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Xeris Biopharma Holdings, Inc.

XERS
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001867096

In the last 90 days, Xeris Biopharma Holdings, Inc. insiders filed 0 open-market purchases and 10 sales; 242 institutions reported holding it in 13F filings for Q2 2026, worth $857.1M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Xeris Biopharma Holdings, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
227
−3 vs. Q3 2025
Shares held
100.9M
+3.95M (+4.1%) vs. Q3 2025
Total value
$792.0M
+$2.83M (+0.4%) vs. Q3 2025
New holders
35
79 more added
Sold out
38
78 more reduced

1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting XERS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 227 institutions
Q1 2021: 103 institutionsQ2 2021: 94 institutionsQ3 2021: 71 institutionsQ4 2021: 92 institutionsQ1 2022: 103 institutionsQ2 2022: 103 institutionsQ3 2022: 101 institutionsQ4 2022: 97 institutionsQ1 2023: 92 institutionsQ2 2023: 105 institutionsQ3 2023: 111 institutionsQ4 2023: 120 institutionsQ1 2024: 142 institutionsQ2 2024: 135 institutionsQ3 2024: 144 institutionsQ4 2024: 162 institutionsQ1 2025: 199 institutionsQ2 2025: 201 institutionsQ3 2025: 231 institutionsQ4 2025: 227 institutionsQ1 2026: 239 institutionsQ2 2026: 242 institutions
Value heldQ4 2025: $792.0M
Q1 2021: $149.7MQ2 2021: $114.9MQ3 2021: $42.9MQ4 2021: $120.2MQ1 2022: $129.2MQ2 2022: $91.3MQ3 2022: $89.3MQ4 2022: $71.6MQ1 2023: $80.6MQ2 2023: $146.7MQ3 2023: $102.3MQ4 2023: $140.8MQ1 2024: $133.7MQ2 2024: $136.6MQ3 2024: $182.2MQ4 2024: $222.2MQ1 2025: $480.9MQ2 2025: $422.9MQ3 2025: $789.3MQ4 2025: $792.0MQ1 2026: $610.3MQ2 2026: $857.1M
Institutions holding XERS and their total value by quarter
QuarterHoldersValue
Q2 2026242$857.1M
Q1 2026239$610.3M
Q4 2025227$792.0M
Q3 2025231$789.3M
Q2 2025201$422.9M
Q1 2025199$480.9M
Q4 2024162$222.2M
Q3 2024144$182.2M
Q2 2024135$136.6M
Q1 2024142$133.7M
Q4 2023120$140.8M
Q3 2023111$102.3M
Q2 2023105$146.7M
Q1 202392$80.6M
Q4 202297$71.6M
Q3 2022101$89.3M
Q2 2022103$91.3M
Q1 2022103$129.2M
Q4 202192$120.2M
Q3 202171$42.9M
Q2 202194$114.9M
Q1 2021103$149.7M

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Xeris Biopharma Holdings, Inc.; share changes are against Q3 2025.

