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Vertex Pharmaceuticals Inc

VRTX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000875320

In the last 90 days, Vertex Pharmaceuticals Inc insiders filed 0 open-market purchases and 3 sales; 1,763 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Vertex Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
1,671
+174 vs. Q3 2025
Shares held
241.6M
+9.62M (+4.1%) vs. Q3 2025
Total value
$109.5B
+$18.8B (+20.7%) vs. Q3 2025
New holders
274
620 more added
Sold out
100
566 more reduced

26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 1,671 institutions
Q1 2021: 1,000 institutionsQ2 2021: 979 institutionsQ3 2021: 936 institutionsQ4 2021: 1,034 institutionsQ1 2022: 1,073 institutionsQ2 2022: 1,110 institutionsQ3 2022: 1,128 institutionsQ4 2022: 1,225 institutionsQ1 2023: 1,213 institutionsQ2 2023: 1,288 institutionsQ3 2023: 1,280 institutionsQ4 2023: 1,442 institutionsQ1 2024: 1,497 institutionsQ2 2024: 1,551 institutionsQ3 2024: 1,551 institutionsQ4 2024: 1,563 institutionsQ1 2025: 1,618 institutionsQ2 2025: 1,564 institutionsQ3 2025: 1,523 institutionsQ4 2025: 1,671 institutionsQ1 2026: 1,698 institutionsQ2 2026: 1,763 institutions
Value heldQ4 2025: $109.5B
Q1 2021: $50.6BQ2 2021: $46.8BQ3 2021: $41.9BQ4 2021: $50.4BQ1 2022: $60.9BQ2 2022: $66.1BQ3 2022: $68.5BQ4 2022: $68.3BQ1 2023: $75.0BQ2 2023: $83.3BQ3 2023: $81.9BQ4 2023: $95.7BQ1 2024: $98.0BQ2 2024: $109.9BQ3 2024: $109.1BQ4 2024: $95.2BQ1 2025: $116.3BQ2 2025: $107.2BQ3 2025: $90.8BQ4 2025: $109.5BQ1 2026: $106.1BQ2 2026: $119.7B
Institutions holding VRTX and their total value by quarter
QuarterHoldersValue
Q2 20261,763$119.7B
Q1 20261,698$106.1B
Q4 20251,671$109.5B
Q3 20251,523$90.8B
Q2 20251,564$107.2B
Q1 20251,618$116.3B
Q4 20241,563$95.2B
Q3 20241,551$109.1B
Q2 20241,551$109.9B
Q1 20241,497$98.0B
Q4 20231,442$95.7B
Q3 20231,280$81.9B
Q2 20231,288$83.3B
Q1 20231,213$75.0B
Q4 20221,225$68.3B
Q3 20221,128$68.5B
Q2 20221,110$66.1B
Q1 20221,073$60.9B
Q4 20211,034$50.4B
Q3 2021936$41.9B
Q2 2021979$46.8B
Q1 20211,000$50.6B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q3 2025.

