Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Septerna, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 153
- +31 vs. Q1 2026
- Shares held
- 47.2M
- +2.41M (+5.4%) vs. Q1 2026
- Total value
- $1.58B
- +$504.7M (+46.8%) vs. Q1 2026
- New holders
- 47
- 49 more added
- Sold out
- 16
- 32 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Renaissance Technologies LLC | 41,419 | $1.39M | 0.00% | +3,719+9.9% | Added |
| HRT Financial LP | 42,022 | $1.41M | 0.00% | +42,022 | New |
| Voleon Capital Management LP | 44,435 | $1.49M | 0.03% | +44,435 | New |
| Jane Street Group, LLC | 45,552 | $1.53M | 0.00% | +45,552 | New |
| D. E. Shaw & Co., Inc. | 46,483 | $1.56M | 0.00% | +46,483 | New |
| Sofinnova Investments, Inc. | 47,506 | $1.59M | 0.08% | 00.0% | Unchanged |
| Nuveen, LLC | 48,229 | $1.62M | 0.00% | +19,053+65.3% | Added |
| Elmind Capital, LP | 49,444 | $1.66M | 0.42% | +49,444 | New |
| Barclays PLC | 49,821 | $1.67M | 0.00% | +27,107+119.3% | Added |
| Millennium Management LLC | 50,562 | $1.69M | 0.00% | −73,539−59.3% | Reduced |
| XTX Topco Ltd | 54,489 | $1.82M | 0.02% | +17,766+48.4% | Added |
| Bank of New York Mellon Corp | 56,176 | $1.88M | 0.00% | −2,533−4.3% | Reduced |
| American Century Companies Inc | 60,973 | $2.04M | 0.00% | −317−0.5% | Reduced |
| Hussman Strategic Advisors, Inc. | 63,000 | $2.11M | 0.49% | −42,000−40.0% | Reduced |
| Jacobs Levy Equity Management, Inc | 68,180 | $2.28M | 0.01% | +39,744+139.8% | Added |
| Arrowstreet Capital, Limited Partnership | 74,649 | $2.50M | 0.00% | +74,649 | New |
| Dimensional Fund Advisors LP | 75,309 | $2.52M | 0.00% | +75,309 | New |
| Lazard Asset Management LLC | 75,425 | $2.53M | 0.00% | +75,425 | New |
| Federated Hermes, Inc. | 86,753 | $2.91M | 0.00% | −2,548−2.9% | Reduced |
| JPMorgan Chase & Co | 85,301 | $2.96M | 0.00% | +627+0.7% | Added |
| UBS Group AG | 89,874 | $3.01M | 0.00% | −27,105−23.2% | Reduced |
| Morgan Stanley | 134,377 | $4.50M | 0.00% | +23,847+21.6% | Added |
| Vanguard Fiduciary Trust Co | 165,656 | $5.55M | 0.00% | +11,172+7.2% | Added |
| Woodline Partners LP | 185,535 | $6.21M | 0.02% | +185,535 | New |
| Charles Schwab Investment Management Inc | 187,041 | $6.26M | 0.00% | +5,461+3.0% | Added |
| Kalehua Capital Management LLC | 194,544 | $6.52M | 3.75% | 00.0% | Unchanged |
| Northern Trust Corp | 201,131 | $6.74M | 0.00% | +36,601+22.2% | Added |
| Two Sigma Investments, LP | 220,885 | $7.40M | 0.01% | +145,518+193.1% | Added |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222,702 | $7.46M | 0.01% | −1,293−0.6% | Reduced |
| Vanguard Portfolio Management LLC | 230,184 | $7.71M | 0.00% | +35,141+18.0% | Added |
| Soleus Capital Management, L.P. | 275,000 | $9.21M | 0.32% | 00.0% | Unchanged |
| Longaeva Partners L.P. | 298,171 | $9.99M | 0.29% | +223,604+299.9% | Added |
