Xeris Biopharma Holdings, Inc.
XERS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001867096
In the last 90 days, Xeris Biopharma Holdings, Inc. insiders filed 0 open-market purchases and 9 sales; 242 institutions reported holding it in 13F filings for Q2 2026, worth $857.1M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Xeris Biopharma Holdings, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 227
- −3 vs. Q3 2025
- Shares held
- 100.9M
- +3.95M (+4.1%) vs. Q3 2025
- Total value
- $792.0M
- +$2.83M (+0.4%) vs. Q3 2025
- New holders
- 35
- 79 more added
- Sold out
- 38
- 78 more reduced
1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting XERS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 242 | $857.1M |
| Q1 2026 | 239 | $610.3M |
| Q4 2025 | 227 | $792.0M |
| Q3 2025 | 231 | $789.3M |
| Q2 2025 | 201 | $422.9M |
| Q1 2025 | 199 | $480.9M |
| Q4 2024 | 162 | $222.2M |
| Q3 2024 | 144 | $182.2M |
| Q2 2024 | 135 | $136.6M |
| Q1 2024 | 142 | $133.7M |
| Q4 2023 | 120 | $140.8M |
| Q3 2023 | 111 | $102.3M |
| Q2 2023 | 105 | $146.7M |
| Q1 2023 | 92 | $80.6M |
| Q4 2022 | 97 | $71.6M |
| Q3 2022 | 101 | $89.3M |
| Q2 2022 | 103 | $91.3M |
| Q1 2022 | 103 | $129.2M |
| Q4 2021 | 92 | $120.2M |
| Q3 2021 | 71 | $42.9M |
| Q2 2021 | 94 | $114.9M |
| Q1 2021 | 103 | $149.7M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Xeris Biopharma Holdings, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 12,639,318 | $99.2M | 0.00% | +711,619+6.0% | Added |
| Vanguard Group Inc | 11,186,677 | $87.8M | 0.00% | +1,358,760+13.8% | Added |
| D. E. Shaw & Co., Inc. | 7,574,850 | $59.5M | 0.05% | +1,734,964+29.7% | Added |
| Geode Capital Management, LLC | 4,275,989 | $33.6M | 0.00% | +135,815+3.3% | Added |
| State Street Corp | 4,116,924 | $32.3M | 0.00% | +378,595+10.1% | Added |
| Qube Research & Technologies Ltd | 3,498,197 | $27.5M | 0.04% | +223,363+6.8% | Added |
| Driehaus Capital Management LLC | 2,980,567 | $23.4M | 0.16% | +361,438+13.8% | Added |
| Nuveen, LLC | 2,806,806 | $22.0M | 0.01% | −21,068−0.7% | Reduced |
| Morgan Stanley | 2,707,783 | $21.3M | 0.00% | −511,918−15.9% | Reduced |
| Wellington Management Group LLP | 2,286,598 | $17.9M | 0.00% | +1,705,636+293.6% | Added |
| Rosalind Advisors, Inc. | 2,111,700 | $16.6M | 6.35% | +315,934+17.6% | Added |
| Two Sigma Investments, LP | 1,732,667 | $13.6M | 0.02% | +118,088+7.3% | Added |
| Parkman Healthcare Partners LLC | 1,691,585 | $13.3M | 1.26% | −100,089−5.6% | Reduced |
| Goldman Sachs Group Inc | 1,568,421 | $12.3M | 0.00% | −227,034−12.6% | Reduced |
| Charles Schwab Investment Management Inc | 1,403,824 | $11.0M | 0.00% | −42,795−3.0% | Reduced |
| Legal & General Group Plc | 1,396,265 | $11.0M | 0.00% | +38,838+2.9% | Added |
| CenterBook Partners LP | 1,391,590 | $10.9M | 0.53% | +693,386+99.3% | Added |
| Northern Trust Corp | 1,386,829 | $10.9M | 0.00% | +23,700+1.7% | Added |
| Granahan Investment Management Inc | 1,223,404 | $9.60M | 0.41% | +873,236+249.4% | Added |
| Kennedy Capital Management, Inc. | 1,213,969 | $9.53M | 0.20% | +2,386+0.2% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 1,058,692 | $8.31M | 0.02% | −640,065−37.7% | Reduced |
