Septerna, Inc.
SEPN- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001984086
In the last 90 days, Septerna, Inc. insiders filed 0 open-market purchases and 7 sales; 153 institutions reported holding it in 13F filings for Q2 2026, worth $1.58B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Septerna, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 122
- +40 vs. Q3 2025
- Shares held
- 45.6M
- +1.04M (+2.3%) vs. Q3 2025
- Total value
- $1.27B
- +$432.9M (+51.7%) vs. Q3 2025
- New holders
- 45
- 31 more added
- Sold out
- 5
- 27 more reduced
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SEPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 153 | $1.58B |
| Q1 2026 | 124 | $1.10B |
| Q4 2025 | 122 | $1.27B |
| Q3 2025 | 82 | $838.0M |
| Q2 2025 | 89 | $469.6M |
| Q1 2025 | 71 | $262.2M |
| Q4 2024 | 71 | $1.01B |
| Q3 2024 | 0 | $0 |
| Q2 2024 | 0 | $0 |
| Q1 2024 | 0 | $0 |
| Q4 2023 | 0 | $0 |
| Q3 2023 | 0 | $0 |
| Q2 2023 | 0 | $0 |
| Q1 2023 | 0 | $0 |
| Q4 2022 | 0 | $0 |
| Q3 2022 | 0 | $0 |
| Q2 2022 | 0 | $0 |
| Q1 2022 | 0 | $0 |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Septerna, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Catalio Capital Management, LP | 294,360 | $8.21M | 1.45% | 00.0% | Unchanged |
| Soleus Capital Management, L.P. | 383,368 | $10.7M | 0.45% | +365,108+1,999.5% | Added |
| Woodline Partners LP | 385,310 | $10.7M | 0.04% | +102,725+36.4% | Added |
| Perceptive Advisors LLC | 433,160 | $12.1M | 0.22% | −108,290−20.0% | Reduced |
| State Street Corp | 540,028 | $15.1M | 0.00% | +121,068+28.9% | Added |
| Primecap Management Co | 546,100 | $15.2M | 0.01% | +546,100 | New |
| Casdin Capital, LLC | 553,268 | $15.4M | 0.96% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 572,734 | $16.0M | 0.00% | +27,033+5.0% | Added |
| VR Adviser, LLC | 610,808 | $17.0M | 0.84% | 00.0% | Unchanged |
| First Light Asset Management, LLC | 620,811 | $17.3M | 1.32% | +620,811 | New |
| ADAR1 Capital Management, LLC | 1,157,611 | $32.3M | 2.41% | −18,880−1.6% | Reduced |
| Avoro Capital Advisors LLC | 1,337,500 | $37.3M | 0.37% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,508,195 | $42.0M | 0.00% | −10,562−0.7% | Reduced |
| BVF Inc | 1,720,782 | $48.0M | 1.61% | −2,295,008−57.1% | Reduced |
| BlackRock, Inc. | 1,801,328 | $50.2M | 0.00% | +341,533+23.4% | Added |
| Siren, L.L.C. | 2,000,000 | $55.8M | 1.66% | −202,514−9.2% | Reduced |
| Goldman Sachs Group Inc | 2,715,129 | $75.7M | 0.01% | +1,260,409+86.6% | Added |
| Samsara BioCapital, LLC | 3,149,128 | $87.8M | 9.06% | 00.0% | Unchanged |
| TRV GP VI, LLC | 4,211,659 | $117.4M | 79.05% | 00.0% | Unchanged |
| Driehaus Capital Management LLC | 4,809,470 | $134.1M | 0.91% | −110,426−2.2% | Reduced |
| TRV GP V, LLC | 6,215,591 | $173.3M | 40.38% | 00.0% | Unchanged |
| Ra Capital Management, L.P. | 6,995,858 | $195.0M | 2.00% | 00.0% | Unchanged |
| Checkpoint Capital L.P. | 0 | $0 | 0.00% | −283,158−100.0% | Sold out |
| Sio Capital Management, LLC | 0 | $0 | 0.00% | −189,199−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −80,341−100.0% | Sold out |
| Verition Fund Management LLC | 0 | $0 | 0.00% | −20,131−100.0% | Sold out |
| National Bank of Canada | 0 | $0 | 0.00% | −8−100.0% | Sold out |