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Vertex Pharmaceuticals Inc

VRTX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000875320

In the last 90 days, Vertex Pharmaceuticals Inc insiders filed 0 open-market purchases and 3 sales; 1,763 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Vertex Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
1,671
+174 vs. Q3 2025
Shares held
241.6M
+9.62M (+4.1%) vs. Q3 2025
Total value
$109.5B
+$18.8B (+20.7%) vs. Q3 2025
New holders
274
620 more added
Sold out
100
566 more reduced

26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 1,671 institutions
Q1 2021: 1,000 institutionsQ2 2021: 979 institutionsQ3 2021: 936 institutionsQ4 2021: 1,034 institutionsQ1 2022: 1,073 institutionsQ2 2022: 1,110 institutionsQ3 2022: 1,128 institutionsQ4 2022: 1,225 institutionsQ1 2023: 1,213 institutionsQ2 2023: 1,288 institutionsQ3 2023: 1,280 institutionsQ4 2023: 1,442 institutionsQ1 2024: 1,497 institutionsQ2 2024: 1,551 institutionsQ3 2024: 1,551 institutionsQ4 2024: 1,563 institutionsQ1 2025: 1,618 institutionsQ2 2025: 1,564 institutionsQ3 2025: 1,523 institutionsQ4 2025: 1,671 institutionsQ1 2026: 1,698 institutionsQ2 2026: 1,763 institutions
Value heldQ4 2025: $109.5B
Q1 2021: $50.6BQ2 2021: $46.8BQ3 2021: $41.9BQ4 2021: $50.4BQ1 2022: $60.9BQ2 2022: $66.1BQ3 2022: $68.5BQ4 2022: $68.3BQ1 2023: $75.0BQ2 2023: $83.3BQ3 2023: $81.9BQ4 2023: $95.7BQ1 2024: $98.0BQ2 2024: $109.9BQ3 2024: $109.1BQ4 2024: $95.2BQ1 2025: $116.3BQ2 2025: $107.2BQ3 2025: $90.8BQ4 2025: $109.5BQ1 2026: $106.1BQ2 2026: $119.7B
Institutions holding VRTX and their total value by quarter
QuarterHoldersValue
Q2 20261,763$119.7B
Q1 20261,698$106.1B
Q4 20251,671$109.5B
Q3 20251,523$90.8B
Q2 20251,564$107.2B
Q1 20251,618$116.3B
Q4 20241,563$95.2B
Q3 20241,551$109.1B
Q2 20241,551$109.9B
Q1 20241,497$98.0B
Q4 20231,442$95.7B
Q3 20231,280$81.9B
Q2 20231,288$83.3B
Q1 20231,213$75.0B
Q4 20221,225$68.3B
Q3 20221,128$68.5B
Q2 20221,110$66.1B
Q1 20221,073$60.9B
Q4 20211,034$50.4B
Q3 2021936$41.9B
Q2 2021979$46.8B
Q1 20211,000$50.6B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q3 2025.

