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Alpine Immune Sciences, Inc.

ALPNDelisted May 20, 2024
Industry
Pharmaceutical Preparations
SEC CIK
0001626199

Alpine Immune Sciences, Inc. was delisted on May 20, 2024; its insiders filed their last Form 4 on May 20, 2024; 180 institutions reported holding it in 13F filings for Q1 2024, worth $2.56B in total; no superinvestor held it.

13F holders, Q1 2022

Institutional positions in Alpine Immune Sciences, Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
56
+3 vs. Q4 2021
Shares held
24.7M
+6.16M (+33.2%) vs. Q4 2021
Total value
$221.8M
−$35.3M (−13.7%) vs. Q4 2021
New holders
10
16 more added
Sold out
7
17 more reduced

Compare with Q4 2021: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting ALPN on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2022: 56 institutions
Q1 2021: 48 institutionsQ2 2021: 47 institutionsQ3 2021: 44 institutionsQ4 2021: 53 institutionsQ1 2022: 56 institutionsQ2 2022: 58 institutionsQ3 2022: 70 institutionsQ4 2022: 64 institutionsQ1 2023: 61 institutionsQ2 2023: 77 institutionsQ3 2023: 88 institutionsQ4 2023: 133 institutionsQ1 2024: 180 institutionsQ2 2024: 0 institutionsQ3 2024: 0 institutionsQ4 2024: 0 institutionsQ1 2025: 0 institutionsQ2 2025: 0 institutionsQ3 2025: 0 institutionsQ4 2025: 0 institutionsQ1 2026: 0 institutionsQ2 2026: 0 institutions
Value heldQ1 2022: $221.8M
Q1 2021: $145.0MQ2 2021: $118.5MQ3 2021: $163.5MQ4 2021: $257.1MQ1 2022: $221.8MQ2 2022: $204.4MQ3 2022: $284.0MQ4 2022: $300.8MQ1 2023: $319.4MQ2 2023: $449.3MQ3 2023: $525.8MQ4 2023: $1.12BQ1 2024: $2.56BQ2 2024: $0Q3 2024: $0Q4 2024: $0Q1 2025: $0Q2 2025: $0Q3 2025: $0Q4 2025: $0Q1 2026: $0Q2 2026: $0
Institutions holding ALPN and their total value by quarter
QuarterHoldersValue
Q2 20260$0
Q1 20260$0
Q4 20250$0
Q3 20250$0
Q2 20250$0
Q1 20250$0
Q4 20240$0
Q3 20240$0
Q2 20240$0
Q1 2024180$2.56B
Q4 2023133$1.12B
Q3 202388$525.8M
Q2 202377$449.3M
Q1 202361$319.4M
Q4 202264$300.8M
Q3 202270$284.0M
Q2 202258$204.4M
Q1 202256$221.8M
Q4 202153$257.1M
Q3 202144$163.5M
Q2 202147$118.5M
Q1 202148$145.0M

Institutions, Q1 2022

Shares, value and share of portfolio for each institution holding Alpine Immune Sciences, Inc.; share changes are against Q4 2021.

