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Vertex Pharmaceuticals Inc

VRTX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000875320

In the last 90 days, Vertex Pharmaceuticals Inc insiders filed 0 open-market purchases and 3 sales; 1,763 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Vertex Pharmaceuticals Inc as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
1,564
−28 vs. Q1 2025
Shares held
240.9M
+1.26M (+0.5%) vs. Q1 2025
Total value
$107.2B
−$8.95B (−7.7%) vs. Q1 2025
New holders
121
619 more added
Sold out
149
608 more reduced

26 institutions that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 1,564 institutions
Q1 2021: 1,000 institutionsQ2 2021: 979 institutionsQ3 2021: 936 institutionsQ4 2021: 1,034 institutionsQ1 2022: 1,073 institutionsQ2 2022: 1,110 institutionsQ3 2022: 1,128 institutionsQ4 2022: 1,225 institutionsQ1 2023: 1,213 institutionsQ2 2023: 1,288 institutionsQ3 2023: 1,280 institutionsQ4 2023: 1,442 institutionsQ1 2024: 1,497 institutionsQ2 2024: 1,551 institutionsQ3 2024: 1,551 institutionsQ4 2024: 1,563 institutionsQ1 2025: 1,618 institutionsQ2 2025: 1,564 institutionsQ3 2025: 1,523 institutionsQ4 2025: 1,671 institutionsQ1 2026: 1,698 institutionsQ2 2026: 1,763 institutions
Value heldQ2 2025: $107.2B
Q1 2021: $50.6BQ2 2021: $46.8BQ3 2021: $41.9BQ4 2021: $50.4BQ1 2022: $60.9BQ2 2022: $66.1BQ3 2022: $68.5BQ4 2022: $68.3BQ1 2023: $75.0BQ2 2023: $83.3BQ3 2023: $81.9BQ4 2023: $95.7BQ1 2024: $98.0BQ2 2024: $109.9BQ3 2024: $109.1BQ4 2024: $95.2BQ1 2025: $116.3BQ2 2025: $107.2BQ3 2025: $90.8BQ4 2025: $109.5BQ1 2026: $106.1BQ2 2026: $119.7B
Institutions holding VRTX and their total value by quarter
QuarterHoldersValue
Q2 20261,763$119.7B
Q1 20261,698$106.1B
Q4 20251,671$109.5B
Q3 20251,523$90.8B
Q2 20251,564$107.2B
Q1 20251,618$116.3B
Q4 20241,563$95.2B
Q3 20241,551$109.1B
Q2 20241,551$109.9B
Q1 20241,497$98.0B
Q4 20231,442$95.7B
Q3 20231,280$81.9B
Q2 20231,288$83.3B
Q1 20231,213$75.0B
Q4 20221,225$68.3B
Q3 20221,128$68.5B
Q2 20221,110$66.1B
Q1 20221,073$60.9B
Q4 20211,034$50.4B
Q3 2021936$41.9B
Q2 2021979$46.8B
Q1 20211,000$50.6B

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q1 2025.

