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Vertex Pharmaceuticals Inc

VRTX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000875320

No open-market purchases or sales by Vertex Pharmaceuticals Inc insiders were filed in the last 90 days; 1,762 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Vertex Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
1,671
+174 vs. Q3 2025
Shares held
241.6M
+9.62M (+4.1%) vs. Q3 2025
Total value
$109.5B
+$18.8B (+20.7%) vs. Q3 2025
New holders
274
620 more added
Sold out
100
566 more reduced

26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 1,671 institutions
Q1 2021: 1,000 institutionsQ2 2021: 979 institutionsQ3 2021: 936 institutionsQ4 2021: 1,034 institutionsQ1 2022: 1,072 institutionsQ2 2022: 1,109 institutionsQ3 2022: 1,127 institutionsQ4 2022: 1,224 institutionsQ1 2023: 1,212 institutionsQ2 2023: 1,287 institutionsQ3 2023: 1,280 institutionsQ4 2023: 1,442 institutionsQ1 2024: 1,497 institutionsQ2 2024: 1,551 institutionsQ3 2024: 1,551 institutionsQ4 2024: 1,563 institutionsQ1 2025: 1,617 institutionsQ2 2025: 1,563 institutionsQ3 2025: 1,523 institutionsQ4 2025: 1,671 institutionsQ1 2026: 1,698 institutionsQ2 2026: 1,762 institutions
Value heldQ4 2025: $109.5B
Q1 2021: $50.6BQ2 2021: $46.8BQ3 2021: $41.9BQ4 2021: $50.4BQ1 2022: $60.9BQ2 2022: $66.1BQ3 2022: $68.5BQ4 2022: $68.3BQ1 2023: $75.0BQ2 2023: $83.3BQ3 2023: $81.9BQ4 2023: $95.7BQ1 2024: $98.0BQ2 2024: $109.9BQ3 2024: $109.1BQ4 2024: $95.2BQ1 2025: $116.3BQ2 2025: $107.2BQ3 2025: $90.8BQ4 2025: $109.5BQ1 2026: $106.1BQ2 2026: $119.7B
Institutions holding VRTX and their total value by quarter
QuarterHoldersValue
Q2 20261,762$119.7B
Q1 20261,698$106.1B
Q4 20251,671$109.5B
Q3 20251,523$90.8B
Q2 20251,563$107.2B
Q1 20251,617$116.3B
Q4 20241,563$95.2B
Q3 20241,551$109.1B
Q2 20241,551$109.9B
Q1 20241,497$98.0B
Q4 20231,442$95.7B
Q3 20231,280$81.9B
Q2 20231,287$83.3B
Q1 20231,212$75.0B
Q4 20221,224$68.3B
Q3 20221,127$68.5B
Q2 20221,109$66.1B
Q1 20221,072$60.9B
Q4 20211,034$50.4B
Q3 2021936$41.9B
Q2 2021979$46.8B
Q1 20211,000$50.6B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q3 2025.