| Balyasny Asset Management LLC | 350,442 | $11.7M | 0.02% | +113,763+48.1% | Added |
| Algert Global LLC | 397,487 | $13.3M | 0.16% | +376,452+1,789.6% | Added |
| Catalio Capital Management, LP | 536,152 | $18.0M | 3.37% | +241,792+82.1% | Added |
| Casdin Capital, LLC | 553,268 | $18.5M | 0.93% | 00.0% | Unchanged |
| Loomis Sayles & Co L P | 624,752 | $20.9M | 0.03% | +624,752 | New |
| State Street Corp | 652,630 | $21.9M | 0.00% | +21,183+3.4% | Added |
| Geode Capital Management, LLC | 679,163 | $22.8M | 0.00% | +34,017+5.3% | Added |
| ADAR1 Capital Management, LLC | 940,747 | $31.5M | 1.48% | −149,071−13.7% | Reduced |
| First Light Asset Management, LLC | 963,260 | $32.3M | 1.96% | +230,400+31.4% | Added |
| Primecap Management Co | 1,167,382 | $39.1M | 0.02% | +118,548+11.3% | Added |
| Vanguard Capital Management LLC | 1,221,673 | $40.9M | 0.00% | +24,711+2.1% | Added |
| Jupiter Topco LLC | 1,307,500 | $43.7M | 0.02% | +1,307,500 | New |
| Avoro Capital Advisors LLC | 1,337,500 | $44.8M | 0.40% | 00.0% | Unchanged |
| Siren, L.L.C. | 1,900,000 | $63.6M | 1.29% | −100,000−5.0% | Reduced |
| BlackRock, Inc. | 1,932,088 | $64.7M | 0.00% | +109,914+6.0% | Added |
| Goldman Sachs Group Inc | 3,062,766 | $102.6M | 0.01% | +156,339+5.4% | Added |
| Samsara BioCapital, LLC | 3,149,128 | $105.5M | 8.66% | 00.0% | Unchanged |
| TRV GP VI, LLC | 4,211,659 | $141.0M | 60.72% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,433,058 | $148.5M | 0.86% | +37,486+0.9% | Added |
| TRV GP V, LLC | 6,215,591 | $208.2M | 41.78% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 6,995,858 | $234.3M | 2.04% | 00.0% | Unchanged |
| BVF Inc | 0 | $0 | 0.00% | −1,353,249−100.0% | Sold out |
| VR Adviser, LLC | 0 | $0 | 0.00% | −506,056−100.0% | Sold out |
| Checkpoint Capital L.P. | 0 | $0 | 0.00% | −100,300−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −39,840−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −25,770−100.0% | Sold out |
| Adage Capital Partners GP, L.L.C. | 0 | $0 | 0.00% | −24,000−100.0% | Sold out |
| VARCOV Co. | 0 | $0 | 0.00% | −16,752−100.0% | Sold out |
| Numerai GP LLC | 0 | $0 | 0.00% | −15,082−100.0% | Sold out |
| EntryPoint Capital, LLC | 0 | $0 | 0.00% | −12,776−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −12,343−100.0% | Sold out |
| Seven Fleet Capital Management LP | 0 | $0 | 0.00% | −11,445−100.0% | Sold out |
| Public Employees Retirement System of Ohio | 0 | $0 | 0.00% | −3,374−100.0% | Sold out |
| Diadema Partners LP | 0 | $0 | 0.00% | −202−100.0% | Sold out |
| Farther Finance Advisors, LLC | 0 | $0 | 0.00% | −7−100.0% | Sold out |
| Quadrant Capital Group LLC | 0 | $0 | 0.00% | −7−100.0% | Sold out |
| MAI Capital Management | 0 | $0 | 0.00% | −6−100.0% | Sold out |
| Janus Henderson Group PLC | – | – | – | – | Not filed |
| CWM, LLC | – | – | – | – | Not filed |