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Opaleye Management Inc.

In the past year, 52 open-market purchase filings worth $19.0M and 11 sale filings worth $22.1M.

Current role at each company

Show 5 more companies

Open-market trades in the past year

Open-market purchases (P) and sales (S) filed in the last 365 days, not counting derivative securities or duplicate filings. Values leave out price outliers.

Bought
$19.0M
52 filings
Sold
$22.1M
11 filings
Net
−$3.03M
Bought minus sold
Companies
7
With open-market trades

Trades

Every Form 4 that lists Opaleye Management Inc. as a reporting owner, including filings made jointly with others, grouped by company. Each row adds up one type of transaction in one filing. Only open-market purchases (P) and sales (S) are shown by default.

ACOG Alpha Cognition Inc.

10% Owner23 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Feb 24, 2026 (view filing)Feb 20-244 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+171.4K$5.86+$1.00MNew position80.0K after6 lots
Mar 2, 2026 (view filing)Feb 26-274 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+4.23K$5.99+$25.3K+0.2%2.29M after2 lots
Mar 4, 2026 (view filing)Mar 2-32 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+71.4K$5.76+$411.6K+525.5%85.0K after3 lots
Mar 6, 2026 (view filing)Mar 4-52 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+66.8K$5.80+$387.7K+288.2%90.0K after3 lots
Mar 10, 2026 (view filing)Mar 6-94 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+4.08K$5.83+$23.8K+0.2%2.42M after2 lots
Mar 13, 2026 (view filing)Mar 12-131 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+13.1K$5.79+$75.7K+0.5%2.43M after2 lots
Mar 18, 2026 (view filing)Mar 162 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+1.33K$5.78+$7.69K+0.1%2.44M after
Mar 20, 2026 (view filing)Mar 18-192 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+4.58K$5.73+$26.2K+0.2%2.44M after2 lots
Mar 26, 2026 (view filing)Mar 24-262 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+20.1K$5.41+$108.6K+0.8%2.46M after3 lots
Mar 31, 2026 (view filing)Mar 27-304 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, no par value+11.8K$5.07+$60.0K+0.5%2.47M after2 lots

See all 23 trades at ACOG

GRCE Grace Therapeutics, Inc.

10% Owner4 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Aug 19, 2026 (view filing)7:44 AM ETAug 145 daysLateOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+11.6K$2.09+$24.2K+0.4%2.76M after
Sep 10, 2026 (view filing)4:05 PM ETSep 8-92 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+15.2K$2.09+$31.9K+0.6%2.78M after2 lots
Oct 1, 2026 (view filing)4:05 PM ETSep 21-2310 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+15.1K$2.10+$31.7K+0.5%2.79M afterAmended2 lots
Oct 1, 2026 (view filing)4:30 PM ETSep 292 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+7.85K$2.09+$16.4K+0.3%2.80M after

SLGL Sol-Gel Technologies Ltd.

10% Owner24 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Nov 21, 2025 (view filing)Nov 201 dayOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+5.78K$35.83+$207.2K+1.6%363.2K after
Nov 26, 2025 (view filing)Nov 24-262 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+949$39.97+$37.9K+0.3%364.1K after2 lots
Dec 3, 2025 (view filing)Dec 1-32 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+6.86K$37.53+$257.6K+1.9%371.0K after2 lots
Dec 9, 2025 (view filing)Dec 5-84 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+744$39.61+$29.5K+0.2%371.7K after2 lots
Dec 16, 2025 (view filing)Dec 124 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+87$40.00+$3.48K0.0%371.8K after
Dec 19, 2025 (view filing)Dec 172 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+2.73K$40.37+$110.4K+0.7%374.5K after
Dec 29, 2025 (view filing)Dec 22-267 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+2.90K$41.49+$120.5K+0.8%377.4K after3 lots
Dec 31, 2025 (view filing)Dec 29-312 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+66.3K$41.97+$2.78M+17.6%443.7K after3 lots
Jan 6, 2026 (view filing)Jan 2-54 daysOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+2.59K$42.00+$108.9K+0.6%447.3K after2 lots
Jan 23, 2026 (view filing)Jan 22-231 dayOpaleye Management Inc.10% OwnerPPurchaseOrdinary Shares, par value NIS 1.00 per share.+3.32K$56.37+$187.4K+0.7%449.8K after2 lots

See all 24 trades at SLGL

ETON Eton Pharmaceuticals, Inc.