Institutions holding VRTX in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Baillie Gifford & Co212,479$94.6M0.07%+78,014+58.0%Added
OrbiMed Advisors LLC210,287$93.6M2.35%+50,387+31.5%Added
Truist Financial Corp210,089$93.5M0.14%−13,881−6.2%Reduced
Danske Bank A/S206,746$92.0M0.23%+46,956+29.4%Added
Connor, Clark & Lunn Investment Management Ltd.206,095$91.8M0.32%+190,842+1,251.2%Added
New York State Teachers Retirement System203,504$90.6M0.19%−1,386−0.7%Reduced
Korea Investment CORP201,734$89.8M0.20%−19,446−8.8%Reduced
Federated Hermes, Inc.193,959$86.4M0.16%+23,726+13.9%Added
Intermede Investment Partners Ltd193,915$86.3M2.66%−10,130−5.0%Reduced
Aviva PLC192,660$85.8M0.18%+11,970+6.6%Added
Congress Asset Management Co188,004$83.7M0.57%+428+0.2%Added
Bowen Hanes & Co Inc180,799$80.5M2.03%+1,890+1.1%Added
Prudential Financial Inc180,236$80.2M0.10%+11,381+6.7%Added
Adage Capital Partners GP, L.L.C.178,192$79.3M0.13%−311,475−63.6%Reduced
Ensign Peak Advisors, Inc177,034$78.8M0.13%−57,687−24.6%Reduced
Skandinaviska Enskilda Banken AB (publ)176,604$78.6M0.34%−9,867−5.3%Reduced
Candriam Luxembourg S.C.A.176,398$78.5M0.45%−21,889−11.0%Reduced
Squarepoint Ops LLC175,687$78.2M0.17%+168,792+2,448.0%Added
Capital International Inc175,233$78.0M0.76%+44,008+33.5%Added
APG Asset Management N.V.201,952$76.6M0.23%−124,776−38.2%Reduced
AXA S.A.171,270$76.2M0.22%+10,477+6.5%Added
Canada Pension Plan Investment Board167,408$74.5M0.06%+12,979+8.4%Added
British Columbia Investment Management Corp166,450$74.1M0.43%+17,797+12.0%Added
Nomura Asset Management Co Ltd158,916$70.7M0.19%+5,621+3.7%Added
Provident Investment Management, Inc.158,707$70.7M6.04%+2,382+1.5%Added
Westwood Holdings Group Inc.154,217$68.7M0.49%+80,249+108.5%Added
Mitsubishi UFJ Trust & Banking Corp150,353$66.9M0.16%−11,545−7.1%Reduced
Birch Hill Investment Advisors LLC148,314$66.0M2.93%+100.0%Added
Mirae Asset Global Investments Co., Ltd.144,588$64.4M0.22%+1,270+0.9%Added
Colony Group, LLC143,109$63.7M0.14%−96−0.1%Reduced
State of Wisconsin Investment Board142,938$63.6M0.16%−9,739−6.4%Reduced
Asset Management One Co.,Ltd.141,561$63.0M0.20%−312−0.2%Reduced
Lansforsakringar Fondforvaltning AB (publ)141,290$62.9M0.36%+4,979+3.7%Added
Van Eck Associates Corp140,701$62.6M0.07%−990−0.7%Reduced
AQR Capital Management LLC141,536$62.2M0.05%−4,335−3.0%Reduced
Schroder Investment Management Group134,967$60.1M0.05%−14,420−9.7%Reduced
ABN AMRO Bank N.V.133,072$59.6M0.78%+5,679+4.5%Added
KBC Group NV132,665$59.1M0.16%+13,360+11.2%Added
Abn Amro Investment Solutions130,291$58.0M1.16%−7,351−5.3%Reduced
Allspring Global Investments Holdings, LLC126,540$57.2M0.10%+18,011+16.6%Added
Man Group plc127,618$56.8M0.12%+112,434+740.5%Added
Capital International Ltd127,607$56.8M2.18%+15,061+13.4%Added
Teacher Retirement System of Texas122,373$54.5M0.23%−4,451−3.5%Reduced
Treasurer of the State of North Carolina120,134$53.5M0.17%+1,759+1.5%Added
Mariner, LLC119,123$53.0M0.08%+2,562+2.2%Added
Toronto Dominion Bank118,626$52.8M0.11%+19,472+19.6%Added
Marshall Wace, LLP117,000$52.1M0.06%−21,000−15.2%Reduced
Allianz Asset Management GmbH116,197$51.7M0.07%−24,888−17.6%Reduced
SG Americas Securities, LLC115,640$51.5M0.23%+93,367+419.2%Added
Raiffeisen Bank International AG113,927$50.8M0.76%−17,682−13.4%Reduced
