Alnylam Pharmaceuticals, Inc.
ALNY- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001178670
No open-market purchases or sales by Alnylam Pharmaceuticals, Inc. insiders were filed in the last 90 days; 794 institutions reported holding it in 13F filings for Q2 2026, worth $40.1B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Alnylam Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 852
- +55 vs. Q3 2025
- Shares held
- 132.8M
- +3.06M (+2.4%) vs. Q3 2025
- Total value
- $52.7B
- −$6.43B (−10.9%) vs. Q3 2025
- New holders
- 172
- 290 more added
- Sold out
- 117
- 291 more reduced
26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ALNY on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 794 | $40.1B |
| Q1 2026 | 793 | $43.4B |
| Q4 2025 | 852 | $52.7B |
| Q3 2025 | 823 | $59.2B |
| Q2 2025 | 653 | $43.1B |
| Q1 2025 | 625 | $34.8B |
| Q4 2024 | 594 | $30.1B |
| Q3 2024 | 569 | $34.1B |
| Q2 2024 | 525 | $29.1B |
| Q1 2024 | 499 | $17.2B |
| Q4 2023 | 501 | $22.4B |
| Q3 2023 | 454 | $20.9B |
| Q2 2023 | 477 | $22.5B |
| Q1 2023 | 478 | $24.0B |
| Q4 2022 | 489 | $28.4B |
| Q3 2022 | 497 | $26.7B |
| Q2 2022 | 424 | $16.6B |
| Q1 2022 | 443 | $18.6B |
| Q4 2021 | 435 | $19.0B |
| Q3 2021 | 407 | $21.1B |
| Q2 2021 | 401 | $19.0B |
| Q1 2021 | 391 | $15.4B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Alnylam Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Capital World Investors | 16,301,772 | $6.48B | 0.88% | −132,481−0.8% | Reduced |
| FMR LLC | 15,902,149 | $6.32B | 0.32% | −865,476−5.2% | Reduced |
| Vanguard Group Inc | 13,553,932 | $5.39B | 0.08% | −11,520−0.1% | Reduced |
| BlackRock, Inc. | 10,400,874 | $4.14B | 0.07% | +497,273+5.0% | Added |
| Capital Research Global Investors | 6,779,708 | $2.70B | 0.50% | −443,132−6.1% | Reduced |
| Invesco Ltd. | 5,133,983 | $2.04B | 0.19% | +3,652,141+246.5% | Added |
| JPMorgan Chase & Co | 4,719,999 | $1.88B | 0.13% | +176,229+3.9% | Added |
| State Street Corp | 3,228,956 | $1.28B | 0.04% | +147,481+4.8% | Added |
| Geode Capital Management, LLC | 2,650,722 | $1.06B | 0.07% | +151,480+6.1% | Added |
| Baillie Gifford & Co | 2,600,979 | $1.03B | 0.86% | −188,377−6.8% | Reduced |
| Norges Bank | 2,252,775 | $895.8M | 0.10% | +2,252,775 | New |
| Dodge & Cox | 1,964,415 | $781.1M | 0.42% | −356,815−15.4% | Reduced |
| T. Rowe Price Investment Management, Inc. | 1,753,640 | $697.3M | 0.44% | −420,344−19.3% | Reduced |
| Price T Rowe Associates Inc | 1,702,831 | $677.1M | 0.07% | −97,463−5.4% | Reduced |
| Wellington Management Group LLP | 1,628,931 | $647.7M | 0.11% | −197,390−10.8% | Reduced |
| Orbis Allan Gray Ltd | 1,618,219 | $643.5M | 2.70% | −332,743−17.1% | Reduced |
| American Century Companies Inc | 1,485,161 | $590.6M | 0.30% | −156,280−9.5% | Reduced |
| Two Sigma Advisers, LP | 1,132,560 | $450.4M | 0.88% | +240,060+26.9% | Added |
| Arrowstreet Capital, Limited Partnership | 1,127,162 | $448.2M | 0.26% | −228,447−16.9% | Reduced |
| Morgan Stanley | 970,157 | $385.8M | 0.02% | +244,096+33.6% | Added |
| Legal & General Group Plc | 961,496 | $382.3M | 0.08% | +73,716+8.3% | Added |
| AQR Capital Management LLC | 919,959 | $365.8M | 0.19% | +175,951+23.6% | Added |