Institutions holding VRTX in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Snowden Capital Advisors LLC3,918$1.78M0.05%+87+2.3%Added
Sound View Wealth Advisors Group, LLC3,870$1.75M0.12%+241+6.6%Added
CWA Asset Management Group, LLC3,789$1.72M0.06%+320+9.2%Added
Alaethes Wealth LLC3,787$1.72M0.48%−167−4.2%Reduced
Nilsine Partners, LLC3,781$1.71M0.15%+229+6.4%Added
Jump Financial, LLC3,762$1.71M0.02%−6,421−63.1%Reduced
Icon Wealth Advisors, LLC3,743$1.70M0.11%+176+4.9%Added
Lighthouse Financial LLC3,730$1.69M1.11%00.0%Unchanged
Roberts Glore & Co Inc3,690$1.67M0.45%−25−0.7%Reduced
Mattern Capital Management, LLC3,689$1.67M0.20%+377+11.4%Added
Dynamic Advisor Solutions LLC3,668$1.66M0.05%−110−2.9%Reduced
Founders Financial Securities LLC3,664$1.66M0.10%+722+24.5%Added
Quantitative Investment Management, LLC3,657$1.66M0.16%+1,985+118.7%Added
F&V Capital Management, LLC3,645$1.65M0.35%+3,645New
Advisory Resource Group3,619$1.64M0.29%+335+10.2%Added
Sagespring Wealth Partners, LLC3,587$1.63M0.03%+657+22.4%Added
Phoenix Holdings Ltd.3,533$1.60M0.02%−308−8.0%Reduced
Clearstead Advisors, LLC3,527$1.60M0.02%00.0%Unchanged
Midwest Professional Planners, LTD.3,524$1.60M0.38%+28+0.8%Added
Simplex Trading, LLC3,511$1.59M0.04%+1,908+119.0%Added
Panagora Asset Management Inc3,485$1.58M0.01%+77+2.3%Added
Moors & Cabot, Inc.3,479$1.58M0.07%−100−2.8%Reduced
Mutual Advisors, LLC3,476$1.58M0.03%−346−9.1%Reduced
Intrust Bank NA3,473$1.57M0.13%+211+6.5%Added
Tealwood Asset Management Inc3,462$1.57M0.70%−21−0.6%Reduced
National Asset Management, Inc.3,455$1.57M0.07%−270−7.2%Reduced
Triglav Skladi, D.O.O.3,450$1.56M0.10%00.0%Unchanged
Wedmont Private Capital3,218$1.56M0.05%−81−2.5%Reduced
Savant Capital, LLC3,407$1.54M0.01%+481+16.4%Added
Ifrah Financial Services, Inc.3,397$1.54M0.40%−79−2.3%Reduced
Berkshire Asset Management LLC3,379$1.53M0.07%+9+0.3%Added
Norden Group LLC3,368$1.53M0.15%+1,016+43.2%Added
Richard Bernstein Advisors LLC3,367$1.53M0.04%−325−8.8%Reduced
Arrowpoint Investment Partners (Singapore) Pte. Ltd.3,364$1.53M0.22%+3,364New
Sculati Wealth Management, LLC3,360$1.52M0.54%+32+1.0%Added
Nelson, Van Denburg & Campbell Wealth Management Group, LLC3,302$1.50M0.05%+164+5.2%Added
Independent Advisor Alliance3,300$1.50M0.04%+74+2.3%Added
Stratos Wealth Partners, LTD.3,299$1.50M0.02%+207+6.7%Added
Frank, Rimerman Advisors LLC3,282$1.49M0.09%+162+5.2%Added
Grange Capital, LLC3,279$1.49M1.43%−275−7.7%Reduced
DSG Capital Advisors, LLC3,380$1.48M0.23%−185−5.2%Reduced
Hohimer Wealth Management, LLC3,251$1.47M0.20%−18−0.6%Reduced
Capstone Investment Advisors, LLC3,239$1.47M0.01%−2,784−46.2%Reduced
Ingalls & Snyder LLC3,227$1.46M0.05%+12+0.4%Added
ISAM Funds (UK) Ltd3,221$1.46M0.53%+1,971+157.7%Added
MWA Asset Management3,216$1.46M0.81%+18+0.6%Added
Institute for Wealth Management, LLC.3,215$1.46M0.15%−8−0.2%Reduced
Syon Capital LLC3,208$1.45M0.07%+369+13.0%Added
Procyon Private Wealth Partners, LLC3,206$1.45M0.07%−139−4.2%Reduced