Institutions holding ALPN in Q1 2022
InstitutionSharesValue% of portfolioChange in sharesAction
Decheng Capital Management III (Cayman), LLC4,708,288$42.2M12.94%+4,708,288New
Frazier Life Sciences Management, L.P.4,185,757$37.5M3.20%+4,185,757New
OrbiMed Advisors LLC4,081,592$36.6M0.59%00.0%Unchanged
Omega Fund Management, LLC2,029,580$18.2M3.73%00.0%Unchanged
BVF Inc1,589,495$14.3M0.57%00.0%Unchanged
Lynx1 Capital Management LP1,484,693$13.3M12.37%+222,766+17.7%Added
Avidity Partners Management LP1,207,000$10.8M0.24%−138,000−10.3%Reduced
TCG Crossover Management, LLC1,034,222$9.28M3.72%−135,990−11.6%Reduced
BlackRock Inc.723,138$6.49M0.00%−5,710−0.8%Reduced
Vanguard Group Inc707,598$6.35M0.00%+9,844+1.4%Added
Artal Group S.A.593,030$5.32M0.22%00.0%Unchanged
Renaissance Technologies LLC386,094$3.46M0.00%−200−0.1%Reduced
Paradigm Biocapital Advisors LP336,229$3.02M0.80%+336,229New
State Street Corp220,621$1.98M0.00%+14,609+7.1%Added
Geode Capital Management, LLC215,156$1.93M0.00%+18,490+9.4%Added
Bridgeway Capital Management, LLC145,611$1.31M0.03%00.0%Unchanged
Jacobs Levy Equity Management, Inc138,279$1.24M0.01%+138,279New
Tiger Management L.L.C.137,728$1.24M0.33%00.0%Unchanged
Two Sigma Advisers, LP114,175$1.02M0.00%+6,400+5.9%Added
Ensign Peak Advisors, Inc110,017$987.0K0.00%+37,087+50.9%Added
Northern Trust Corp101,708$912.0K0.00%−3,887−3.7%Reduced
Dimensional Fund Advisors LP53,064$476.0K0.00%00.0%Unchanged
Bank of New York Mellon Corp49,155$441.0K0.00%−2,590−5.0%Reduced
Two Sigma Investments, LP47,708$428.0K0.00%−31,974−40.1%Reduced
Walleye Capital LLC41,746$374.0K0.01%−68,353−62.1%Reduced
Charles Schwab Investment Management Inc32,417$291.0K0.00%+2,294+7.6%Added
Alps Advisors Inc30,030$269.0K0.00%−3,785−11.2%Reduced
Kingsbury Capital Investment Advisors LLC29,153$262.0K0.29%+29,153New
Connor, Clark & Lunn Investment Management Ltd.28,316$254.0K0.00%+9,290+48.8%Added
Goldman Sachs Group Inc22,850$205.0K0.00%+9,471+70.8%Added
Nuveen Asset Management, LLC18,446$160.0K0.00%00.0%Unchanged
Allspring Global Investments Holdings, LLC16,862$151.0K0.00%+10,835+179.8%Added
Bank of America Corp15,442$138.0K0.00%+10,498+212.3%Added
Hikari Power Ltd12,445$112.0K0.01%+2,000+19.1%Added
Susquehanna International Group, LLP12,421$111.0K0.00%+12,421New
Morgan Stanley9,277$83.0K0.00%+132+1.4%Added
JPMorgan Chase & Co8,947$80.0K0.00%+1,697+23.4%Added
Deutsche Bank AG6,300$57.0K0.00%−742−10.5%Reduced
American International Group, Inc.5,767$52.0K0.00%−406−6.6%Reduced
Wells Fargo & Company5,703$51.0K0.00%−3,735−39.6%Reduced
STRS Ohio5,500$49.0K0.00%00.0%Unchanged
New York State Common Retirement Fund5,397$48.0K0.00%00.0%Unchanged
California State Teachers Retirement System4,967$45.0K0.00%−1,183−19.2%Reduced
BNP Paribas Arbitrage, SA3,777$33.9K0.00%+531+16.4%Added
UBS Group AG2,369$22.0K0.00%−2,627−52.6%Reduced
Zurcher Kantonalbank (Zurich Cantonalbank)2,257$20.0K0.00%+2,257New
Tower Research Capital LLC (TRC)2,004$18.0K0.00%+1,199+148.9%Added
Barclays PLC1,886$17.0K0.00%−12,212−86.6%Reduced
Amalgamated Bank1,891$17.0K0.00%+1,891New
Amalgamated Financial Corp.1,891$17.0K0.00%+1,891New
Legal & General Group Plc1,227$11.0K0.00%00.0%Unchanged
Citigroup Inc1,043$9.00K0.00%−2,723−72.3%Reduced
Ameritas Investment Partners, Inc.911$8.00K0.00%00.0%Unchanged
Royal Bank of Canada713$6.00K0.00%−1,899−72.7%Reduced
FMR LLC266$2.00K0.00%+266New
Daiwa Securities Group Inc.85$1.00K0.00%00.0%Unchanged
Frazier Management LLC0$00.00%−1,784,913−100.0%Sold out
Logos Global Management LP0$00.00%−1,120,000−100.0%Sold out
Acuta Capital Partners, LLC0$00.00%−230,000−100.0%Sold out
Westwood Holdings Group Inc.0$00.00%−23,079−100.0%Sold out
Jump Financial, LLC0$00.00%−12,600−100.0%Sold out
Western Wealth Management, LLC0$00.00%−12,360−100.0%Sold out
Parametric Portfolio Associates LLC0$00.00%−10,875−100.0%Sold out