10% Owner12 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Aug 6, 2021 (view filing)Aug 4-62 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−604.5K$5.83−$3.52M−83.8%117.1K after6 lots
Oct 13, 2021 (view filing)Oct 8-125 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−165.1K$5.03−$831.1K−58.5%117.1K after6 lots
Nov 5, 2021 (view filing)Nov 3-42 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−202.2K$6.49−$1.31M−67.5%97.5K after4 lots
Nov 9, 2021 (view filing)Nov 5-84 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−220.4K$6.25−$1.38M−71.8%86.4K after4 lots
Nov 17, 2021 (view filing)Nov 15-162 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−15.4K$4.85−$74.8K−15.4%85.0K after4 lots
Nov 19, 2021 (view filing)Nov 172 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−25.0K$4.67−$116.8K−1.0%2.38M after
Sep 12, 2024 (view filing)Sep 10-112 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+107.5K$4.70+$504.9KNew position75.0K after4 lots
Oct 8, 2024 (view filing)Oct 4-84 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+62.1K$6.99+$434.1K+310.3%82.1K after6 lots
Oct 25, 2024 (view filing)Oct 232 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+10.0K$7.98+$79.8K+0.4%2.77M after
Jun 12, 2025 (view filing)Jun 102 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+7.93K$15.82+$125.5K+10.3%85.0K after2 lots

See all 12 trades at ETON

SNWV SANUWAVE Health, Inc.

10% Owner6 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Nov 1, 2024 (view filing)Oct 30-Nov 12 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+27.9K$15.75+$438.9KNew position12.0K after5 lots
Apr 30, 2025 (view filing)Apr 291 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+8.00K$25.49+$203.9K+114.2%15.0K after2 lots
Oct 9, 2025 (view filing)Oct 63 daysLateOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+1.27K$30.28+$38.4K+0.1%966.3K after
Apr 21, 2026 (view filing)Apr 17-214 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−16.5K$20.46−$337.0K−1.7%954.8K after3 lots
Apr 30, 2026 (view filing)Apr 28-292 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−70.6K$18.05−$1.28M−91.6%6.50K after4 lots
May 4, 2026 (view filing)Apr 30-May 14 daysOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share−35.6K$16.14−$574.2K−87.7%5.00K after4 lots

HROW Harrow, Inc.

10% Owner24 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Jul 22, 2021 (view filing)Jul 19-213 daysLateOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+20.0K$7.32+$146.3K+16.0%145.0K after6 lots
Aug 19, 2021 (view filing)Aug 17-182 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+72.5K$8.61+$624.6K+96.7%147.5K after4 lots
Aug 23, 2021 (view filing)Aug 194 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.0001 per share+52.5K$8.45+$443.6K+53.8%150.0K after2 lots
Jan 31, 2022 (view filing)Jan 283 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+6.34K$6.89+$43.7K+4.4%150.0K after2 lots
Apr 13, 2022 (view filing)Apr 12-131 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+41.4K$6.75+$279.5K+35.6%157.7K after4 lots
Sep 30, 2022 (view filing)Sep 282 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+11.1K$9.77+$108.3K+7.5%158.8K after2 lots
Dec 14, 2022 (view filing)Dec 14Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+431.2K$10.52+$4.54MNew position175.0K after2 lots
Sep 20, 2023 (view filing)Sep 19-201 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+20.0K$14.60+$292.0K+0.6%3.62M after2 lots
Nov 16, 2023 (view filing)Nov 151 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+25.0K$8.03+$200.8K+0.7%3.65M after
Mar 22, 2024 (view filing)Mar 202 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+50.6K$9.65+$488.3K+1.4%3.70M after

See all 24 trades at HROW

CDXS Codexis, Inc.

10% Owner27 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Sep 19, 2024 (view filing)Sep 181 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+61.0K$3.16+$192.8K+42.4%205.0K after2 lots
Sep 23, 2024 (view filing)Sep 20-233 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+1.10M$3.01+$3.31M+15.0%8.44M after3 lots
Sep 26, 2024 (view filing)Sep 24-252 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+85.0K$2.94+$249.5K+1.0%8.52M after2 lots
Oct 28, 2024 (view filing)Oct 253 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+25.0K$2.91+$72.8K+0.3%8.54M after
Jan 2, 2025 (view filing)Dec 30-31, 20243 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+45.0K$4.69+$211.1K+0.5%8.59M after2 lots
Jan 31, 2025 (view filing)Jan 30-311 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+65.0K$4.35+$282.9K+0.8%8.65M after2 lots
Feb 12, 2025 (view filing)Feb 10-122 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+50.0K$4.11+$205.4K+0.6%8.71M after3 lots
Mar 4, 2025 (view filing)Feb 28-Mar 34 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+195.0K$2.95+$574.5K+2.2%8.90M after2 lots
Mar 6, 2025 (view filing)Mar 4-52 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+65.0K$2.65+$172.1K+0.7%8.96M after2 lots
Mar 10, 2025 (view filing)Mar 64 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+100.0K$2.61+$261.0K+1.1%9.06M after

See all 27 trades at CDXS

TARA Protara Therapeutics, Inc.