Institutions holding VRTX in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Hansen & Associates Financial Group, Inc.441$204.4K0.11%+441New
Fielder Capital Group LLC452$204.9K0.04%+452New
Ledyard National Bank453$205.4K0.02%+453New
PKS Advisory Services, LLC453$205.4K0.05%+453New
Englebert Financial Advisers, LLC453$205.4K0.24%+453New
Mitsubishi UFJ Morgan Stanley Securities Co., Ltd.454$205.8K0.32%+454New
Stratos Wealth Advisors, LLC454$205.8K0.01%+454New
Mainsail Asset Management, LLC454$205.8K0.09%+454New
Planning Alternatives Ltd454$205.8K0.03%+454New
Hutchens & Kramer Investment Management Group, LLC457$207.2K0.07%+457New
Liberty Wealth Management LLC459$208.1K0.03%+459New
Sentinus, LLC461$209.0K0.02%+461New
Wall Street Financial Group, Inc.461$209.0K0.15%+461New
S Harris Financial Group, LLC461$209.0K0.20%+461New
Cornerstone Wealth Group, LLC463$209.9K0.01%+463New
Prelude Capital Management, LLC463$209.9K0.02%+463New
Klingman & Associates, LLC465$210.8K0.01%+465New
United Advisor Group, LLC468$212.2K0.03%−270−36.6%Reduced
Safe Harbor Wealth Advisors, LLC457$212.5K0.21%+457New
Retirement Planning Group470$213.1K0.01%+470New
Great Lakes Advisors, LLC471$213.5K0.00%+471New
Sage Capital Management, LLC472$214.0K0.10%+472New
Inscription Capital, LLC473$214.4K0.02%−147−23.7%Reduced
Fieldview Capital Management, LLC473$214.4K0.04%+473New
Pathway Wealth Management LLC475$215.3K0.20%+475New
Guerra Pan Advisors, LLC478$216.7K0.13%+478New
Ponta Wealth Partners, LLC479$217.2K0.20%+479New
Jupiter Asset Management Ltd480$217.6K0.00%−65,139−99.3%Reduced
Trinity Legacy Partners, LLC480$217.6K0.05%00.0%Unchanged
Impact Partnership Wealth, LLC480$217.6K0.03%+480New
Pictet & Cie (Europe) SA482$218.5K0.00%+482New
LaFleur & Godfrey LLC482$218.5K0.03%+482New
Washington Trust Advisors, Inc.483$218.9K0.02%+134+38.4%Added
Adirondack Trust Co483$219.0K0.07%+26+5.7%Added
Bourgeon Capital Management LLC483$219.0K0.04%+483New
Capstone Capital Management Ltd484$219.4K0.21%+484New
Epoch Investment Partners, Inc.485$219.9K0.00%−149−23.5%Reduced
Boston Trust Walden Corp485$219.9K0.00%+485New
Loudon Investment Management, LLC485$219.9K0.11%+485New
Stanley-Laman Group, Ltd.485$219.9K0.03%+485New
Covestor Ltd484$220.0K0.12%+262+118.0%Added
Heritage Investors Management Corp486$220.0K0.01%+486New
Commonwealth Financial Services, LLC485$220.0K0.04%+485New
SHP Wealth Management486$220.3K0.02%+486New
Beaumont Financial Advisors, LLC486$220.3K0.01%+486New
Investment Advisory Group, LLC489$221.7K0.06%−120−19.7%Reduced
SevenBridge Financial Group, LLC465$221.7K0.04%−15−3.1%Reduced
SeaCrest Wealth Management, LLC459$222.2K0.02%+459New
Onyx Bridge Wealth Group LLC491$222.6K0.02%+491New
Joel Isaacson & Co., LLC492$223.1K0.01%+492New
Mesirow Financial Investment Management, Inc.493$223.5K0.00%−186−27.4%Reduced
Harbour Investments, Inc.493$223.5K0.00%+29+6.3%Added
Drucker Wealth 3.0, LLC494$223.8K0.04%+494New
Salem Investment Counselors Inc494$224.0K0.01%+135+37.6%Added
WSFS Capital Management, LLC494$224.0K0.01%+494New
Anchor Investment Management, LLC495$224.4K0.02%−1,892−79.3%Reduced
Putney Financial Group LLC495$224.4K0.21%−79−13.8%Reduced
Chatterton & Associates Inc.495$224.4K0.19%+495New
Equitable Trust Co496$224.9K0.01%+496New
HMS Capital Management, LLC497$225.3K0.09%−448−47.4%Reduced
Trust Point Inc.500$226.7K0.02%+500New
Mengis Capital Management, Inc.500$226.7K0.04%+500New
Arlington Financial Advisors, LLC500$226.7K0.03%+500New
McHugh Group, LLC500$226.7K0.13%+500New
Corient IA LLC500$226.7K0.21%+500New
Symphony Financial, Ltd. Co.501$227.3K0.03%−171−25.4%Reduced
BKD Wealth Advisors, LLC502$227.6K0.00%−90−15.2%Reduced
Spirepoint Private Client, LLC502$227.6K0.02%+502New
Smithfield Trust Co503$228.0K0.01%00.0%Unchanged
Warren Street Wealth Advisors, LLC503$228.0K0.07%−56−10.0%Reduced
US Asset Management LLC503$228.0K0.19%+503New
Crewe Advisors LLC504$228.5K0.02%+3+0.6%Added
Miller Capital Partners, Inc.505$228.9K0.12%+505New
Sound Income Strategies, LLC520$229.5K0.01%+14+2.8%Added
Morris Financial Concepts, Inc.507$229.9K0.08%−4−0.8%Reduced
Five Oceans Advisors507$229.9K0.08%+507New
Heartwood Wealth Advisors LLC511$231.7K0.02%−21−3.9%Reduced
Ethos Financial Group, LLC511$231.7K0.02%+511New
First Foundation Advisors515$233.5K0.01%00.0%Unchanged
Vilga Financial Planning LLC515$233.5K0.22%+515New
Victory Financial Group, LLC516$233.9K0.03%+516New
Tritonpoint Wealth, LLC517$234.4K0.02%−31−5.7%Reduced
CoreCap Advisors, LLC520$235.7K0.01%+30+6.1%Added
Brian Low Financial Group, LLC523$237.1K0.17%+523New
Focus Financial Network, Inc.524$237.6K0.01%−15−2.8%Reduced
GM Advisory Group, Inc.527$238.9K0.01%+527New
Virtue Capital Management, LLC529$239.2K0.04%+529New
BLB&B Advisors, LLC528$239.4K0.01%+7+1.3%Added
Clark Capital Management Group, Inc.530$240.3K0.00%−42−7.3%Reduced
Vanguard Capital Wealth Advisors530$240.3K0.19%00.0%Unchanged
Elm Partners Management LLC531$240.7K0.01%+1+0.2%Added
Sustainable Insight Capital Management, LLC531$240.7K0.08%+531New
JGP Global Gestao de Recursos Ltda.532$241.2K0.14%−54−9.2%Reduced
Cidel Asset Management Inc532$241.2K0.02%+532New
Collaborative Wealth Managment Inc.534$242.1K0.09%+534New
Pursuit Wealth Strategies, LLC534$242.1K0.34%+534New
Brookstone Capital Management535$242.6K0.00%−4−0.7%Reduced
Banque Transatlantique SA539$244.3K0.01%−75−12.2%Reduced
Tillman Hartley LLC540$244.8K0.06%+4+0.7%Added
Private Trust Co NA540$244.8K0.02%+8+1.5%Added