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Xeris Biopharma Holdings, Inc.

XERS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001867096

In the last 90 days, Xeris Biopharma Holdings, Inc. insiders filed 0 open-market purchases and 9 sales; 242 institutions reported holding it in 13F filings for Q2 2026, worth $857.1M in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Xeris Biopharma Holdings, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
201
+3 vs. Q1 2025
Shares held
90.6M
+2.96M (+3.4%) vs. Q1 2025
Total value
$422.9M
−$58.0M (−12.1%) vs. Q1 2025
New holders
26
79 more added
Sold out
23
59 more reduced

1 institution that held it in Q1 2025 haven't filed for Q2 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XERS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 201 institutions
Q1 2021: 103 institutionsQ2 2021: 94 institutionsQ3 2021: 71 institutionsQ4 2021: 92 institutionsQ1 2022: 103 institutionsQ2 2022: 103 institutionsQ3 2022: 101 institutionsQ4 2022: 97 institutionsQ1 2023: 92 institutionsQ2 2023: 105 institutionsQ3 2023: 111 institutionsQ4 2023: 120 institutionsQ1 2024: 142 institutionsQ2 2024: 135 institutionsQ3 2024: 144 institutionsQ4 2024: 162 institutionsQ1 2025: 199 institutionsQ2 2025: 201 institutionsQ3 2025: 231 institutionsQ4 2025: 227 institutionsQ1 2026: 239 institutionsQ2 2026: 242 institutions
Value heldQ2 2025: $422.9M
Q1 2021: $149.7MQ2 2021: $114.9MQ3 2021: $42.9MQ4 2021: $120.2MQ1 2022: $129.2MQ2 2022: $91.3MQ3 2022: $89.3MQ4 2022: $71.6MQ1 2023: $80.6MQ2 2023: $146.7MQ3 2023: $102.3MQ4 2023: $140.8MQ1 2024: $133.7MQ2 2024: $136.6MQ3 2024: $182.2MQ4 2024: $222.2MQ1 2025: $480.9MQ2 2025: $422.9MQ3 2025: $789.3MQ4 2025: $792.0MQ1 2026: $610.3MQ2 2026: $857.1M
Institutions holding XERS and their total value by quarter
QuarterHoldersValue
Q2 2026242$857.1M
Q1 2026239$610.3M
Q4 2025227$792.0M
Q3 2025231$789.3M
Q2 2025201$422.9M
Q1 2025199$480.9M
Q4 2024162$222.2M
Q3 2024144$182.2M
Q2 2024135$136.6M
Q1 2024142$133.7M
Q4 2023120$140.8M
Q3 2023111$102.3M
Q2 2023105$146.7M
Q1 202392$80.6M
Q4 202297$71.6M
Q3 2022101$89.3M
Q2 2022103$91.3M
Q1 2022103$129.2M
Q4 202192$120.2M
Q3 202171$42.9M
Q2 202194$114.9M
Q1 2021103$149.7M

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Xeris Biopharma Holdings, Inc.; share changes are against Q1 2025.

