1.72M | 0.00% | +11,755+14.7% | Added |
| SummitTX Capital, L.P. | 112,404 | $2.11M | 0.09% | +112,404 | New |
| Ikarian Capital, LLC | 161,113 | $3.03M | 0.69% | +161,113 | New |
| Schonfeld Strategic Advisors LLC | 190,244 | $3.58M | 0.02% | −175,546−48.0% | Reduced |
| Goldman Sachs Group Inc | 223,214 | $4.20M | 0.00% | +223,214 | New |
| Northern Trust Corp | 254,719 | $4.79M | 0.00% | +25,416+11.1% | Added |
| UBS Group AG | 272,271 | $5.12M | 0.00% | +39,384+16.9% | Added |
| Charles Schwab Investment Management Inc | 284,828 | $5.36M | 0.00% | +106,575+59.8% | Added |
| Great Point Partners LLC | 300,000 | $5.64M | 2.36% | 00.0% | Unchanged |
| Integral Health Asset Management, LLC | 575,000 | $10.8M | 0.79% | +575,000 | New |
| Nantahala Capital Management, LLC | 594,971 | $11.2M | 0.69% | 00.0% | Unchanged |
| Woodline Partners LP | 602,252 | $11.3M | 0.05% | +44,000+7.9% | Added |
| Siren, L.L.C. | 788,450 | $14.8M | 0.58% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 817,109 | $15.4M | 0.00% | +170,474+26.4% | Added |
| Parkman Healthcare Partners LLC | 843,502 | $15.9M | 1.74% | +127,998+17.9% | Added |
| Marshall Wace, LLP | 867,999 | $16.3M | 0.02% | +577,473+198.8% | Added |
| Samsara BioCapital, LLC | 962,154 | $18.1M | 2.36% | −481,077−33.3% | Reduced |
| State Street Corp | 1,114,581 | $21.0M | 0.00% | +633,206+131.5% | Added |
| Wellington Management Group LLP | 1,125,395 | $21.2M | 0.00% | −99,900−8.2% | Reduced |
| VR Adviser, LLC | 1,169,298 | $22.0M | 1.24% | −1,126,021−49.1% | Reduced |
| Omega Fund Management, LLC | 1,356,293 | $25.5M | 11.47% | −680,000−33.4% | Reduced |
| Altshuler Shaham Ltd | 1,416,822 | $26.7M | 0.44% | −1,977,619−58.3% | Reduced |
| TCG Crossover Management, LLC | 2,117,103 | $39.8M | 1.96% | −684,660−24.4% | Reduced |
| Bain Capital Life Sciences Investors, LLC | 2,439,538 | $45.9M | 3.05% | 00.0% | Unchanged |
| Vanguard Group Inc | 2,442,551 | $45.9M | 0.00% | +271,718+12.5% | Added |
| Enavate Sciences GP, LLC | 2,459,703 | $46.3M | 14.13% | 00.0% | Unchanged |
| BlackRock, Inc. | 2,603,706 | $49.0M | 0.00% | +507,200+24.2% | Added |
| Decheng Capital LLC | 3,285,293 | $61.8M | 10.78% | 00.0% | Unchanged |
| OrbiMed Advisors LLC | 5,693,589 | $107.1M | 2.57% | 00.0% | Unchanged |
| FMR LLC | 8,086,413 | $152.1M | 0.01% | +149,533+1.9% | Added |
| Deep Track Capital, LP | 0 | $0 | 0.00% | −1,442,767−100.0% | Sold out |
| Lynx1 Capital Management LP | 0 | $0 | 0.00% | −219,247−100.0% | Sold out |
| Velan Capital Investment Management LP | 0 | $0 | 0.00% | −107,000−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −85,000−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −42,263−100.0% | Sold out |