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Opaleye Management Inc.

In the past year, 50 open-market purchase filings worth $18.8M and 11 sale filings worth $22.1M.

Current role at each company

Show 5 more companies

Open-market trades in the past year

Open-market purchases (P) and sales (S) filed in the last 365 days, not counting derivative securities or duplicate filings. Values leave out price outliers.

Bought
$18.8M
50 filings
Sold
$22.1M
11 filings
Net
−$3.22M
Bought minus sold
Companies
7
With open-market trades

Trades

Every Form 4 that lists Opaleye Management Inc. as a reporting owner, including filings made jointly with others, grouped by company. Each row adds up one type of transaction in one filing. Only open-market purchases (P) and sales (S) are shown by default.

ACOG Alpha Cognition Inc.

10% Owner22 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Sep 28, 2026 (view filing)7:57 PM ETSep 24-254 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+31.8K$8.53+$270.8K+1.0%3.20M after2 lots
Sep 16, 2026 (view filing)5:57 PM ETSep 14-162 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+123.9K$8.57+$1.06M+4.1%3.17M after4 lots
Aug 4, 2026 (view filing)4:50 PM ETJul 31-Aug 34 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+52.9K$8.00+$423.0K+1.8%3.05M after2 lots
Jul 28, 2026 (view filing)4:05 PM ETJul 244 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+130$7.90+$1.03K0.0%3.00M after
Jul 24, 2026 (view filing)4:05 PM ETJul 22-232 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+200.1K$7.82+$1.57M+7.2%3.00M after3 lots
Jun 29, 2026 (view filing)Jun 25-264 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+152.5K$6.40+$976.2K+5.8%2.81M after2 lots
Jun 15, 2026 (view filing)Jun 11-154 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+7.68K$5.96+$45.8K+0.3%2.65M after3 lots
Jun 11, 2026 (view filing)Jun 9-102 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+30.7K$5.98+$183.8K+1.2%2.64M after2 lots
Jun 9, 2026 (view filing)Jun 54 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+10.1K$5.83+$58.6K+0.4%2.61M after
May 29, 2026 (view filing)May 27-292 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+73.7K$5.90+$434.7K+2.9%2.60M after3 lots

See all 22 trades at ACOG

GRCE Grace Therapeutics, Inc.

10% Owner3 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Sep 23, 2026 (view filing)6:19 PM ETSep 21-232 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+15.1K$2.10+$31.7K+0.5%2.86M after2 lots
Sep 10, 2026 (view filing)4:05 PM ETSep 8-92 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+15.2K$2.09+$31.9K+0.6%2.78M after2 lots
Aug 19, 2026 (view filing)7:44 AM ETAug 145 daysLateOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+11.6K$2.09+$24.2K+0.4%2.76M after

SLGL Sol-Gel Technologies Ltd.

10% Owner24 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Sep 14, 2026 (view filing)5:23 PM ETSep 10-114 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share+3.12K$66.39+$207.4K+0.6%540.0K after2 lots
Sep 9, 2026 (view filing)7:18 PM ETSep 4-95 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share+9.98K$68.88+$687.2K+1.9%536.9K after5 lots
Sep 3, 2026 (view filing)4:05 PM ETSep 1-22 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share+1.68K$69.21+$116.5K+0.3%526.9K after2 lots
Aug 31, 2026 (view filing)6:24 PM ETAug 28-313 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share+40.3K$69.19+$2.79M+8.3%525.2K after5 lots
Aug 14, 2026 (view filing)4:05 PM ETAug 122 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share+951$71.50+$68.0K+0.2%494.9K after
Jul 15, 2026 (view filing)4:05 PM ETJul 13-142 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share+1.70K$73.64+$124.8K+0.3%493.9K after2 lots
Jul 10, 2026 (view filing)4:41 PM ETJul 8-102 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share+529$73.80+$39.0K+0.1%492.2K after2 lots
Jul 2, 2026 (view filing)6:11 PM ETJul 1-21 dayOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share+1.71K$71.97+$123.2K+0.3%491.7K after2 lots
May 22, 2026 (view filing)May 202 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+1.56K$64.43+$100.7K+0.3%490.0K after
May 14, 2026 (view filing)May 12-132 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+3.44K$67.35+$231.5K+0.7%488.4K after2 lots

See all 24 trades at SLGL

ETON Eton Pharmaceuticals, Inc.

