Vertex Pharmaceuticals Inc
VRTX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000875320
No open-market purchases or sales by Vertex Pharmaceuticals Inc insiders were filed in the last 90 days; 1,762 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Vertex Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 1,671
- +174 vs. Q3 2025
- Shares held
- 241.6M
- +9.62M (+4.1%) vs. Q3 2025
- Total value
- $109.5B
- +$18.8B (+20.7%) vs. Q3 2025
- New holders
- 274
- 620 more added
- Sold out
- 100
- 566 more reduced
26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 1,762 | $119.7B |
| Q1 2026 | 1,698 | $106.1B |
| Q4 2025 | 1,671 | $109.5B |
| Q3 2025 | 1,523 | $90.8B |
| Q2 2025 | 1,563 | $107.2B |
| Q1 2025 | 1,617 | $116.3B |
| Q4 2024 | 1,563 | $95.2B |
| Q3 2024 | 1,551 | $109.1B |
| Q2 2024 | 1,551 | $109.9B |
| Q1 2024 | 1,497 | $98.0B |
| Q4 2023 | 1,442 | $95.7B |
| Q3 2023 | 1,280 | $81.9B |
| Q2 2023 | 1,287 | $83.3B |
| Q1 2023 | 1,212 | $75.0B |
| Q4 2022 | 1,224 | $68.3B |
| Q3 2022 | 1,127 | $68.5B |
| Q2 2022 | 1,109 | $66.1B |
| Q1 2022 | 1,072 | $60.9B |
| Q4 2021 | 1,034 | $50.4B |
| Q3 2021 | 936 | $41.9B |
| Q2 2021 | 979 | $46.8B |
| Q1 2021 | 1,000 | $50.6B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Capital International Ltd | 95,612 | $43.3M | 1.53% | −25,675−21.2% | Reduced |
| Bank of Nova Scotia | 97,920 | $44.4M | 0.07% | +11,668+13.5% | Added |
| Banco Santander, S.A. | 98,027 | $44.4M | 0.33% | +18,621+23.5% | Added |
| Two Sigma Advisers, LP | 98,360 | $44.6M | 0.09% | +86,860+755.3% | Added |
| Kovitz Investment Group Partners, LLC | 98,375 | $44.6M | 0.99% | +17,788+22.1% | Added |
| Creative Planning | 100,513 | $45.6M | 0.03% | +5,649+6.0% | Added |
| Country Trust Bank | 100,593 | $45.6M | 0.83% | +2,061+2.1% | Added |
| Guggenheim Capital LLC | 101,041 | $45.8M | 0.34% | −2,084−2.0% | Reduced |
| CI Private Wealth, LLC | 102,570 | $46.5M | 0.06% | +839+0.8% | Added |
| Public Employees Retirement System of Ohio | 102,663 | $46.5M | 0.15% | −69−0.1% | Reduced |
| Vontobel Holding Ltd. | 105,287 | $47.7M | 0.16% | −5,355−4.8% | Reduced |
| CIBC Asset Management Inc | 107,641 | $48.8M | 0.12% | +26,636+32.9% | Added |
| Treasurer of the State of North Carolina | 107,758 | $48.9M | 0.16% | −7,871−6.8% | Reduced |
| Worldquant Millennium Advisors LLC | 108,002 | $49.0M | 0.19% | +108,002 | New |
| Storebrand Asset Management AS | 109,573 | $49.7M | 0.13% | −2,295−2.1% | Reduced |
| Teacher Retirement System of Texas | 111,010 | $50.3M | 0.17% | −7,638−6.4% | Reduced |
| Raiffeisen Bank International AG | 112,645 | $51.1M | 0.66% | +540.0% | Added |
| Balyasny Asset Management LLC | 113,488 | $51.5M | 0.10% | +113,488 | New |
| Caisse de Depot Et Placement du Quebec | 113,768 | $51.6M | 0.09% | −108,494−48.8% | Reduced |
| SG Americas Securities, LLC | 115,899 | $52.5M | 0.07% | +55,837+93.0% | Added |
| DnB Asset Management AS | 119,685 | $54.3M | 0.19% | +24,271+25.4% | Added |
| Nomura Asset Management Co Ltd | 119,698 | $54.3M | 0.14% | +7,365+6.6% | Added |
| Allspring Global Investments Holdings, LLC | 122,210 | $55.3M | 0.09% | −4,653−3.7% | Reduced |
| Schroder Investment Management Group | 123,252 | $55.9M | 0.04% | +1,665+1.4% | Added |
