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Alnylam Pharmaceuticals, Inc.

ALNY
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001178670

No open-market purchases or sales by Alnylam Pharmaceuticals, Inc. insiders were filed in the last 90 days; 794 institutions reported holding it in 13F filings for Q2 2026, worth $40.1B in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Alnylam Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
852
+55 vs. Q3 2025
Shares held
132.8M
+3.06M (+2.4%) vs. Q3 2025
Total value
$52.7B
−$6.43B (−10.9%) vs. Q3 2025
New holders
172
290 more added
Sold out
117
291 more reduced

26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting ALNY on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 852 institutions
Q1 2021: 391 institutionsQ2 2021: 401 institutionsQ3 2021: 407 institutionsQ4 2021: 435 institutionsQ1 2022: 443 institutionsQ2 2022: 424 institutionsQ3 2022: 497 institutionsQ4 2022: 489 institutionsQ1 2023: 478 institutionsQ2 2023: 477 institutionsQ3 2023: 454 institutionsQ4 2023: 501 institutionsQ1 2024: 499 institutionsQ2 2024: 525 institutionsQ3 2024: 569 institutionsQ4 2024: 594 institutionsQ1 2025: 625 institutionsQ2 2025: 653 institutionsQ3 2025: 823 institutionsQ4 2025: 852 institutionsQ1 2026: 793 institutionsQ2 2026: 794 institutions
Value heldQ4 2025: $52.7B
Q1 2021: $15.4BQ2 2021: $19.0BQ3 2021: $21.1BQ4 2021: $19.0BQ1 2022: $18.6BQ2 2022: $16.6BQ3 2022: $26.7BQ4 2022: $28.4BQ1 2023: $24.0BQ2 2023: $22.5BQ3 2023: $20.9BQ4 2023: $22.4BQ1 2024: $17.2BQ2 2024: $29.1BQ3 2024: $34.1BQ4 2024: $30.1BQ1 2025: $34.8BQ2 2025: $43.1BQ3 2025: $59.2BQ4 2025: $52.7BQ1 2026: $43.4BQ2 2026: $40.1B
Institutions holding ALNY and their total value by quarter
QuarterHoldersValue
Q2 2026794$40.1B
Q1 2026793$43.4B
Q4 2025852$52.7B
Q3 2025823$59.2B
Q2 2025653$43.1B
Q1 2025625$34.8B
Q4 2024594$30.1B
Q3 2024569$34.1B
Q2 2024525$29.1B
Q1 2024499$17.2B
Q4 2023501$22.4B
Q3 2023454$20.9B
Q2 2023477$22.5B
Q1 2023478$24.0B
Q4 2022489$28.4B
Q3 2022497$26.7B
Q2 2022424$16.6B
Q1 2022443$18.6B
Q4 2021435$19.0B
Q3 2021407$21.1B
Q2 2021401$19.0B
Q1 2021391$15.4B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Alnylam Pharmaceuticals, Inc.; share changes are against Q3 2025.