10% Owner12 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Jul 17, 2026 (view filing)7:12 PM ETJul 143 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−28.3K$37.54−$1.06M−41.4%40.0K afterAmended2 lots
Jul 7, 2026 (view filing)6:29 PM ETJul 2-75 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−126.7K$37.64−$4.77M−70.4%53.3K after5 lots
Jun 12, 2025 (view filing)Jun 102 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+7.93K$15.82+$125.5K+10.3%85.0K after2 lots
Oct 25, 2024 (view filing)Oct 232 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+10.0K$7.98+$79.8K+0.4%2.77M after
Oct 8, 2024 (view filing)Oct 4-84 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+62.1K$6.99+$434.1K+310.3%82.1K after6 lots
Sep 12, 2024 (view filing)Sep 10-112 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+107.5K$4.70+$504.9KNew position75.0K after4 lots
Nov 19, 2021 (view filing)Nov 172 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−25.0K$4.67−$116.8K−1.0%2.38M after
Nov 17, 2021 (view filing)Nov 15-162 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−15.4K$4.85−$74.8K−15.4%85.0K after4 lots
Nov 9, 2021 (view filing)Nov 5-84 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−220.4K$6.25−$1.38M−71.8%86.4K after4 lots
Nov 5, 2021 (view filing)Nov 3-42 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−202.2K$6.49−$1.31M−67.5%97.5K after4 lots

See all 12 trades at ETON

SNWV SANUWAVE Health, Inc.

10% Owner6 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
May 4, 2026 (view filing)Apr 30-May 14 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−35.6K$16.14−$574.2K−87.7%5.00K after4 lots
Apr 30, 2026 (view filing)Apr 28-292 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−70.6K$18.05−$1.28M−91.6%6.50K after4 lots
Apr 21, 2026 (view filing)Apr 17-214 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−16.5K$20.46−$337.0K−1.7%954.8K after3 lots
Oct 9, 2025 (view filing)Oct 63 daysLateOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+1.27K$30.28+$38.4K+0.1%966.3K after
Apr 30, 2025 (view filing)Apr 291 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+8.00K$25.49+$203.9K+114.2%15.0K after2 lots
Nov 1, 2024 (view filing)Oct 30-Nov 12 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+27.9K$15.75+$438.9KNew position12.0K after5 lots

HROW Harrow, Inc.

10% Owner24 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Mar 5, 2026 (view filing)Mar 3-42 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−198.6K$39.51−$7.85M−77.0%59.4K after4 lots
Mar 3, 2026 (view filing)Feb 274 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−5.00K$54.18−$270.9K−7.1%65.0K after
Jan 8, 2026 (view filing)Jan 62 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−20.0K$53.35−$1.07M−22.2%70.0K after
Jun 11, 2025 (view filing)Jun 9-102 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−30.2K$30.58−$923.7K−25.1%90.0K after2 lots
Jun 5, 2025 (view filing)Jun 3-42 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−4.80K$30.03−$144.0K−3.8%120.2K after2 lots
May 14, 2025 (view filing)May 12-132 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−15.0K$26.13−$391.9K−10.7%125.0K after2 lots
May 14, 2025 (view filing)Mar 1857 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−5.00K$29.64−$148.2K−3.3%145.0K afterAmended
May 14, 2025 (view filing)Mar 2451 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−5.00K$30.01−$150.1K−3.4%140.0K afterAmended
Mar 4, 2025 (view filing)Feb 284 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−5.00K$28.05−$140.3K−3.2%150.0K after
Jan 24, 2025 (view filing)Jan 222 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−20.0K$35.59−$711.8K−11.4%155.0K after

See all 24 trades at HROW

CDXS Codexis, Inc.

10% Owner27 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Dec 15, 2025 (view filing)Nov 26-Dec 119 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−514.3K$1.71−$878.3K−74.1%180.0K afterAmended6 lots
Dec 15, 2025 (view filing)Nov 7-1138 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−1.06M$1.76−$1.87M−82.6%223.5K afterAmended6 lots
Nov 14, 2025 (view filing)Nov 122 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share+890.0K$1.94+$1.73M+9.1%10.6M after
Nov 14, 2025 (view filing)Nov 122 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−192.5K$1.96−$376.7K−1.8%10.5M after2 lots
Aug 4, 2025 (view filing)Jul 31-Aug 44 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+85.0K$2.68+$227.9K+0.7%12.5M after2 lots
Jul 31, 2025 (view filing)Jul 29-302 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+10.0K$2.82+$28.2K+0.1%12.5M after2 lots
Jul 22, 2025 (view filing)Jul 184 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+100.0K$2.82+$282.0K+0.8%12.4M after
Jul 1, 2025 (view filing)Jun 274 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+100.0K$2.39+$239.0K+0.8%12.3M after
Jun 16, 2025 (view filing)Jun 12-164 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+250.0K$2.24+$560.0K+2.1%12.3M after3 lots
May 28, 2025 (view filing)May 23-285 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+2.33M$2.36+$5.49M+24.0%12.0M after2 lots

See all 27 trades at CDXS

TARA Protara Therapeutics, Inc.