| Truist Financial Corp | 126,193 | $57.2M | 0.08% | −17,671−12.3% | Reduced |
| Woodline Partners LP | 127,726 | $57.9M | 0.22% | −25,546−16.7% | Reduced |
| Mariner, LLC | 128,465 | $58.2M | 0.07% | +18,214+16.5% | Added |
| Tredje AP-fonden | 131,727 | $59.7M | 0.45% | −53,585−28.9% | Reduced |
| Colony Group, LLC | 132,846 | $60.2M | 0.07% | −6,369−4.6% | Reduced |
| Intermede Investment Partners Ltd | 133,378 | $60.5M | 2.48% | −6,645−4.7% | Reduced |
| Bowen Hanes & Co Inc | 133,504 | $60.5M | 1.52% | +9,070+7.3% | Added |
| Prudential Financial Inc | 134,619 | $61.0M | 0.07% | −91,195−40.4% | Reduced |
| Rockefeller Capital Management L.P. | 135,232 | $61.3M | 0.11% | +42,418+45.7% | Added |
| PFA Pension, Forsikringsaktieselskab | 135,188 | $61.3M | 0.17% | +135,188 | New |
| State of Wisconsin Investment Board | 137,909 | $62.5M | 0.14% | −10,440−7.0% | Reduced |
| KBC Group NV | 141,120 | $64.0M | 0.15% | +7,518+5.6% | Added |
| AQR Capital Management LLC | 143,651 | $65.1M | 0.03% | −18,032−11.2% | Reduced |
| AMF Pensionsforsakring AB | 145,949 | $66.2M | 0.41% | +83,487+133.7% | Added |
| NEOS Investment Management LLC | 146,198 | $66.3M | 0.38% | +32,665+28.8% | Added |
| Provident Investment Management, Inc. | 149,258 | $67.7M | 6.16% | −4,148−2.7% | Reduced |
| Van Eck Associates Corp | 149,451 | $67.8M | 0.06% | +395+0.3% | Added |
| Asset Management One Co.,Ltd. | 150,106 | $69.0M | 0.19% | +3,242+2.2% | Added |
| Stifel Financial Corp | 152,447 | $69.1M | 0.06% | +9,918+7.0% | Added |
| Birch Hill Investment Advisors LLC | 152,485 | $69.1M | 2.89% | −1,117−0.7% | Reduced |
| ABN AMRO Bank N.V. | 155,221 | $70.1M | 0.66% | +13,350+9.4% | Added |
| Danske Bank A/S | 157,165 | $71.3M | 0.17% | −7,315−4.4% | Reduced |
| Capital International Inc | 159,660 | $72.4M | 0.57% | −31,681−16.6% | Reduced |
| APG Asset Management N.V. | 188,385 | $72.7M | 0.21% | −12,203−6.1% | Reduced |
| Mitsubishi UFJ Trust & Banking Corp | 162,206 | $73.5M | 0.17% | +12,351+8.2% | Added |
| Groupama Asset Managment | 163,144 | $74.0M | 1.08% | +119,763+276.1% | Added |
| Hudson Bay Capital Management LP | 164,518 | $74.6M | 0.43% | +119,203+263.1% | Added |
| Sofinnova Investments, Inc. | 164,594 | $74.6M | 3.22% | +46,719+39.6% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 170,775 | $77.2M | 0.12% | +4,830+2.9% | Added |
| Mirae Asset Global Investments Co., Ltd. | 174,347 | $79.0M | 0.22% | +23,291+15.4% | Added |
| Skandinaviska Enskilda Banken AB (publ) | 174,466 | $79.1M | 0.32% | +20,218+13.1% | Added |
| Nomura Asset Management International Inc. | 178,365 | $80.9M | 0.12% | +178,365 | New |
| TD Asset Management Inc | 182,613 | $82.8M | 0.07% | −34,926−16.1% | Reduced |
| Great West Life Assurance Co | 187,604 | $85.1M | 0.15% | −86,532−31.6% | Reduced |
| Carmignac Gestion | 191,571 | $86.9M | 1.17% | +4,032+2.1% | Added |
| Korea Investment CORP | 193,435 | $87.7M | 0.17% | −12,310−6.0% | Reduced |
| Capital International Sarl | 193,438 | $87.7M | 1.41% | −32,296−14.3% | Reduced |
| Lazard Asset Management LLC | 198,950 | $90.2M | 0.15% | −345,873−63.5% | Reduced |
