Silence Therapeutics plc
SLN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001479615
No open-market purchases or sales by Silence Therapeutics plc insiders were filed in the last 90 days; 72 institutions reported holding it in 13F filings for Q2 2026, worth $236.2M in total; no superinvestor holds it.
Other share classesSLNCF
13F holders, Q4 2025
Institutional positions in Silence Therapeutics plc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 58
- +4 vs. Q3 2025
- Shares held
- 18.1M
- −1.61M (−8.2%) vs. Q3 2025
- Total value
- $106.1M
- +$9.64M (+10.0%) vs. Q3 2025
- New holders
- 14
- 15 more added
- Sold out
- 10
- 17 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SLN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 72 | $236.2M |
| Q1 2026 | 56 | $102.1M |
| Q4 2025 | 58 | $106.1M |
| Q3 2025 | 54 | $96.4M |
| Q2 2025 | 55 | $108.0M |
| Q1 2025 | 59 | $60.6M |
| Q4 2024 | 65 | $168.2M |
| Q3 2024 | 69 | $493.1M |
| Q2 2024 | 71 | $502.1M |
| Q1 2024 | 64 | $588.0M |
| Q4 2023 | 34 | $343.9M |
| Q3 2023 | 28 | $187.6M |
| Q2 2023 | 29 | $101.8M |
| Q1 2023 | 29 | $110.2M |
| Q4 2022 | 27 | $275.7M |
| Q3 2022 | 29 | $183.4M |
| Q2 2022 | 25 | $116.4M |
| Q1 2022 | 26 | $218.3M |
| Q4 2021 | 22 | $246.6M |
| Q3 2021 | 7 | $39.4M |
| Q2 2021 | 6 | $56.4M |
| Q1 2021 | 6 | $55.9M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Silence Therapeutics plc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 3,033,560 | $18.4M | 0.61% | 00.0% | Unchanged |
| Siren, L.L.C. | 2,911,438 | $17.7M | 0.53% | 00.0% | Unchanged |
| Redmile Group, LLC | 2,164,777 | $13.2M | 0.97% | 00.0% | Unchanged |
| Nantahala Capital Management, LLC | 1,542,427 | $9.38M | 0.56% | +500,000+48.0% | Added |
| Vivo Capital, LLC | 1,105,454 | $6.72M | 0.43% | 00.0% | Unchanged |
| Nextech Invest, Ltd. | 952,400 | $5.79M | 0.56% | 00.0% | Unchanged |
| Great Point Partners LLC | 808,032 | $4.91M | 1.59% | +808,032 | New |
| Millennium Management LLC | 659,592 | $4.01M | 0.00% | +361,080+121.0% | Added |
| 5AM Venture Management, LLC | 476,200 | $2.90M | 0.91% | 00.0% | Unchanged |
| Polygon Management Ltd. | 365,369 | $2.22M | 0.47% | +365,369 | New |
| Morgan Stanley | 324,630 | $1.97M | 0.00% | −883,094−73.1% | Reduced |
| Ikarian Capital, LLC | 865,784 | $1.73M | 0.22% | −35,000−3.9% | Reduced |
| SG Americas Securities, LLC | 256,340 | $1.56M | 0.00% | −51,949−16.9% | Reduced |
| Citadel Advisors LLC | 244,061 | $1.48M | 0.00% | +222,556+1,034.9% | Added |
| Ishara Investments LP | 240,000 | $1.46M | 1.70% | +240,000 | New |
| Boothbay Fund Management, LLC | 209,088 | $1.27M | 0.03% | −70,549−25.2% | Reduced |
| UBS Group AG | 207,513 | $1.26M | 0.00% | −99,850−32.5% | Reduced |
| Lombard Odier Asset Management (USA) Corp | 255,901 | $1.15M | 0.47% | −1,589,047−86.1% | Reduced |
| M28 Capital Management LP | 185,100 | $1.13M | 0.82% | 00.0% | Unchanged |
| HSBC Holdings PLC | 172,834 | $1.07M | 0.00% | −390.0% | Reduced |
| Bank of Montreal | 160,474 | $975.7K | 0.00% | +6,692+4.4% | Added |
| Marshall Wace, LLP | 155,680 | $946.5K | 0.00% | +72,461+87.1% | Added |
| Seven Fleet Capital Management LP | 147,600 | $897.4K | 0.61% | +147,600 | New |
| Point72 Asset Management, L.P. | 114,070 | $693.5K | 0.00% | +114,070 | New |