Institutions holding XERS in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
BlackRock, Inc.11,536,321$53.9M0.00%+741,720+6.9%Added
Vanguard Group Inc9,816,937$45.8M0.00%+1,707,293+21.1%Added
D. E. Shaw & Co., Inc.3,835,407$17.9M0.02%+783,035+25.7%Added
State Street Corp3,783,200$17.7M0.00%+457,945+13.8%Added
Geode Capital Management, LLC3,650,688$17.1M0.00%+244,862+7.2%Added
Morgan Stanley3,642,584$17.0M0.00%−645,697−15.1%Reduced
Qube Research & Technologies Ltd3,089,771$14.4M0.02%+1,245,188+67.5%Added
Millennium Management LLC2,933,620$13.7M0.01%+615,648+26.6%Added
Nuveen, LLC2,600,442$12.1M0.00%+370,935+16.6%Added
Goldman Sachs Group Inc2,271,486$10.6M0.00%−518,528−18.6%Reduced
Rosalind Advisors, Inc.2,155,594$10.1M4.87%−340,392−13.6%Reduced
Parkman Healthcare Partners LLC2,107,483$9.84M1.14%+327,029+18.4%Added
Driehaus Capital Management LLC2,071,075$9.67M0.08%+659,535+46.7%Added
Renaissance Technologies LLC2,055,340$9.60M0.01%−107,300−5.0%Reduced
Legal & General Group Plc1,804,203$8.43M0.00%+392,589+27.8%Added
Bank of America Corp1,663,490$7.77M0.00%−45,919−2.7%Reduced
CenterBook Partners LP1,594,229$7.45M0.41%+1,122,154+237.7%Added
Prudential Financial Inc1,556,629$7.27M0.01%+457,784+41.7%Added
Northern Trust Corp1,293,530$6.04M0.00%+92,330+7.7%Added
Connor, Clark & Lunn Investment Management Ltd.1,227,959$5.73M0.02%+638,488+108.3%Added
Two Sigma Investments, LP1,214,699$5.67M0.01%+324,362+36.4%Added
Knott David M Jr1,060,000$4.95M2.24%−50,000−4.5%Reduced
Two Sigma Advisers, LP1,056,779$4.94M0.01%+131,164+14.2%Added
AQR Capital Management LLC1,048,993$4.90M0.00%+102,227+10.8%Added
JPMorgan Chase & Co1,032,262$4.82M0.00%−1,082,447−51.2%Reduced
Voloridge Investment Management, LLC994,381$4.64M0.02%−356,733−26.4%Reduced
Cubist Systematic Strategies, LLC880,314$4.11M0.04%+68,707+8.5%Added
Kennedy Capital Management, Inc.816,147$3.81M0.09%+81,060+11.0%Added
Jump Financial, LLC756,403$3.53M0.04%+332,880+78.6%Added
Deutsche Bank AG736,927$3.44M0.00%−19,480−2.6%Reduced
Essex Investment Management Co LLC725,774$3.39M0.62%−4,670−0.6%Reduced
Federated Hermes, Inc.691,381$3.23M0.01%+3,598+0.5%Added
EAM Investors, LLC586,865$2.74M0.42%−347,781−37.2%Reduced
Charles Schwab Investment Management Inc567,538$2.65M0.00%+143,763+33.9%Added
Norges Bank561,700$2.62M0.00%−262,100−31.8%Reduced
Redmile Group, LLC451,099$2.11M0.22%00.0%Unchanged
Barclays PLC424,248$1.98M0.00%+143,613+51.2%Added
Susquehanna International Group, LLP406,202$1.90M0.00%−231,580−36.3%Reduced
Wellington Management Group LLP399,291$1.86M0.00%+7,192+1.8%Added
Schonfeld Strategic Advisors LLC389,066$1.82M0.01%−211,101−35.2%Reduced
Acadian Asset Management LLC383,237$1.79M0.00%+365,641+2,078.0%Added
Bank of New York Mellon Corp377,127$1.76M0.00%+16,803+4.7%Added
Y-Intercept (Hong Kong) Ltd336,214$1.57M0.04%+291,696+655.2%Added
FMR LLC326,420$1.52M0.00%+14,948+4.8%Added
Voss Capital, LLC319,800$1.49M0.10%+44,800+16.3%Added
Squarepoint Ops LLC284,567$1.33M0.00%+268,572+1,679.1%Added
State of Wisconsin Investment Board278,020$1.30M0.00%+257,745+1,271.2%Added
Thompson Siegel & Walmsley LLC266,387$1.24M0.02%+93,603+54.2%Added