| Baillie Gifford & Co | 201,088 | $91.2M | 0.08% | −5,968−2.9% | Reduced |
| First Trust Advisors LP | 201,290 | $91.3M | 0.07% | +13,129+7.0% | Added |
| Canada Pension Plan Investment Board | 202,333 | $91.7M | 0.06% | −44,031−17.9% | Reduced |
| Marshall Wace, LLP | 204,032 | $92.5M | 0.09% | +158,147+344.7% | Added |
| New York State Teachers Retirement System | 211,092 | $95.7M | 0.19% | −1,737−0.8% | Reduced |
| Davenport & Co LLC | 211,577 | $95.9M | 0.52% | −5,707−2.6% | Reduced |
| Massachusetts Financial Services Co | 211,934 | $96.1M | 0.03% | −291,226−57.9% | Reduced |
| Aviva PLC | 216,211 | $98.0M | 0.17% | +11,322+5.5% | Added |
| Handelsbanken Fonder AB | 216,331 | $98.1M | 0.30% | +1,571+0.7% | Added |
| Welch & Forbes LLC | 218,198 | $98.9M | 1.20% | −2,148−1.0% | Reduced |
| Candriam Luxembourg S.C.A. | 225,292 | $102.1M | 0.51% | +50,725+29.1% | Added |
| State Board of Administration of Florida Retirement System | 226,000 | $102.5M | 0.18% | −7,612−3.3% | Reduced |
| National Bank of Canada | 238,548 | $108.1M | 0.11% | −9,393−3.8% | Reduced |
| Swedbank AB | 260,743 | $118.2M | 0.11% | +6,647+2.6% | Added |
| Cerity Partners LLC | 261,553 | $118.6M | 0.17% | +2,745+1.1% | Added |
| Standard Life Aberdeen plc | 262,057 | $118.8M | 0.18% | −52,832−16.8% | Reduced |
| Los Angeles Capital Management LLC | 293,301 | $123.2M | 0.42% | +257,829+726.9% | Added |
| Adage Capital Partners GP, L.L.C. | 272,474 | $123.5M | 0.19% | −210,021−43.5% | Reduced |
| Royal London Asset Management Ltd | 273,433 | $124.0M | 0.26% | −3,763−1.4% | Reduced |
| LPL Financial LLC | 276,878 | $125.5M | 0.03% | +12,696+4.8% | Added |
| New York State Common Retirement Fund | 297,414 | $134.8M | 0.18% | −11,163−3.6% | Reduced |
| Ensign Peak Advisors, Inc | 303,784 | $137.7M | 0.24% | −8,214−2.6% | Reduced |
| Public Employees Retirement Association of Colorado | 329,745 | $149.5M | 0.55% | −6,346−1.9% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 334,898 | $151.8M | 0.25% | +15,431+4.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 345,383 | $156.6M | 0.41% | +124,582+56.4% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 353,488 | $160.3M | 0.35% | −34,823−9.0% | Reduced |
| Alyeska Investment Group, L.P. | 354,334 | $160.6M | 0.45% | +87,165+32.6% | Added |
| SEI Investments Co | 364,023 | $165.0M | 0.16% | +187,496+106.2% | Added |
| Millennium Management LLC | 365,664 | $165.8M | 0.12% | +324,622+791.0% | Added |
| Bank Julius Baer & Co. Ltd, Zurich | 366,341 | $166.1M | 0.46% | −10,154−2.7% | Reduced |
| Life Cycle Investment Partners Ltd | 366,854 | $166.3M | 1.16% | +366,854 | New |
| Man Group plc | 380,735 | $172.6M | 0.33% | +17,961+5.0% | Added |
| Russell Investments Group, Ltd. | 381,462 | $173.0M | 0.19% | +40,414+11.8% | Added |
| California State Teachers Retirement System | 385,751 | $174.9M | 0.17% | −8,831−2.2% | Reduced |
| Squarepoint Ops LLC | 389,020 | $176.4M | 0.36% | −218,816−36.0% | Reduced |
| Harding Loevner LP | 391,865 | $177.7M | 1.56% | −64,123−14.1% | Reduced |
| Robeco Institutional Asset Management B.V. | 394,200 | $178.7M | 0.25% | +14,829+3.9% | Added |
| Chevy Chase Trust Holdings, Inc. | 408,363 | $185.1M | 0.50% | −10,146−2.4% | Reduced |