| Acadian Asset Management LLC | 971,598 | $7.62M | 0.01% | +50,495+5.5% | Added |
| Knott David M Jr | 970,000 | $7.61M | 3.53% | −45,000−4.4% | Reduced |
| AQR Capital Management LLC | 957,579 | $7.52M | 0.00% | −26,021−2.6% | Reduced |
| Deutsche Bank AG | 940,592 | $7.38M | 0.00% | −627,053−40.0% | Reduced |
| JPMorgan Chase & Co | 895,059 | $7.03M | 0.00% | −10,017−1.1% | Reduced |
| Millennium Management LLC | 859,051 | $6.74M | 0.00% | +334,302+63.7% | Added |
| Federated Hermes, Inc. | 854,888 | $6.71M | 0.01% | +150,505+21.4% | Added |
| Two Sigma Advisers, LP | 849,334 | $6.67M | 0.01% | −43,908−4.9% | Reduced |
| Voloridge Investment Management, LLC | 811,129 | $6.37M | 0.02% | −223,424−21.6% | Reduced |
| Norges Bank | 800,700 | $6.29M | 0.00% | +800,700 | New |
| Ishara Investments LP | 800,000 | $6.28M | 7.31% | +800,000 | New |
| Essex Investment Management Co LLC | 734,532 | $5.77M | 0.88% | −15,502−2.1% | Reduced |
| Algert Global LLC | 718,844 | $5.64M | 0.09% | +560,884+355.1% | Added |
| Bank of America Corp | 717,914 | $5.64M | 0.00% | −876,952−55.0% | Reduced |
| UBS Asset Management Americas Inc | 651,445 | $5.11M | 0.00% | +467,986+255.1% | Added |
| Renaissance Technologies LLC | 619,660 | $4.86M | 0.01% | −1,003,180−61.8% | Reduced |
| Prudential Financial Inc | 618,949 | $4.86M | 0.01% | −815,255−56.8% | Reduced |
| Point72 Asset Management, L.P. | 608,080 | $4.77M | 0.01% | +608,080 | New |
| UBS Group AG | 601,834 | $4.72M | 0.00% | −1,180,900−66.2% | Reduced |
| Healthcare of Ontario Pension Plan Trust Fund | 537,483 | $4.22M | 0.01% | +283,483+111.6% | Added |
| Squarepoint Ops LLC | 482,832 | $3.79M | 0.01% | −196,249−28.9% | Reduced |
| Voya Investment Management LLC | 458,329 | $3.60M | 0.00% | +58,250+14.6% | Added |
| Castleark Management LLC | 445,950 | $3.50M | 0.10% | +445,950 | New |
| FMR LLC | 439,705 | $3.45M | 0.00% | +79,527+22.1% | Added |
| Bank of New York Mellon Corp | 434,262 | $3.41M | 0.00% | −5,576−1.3% | Reduced |
| Citadel Advisors LLC | 409,820 | $3.22M | 0.00% | −27,792−6.4% | Reduced |
| SEI Investments Co | 399,347 | $3.13M | 0.00% | +278,171+229.6% | Added |
| Canada Pension Plan Investment Board | 390,600 | $3.07M | 0.00% | +14,900+4.0% | Added |
| Voss Capital, LLC | 371,709 | $2.92M | 0.16% | +371,709 | New |
| Russell Investments Group, Ltd. | 364,786 | $2.86M | 0.00% | +113,408+45.1% | Added |
| Barclays PLC | 362,751 | $2.85M | 0.00% | +16,112+4.6% | Added |
| State of Wisconsin Investment Board | 357,453 | $2.81M | 0.01% | +6,924+2.0% | Added |
| Jump Financial, LLC | 341,068 | $2.68M | 0.03% | −262,176−43.5% | Reduced |
| HRT Financial LP | 332,326 | $2.61M | 0.01% | +259,783+358.1% | Added |
| Swiss National Bank | 318,400 | $2.50M | 0.00% | +8,000+2.6% | Added |
| Harvest Investment Services, LLC | 292,677 | $2.30M | 0.43% | −32,878−10.1% | Reduced |
| IHT Wealth Management, LLC | 263,531 | $2.07M | 0.05% | +5,356+2.1% | Added |
| BNP Paribas Arbitrage, SA | 258,368 | $2.03M | 0.00% | −323,351−55.6% | Reduced |
| Apella Capital, LLC | 245,897 | $1.93M | 0.04% | +235,897+2,359.0% | Added |
