Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 6 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Septerna, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 124
- +4 vs. Q4 2025
- Shares held
- 45.7M
- +1.64M (+3.7%) vs. Q4 2025
- Total value
- $1.10B
- −$130.2M (−10.6%) vs. Q4 2025
- New holders
- 28
- 43 more added
- Sold out
- 24
- 30 more reduced
2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Vanguard Portfolio Management LLC | 195,043 | $4.69M | 0.00% | +195,043 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 223,995 | $5.38M | 0.01% | +1,293+0.6% | Added |
| Balyasny Asset Management LLC | 236,679 | $5.69M | 0.01% | +233,108+6,527.8% | Added |
| Soleus Capital Management, L.P. | 275,000 | $6.61M | 0.27% | −108,368−28.3% | Reduced |
| Catalio Capital Management, LP | 294,360 | $7.07M | 1.48% | 00.0% | Unchanged |
| VR Adviser, LLC | 506,056 | $12.2M | 0.45% | −104,752−17.1% | Reduced |
| Casdin Capital, LLC | 553,268 | $13.3M | 1.01% | 00.0% | Unchanged |
| State Street Corp | 631,447 | $15.2M | 0.00% | +91,419+16.9% | Added |
| Geode Capital Management, LLC | 645,146 | $15.5M | 0.00% | +72,412+12.6% | Added |
| First Light Asset Management, LLC | 732,860 | $17.6M | 1.58% | +112,049+18.0% | Added |
| Janus Henderson Group PLC | 890,754 | $21.3M | 0.01% | +890,754 | New |
| Primecap Management Co | 1,048,834 | $25.2M | 0.02% | +502,734+92.1% | Added |
| ADAR1 Capital Management, LLC | 1,089,818 | $26.2M | 1.57% | −67,793−5.9% | Reduced |
| Vanguard Capital Management LLC | 1,196,962 | $28.8M | 0.00% | +1,196,962 | New |
| Avoro Capital Advisors LLC | 1,337,500 | $32.1M | 0.32% | 00.0% | Unchanged |
| BVF Inc | 1,353,249 | $32.5M | 1.04% | −367,533−21.4% | Reduced |
| BlackRock, Inc. | 1,822,174 | $43.8M | 0.00% | +20,846+1.2% | Added |
| Siren, L.L.C. | 2,000,000 | $48.1M | 1.33% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 2,906,427 | $69.8M | 0.01% | +191,298+7.0% | Added |
| Samsara BioCapital, LLC | 3,149,128 | $75.7M | 7.35% | 00.0% | Unchanged |
| TRV GP VI, LLC | 4,211,659 | $101.2M | 74.64% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,395,572 | $105.6M | 0.78% | −413,898−8.6% | Reduced |
| TRV GP V, LLC | 6,215,591 | $149.4M | 37.25% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 6,995,858 | $168.1M | 1.78% | 00.0% | Unchanged |
| Perceptive Advisors LLC | 0 | $0 | 0.00% | −433,160−100.0% | Sold out |
| Woodline Partners LP | 0 | $0 | 0.00% | −385,310−100.0% | Sold out |
| HighVista Strategies LLC | 0 | $0 | 0.00% | −78,682−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −75,945−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −44,070−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −37,867−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −25,700−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −18,053−100.0% | Sold out |
| Franklin Resources Inc | 0 | $0 | 0.00% | −16,852−100.0% | Sold out |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −14,090−100.0% | Sold out |
| Intech Investment Management LLC | 0 | $0 | 0.00% | −13,283−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −10,810−100.0% | Sold out |
| PharVision Advisers, LLC | 0 | $0 | 0.00% | −10,739−100.0% | Sold out |
| Baader Bank INC | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Atom Investors LP | 0 | $0 | 0.00% | −9,791−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −8,971−100.0% | Sold out |
| Bank of Nova Scotia | 0 | $0 | 0.00% | −8,300−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −944−100.0% | Sold out |
| Quarry LP | 0 | $0 | 0.00% | −724−100.0% | Sold out |
| Amalgamated Bank | 0 | $0 | 0.00% | −672−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −628−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −149−100.0% | Sold out |
| Aster Capital Management (DIFC) Ltd | 0 | $0 | 0.00% | −20−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −3−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |
| Global Retirement Partners, LLC | – | – | – | – | Not filed |