Institutions holding VRTX in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Tidemark, LLC23$10.4K0.00%−5−17.9%Reduced
LFA - Lugano Financial Advisors SA23$10.4K0.01%00.0%Unchanged
Turning Point Benefit Group, Inc.24$10.9K0.01%+23+2,300.0%Added
Wealth Watch Advisors, INC24$10.9K0.00%−8−25.0%Reduced
Creative Capital Management Investments LLC24$10.9K0.00%00.0%Unchanged
Signature Resources Capital Management, LLC24$10.9K0.01%+18+300.0%Added
Legacy Bridge, LLC24$10.9K0.00%+24New
Quattro Advisors LLC24$10.9K0.01%+24New
Highline Wealth Partners LLC25$11.3K0.00%−13−34.2%Reduced
Tanglewood Legacy Advisors, LLC25$11.3K0.00%00.0%Unchanged
DiNuzzo Private Wealth, Inc.26$11.8K0.00%+3+13.0%Added
ZRC Wealth Management, LLC26$11.8K0.00%+13+100.0%Added
Team Financial Group, LLC27$12.2K0.01%00.0%Unchanged
SJS Investment Consulting Inc.27$12.2K0.00%00.0%Unchanged
Proffitt & Goodson Inc28$12.7K0.00%−32−53.3%Reduced
Lummis Asset Management, LP29$13.1K0.01%00.0%Unchanged
FWL Investment Management, LLC30$13.6K0.00%00.0%Unchanged
Innovative Advisory Group, LLC30$13.6K0.01%00.0%Unchanged
Strategic Wealth Advisors LLC32$14.0K0.01%+32New
Caitlin John, LLC31$14.1K0.01%00.0%Unchanged
City Holding Co32$14.5K0.00%00.0%Unchanged
Orion Capital Management LLC32$14.5K0.00%00.0%Unchanged
Modus Advisors, LLC32$14.5K0.00%+32New
Beaird Harris Wealth Management, LLC33$15.0K0.00%00.0%Unchanged
Wilkerson Advisory Group LLC33$15.0K0.01%+33New
Avion Wealth34$15.0K0.00%+12+54.5%Added
United Community Bank35$15.9K0.01%−27−43.5%Reduced
Private Wealth Management Group, LLC35$15.9K0.00%−7−16.7%Reduced
Indiana Trust & Investment Management CO35$15.9K0.00%00.0%Unchanged
Evermay Wealth Management LLC36$16.3K0.00%−57−61.3%Reduced
Trust Co38$17.2K0.00%−1−2.6%Reduced
Cedar Mountain Advisors, LLC38$17.2K0.00%00.0%Unchanged
Measured Wealth Private Client Group, LLC39$17.7K0.00%00.0%Unchanged
Dogwood Wealth Management LLC39$17.7K0.01%+38+3,800.0%Added
Marquette Asset Management, LLC42$19.0K0.00%+10+31.3%Added
Prosperity Bancshares Inc43$19.5K0.02%+43New
Valued Wealth Advisors LLC44$19.9K0.01%−9−17.0%Reduced
DT Investment Partners, LLC44$19.9K0.00%00.0%Unchanged
Signature Equity Partners, LLC44$19.9K0.01%+44New
Evelyn Partners Asset Management Ltd47$21.3K0.00%00.0%Unchanged
Scarborough Advisors, LLC47$21.4K0.00%+3+6.8%Added
Quaker Wealth Management, LLC48$21.8K0.01%+1+2.1%Added
Sachetta, LLC49$22.2K0.01%00.0%Unchanged
Center for Financial Planning, Inc.50$22.7K0.00%00.0%Unchanged
Hilton Head Capital Partners, LLC50$22.7K0.01%+50New
Fortitude Family Office, LLC51$23.1K0.01%00.0%Unchanged
Access Investment Management LLC60$23.5K0.01%00.0%Unchanged
Colonial Trust Co53$24.2K0.00%−17−24.3%Reduced
Pinnacle Bancorp, Inc.54$24.5K0.01%00.0%Unchanged
Aventura Private Wealth, LLC54$24.5K0.01%+2+3.8%Added
BFSG, LLC54$24.5K0.00%00.0%Unchanged
Bullock Wealth Management Group55$24.9K0.01%00.0%Unchanged
Howard Hughes Medical Institute55$24.9K0.01%00.0%Unchanged
Riverview Trust Co55$24.9K0.03%00.0%Unchanged
Motiv8 Investments LLC58$26.0K0.01%+58New
Strategic Investment Solutions, Inc.58$26.3K0.01%00.0%Unchanged
Raffa Wealth Management, LLC61$27.7K0.00%+8+15.1%Added
Swiss Re Ltd61$27.7K0.00%+61New
Canton Hathaway, LLC62$28.1K0.01%00.0%Unchanged
North Star Investment Management Corp.62$28.1K0.00%+19+44.2%Added
South State Corp.62$28.1K0.00%+15+31.9%Added
Chesapeake Asset Management LLC63$28.6K0.02%00.0%Unchanged
Pingora Partners LLC65$29.5K0.02%00.0%Unchanged
Eagle Bay Advisors LLC65$29.5K0.02%+65New
Solstein Capital, LLC67$30.4K0.01%00.0%Unchanged
IMG Wealth Management, Inc.68$30.8K0.02%+50+277.8%Added
Estabrook Capital Management69$31.3K0.00%00.0%Unchanged
Abound Wealth Management70$31.6K0.01%00.0%Unchanged
Legacy Wealth Managment, LLC72$32.6K0.02%+6+9.1%Added
Ares Financial Consulting, LLC73$33.1K0.03%+73New
Vega Investment Solutions73$33.1K0.01%+73New
Archer Investment Corp74$33.5K0.01%+35+89.7%Added
TD Capital Management LLC75$34.0K0.00%00.0%Unchanged
Founders Capital Management75$34.0K0.02%00.0%Unchanged
Thurston, Springer, Miller, Herd & Titak, Inc.76$34.5K0.01%−164−68.3%Reduced
American National Bank76$34.5K0.00%00.0%Unchanged
Financial Management Professionals, Inc.76$34.5K0.00%00.0%Unchanged
Stone House Investment Management, LLC77$34.9K0.01%+2+2.7%Added
Clayton Financial Group LLC77$34.9K0.02%+15+24.2%Added
Torren Management, LLC77$34.9K0.02%+77New
Ogorek Anthony Joseph78$35.0K0.01%+8+11.4%Added
Capital Advisors, Ltd. LLC77$35.0K0.00%+27+54.0%Added
SOA Wealth Advisors, LLC.78$35.4K0.01%00.0%Unchanged
First Command Advisory Services, Inc.79$35.8K0.00%+9+12.9%Added
Brown, Lisle/Cummings, Inc.82$37.2K0.01%00.0%Unchanged
Rational Advisors LLC84$38.1K0.00%+10+13.5%Added
High Note Wealth, LLC85$38.5K0.01%+17+25.0%Added
Centerpoint Advisors, LLC87$39.0K0.01%+55+171.9%Added
Strengthening Families & Communities, LLC87$39.4K0.01%+77+770.0%Added
Wolff Wiese Magana LLC89$40.4K0.02%00.0%Unchanged
University of Texas/Texas Am Investment Managment Co95$43.1K0.01%−68−41.7%Reduced
Entrust Financial LLC96$43.5K0.03%+96New
Catalyst Capital Advisors LLC98$44.4K0.00%−26−21.0%Reduced
Financial Network Wealth Advisors LLC99$44.9K0.05%+13+15.1%Added
Spirit of America Management Corp100$45.3K0.01%00.0%Unchanged
Wall Street Access Asset Management, LLC100$45.3K0.01%00.0%Unchanged
GoalVest Advisory LLC100$45.3K0.01%00.0%Unchanged
MPWM Advisory Solutions, LLC100$45.3K0.03%00.0%Unchanged
Sfam, LLC100$45.3K0.04%+100New
Midwest Capital Advisors, LLC101$45.8K0.02%00.0%Unchanged