Institutions holding ALNY in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
West Family Investments, Inc.646$256.9K0.06%−176−21.4%Reduced
Sowell Financial Services LLC645$256.5K0.01%−9−1.4%Reduced
Plante Moran Financial Advisors, LLC635$252.5K0.02%−2−0.3%Reduced
Journey Retirement Planning & Investment Management LLC630$250.5K0.05%+630New
Evoke Wealth, LLC621$246.9K0.00%−275−30.7%Reduced
Transcend Wealth Collective, LLC620$246.5K0.02%−279−31.0%Reduced
Everpar Advisors LLC620$246.5K0.09%+37+6.3%Added
Quadrant Capital Group LLC615$244.6K0.01%+62+11.2%Added
Independent Advisor Alliance605$240.6K0.01%−74−10.9%Reduced
Waterloo Capital, L.P.605$240.6K0.02%−25−4.0%Reduced
PCM Encore, LLC605$240.4K0.05%+605New
Covenant Partners, LLC604$240.2K0.07%00.0%Unchanged
LeConte Wealth Management, LLC604$240.2K0.16%+78+14.8%Added
AlTi Global, Inc.602$239.4K0.01%+26+4.5%Added
Evercore Wealth Management, LLC600$238.6K0.00%00.0%Unchanged
Premier Path Wealth Partners, LLC596$236.8K0.03%+92+18.3%Added
Graham Capital Management, L.P.588$233.8K0.01%−2,427−80.5%Reduced
LVW Advisors, LLC582$231.4K0.02%−8−1.4%Reduced
Northwestern Mutual Wealth Management Co581$231.0K0.00%+14+2.5%Added
Cooper Financial Group580$230.6K0.02%−17−2.8%Reduced
Algert Global LLC580$230.6K0.00%+580New
Kingswood Wealth Advisors, LLC574$228.3K0.01%+574New
Oversea-Chinese Banking CORP Ltd565$224.7K0.01%+565New
Northwest Wealth Management, LLC565$224.7K0.04%+565New
Fidelis Capital Partners, LLC563$223.9K0.02%+24+4.5%Added
Alta Advisers Ltd557$221.5K0.08%−200−26.4%Reduced
Chicago Partners Investment Group LLC617$220.9K0.01%−355−36.5%Reduced
Gabelli Funds LLC550$218.7K0.00%+550New
Portside Wealth Group, LLC546$217.1K0.03%−205−27.3%Reduced
Essex LLC546$217.1K0.04%−1−0.2%Reduced
Capital Performance Advisors LLP541$215.1K0.02%−47−8.0%Reduced
Fi3 FINANCIAL ADVISORS, LLC539$214.3K0.07%−2−0.4%Reduced
Intrust Bank NA538$213.9K0.02%+538New
Towarzystwo Funduszy Inwestycyjnych Pzu SA530$210.8K0.05%00.0%Unchanged
Soltis Investment Advisors LLC530$210.6K0.01%+530New
AlphaCore Capital LLC527$209.6K0.00%+527New
Ariadne Wealth Management, LP677$208.8K0.09%−26−3.7%Reduced
GTS Securities LLC525$208.8K0.01%+525New
Cascade Financial Partners, LLC523$207.9K0.02%−104−16.6%Reduced
Fortitude Family Office, LLC517$205.6K0.05%00.0%Unchanged
Resources Investment Advisors, LLC.510$202.7K0.00%−220−30.1%Reduced
PharVision Advisers, LLC504$200.4K0.10%+504New
Align Financial, LLC198,825$198.8K0.12%+198,825New
Perkins Coie Trust Co500$198.8K0.04%+500New
Horizon Investments, LLC451$179.3K0.00%+48+11.9%Added
MAI Capital Management447$177.9K0.00%−2−0.4%Reduced
Essential Partners LLC445$177.0K0.05%−791−64.0%Reduced
USA Financial Portformulas Corp424$168.6K0.03%+424New
Versant Capital Management, Inc416$165.4K0.02%+24+6.1%Added
Bayforest Capital Ltd412$163.8K0.12%+412New
SageView Advisory Group, LLC398$158.3K0.01%+398New
Rothschild Investment LLC360$143.2K0.01%−718−66.6%Reduced
Quantbot Technologies LP350$139.2K0.00%−825−70.2%Reduced
Globeflex Capital L P335$133.2K0.02%+335New
E Fund Management (Hong Kong) Co., Ltd.389$131.9K0.06%+389New
TD Waterhouse Canada Inc.330$131.2K0.00%00.0%Unchanged
Havemeyer Place LP298$118.5K0.02%+298New
Ronald Blue Trust, Inc.284$112.9K0.00%−65−18.6%Reduced
Munich Reinsurance Co Stock Corp in Munich275$109.2K0.00%+275New
Greenline Wealth Management LLC242$96.1K0.10%+242New
Larson Financial Group LLC241$95.8K0.00%−59−19.7%Reduced
Torren Management, LLC235$93.4K0.05%+235New
Atlantic Union Bankshares Corp231$91.9K0.00%+40+20.9%Added
Bessemer Group Inc227$90.0K0.00%+5+2.3%Added
Clear Street Markets LLC202$80.3K0.01%+202New
Spire Wealth Management202$80.3K0.00%−5−2.4%Reduced
Concord Wealth Partners200$79.5K0.01%00.0%Unchanged
Massmutual Trust Co FSB194$77.1K0.00%−3−1.5%Reduced
LRI Investments, LLC192$76.2K0.01%+2+1.1%Added
Rakuten Securities, Inc.189$75.2K0.02%+185+4,625.0%Added
Brown Brothers Harriman & Co180$71.6K0.00%+7+4.0%Added
Evelyn Partners Investment Management LLP175$69.6K0.00%00.0%Unchanged
Prestige Wealth Management Group LLC173$68.8K0.01%−11−6.0%Reduced
First Horizon Corp163$64.8K0.00%+28+20.7%Added
Capital Advisors, Ltd. LLC162$64.0K0.01%00.0%Unchanged
Reflection Asset Management159$63.2K0.04%+159New
True Wealth Design, LLC155$61.5K0.02%−73−32.0%Reduced
Meeder Asset Management Inc154$61.2K0.00%+125+431.0%Added
CoreCap Advisors, LLC152$60.4K0.00%−228−60.0%Reduced
Clearstead Advisors, LLC147$58.5K0.00%−617−80.8%Reduced
SBI Securities Co., Ltd.147$58.5K0.00%+84+133.3%Added
Zions Bancorporation, National Association147$58.5K0.00%+138+1,533.3%Added
Quarry LP144$57.3K0.01%+123+585.7%Added
Itau Unibanco Holding S.A.141$56.1K0.00%−27−16.1%Reduced
Stephenson National Bank & Trust135$53.7K0.02%−50−27.0%Reduced
Brown, Lisle/Cummings, Inc.132$52.5K0.01%00.0%Unchanged
Fifth Third Bancorp127$50.5K0.00%+70+122.8%Added
Park Place Capital Corp126$50.1K0.01%00.0%Unchanged
Fideuram Asset Management (Ireland) dac122$49.8K0.00%+122New
Rossby Financial, LCC124$49.3K0.02%+12+10.7%Added
Basecamp Wealth Advisors LLC123$48.8K0.01%+123New
Harbour Investments, Inc.116$46.1K0.00%−11−8.7%Reduced
SHP Wealth Management109$43.2K0.00%+109New
Activest Wealth Management108$42.9K0.01%+107+10,700.0%Added
Titan Wealth (CI) Ltd105$41.8K0.02%+105New
Leonteq Securities AG105$41.8K0.00%+102+3,400.0%Added
Eastern Bank105$41.8K0.00%+105New
Keating Financial Advisory Services, Inc.104$41.4K0.01%+104New
Huntington National Bank102$40.6K0.00%+1+1.0%Added
Hartford Financial Management Inc.100$39.8K0.01%00.0%Unchanged