IHT Wealth Management, LLC263,805$1.23M0.03%+1,000+0.4%Added
Healthcare of Ontario Pension Plan Trust Fund252,000$1.18M0.00%00.0%Unchanged
Walleye Capital LLC243,275$1.14M0.01%−448,444−64.8%Reduced
UBS Group AG227,865$1.06M0.00%−635,911−73.6%Reduced
Tudor Investment Corp Et Al225,186$1.05M0.01%00.0%Unchanged
Legato Capital Management LLC216,805$1.01M0.12%−513−0.2%Reduced
Rhumbline Advisers215,691$1.01M0.00%+23,410+12.2%Added
Raymond James Financial Inc209,146$976.7K0.00%+28,830+16.0%Added
Stonepine Capital Management, LLC205,100$957.8K0.94%+102,835+100.6%Added
Brevan Howard Capital Management LP205,024$957.5K0.01%+12,748+6.6%Added
Commonwealth Equity Services, LLC197,743$923.0K0.00%+300+0.2%Added
Jacobs Levy Equity Management, Inc181,877$849.4K0.00%−73,683−28.8%Reduced
Occudo Quantitative Strategies LP179,354$837.6K0.09%+58,930+48.9%Added
Diversified Trust Co170,235$795.0K0.02%−5,504−3.1%Reduced
Quarry LP162,500$758.9K0.18%+91,749+129.7%Added
Principal Financial Group Inc153,937$718.9K0.00%+40,191+35.3%Added
Price T Rowe Associates Inc153,271$716.0K0.00%−23,122−13.1%Reduced
Alpine Global Management, LLC150,000$700.5K0.16%+50,000+50.0%Added
Ameriprise Financial Inc149,028$696.0K0.00%−19,074−11.3%Reduced
Alliancebernstein L.P.144,830$676.4K0.00%00.0%Unchanged
Mackenzie Financial Corp138,092$644.9K0.00%−4,012−2.8%Reduced
Options Solutions, LLC132,994$621.1K0.22%+47,883+56.3%Added
Polen Capital Management LLC132,994$621.1K0.00%+132,994New
Campbell & CO Investment Adviser LLC132,382$618.2K0.04%+132,382New
Man Group plc130,849$611.1K0.00%−44,398−25.3%Reduced
Graham Capital Management, L.P.125,417$585.7K0.02%−8,251−6.2%Reduced
Russell Investments Group, Ltd.123,189$575.3K0.00%−8,498−6.5%Reduced
Roundview Capital LLC120,000$560.4K0.04%00.0%Unchanged
Creative Planning117,755$549.9K0.00%+11,023+10.3%Added
SEI Investments Co116,534$544.2K0.00%+19,043+19.5%Added
Brown Advisory Inc114,698$535.6K0.00%00.0%Unchanged
Harvest Investment Services, LLC111,970$522.9K0.12%+65,513+141.0%Added
Ieq Capital, LLC108,495$506.7K0.00%−46,689−30.1%Reduced
Franklin Resources Inc103,278$482.3K0.00%−4,658−4.3%Reduced
Intech Investment Management LLC94,437$441.0K0.00%+44,330+88.5%Added
MetLife Investment Management87,318$407.8K0.00%+5,549+6.8%Added
Invesco Ltd.86,194$402.5K0.00%−940,644−91.6%Reduced
Mirae Asset Global ETFs Holdings Ltd.82,138$383.6K0.00%−1,844−2.2%Reduced
Globeflex Capital L P80,431$375.6K0.03%−44,779−35.8%Reduced
OrbiMed Advisors LLC80,420$375.6K0.01%00.0%Unchanged
Wells Fargo & Company80,366$375.3K0.00%+10,485+15.0%Added
Citigroup Inc77,534$362.1K0.00%−40,674−34.4%Reduced
Simplex Trading, LLC76,644$357.0K0.01%+76,644New
EntryPoint Capital, LLC72,899$340.4K0.17%−2,807−3.7%Reduced
STRS Ohio65,500$305.9K0.00%+4,600+7.6%Added
GPS Wealth Strategies Group, LLC64,925$303.2K0.03%−2,000−3.0%Reduced
Gsa Capital Partners LLP62,322$291.0K0.02%−76,413−55.1%Reduced
CWM, LLC55,111$257.0K0.00%−11,861−17.7%Reduced
Manufacturers Life Insurance Company, The54,472$254.4K0.00%+3,562+7.0%Added
Chevy Chase Trust Holdings, Inc.51,243$239.3K0.00%00.0%Unchanged
Weiss Asset Management LP50,001$233.5K0.00%00.0%Unchanged
Quadrature Capital Ltd46,756$218.8K0.00%+15,623+50.2%Added