10% Owner21 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Sep 12, 2024 (view filing)Sep 11-121 dayOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−158.9K$1.71−$271.7K−77.9%45.0K after4 lots
Sep 10, 2024 (view filing)Sep 9-101 dayOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−62.0K$1.84−$114.1K−53.9%53.1K after4 lots
Jul 18, 2024 (view filing)Jul 162 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−11.4K$2.44−$27.8K−16.8%56.5K after2 lots
Jul 11, 2024 (view filing)Jul 9-112 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−74.6K$2.36−$175.7K−55.4%60.0K after6 lots
Jul 3, 2024 (view filing)Jul 12 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−8.29K$2.12−$17.6K−8.7%87.5K after2 lots
Jun 28, 2024 (view filing)Jun 27-281 dayOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−64.6K$2.21−$142.5K−43.2%85.0K after4 lots
Jun 27, 2024 (view filing)Jun 252 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−12.7K$2.26−$28.8K−11.0%102.5K after2 lots
May 31, 2024 (view filing)May 30-311 dayOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−15.1K$2.92−$44.0K−12.2%108.7K after2 lots
May 23, 2024 (view filing)May 21-222 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−42.8K$3.05−$130.6K−25.7%123.8K after4 lots
May 17, 2024 (view filing)May 17Same dayOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−70.9K$3.25−$230.4K−36.0%126.0K after4 lots

See all 21 trades at TARA

TCON Tracon Pharmaceuticals, Inc.

10% Owner30 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Nov 14, 2023 (view filing)4:05 PM ETNov 104 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−4.76M$0.2942−$1.40M−100.0%0 after2 lots
Mar 13, 2023 (view filing)Mar 94 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+174.5K$1.38+$240.8K+4.2%4.32M after
Dec 16, 2022 (view filing)Dec 142 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+167.5K$1.26+$210.5K+61.5%440.0K after2 lots
Dec 8, 2022 (view filing)6:49 PM ETDec 62 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.01 per share−1.54K$1.44−$2.22K0.0%4.01M after
Oct 19, 2022 (view filing)Oct 181 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+12.5K$1.65+$20.6K+0.3%4.13M after2 lots
Oct 3, 2022 (view filing)Sep 294 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+9.40K$1.74+$16.4K+2.3%410.0K after
Sep 28, 2022 (view filing)Sep 271 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+1.70K$1.69+$2.87K+0.4%400.6K after
Sep 22, 2022 (view filing)Sep 22Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+17.3K$1.73+$29.9K+4.5%398.9K after2 lots
Sep 20, 2022 (view filing)Sep 20Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+10.0K$1.85+$18.5K+2.7%385.0K after
Sep 19, 2022 (view filing)Sep 19Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+5.00K$1.87+$9.35K+1.4%375.0K after

See all 30 trades at TCON

TELA TELA Bio, Inc.

Other: Former 10% Owner.17 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Nov 4, 2022 (view filing)Nov 31 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+20.3K$7.81+$158.2K+19.4%124.8K after2 lots
Oct 11, 2022 (view filing)Oct 11Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+16.0K$8.00+$128.0K+14.9%123.6K after2 lots
Sep 26, 2022 (view filing)Sep 233 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+6.80K$7.99+$54.4K+5.9%122.6K after2 lots
Sep 19, 2022 (view filing)Sep 19Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+18.0K$8.09+$145.6K+17.3%122.2K after2 lots
Sep 16, 2022 (view filing)Sep 15-161 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+6.53K$8.09+$52.8K+5.7%121.2K after4 lots
Sep 15, 2022 (view filing)Aug 1630 daysLateOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+5.22K$8.10+$42.3K+4.5%120.2K after2 lots
Aug 16, 2022 (view filing)Aug 16Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+315.0K$8.00+$2.52MNew position120.0K after2 lots
Aug 12, 2022 (view filing)Aug 111 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+4.98K$7.96+$39.6K+5.2%100.7K afterAmended2 lots
Aug 12, 2022 (view filing)Aug 102 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+12.0K$8.52+$102.1K+12.9%105.0K after2 lots
Jul 22, 2022 (view filing)Jul 22Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+5.20K$8.02+$41.7K+5.5%100.2K after2 lots

See all 17 trades at TELA