STRS Ohio112,758$50.2M0.19%+34,907+44.8%Added
Storebrand Asset Management AS108,283$48.2M0.14%+7,163+7.1%Added
Hardman Johnston Global Advisors LLC108,225$48.2M2.14%−9,855−8.3%Reduced
Public Employees Retirement System of Ohio106,055$47.2M0.16%−3,227−3.0%Reduced
State of Tennessee, Treasury Department105,759$47.1M0.17%+7,410+7.5%Added
Capital Group Private Client Services, Inc.104,537$46.5M0.40%+78,905+307.8%Added
CI Private Wealth, LLC102,816$45.8M0.07%−3,734−3.5%Reduced
Stifel Financial Corp101,545$45.2M0.04%−5,446−5.1%Reduced
Guggenheim Capital LLC101,220$45.1M0.37%−783−0.8%Reduced
Rockefeller Capital Management L.P.99,738$44.4M0.10%+8,774+9.6%Added
Healthcare of Ontario Pension Plan Trust Fund98,561$43.9M0.09%−50,979−34.1%Reduced
Resona Asset Management Co.,Ltd.96,449$42.9M0.21%+5,687+6.3%Added
Banco Bilbao Vizcaya Argentaria, S.A.93,689$41.7M0.38%−4,532−4.6%Reduced
KLP Kapitalforvaltning AS92,841$41.3M0.18%+5,100+5.8%Added
Assetmark, Inc92,391$41.1M0.10%+7,094+8.3%Added
Woodline Partners LP91,664$40.8M0.22%−61,496−40.2%Reduced
Fjarde Ap-Fonden /Fourth Swedish National Pension Fund91,088$40.6M0.37%+17,200+23.3%Added
Country Trust Bank90,136$40.1M0.90%+312+0.3%Added
Thrivent Financial for Lutherans88,202$39.3M0.09%+1,119+1.3%Added
Polar Capital Holdings Plc87,500$39.0M0.20%−37,500−30.0%Reduced
Creative Planning87,174$38.8M0.03%−1,666−1.9%Reduced
DnB Asset Management AS86,931$38.7M0.16%−89,600−50.8%Reduced
State of New Jersey Common Pension Fund D86,729$38.6M0.15%00.0%Unchanged
Wealth Enhancement Advisory Services, LLC82,641$38.0M0.06%+2,452+3.1%Added
CIBC Asset Management Inc80,986$36.1M0.11%−4,393−5.1%Reduced
MetLife Investment Management77,148$34.3M0.20%+4,787+6.6%Added
Beacon Investment Advisory Services, Inc.77,031$34.3M1.51%−870−1.1%Reduced
NEOS Investment Management LLC76,237$33.9M0.42%+24,915+48.5%Added
The PNC Financial Services Group, Inc.76,156$33.9M0.02%−2,005−2.6%Reduced
Daiwa Securities Group Inc.75,832$33.8M0.12%+4,600+6.5%Added
Rafferty Asset Management, LLC75,108$33.4M0.11%+4,278+6.0%Added
Arizona State Retirement System75,094$33.4M0.19%−443−0.6%Reduced
Erste Asset Management GmbH73,903$32.6M0.27%+5,133+7.5%Added
State of Michigan Retirement System72,523$32.3M0.17%+400+0.6%Added
Janney Montgomery Scott LLC71,890$32.0M0.08%+3,271+4.8%Added
Vontobel Holding Ltd.71,798$32.0M0.11%−3,008−4.0%Reduced
Capitolis Liquid Global Markets LLC71,000$31.6M0.23%+71,000New
Banco Santander, S.A.70,188$31.2M0.30%+6,160+9.6%Added
Teachers Retirement System of the State of Kentucky68,180$30.4M0.25%+5,185+8.2%Added
Gateway Investment Advisers LLC65,794$29.3M0.32%−59−0.1%Reduced
Nissay Asset Management Corp65,638$29.2M0.17%+1,828+2.9%Added
Nisa Investment Advisors, LLC65,417$29.1M0.13%−2,883−4.2%Reduced
Alyeska Investment Group, L.P.65,000$28.9M0.10%−366,804−84.9%Reduced
AMF Pensionsforsakring AB64,705$28.8M0.19%+3,710+6.1%Added
Comerica Bank64,675$28.8M0.11%−746−1.1%Reduced
Caisse de Depot Et Placement du Quebec64,396$28.7M0.06%−60,451−48.4%Reduced
Davidson Investment Advisors63,689$28.4M1.27%+806+1.3%Added
Commonwealth of Pennsylvania Public School Empls Retrmt Sys62,981$28.0M0.15%+4,256+7.2%Added
Czech National Bank62,770$27.9M0.22%+3,790+6.4%Added
Xponance, Inc.62,600$27.9M0.23%+13,431+27.3%Added