| Northern Trust Corp | 857,742 | $341.1M | 0.04% | +24,591+3.0% | Added |
| UBS Group AG | 825,840 | $328.4M | 0.07% | +337,636+69.2% | Added |
| Franklin Resources Inc | 787,623 | $313.2M | 0.08% | +73,611+10.3% | Added |
| Qube Research & Technologies Ltd | 774,676 | $308.0M | 0.44% | −36,602−4.5% | Reduced |
| Deutsche Bank AG | 711,975 | $283.1M | 0.09% | +105,655+17.4% | Added |
| Bank of America Corp | 685,177 | $272.5M | 0.02% | −813,314−54.3% | Reduced |
| UBS Asset Management Americas Inc | 652,366 | $259.4M | 0.05% | −56,198−7.9% | Reduced |
| Charles Schwab Investment Management Inc | 647,839 | $257.6M | 0.04% | +29,069+4.7% | Added |
| Federated Hermes, Inc. | 628,063 | $249.7M | 0.42% | +77,959+14.2% | Added |
| Two Sigma Investments, LP | 616,120 | $245.0M | 0.37% | +20,194+3.4% | Added |
| Amundi | 608,879 | $242.1M | 0.07% | +224,607+58.5% | Added |
| Clearbridge Investments, LLC | 597,013 | $237.4M | 0.19% | −25,422−4.1% | Reduced |
| Royal Bank of Canada | 591,495 | $235.2M | 0.04% | +154,737+35.4% | Added |
| Nuveen, LLC | 565,789 | $225.0M | 0.06% | −22,032−3.7% | Reduced |
| Marshall Wace, LLP | 549,922 | $218.7M | 0.21% | +41,551+8.2% | Added |
| Bank of New York Mellon Corp | 504,133 | $200.5M | 0.04% | +84,350+20.1% | Added |
| Massachusetts Financial Services Co | 495,307 | $197.0M | 0.06% | +138,778+38.9% | Added |
| Loomis Sayles & Co L P | 488,897 | $194.4M | 0.23% | −11,775−2.4% | Reduced |
| Bellevue Group AG | 445,903 | $177.3M | 3.36% | −621−0.1% | Reduced |
| D. E. Shaw & Co., Inc. | 444,493 | $176.8M | 0.13% | +245,076+122.9% | Added |
| 1832 Asset Management L.P. | 440,145 | $175.0M | 0.22% | −19,200−4.2% | Reduced |
| Jacobs Levy Equity Management, Inc | 401,371 | $159.6M | 0.62% | −8,971−2.2% | Reduced |
| BNP Paribas Arbitrage, SA | 389,435 | $154.9M | 0.10% | +236,396+154.5% | Added |
| Raymond James Financial Inc | 388,705 | $154.4M | 0.05% | +11,411+3.0% | Added |
| Goldman Sachs Group Inc | 375,323 | $149.2M | 0.02% | −163,023−30.3% | Reduced |
| Swiss National Bank | 359,200 | $142.8M | 0.09% | −16,600−4.4% | Reduced |
| Squarepoint Ops LLC | 350,969 | $139.6M | 0.28% | +205,404+141.1% | Added |
| KBC Group NV | 348,194 | $138.5M | 0.32% | +74,842+27.4% | Added |
| Worldquant Millennium Advisors LLC | 343,431 | $136.6M | 0.53% | +122,797+55.7% | Added |
| Sumitomo Mitsui Trust Holdings, Inc. | 327,763 | $130.3M | 0.08% | +13,311+4.2% | Added |
| Gilder Gagnon Howe & Co LLC | 319,305 | $127.0M | 1.34% | −10,016−3.0% | Reduced |
| Pictet Asset Management Holding SA | 316,053 | $125.8M | 0.12% | −71,493−18.4% | Reduced |
| Nomura Asset Management International Inc. | 311,757 | $124.0M | 0.19% | +311,757 | New |
| Jane Street Group, LLC | 311,288 | $123.8M | 0.15% | −647,462−67.5% | Reduced |
| Dimensional Fund Advisors LP | 301,865 | $120.0M | 0.03% | +59,931+24.8% | Added |
| OrbiMed Advisors LLC | 288,800 | $114.8M | 2.35% | −12,800−4.2% | Reduced |
| Allspring Global Investments Holdings, LLC | 278,657 | $111.5M | 0.18% | −32,147−10.3% | Reduced |
| Jennison Associates LLC | 277,759 | $110.5M | 0.07% | −27,104−8.9% | Reduced |
| Los Angeles Capital Management LLC | 240,052 | $107.9M | 0.37% | +80,658+50.6% | Added |
| Congress Asset Management Co | 269,239 | $107.1M | 0.75% | +150,439+126.6% | Added |