10% Owner21 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Nov 8, 2021 (view filing)Nov 44 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+6.56K$6.50+$42.6K+7.0%100.6K after2 lots
Nov 19, 2021 (view filing)Nov 17-182 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+24.3K$6.98+$169.8K+31.1%102.6K after4 lots
Dec 20, 2021 (view filing)Dec 16-174 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+10.4K$6.46+$66.9K+11.0%104.2K after4 lots
Dec 22, 2021 (view filing)Dec 202 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+703$6.49+$4.56K0.0%2.50M after
Dec 27, 2021 (view filing)Dec 23-274 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+38.0K$6.53+$248.2K+52.8%110.0K after4 lots
Dec 29, 2021 (view filing)Dec 28-291 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+11.6K$6.60+$76.5K+10.7%120.0K after3 lots
Jan 31, 2022 (view filing)Jan 283 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+24.0K$4.96+$119.2K+24.0%124.0K after2 lots
Apr 15, 2022 (view filing)Apr 7-88 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+10.1K$4.79+$48.5K+8.6%127.5K afterAmended4 lots
Sep 15, 2022 (view filing)Sep 14-151 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+23.9K$3.93+$93.8K+22.0%132.3K after4 lots
Dec 30, 2022 (view filing)Dec 30Same dayOpaleye Management Inc.10% OwnerSSaleCommon Stock, par value $0.001 per share+15.5K$2.71+$41.9K+13.5%130.0K after2 lots

See all 21 trades at TARA

TCON Tracon Pharmaceuticals, Inc.

10% Owner30 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Dec 3, 2021 (view filing)Dec 1-22 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+60.5K$2.39+$144.7K+35.6%230.5K after4 lots
Dec 7, 2021 (view filing)Dec 3-64 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+112.0K$2.29+$256.7K+85.8%242.5K after4 lots
Dec 15, 2021 (view filing)Dec 13-142 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+57.2K$2.56+$146.4K+29.6%250.7K after4 lots
Dec 16, 2021 (view filing)Dec 151 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+22.0K$2.43+$53.4K+9.5%252.7K after2 lots
Dec 29, 2021 (view filing)Dec 27-282 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+107.5K$2.87+$307.9K+60.5%285.0K after4 lots
Dec 29, 2021 (view filing)Dec 29Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+52.3K$2.51+$131.3K+20.7%305.0K after2 lots
Jan 21, 2022 (view filing)Jan 19-202 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+45.0K$2.24+$101.0K+17.0%310.0K after4 lots
Jan 24, 2022 (view filing)Jan 21-243 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+52.4K$2.14+$112.2K+19.8%317.4K after4 lots
Jan 31, 2022 (view filing)Jan 283 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+500$2.20+$1.10K0.0%2.82M after
Mar 17, 2022 (view filing)Mar 161 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+2.23K$2.20+$4.92K+0.1%2.84M after

See all 30 trades at TCON

TELA TELA Bio, Inc.

Other: Former 10% Owner.17 trades

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Jun 10, 2022 (view filing)Jun 10Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+27.5K$5.60+$154.0K+40.7%95.0K after2 lots
Jun 22, 2022 (view filing)Jun 10-2212 daysLateOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+52.4K$6.50+$340.6K+116.4%97.4K after2 lots
Jun 24, 2022 (view filing)Jun 222 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+2.40K$6.99+$16.8K+2.5%97.8K after2 lots
Jun 30, 2022 (view filing)Jun 29-301 dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+3.57K$7.00+$25.0K+3.8%98.4K after3 lots
Jul 5, 2022 (view filing)Jul 14 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+200$7.00+$1.40K+0.2%98.6K after
Jul 20, 2022 (view filing)Jul 20Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+5.10K$8.08+$41.2K+5.4%99.2K after2 lots
Jul 21, 2022 (view filing)Jul 21Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+10.3K$8.03+$83.0K+11.5%100.0K after2 lots
Jul 22, 2022 (view filing)Jul 22Same dayOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+5.20K$8.02+$41.7K+5.5%100.2K after2 lots
Aug 12, 2022 (view filing)Aug 102 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+12.0K$8.52+$102.1K+12.9%105.0K after2 lots
Aug 12, 2022 (view filing)Aug 111 daysOpaleye Management Inc.10% OwnerPPurchaseCommon Stock, par value $0.001 per share+4.98K$7.96+$39.6K+5.2%100.7K afterAmended2 lots

See all 17 trades at TELA