Zymeworks Inc.
ZYME- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001937653
No open-market purchases or sales by Zymeworks Inc. insiders were filed in the last 90 days; 202 institutions reported holding it in 13F filings for Q2 2026, worth $1.79B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Zymeworks Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 210
- +28 vs. Q3 2025
- Shares held
- 71.5M
- −2.08M (−2.8%) vs. Q3 2025
- Total value
- $1.88B
- +$625.5M (+49.8%) vs. Q3 2025
- New holders
- 47
- 71 more added
- Sold out
- 19
- 62 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ZYME on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 202 | $1.79B |
| Q1 2026 | 212 | $1.76B |
| Q4 2025 | 210 | $1.88B |
| Q3 2025 | 184 | $1.26B |
| Q2 2025 | 182 | $949.0M |
| Q1 2025 | 186 | $840.9M |
| Q4 2024 | 174 | $973.2M |
| Q3 2024 | 163 | $834.7M |
| Q2 2024 | 164 | $580.6M |
| Q1 2024 | 171 | $713.0M |
| Q4 2023 | 157 | $674.0M |
| Q3 2023 | 140 | $395.5M |
| Q2 2023 | 137 | $547.9M |
| Q1 2023 | 116 | $512.6M |
| Q4 2022 | 96 | $449.9M |
| Q3 2022 | 91 | $293.7M |
| Q2 2022 | 114 | $253.3M |
| Q1 2022 | 120 | $327.3M |
| Q4 2021 | 114 | $693.9M |
| Q3 2021 | 123 | $1.07B |
| Q2 2021 | 109 | $1.20B |
| Q1 2021 | 125 | $1.12B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Zymeworks Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Deutsche Bank AG | 1,595,833 | $42.0M | 0.01% | +50,935+3.3% | Added |
| Siren, L.L.C. | 1,680,121 | $44.2M | 1.32% | +1,680,121 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,822,048 | $48.0M | 0.06% | +1,822,048 | New |
| Vanguard Group Inc | 2,328,727 | $61.3M | 0.00% | +174,293+8.1% | Added |
| Morgan Stanley | 2,593,080 | $68.3M | 0.00% | −1,391,505−34.9% | Reduced |
| Perceptive Advisors LLC | 3,261,850 | $85.9M | 1.57% | +1,171,187+56.0% | Added |
| BVF Inc | 3,938,641 | $103.7M | 3.49% | 00.0% | Unchanged |
| BlackRock, Inc. | 4,595,548 | $121.0M | 0.00% | +606,015+15.2% | Added |
| Rubric Capital Management LP | 5,750,000 | $151.4M | 1.81% | +1,039,449+22.1% | Added |
| EcoR1 Capital, LLC | 22,970,388 | $604.8M | 27.72% | 00.0% | Unchanged |
| Blackstone Group Inc. | 0 | $0 | 0.00% | −1,616,290−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −219,948−100.0% | Sold out |
| Samsara BioCapital, LLC | 0 | $0 | 0.00% | −207,901−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −154,858−100.0% | Sold out |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | $0 | 0.00% | −96,800−100.0% | Sold out |
| Tejara Capital Ltd | 0 | $0 | 0.00% | −85,163−100.0% | Sold out |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −72,787−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −56,318−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −37,167−100.0% | Sold out |
| Oxford Asset Management LLP | 0 | $0 | 0.00% | −36,359−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −32,757−100.0% | Sold out |
| DLD Asset Management, LP | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| PharVision Advisers, LLC | 0 | $0 | 0.00% | −17,790−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −16,145−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −12,225−100.0% | Sold out |
| TPG Financial Advisors, LLC | 0 | $0 | 0.00% | −10,017−100.0% | Sold out |
| Clearstead Advisors, LLC | 0 | $0 | 0.00% | −5,001−100.0% | Sold out |
| Clear Street Markets LLC | 0 | $0 | 0.00% | −472−100.0% | Sold out |
| Bessemer Group Inc | 0 | $0 | 0.00% | −73−100.0% | Sold out |
| AXA Investment Managers S.A. | – | – | – | – | Not filed |
| Shell Asset Management Co | – | – | – | – | Not filed |