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Xeris Biopharma Holdings, Inc.

XERS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001867096

In the last 90 days, Xeris Biopharma Holdings, Inc. insiders filed 0 open-market purchases and 11 sales; 242 institutions reported holding it in 13F filings for Q2 2026, worth $857.1M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Xeris Biopharma Holdings, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
227
−3 vs. Q3 2025
Shares held
100.9M
+3.95M (+4.1%) vs. Q3 2025
Total value
$792.0M
+$2.83M (+0.4%) vs. Q3 2025
New holders
35
79 more added
Sold out
38
78 more reduced

1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XERS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 227 institutions
Q1 2021: 103 institutionsQ2 2021: 94 institutionsQ3 2021: 71 institutionsQ4 2021: 92 institutionsQ1 2022: 103 institutionsQ2 2022: 103 institutionsQ3 2022: 101 institutionsQ4 2022: 97 institutionsQ1 2023: 92 institutionsQ2 2023: 105 institutionsQ3 2023: 111 institutionsQ4 2023: 120 institutionsQ1 2024: 142 institutionsQ2 2024: 135 institutionsQ3 2024: 144 institutionsQ4 2024: 162 institutionsQ1 2025: 199 institutionsQ2 2025: 201 institutionsQ3 2025: 231 institutionsQ4 2025: 227 institutionsQ1 2026: 239 institutionsQ2 2026: 242 institutions
Value heldQ4 2025: $792.0M
Q1 2021: $149.7MQ2 2021: $114.9MQ3 2021: $42.9MQ4 2021: $120.2MQ1 2022: $129.2MQ2 2022: $91.3MQ3 2022: $89.3MQ4 2022: $71.6MQ1 2023: $80.6MQ2 2023: $146.7MQ3 2023: $102.3MQ4 2023: $140.8MQ1 2024: $133.7MQ2 2024: $136.6MQ3 2024: $182.2MQ4 2024: $222.2MQ1 2025: $480.9MQ2 2025: $422.9MQ3 2025: $789.3MQ4 2025: $792.0MQ1 2026: $610.3MQ2 2026: $857.1M
Institutions holding XERS and their total value by quarter
QuarterHoldersValue
Q2 2026242$857.1M
Q1 2026239$610.3M
Q4 2025227$792.0M
Q3 2025231$789.3M
Q2 2025201$422.9M
Q1 2025199$480.9M
Q4 2024162$222.2M
Q3 2024144$182.2M
Q2 2024135$136.6M
Q1 2024142$133.7M
Q4 2023120$140.8M
Q3 2023111$102.3M
Q2 2023105$146.7M
Q1 202392$80.6M
Q4 202297$71.6M
Q3 2022101$89.3M
Q2 2022103$91.3M
Q1 2022103$129.2M
Q4 202192$120.2M
Q3 202171$42.9M
Q2 202194$114.9M
Q1 2021103$149.7M

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Xeris Biopharma Holdings, Inc.; share changes are against Q3 2025.