| Legato Capital Management LLC | 237,431 | $1.86M | 0.16% | +20,626+9.5% | Added |
| Schonfeld Strategic Advisors LLC | 234,723 | $1.84M | 0.01% | −69,781−22.9% | Reduced |
| Arrowstreet Capital, Limited Partnership | 214,786 | $1.69M | 0.00% | +214,786 | New |
| Trexquant Investment LP | 213,581 | $1.68M | 0.01% | −15,839−6.9% | Reduced |
| Raymond James Financial Inc | 211,419 | $1.66M | 0.00% | +6,206+3.0% | Added |
| Commonwealth Equity Services, LLC | 197,815 | $1.55M | 0.00% | +720.0% | Added |
| Rhumbline Advisers | 189,567 | $1.49M | 0.00% | −24,177−11.3% | Reduced |
| Jane Street Group, LLC | 177,822 | $1.40M | 0.00% | −735,936−80.5% | Reduced |
| Caxton Associates LLP | 174,102 | $1.37M | 0.03% | −107,235−38.1% | Reduced |
| Price T Rowe Associates Inc | 173,463 | $1.36M | 0.00% | +6,675+4.0% | Added |
| Wells Fargo & Company | 170,796 | $1.34M | 0.00% | +73,600+75.7% | Added |
| Diadema Partners LP | 170,568 | $1.34M | 0.80% | +95,815+128.2% | Added |
| California State Teachers Retirement System | 151,171 | $1.19M | 0.00% | −715−0.5% | Reduced |
| Principal Financial Group Inc | 150,559 | $1.18M | 0.00% | +45,066+42.7% | Added |
| Alliancebernstein L.P. | 144,830 | $1.14M | 0.00% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 143,463 | $1.13M | 0.00% | −10,705−6.9% | Reduced |
| Polen Capital Management LLC | 133,416 | $1.05M | 0.00% | +225+0.2% | Added |
| Group One Trading, L.P. | 123,561 | $970.0K | 0.03% | +117,537+1,951.1% | Added |
| Globeflex Capital L P | 123,184 | $967.0K | 0.15% | 00.0% | Unchanged |
| Franklin Resources Inc | 121,428 | $953.2K | 0.00% | +12,286+11.3% | Added |
| Susquehanna International Group, LLP | 117,355 | $921.2K | 0.00% | +35,884+44.0% | Added |
| Creative Planning | 116,538 | $914.8K | 0.00% | −10,442−8.2% | Reduced |
| Invesco Ltd. | 112,130 | $880.2K | 0.00% | −470,978−80.8% | Reduced |
| SG Americas Securities, LLC | 110,180 | $865.0K | 0.00% | +26,966+32.4% | Added |
| Ambassador Advisors, LLC | 106,730 | $837.8K | 0.12% | +106,730 | New |
| Thompson Siegel & Walmsley LLC | 100,884 | $792.0K | 0.01% | 00.0% | Unchanged |
| Resolute Capital Asset Partners LLC | 100,000 | $785.0K | 0.38% | +100,000 | New |
| Calamos Advisors LLC | 99,117 | $778.1K | 0.00% | −37,980−27.7% | Reduced |
| Citigroup Inc | 98,746 | $775.2K | 0.00% | +28,491+40.6% | Added |
| Round Rock Advisors, LLC | 96,816 | $760.0K | 0.11% | +33,044+51.8% | Added |
| Brevan Howard Capital Management LP | 92,416 | $725.5K | 0.01% | −39,744−30.1% | Reduced |
| Y-Intercept (Hong Kong) Ltd | 90,645 | $711.6K | 0.02% | +8,464+10.3% | Added |
| Engineers Gate Manager LP | 89,404 | $701.8K | 0.01% | −20,590−18.7% | Reduced |
| Jefferies Financial Group Inc. | 87,800 | $689.2K | 0.01% | +87,800 | New |
| Ieq Capital, LLC | 86,520 | $679.2K | 0.00% | −21,433−19.9% | Reduced |
| LPL Financial LLC | 84,861 | $666.2K | 0.00% | +51,559+154.8% | Added |
| MetLife Investment Management | 81,594 | $640.5K | 0.00% | −5,724−6.6% | Reduced |
| EAM Investors, LLC | 80,154 | $629.2K | 0.07% | −522,947−86.7% | Reduced |
| Quarry LP | 80,000 | $628.0K | 0.10% | −2,500−3.0% | Reduced |
| Quantbot Technologies LP | 77,648 | $609.5K | 0.02% | +8,283+11.9% | Added |