Institutions holding XERS in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Clearstead Advisors, LLC2$160.00%−579−99.7%Reduced
SJS Investment Consulting Inc.19$1500.00%+19New
GAMMA Investing LLC23$1810.00%−1−4.2%Reduced
MAI Capital Management27$2120.00%+27New
Atlantic Private Wealth, LLC30$2360.00%+30New
Steigerwald, Gordon & Koch Inc.37$2900.00%00.0%Unchanged
Sunbelt Securities, Inc.81$6360.00%00.0%Unchanged
Covestor Ltd175$1.00K0.00%−146−45.5%Reduced
Bessemer Group Inc68$1.00K0.00%00.0%Unchanged
IFP Advisors, Inc140$1.10K0.00%+120+600.0%Added
Parkside Financial Bank & Trust155$1.22K0.00%00.0%Unchanged
Spurstone Advisory Services, LLC200$1.57K0.02%00.0%Unchanged
Smartleaf Asset Management LLC225$1.65K0.00%+225New
Global Retirement Partners, LLC300$2.35K0.00%00.0%Unchanged
Daiwa Securities Group Inc.404$3.00K0.00%00.0%Unchanged
The PNC Financial Services Group, Inc.399$3.13K0.00%−222−35.7%Reduced
Rothschild Investment LLC449$3.52K0.00%+29+6.9%Added
Rockefeller Capital Management L.P.594$4.66K0.00%+594New
Massmutual Trust Co FSB678$5.32K0.00%−216−24.2%Reduced
Signaturefd, LLC720$5.65K0.00%+89+14.1%Added
TSFG, LLC708$6.00K0.00%−350−33.1%Reduced
Hillsdale Investment Management Inc.1,000$7.85K0.00%00.0%Unchanged
Activest Wealth Management1,000$7.85K0.00%00.0%Unchanged
True Wealth Design, LLC1,011$7.94K0.00%00.0%Unchanged
Sterling Capital Management LLC1,020$8.01K0.00%+648+174.2%Added
Sound Income Strategies, LLC1,149$8.64K0.00%+1,149New
Quest Partners LLC1,204$9.45K0.00%−3,096−72.0%Reduced
Essential Partners LLC1,288$10.1K0.00%−139−9.7%Reduced
Fortitude Family Office, LLC1,553$12.2K0.00%00.0%Unchanged
SRS Capital Advisors, Inc.1,632$12.8K0.00%−14,227−89.7%Reduced
Allworth Financial LP1,686$13.2K0.00%−79−4.5%Reduced
Caitong International Asset Management Co., Ltd1,714$13.5K0.00%+1,634+2,042.5%Added
SBI Securities Co., Ltd.1,907$15.0K0.00%−6−0.3%Reduced
Creative Financial Designs Inc2,200$17.3K0.00%00.0%Unchanged
Nisa Investment Advisors, LLC2,204$17.3K0.00%00.0%Unchanged
BNP PARIBAS ASSET MANAGEMENT Holding S.A.2,353$18.0K0.00%+2,353New
Farther Finance Advisors, LLC2,571$20.2K0.00%+190+8.0%Added
EverSource Wealth Advisors, LLC2,818$22.1K0.00%+941+50.1%Added
Northwestern Mutual Wealth Management Co2,821$22.1K0.00%−4,968−63.8%Reduced
Webster Bank, N. A.3,000$23.6K0.00%−1,000−25.0%Reduced
Kestra Advisory Services, LLC3,192$25.1K0.00%+3,192New
GF Fund Management Co. Ltd.3,260$25.6K0.00%−214−6.2%Reduced
Amalgamated Bank4,824$38.0K0.00%−10−0.2%Reduced
Jones Financial Companies LLLP5,707$44.8K0.00%+2,926+105.2%Added
CIBC Private Wealth Group, LLC6,664$52.3K0.00%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.8,063$63.3K0.00%+1,820+29.2%Added
Truvestments Capital LLC8,118$63.7K0.01%+3,979+96.1%Added
State of Alaska, Department of Revenue8,457$66.0K0.00%00.0%Unchanged
Kemnay Advisory Services Inc.8,480$66.6K0.01%+8,480New
Kingsview Wealth Management, LLC10,000$78.5K0.00%+10,000New
CIBC World Markets Corp10,158$79.7K0.00%+10,158New
Tower Research Capital LLC (TRC)10,740$84.3K0.00%+6,286+141.1%Added