| TD Asset Management Inc | 269,101 | $107.0M | 0.09% | −43,416−13.9% | Reduced |
| Canada Pension Plan Investment Board | 258,711 | $102.9M | 0.07% | +122,380+89.8% | Added |
| Wells Fargo & Company | 257,640 | $102.5M | 0.02% | −22,928−8.2% | Reduced |
| First Trust Advisors LP | 256,954 | $102.2M | 0.07% | +46,571+22.1% | Added |
| Royal London Asset Management Ltd | 253,072 | $100.6M | 0.21% | −4,241−1.6% | Reduced |
| Polar Capital Holdings Plc | 240,606 | $95.7M | 0.44% | −10,854−4.3% | Reduced |
| California Public Employees Retirement System | 237,005 | $94.2M | 0.05% | +7,364+3.2% | Added |
| Candriam Luxembourg S.C.A. | 224,330 | $89.2M | 0.44% | +11,914+5.6% | Added |
| Barclays PLC | 222,561 | $88.5M | 0.04% | +128,153+135.7% | Added |
| Victory Capital Management Inc | 220,866 | $87.8M | 0.05% | +40,517+22.5% | Added |
| FengHe Fund Management Pte. Ltd. | 218,700 | $87.0M | 4.90% | +218,700 | New |
| ProShare Advisors LLC | 211,077 | $83.9M | 0.15% | +206,446+4,457.9% | Added |
| California State Teachers Retirement System | 201,816 | $80.3M | 0.08% | −1,962−1.0% | Reduced |
| CIBC Private Wealth Group, LLC | 200,425 | $79.7M | 0.13% | −13,788−6.4% | Reduced |
| Voya Investment Management LLC | 198,613 | $79.0M | 0.08% | −174,743−46.8% | Reduced |
| Rhumbline Advisers | 195,266 | $77.6M | 0.06% | −1,231−0.6% | Reduced |
| Susquehanna International Group, LLP | 191,820 | $76.3M | 0.10% | −385,812−66.8% | Reduced |
| Korea Investment CORP | 189,769 | $75.5M | 0.15% | −7,143−3.6% | Reduced |
| Ameriprise Financial Inc | 181,137 | $72.0M | 0.02% | −44,742−19.8% | Reduced |
| Citigroup Inc | 172,562 | $68.6M | 0.05% | +111,696+183.5% | Added |
| National Pension Service | 168,149 | $66.9M | 0.05% | −9,089−5.1% | Reduced |
| Russell Investments Group, Ltd. | 165,740 | $65.9M | 0.07% | −30,176−15.4% | Reduced |
| Voloridge Investment Management, LLC | 160,577 | $63.9M | 0.22% | −196,229−55.0% | Reduced |
| SCS Capital Management LLC | 149,611 | $59.5M | 0.63% | −1,057−0.7% | Reduced |
| Robeco Institutional Asset Management B.V. | 144,721 | $57.5M | 0.08% | +31,647+28.0% | Added |
| Man Group plc | 144,210 | $57.3M | 0.11% | +72,537+101.2% | Added |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 138,795 | $55.5M | 0.04% | +18,008+14.9% | Added |
| Janus Henderson Group PLC | 136,425 | $54.3M | 0.02% | +570+0.4% | Added |
| Handelsbanken Fonder AB | 136,185 | $54.2M | 0.16% | −19,184−12.3% | Reduced |
| Standard Life Aberdeen plc | 132,846 | $52.8M | 0.08% | −24,550−15.6% | Reduced |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 124,645 | $49.4M | 0.08% | +14,093+12.7% | Added |
| Envestnet Asset Management Inc | 120,521 | $47.9M | 0.01% | +1,557+1.3% | Added |
| Capital International Sarl | 119,352 | $47.5M | 0.76% | −10,350−8.0% | Reduced |
| Neuberger Berman Group LLC | 115,203 | $45.8M | 0.03% | −15,341−11.8% | Reduced |
| State Board of Administration of Florida Retirement System | 114,603 | $45.6M | 0.08% | −2,623−2.2% | Reduced |
| SEI Investments Co | 111,112 | $44.2M | 0.04% | +16,631+17.6% | Added |
| Aviva PLC | 110,662 | $44.0M | 0.07% | +7,456+7.2% | Added |
| Tremblant Capital Group | 110,132 | $43.8M | 1.12% | +110,132 | New |