Institutions holding XERS in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Western Wealth Management, LLC75,675$594.0K0.03%+75,675New
Teachers Retirement System of the State of Kentucky72,907$572.0K0.00%+72,907New
Mirae Asset Global ETFs Holdings Ltd.71,311$559.8K0.00%−200.0%Reduced
Janus Henderson Group PLC69,887$548.3K0.00%00.0%Unchanged
EntryPoint Capital, LLC68,083$534.5K0.21%+15,068+28.4%Added
Integrated Quantitative Investments LLC66,170$519.4K0.11%+66,170New
Zurcher Kantonalbank (Zurich Cantonalbank)65,767$516.3K0.00%+33,115+101.4%Added
STRS Ohio65,500$514.2K0.00%00.0%Unchanged
Intech Investment Management LLC65,090$511.0K0.00%+9,754+17.6%Added
Winton Group Ltd64,597$507.1K0.02%−26,196−28.9%Reduced
CWM, LLC55,356$435.0K0.00%−83−0.1%Reduced
Advisor Group Holdings, Inc.52,285$410.4K0.00%+11,934+29.6%Added
Deerfield Management Company, L.P. (Series C)52,230$410.0K0.01%−68,670−56.8%Reduced
Dark Forest Capital Management LP52,043$408.5K0.02%−84,688−61.9%Reduced
Weiss Asset Management LP50,001$392.5K0.01%00.0%Unchanged
Penn Capital Management Co Inc48,064$377.3K0.03%+48,064New
Man Group plc47,775$375.0K0.00%+47,775New
Campbell & CO Investment Adviser LLC47,454$372.5K0.02%−56,162−54.2%Reduced
Axq Capital, LP46,454$364.7K0.08%+20,098+76.3%Added
Manufacturers Life Insurance Company, The45,801$359.5K0.00%−4,343−8.7%Reduced
Persistent Asset Partners Ltd45,609$358.0K0.17%+28,407+165.1%Added
Arizona State Retirement System45,269$355.4K0.00%−2,093−4.4%Reduced
New York State Common Retirement Fund43,422$340.9K0.00%00.0%Unchanged
AlphaCentric Advisors LLC43,392$340.6K0.34%+43,392New
State of Wyoming42,458$333.3K0.04%+29,558+229.1%Added
LJI Wealth Management, LLC42,350$332.4K0.05%00.0%Unchanged
Police & Firemen's Retirement System of New Jersey40,738$319.8K0.00%−624−1.5%Reduced
Savvy Advisors, Inc.40,465$317.6K0.01%00.0%Unchanged
Profund Advisors LLC38,947$305.7K0.01%+12,383+46.6%Added
Royal Bank of Canada38,636$304.0K0.00%+2,351+6.5%Added
Cetera Investment Advisers38,647$303.4K0.00%−1,371−3.4%Reduced
State Board of Administration of Florida Retirement System37,970$298.1K0.00%00.0%Unchanged
Virtus Investment Advisers, Inc.37,102$291.3K0.08%+11,358+44.1%Added
Ausbil Investment Management Ltd37,000$290.4K0.17%+37,000New
Gotham Asset Management, LLC35,412$278.0K0.00%−7,329−17.1%Reduced
ProShare Advisors LLC35,390$277.8K0.00%+3,383+10.6%Added
Gsa Capital Partners LLP34,665$272.0K0.02%−34,051−49.6%Reduced
Cambridge Investment Research Advisors, Inc.34,642$272.0K0.00%00.0%Unchanged
Rafferty Asset Management, LLC33,689$264.5K0.00%+16,278+93.5%Added
KLP Kapitalforvaltning AS33,400$262.2K0.00%00.0%Unchanged
Diversified Trust Co32,062$251.7K0.00%00.0%Unchanged
VARCOV Co.31,005$243.4K0.10%+31,005New
Cerity Partners LLC29,578$232.2K0.00%−1,455−4.7%Reduced
Wealth Enhancement Advisory Services, LLC31,105$216.5K0.00%−20.0%Reduced
China Universal Asset Management Co., Ltd.27,037$212.2K0.02%−1,268−4.5%Reduced
Asset Management Group, Inc.26,480$207.9K0.03%00.0%Unchanged
Fox Run Management, L.L.C.26,174$205.5K0.03%+26,174New
Swiss Life Asset Management Ltd26,059$204.6K0.00%+26,059New
9823 Capital, L.P.24,917$195.6K0.13%+24,917New