Pallas Capital Advisors LLC11,003$86.4K0.00%−24−0.2%Reduced
Jain Global LLC11,114$87.2K0.00%+11,114New
O'Shaughnessy Asset Management, LLC11,423$89.7K0.00%+1,263+12.4%Added
Skopos Labs, Inc.12,195$90.6K0.00%+12,195New
Captrust Financial Advisors11,816$92.8K0.00%−88−0.7%Reduced
Xponance, Inc.12,112$95.1K0.00%+127+1.1%Added
Aigen Investment Management, LP12,262$96.3K0.02%−6,867−35.9%Reduced
Ameritas Investment Partners, Inc.12,827$100.7K0.00%00.0%Unchanged
Universal- Beteiligungs- und Servicegesellschaft mbH14,192$111.4K0.00%+1,037+7.9%Added
Bailard, Inc.15,300$120.1K0.00%+15,300New
Landscape Capital Management, L.L.C.15,709$123.3K0.01%00.0%Unchanged
Empirical Financial Services, LLC d.b.a. Empirical Wealth Management16,070$126.2K0.00%+2,420+17.7%Added
Jacksonville Wealth Management, LLC17,000$133.4K0.09%00.0%Unchanged
Numerai GP LLC17,148$134.6K0.02%−1,359−7.3%Reduced
Dynamic Technology Lab Private Ltd17,200$135.0K0.03%+17,200New
Modern Wealth Management, LLC17,712$139.0K0.00%+80.0%Added
Victory Capital Management Inc17,840$140.0K0.00%+585+3.4%Added
Aspiriant, LLC20,000$157.0K0.00%00.0%Unchanged
Van Hulzen Asset Management, LLC20,382$160.0K0.01%−1,800−8.1%Reduced
Los Angeles Capital Management LLC17,901$173.8K0.00%00.0%Unchanged
Tudor Investment Corp Et Al22,186$174.2K0.00%−15,808−41.6%Reduced
Pictet Asset Management Holding SA23,196$182.1K0.00%00.0%Unchanged
Teacher Retirement System of Texas23,936$187.9K0.00%−15,385−39.1%Reduced
Palumbo Wealth Management LLC24,349$191.1K0.05%−38,840−61.5%Reduced
Janney Montgomery Scott LLC24,450$192.0K0.00%−1,750−6.7%Reduced
Quantinno Capital Management LP24,696$193.9K0.00%+7,002+39.6%Added
9823 Capital, L.P.24,917$195.6K0.13%+24,917New
Swiss Life Asset Management Ltd26,059$204.6K0.00%+26,059New
Fox Run Management, L.L.C.26,174$205.5K0.03%+26,174New
Asset Management Group, Inc.26,480$207.9K0.03%00.0%Unchanged
China Universal Asset Management Co., Ltd.27,037$212.2K0.02%−1,268−4.5%Reduced
Wealth Enhancement Advisory Services, LLC31,105$216.5K0.00%−20.0%Reduced
Cerity Partners LLC29,578$232.2K0.00%−1,455−4.7%Reduced
VARCOV Co.31,005$243.4K0.10%+31,005New
Diversified Trust Co32,062$251.7K0.00%00.0%Unchanged
KLP Kapitalforvaltning AS33,400$262.2K0.00%00.0%Unchanged
Rafferty Asset Management, LLC33,689$264.5K0.00%+16,278+93.5%Added
Gsa Capital Partners LLP34,665$272.0K0.02%−34,051−49.6%Reduced
Cambridge Investment Research Advisors, Inc.34,642$272.0K0.00%00.0%Unchanged
ProShare Advisors LLC35,390$277.8K0.00%+3,383+10.6%Added
Gotham Asset Management, LLC35,412$278.0K0.00%−7,329−17.1%Reduced
Ausbil Investment Management Ltd37,000$290.4K0.17%+37,000New
Virtus Investment Advisers, Inc.37,102$291.3K0.08%+11,358+44.1%Added
State Board of Administration of Florida Retirement System37,970$298.1K0.00%00.0%Unchanged
Cetera Investment Advisers38,647$303.4K0.00%−1,371−3.4%Reduced
Royal Bank of Canada38,636$304.0K0.00%+2,351+6.5%Added
Profund Advisors LLC38,947$305.7K0.01%+12,383+46.6%Added
Savvy Advisors, Inc.40,465$317.6K0.01%00.0%Unchanged