| Opaleye Management Inc. | 78,926 | $479.9K | 0.06% | +78,926 | New |
| BlackRock, Inc. | 73,153 | $444.8K | 0.00% | +11,321+18.3% | Added |
| Quadrature Capital Ltd | 54,380 | $330.6K | 0.00% | +54,380 | New |
| Two Sigma Investments, LP | 39,344 | $239.2K | 0.00% | −23,903−37.8% | Reduced |
| Qube Research & Technologies Ltd | 34,962 | $212.6K | 0.00% | +34,962 | New |
| Geode Capital Management, LLC | 29,538 | $179.6K | 0.00% | 00.0% | Unchanged |
| Jane Street Group, LLC | 29,168 | $177.3K | 0.00% | +29,168 | New |
| Raymond James Financial Inc | 25,000 | $152.0K | 0.00% | +25,000 | New |
| ADAR1 Capital Management, LLC | 23,643 | $143.7K | 0.01% | +5,000+26.8% | Added |
| Goldman Sachs Group Inc | 18,114 | $110.1K | 0.00% | −4,530−20.0% | Reduced |
| Susquehanna International Group, LLP | 16,866 | $102.5K | 0.00% | +16,866 | New |
| Two Sigma Advisers, LP | 15,900 | $96.7K | 0.00% | −26,700−62.7% | Reduced |
| China Universal Asset Management Co., Ltd. | 13,653 | $83.0K | 0.01% | +5,421+65.9% | Added |
| Rhumbline Advisers | 12,999 | $79.0K | 0.00% | +7,134+121.6% | Added |
| BNP Paribas Arbitrage, SA | 12,027 | $73.1K | 0.00% | +11,427+1,904.5% | Added |
| XTX Topco Ltd | 11,718 | $71.2K | 0.00% | +11,718 | New |
| GAMMA Investing LLC | 10,112 | $61.5K | 0.00% | +197+2.0% | Added |
| JPMorgan Chase & Co | 7,942 | $48.3K | 0.00% | +176+2.3% | Added |
| Barclays PLC | 5,065 | $30.8K | 0.00% | −2,071−29.0% | Reduced |
| Simplex Trading, LLC | 3,991 | $24.3K | 0.00% | +3,340+513.1% | Added |
| Bank of America Corp | 2,966 | $18.0K | 0.00% | −565−16.0% | Reduced |
| Jones Financial Companies LLLP | 2,500 | $15.2K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 2,448 | $14.9K | 0.00% | +10.0% | Added |
| Mirae Asset Global Investments Co., Ltd. | 2,282 | $13.9K | 0.00% | +466+25.7% | Added |
| Citigroup Inc | 1,621 | $9.86K | 0.00% | −152−8.6% | Reduced |
| Parallel Advisors, LLC | 1,300 | $7.90K | 0.00% | 00.0% | Unchanged |
| Global Retirement Partners, LLC | 1,000 | $6.08K | 0.00% | +1,000 | New |
| GF Fund Management Co. Ltd. | 922 | $5.61K | 0.00% | −56−5.7% | Reduced |
| Steward Partners Investment Advisory, LLC | 100 | $608 | 0.00% | 00.0% | Unchanged |
| Rockefeller Capital Management L.P. | 45 | $274 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 28 | $170 | 0.00% | −1−3.4% | Reduced |
| SageView Advisory Group, LLC | 11 | $67 | 0.00% | +11 | New |
| Advisor Group Holdings, Inc. | 3 | $18 | 0.00% | −62,168−100.0% | Reduced |
| Royal Bank of Canada | 16 | $0 | 0.00% | −1,120−98.6% | Reduced |
| Frazier Life Sciences Management, L.P. | 0 | $0 | 0.00% | −970,130−100.0% | Sold out |
| Cantor Fitzgerald, L. P. | 0 | $0 | 0.00% | −801,306−100.0% | Sold out |
| Woodline Partners LP | 0 | $0 | 0.00% | −62,459−100.0% | Sold out |
| Virtus Investment Advisers, Inc. | 0 | $0 | 0.00% | −20,374−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −10,887−100.0% | Sold out |
| EHP Funds Inc. | 0 | $0 | 0.00% | −10,673−100.0% | Sold out |
| Cambridge Investment Research Advisors, Inc. | 0 | $0 | 0.00% | −10,194−100.0% | Sold out |
| Wexford Capital LP | 0 | $0 | 0.00% | −7,708−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −4,218−100.0% | Sold out |
| Principal Securities, Inc. | 0 | $0 | 0.00% | −17−100.0% | Sold out |