Quantinno Capital Management LP24,696$193.9K0.00%+7,002+39.6%Added
Janney Montgomery Scott LLC24,450$192.0K0.00%−1,750−6.7%Reduced
Palumbo Wealth Management LLC24,349$191.1K0.05%−38,840−61.5%Reduced
Teacher Retirement System of Texas23,936$187.9K0.00%−15,385−39.1%Reduced
Pictet Asset Management Holding SA23,196$182.1K0.00%00.0%Unchanged
Tudor Investment Corp Et Al22,186$174.2K0.00%−15,808−41.6%Reduced
Los Angeles Capital Management LLC17,901$173.8K0.00%00.0%Unchanged
Van Hulzen Asset Management, LLC20,382$160.0K0.01%−1,800−8.1%Reduced
Aspiriant, LLC20,000$157.0K0.00%00.0%Unchanged
Victory Capital Management Inc17,840$140.0K0.00%+585+3.4%Added
Modern Wealth Management, LLC17,712$139.0K0.00%+80.0%Added
Dynamic Technology Lab Private Ltd17,200$135.0K0.03%+17,200New
Numerai GP LLC17,148$134.6K0.02%−1,359−7.3%Reduced
Jacksonville Wealth Management, LLC17,000$133.4K0.09%00.0%Unchanged
Empirical Financial Services, LLC d.b.a. Empirical Wealth Management16,070$126.2K0.00%+2,420+17.7%Added
Landscape Capital Management, L.L.C.15,709$123.3K0.01%00.0%Unchanged
Bailard, Inc.15,300$120.1K0.00%+15,300New
Universal- Beteiligungs- und Servicegesellschaft mbH14,192$111.4K0.00%+1,037+7.9%Added
Ameritas Investment Partners, Inc.12,827$100.7K0.00%00.0%Unchanged
Aigen Investment Management, LP12,262$96.3K0.02%−6,867−35.9%Reduced
Xponance, Inc.12,112$95.1K0.00%+127+1.1%Added
Captrust Financial Advisors11,816$92.8K0.00%−88−0.7%Reduced
Skopos Labs, Inc.12,195$90.6K0.00%+12,195New
O'Shaughnessy Asset Management, LLC11,423$89.7K0.00%+1,263+12.4%Added
Jain Global LLC11,114$87.2K0.00%+11,114New
Pallas Capital Advisors LLC11,003$86.4K0.00%−24−0.2%Reduced
Tower Research Capital LLC (TRC)10,740$84.3K0.00%+6,286+141.1%Added
CIBC World Markets Corp10,158$79.7K0.00%+10,158New
Kingsview Wealth Management, LLC10,000$78.5K0.00%+10,000New
Kemnay Advisory Services Inc.8,480$66.6K0.01%+8,480New
State of Alaska, Department of Revenue8,457$66.0K0.00%00.0%Unchanged
Truvestments Capital LLC8,118$63.7K0.01%+3,979+96.1%Added
Mirae Asset Global Investments Co., Ltd.8,063$63.3K0.00%+1,820+29.2%Added
CIBC Private Wealth Group, LLC6,664$52.3K0.00%00.0%Unchanged
Jones Financial Companies LLLP5,707$44.8K0.00%+2,926+105.2%Added
Amalgamated Bank4,824$38.0K0.00%−10−0.2%Reduced
GF Fund Management Co. Ltd.3,260$25.6K0.00%−214−6.2%Reduced
Kestra Advisory Services, LLC3,192$25.1K0.00%+3,192New
Webster Bank, N. A.3,000$23.6K0.00%−1,000−25.0%Reduced
Northwestern Mutual Wealth Management Co2,821$22.1K0.00%−4,968−63.8%Reduced
EverSource Wealth Advisors, LLC2,818$22.1K0.00%+941+50.1%Added
Farther Finance Advisors, LLC2,571$20.2K0.00%+190+8.0%Added
BNP PARIBAS ASSET MANAGEMENT Holding S.A.2,353$18.0K0.00%+2,353New
Nisa Investment Advisors, LLC2,204$17.3K0.00%00.0%Unchanged
Creative Financial Designs Inc2,200$17.3K0.00%00.0%Unchanged
SBI Securities Co., Ltd.1,907$15.0K0.00%−6−0.3%Reduced
Caitong International Asset Management Co., Ltd1,714$13.5K0.00%+1,634+2,042.5%Added
Allworth Financial LP1,686$13.2K0.00%−79−4.5%Reduced
SRS Capital Advisors, Inc.1,632$12.8K0.00%−14,227−89.7%Reduced
Fortitude Family Office, LLC1,553$12.2K0.00%00.0%Unchanged
Essential Partners LLC1,288$10.1K0.00%−139−9.7%Reduced