Strategy Asset Managers LLC3,191$1.45M0.24%+198+6.6%Added
Murphy & Mullick Capital Management Corp3,186$1.44M1.04%−38−1.2%Reduced
Sandro Wealth Management LLC3,167$1.44M1.19%+3,167New
FRG Family Wealth Advisors LLC3,150$1.43M0.22%−30−0.9%Reduced
MN Wealth Advisors, LLC3,150$1.43M0.72%+266+9.2%Added
Milestone Asset Management, LLC3,139$1.42M0.27%+561+21.8%Added
Community Bank, N.A.3,127$1.42M0.17%+265+9.3%Added
Pure Financial Advisors, Inc.3,110$1.41M0.02%−220−6.6%Reduced
Baker Tilly Wealth Management, LLC3,109$1.41M0.35%+28+0.9%Added
Stephens Inc3,094$1.40M0.02%−470−13.2%Reduced
Arrow Financial Corp3,085$1.40M0.14%−152−4.7%Reduced
IFP Advisors, Inc3,082$1.40M0.03%+797+34.9%Added
Hartford Funds Management Co LLC3,073$1.39M0.11%+1,512+96.9%Added
Boston Private Wealth LLC3,061$1.39M0.08%−4,354−58.7%Reduced
Aviso Financial Inc.3,052$1.38M0.05%−113−3.6%Reduced
Patriot Financial Group Insurance Agency, LLC3,034$1.38M0.16%−226−6.9%Reduced
AustralianSuper Pty Ltd3,032$1.37M0.01%00.0%Unchanged
WP Advisors, LLC3,018$1.37M0.34%−190−5.9%Reduced
Hilltop Holdings Inc.3,015$1.37M0.08%−1,919−38.9%Reduced
United Asset Strategies, Inc.3,010$1.36M0.11%+66+2.2%Added
J. Safra Sarasin Holding AG3,000$1.36M0.02%−827−21.6%Reduced
Shepherd Street Advisors LLC2,995$1.36M1.30%+2,995New
ZWJ Investment Counsel Inc2,987$1.35M0.05%−804−21.2%Reduced
Hamrick Investment Counsel, llc2,983$1.35M1.01%+2,983New
Legacy Financial Advisors, Inc.2,975$1.35M0.19%+49+1.7%Added
Capital Investment Advisory Services, LLC2,962$1.34M0.09%−186−5.9%Reduced
Oak Ridge Investments LLC2,940$1.33M0.08%+1,126+62.1%Added
Centaurus Financial, Inc.2,936$1.33M0.06%−91−3.0%Reduced
Lifeworks Advisors, LLC2,923$1.33M0.17%+9+0.3%Added
Employees Retirement System of Texas2,918$1.32M0.01%+2,918New
Bluebird Wealth Management LLC2,906$1.32M1.23%+2,906New
Ashton Thomas Securities, LLC2,902$1.32M0.25%−79−2.7%Reduced
Pinebridge Investments LLC2,901$1.32M0.01%+2,901New
111 Capital2,892$1.31M0.29%−1,471−33.7%Reduced
Trust Asset Management LLC2,856$1.29M0.09%−106−3.6%Reduced
Sowell Financial Services LLC2,814$1.28M0.05%−1,198−29.9%Reduced
Cravens & Co Advisors, LLC2,797$1.27M0.83%−480−14.6%Reduced
Crossmark Global Holdings, Inc.2,797$1.27M0.02%−3,346−54.5%Reduced
Avestar Capital, LLC2,795$1.27M0.09%−1,077−27.8%Reduced
Park Circle Co2,764$1.25M1.13%00.0%Unchanged
AE Wealth Management LLC2,730$1.24M0.01%+958+54.1%Added
Persistent Asset Partners Ltd2,666$1.21M0.58%+2,666New
Connecticut Wealth Management, LLC2,648$1.20M0.05%00.0%Unchanged
Adviser Investments LLC2,637$1.20M0.01%+747+39.5%Added
Philip James Wealth Mangement, LLC2,628$1.19M0.14%−1,431−35.3%Reduced
Dakota Wealth Management2,623$1.19M0.02%+43+1.7%Added
GTS Securities LLC2,622$1.19M0.04%−3,112−54.3%Reduced
Westpac Banking Corp2,605$1.18M0.07%+131+5.3%Added
Qtron Investments LLC2,602$1.18M0.15%+728+38.8%Added
Koa Wealth Management, LLC2,583$1.17M0.80%−11−0.4%Reduced
MAI Capital Management2,564$1.16M0.01%+718+38.9%Added