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Vertex Pharmaceuticals Inc

VRTX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000875320

No open-market purchases or sales by Vertex Pharmaceuticals Inc insiders were filed in the last 90 days; 1,762 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Vertex Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
1,671
+174 vs. Q3 2025
Shares held
241.6M
+9.62M (+4.1%) vs. Q3 2025
Total value
$109.5B
+$18.8B (+20.7%) vs. Q3 2025
New holders
274
620 more added
Sold out
100
566 more reduced

26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 1,671 institutions
Q1 2021: 1,000 institutionsQ2 2021: 979 institutionsQ3 2021: 936 institutionsQ4 2021: 1,034 institutionsQ1 2022: 1,072 institutionsQ2 2022: 1,109 institutionsQ3 2022: 1,127 institutionsQ4 2022: 1,224 institutionsQ1 2023: 1,212 institutionsQ2 2023: 1,287 institutionsQ3 2023: 1,280 institutionsQ4 2023: 1,442 institutionsQ1 2024: 1,497 institutionsQ2 2024: 1,551 institutionsQ3 2024: 1,551 institutionsQ4 2024: 1,563 institutionsQ1 2025: 1,617 institutionsQ2 2025: 1,563 institutionsQ3 2025: 1,523 institutionsQ4 2025: 1,671 institutionsQ1 2026: 1,698 institutionsQ2 2026: 1,762 institutions
Value heldQ4 2025: $109.5B
Q1 2021: $50.6BQ2 2021: $46.8BQ3 2021: $41.9BQ4 2021: $50.4BQ1 2022: $60.9BQ2 2022: $66.1BQ3 2022: $68.5BQ4 2022: $68.3BQ1 2023: $75.0BQ2 2023: $83.3BQ3 2023: $81.9BQ4 2023: $95.7BQ1 2024: $98.0BQ2 2024: $109.9BQ3 2024: $109.1BQ4 2024: $95.2BQ1 2025: $116.3BQ2 2025: $107.2BQ3 2025: $90.8BQ4 2025: $109.5BQ1 2026: $106.1BQ2 2026: $119.7B
Institutions holding VRTX and their total value by quarter
QuarterHoldersValue
Q2 20261,762$119.7B
Q1 20261,698$106.1B
Q4 20251,671$109.5B
Q3 20251,523$90.8B
Q2 20251,563$107.2B
Q1 20251,617$116.3B
Q4 20241,563$95.2B
Q3 20241,551$109.1B
Q2 20241,551$109.9B
Q1 20241,497$98.0B
Q4 20231,442$95.7B
Q3 20231,280$81.9B
Q2 20231,287$83.3B
Q1 20231,212$75.0B
Q4 20221,224$68.3B
Q3 20221,127$68.5B
Q2 20221,109$66.1B
Q1 20221,072$60.9B
Q4 20211,034$50.4B
Q3 2021936$41.9B
Q2 2021979$46.8B
Q1 20211,000$50.6B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q3 2025.

Institutions holding VRTX in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Humankind Investments LLC0$00.00%−2,864−100.0%Sold out
Magnetar Financial LLC0$00.00%−2,757−100.0%Sold out
Scientech Research LLC0$00.00%−2,578−100.0%Sold out
Wealthedge Investment Advisors, LLC0$00.00%−2,465−100.0%Sold out
Mitsubishi UFJ Asset Management (UK) Ltd.0$00.00%−2,200−100.0%Sold out
Hobbs Group Advisors, LLC0$00.00%−1,871−100.0%Sold out
Prosperity Wealth Management, Inc.0$00.00%−1,757−100.0%Sold out
Perbak Capital Partners LLP0$00.00%−1,727−100.0%Sold out
R Squared Ltd0$00.00%−1,680−100.0%Sold out
New England Research & Management, Inc.0$00.00%−1,535−100.0%Sold out
Brookwood Investment Group LLC0$00.00%−1,404−100.0%Sold out
Arete Wealth Advisors, LLC0$00.00%−1,371−100.0%Sold out
American Trust0$00.00%−1,322−100.0%Sold out
Blueshift Asset Management, LLC0$00.00%−1,213−100.0%Sold out
Pitcairn Co0$00.00%−1,178−100.0%Sold out
Pekin Hardy Strauss, Inc.0$00.00%−1,106−100.0%Sold out
Beirne Wealth Consulting Services, LLC0$00.00%−1,048−100.0%Sold out
Consolidated Portfolio Review Corp0$00.00%−1,002−100.0%Sold out
NJ State Employees Deferred Compensation Plan0$00.00%−1,000−100.0%Sold out
Bridgefront Capital, LLC0$00.00%−903−100.0%Sold out
Cozad Asset Management Inc0$00.00%−900−100.0%Sold out
Lockerman Financial Group, Inc.0$00.00%−863−100.0%Sold out
Capula Management Ltd0$00.00%−770−100.0%Sold out
Requisite Capital Management, LLC0$00.00%−768−100.0%Sold out
Leeward Financial Partners, LLC0$00.00%−716−100.0%Sold out
Qsemble Capital Management, LP0$00.00%−709−100.0%Sold out
Facet Wealth, Inc.0$00.00%−691−100.0%Sold out
Opinicus Capital, Inc.0$00.00%−673−100.0%Sold out
Lombard Odier Asset Management (USA) Corp0$00.00%−651−100.0%Sold out
Boothbay Fund Management, LLC0$00.00%−611−100.0%Sold out
Main Street Financial Solutions, LLC0$00.00%−609−100.0%Sold out
Sanibel Captiva Trust Company, Inc.0$00.00%−607−100.0%Sold out
Gsa Capital Partners LLP0$00.00%−569−100.0%Sold out
Sageworth Trust Co0$00.00%−561−100.0%Sold out
Kesler, Norman & Wride, LLC0$00.00%−538−100.0%Sold out
Acropolis Investment Management, LLC0$00.00%−469−100.0%Sold out
KMG Fiduciary Partners, LLC0$00.00%−531−100.0%Sold out
MONECO Advisors, LLC0$00.00%−514−100.0%Sold out
Gamco Investors, Inc. Et Al0$00.00%−512−100.0%Sold out
Aster Capital Management (DIFC) Ltd0$00.00%−445−100.0%Sold out
Groupe la Francaise0$00.00%−432−100.0%Sold out
TruNorth Capital Management, LLC0$00.00%−200−100.0%Sold out
Alpine Bank Wealth Management0$00.00%−192−100.0%Sold out
Rise Advisors, LLC0$00.00%−170−100.0%Sold out
Union Bancaire Privee, UBP SA0$00.00%−139−100.0%Sold out
JPL Wealth Management, LLC0$00.00%−128−100.0%Sold out
Exane Asset Management0$00.00%−100−100.0%Sold out
Future Financial Wealth Managment LLC0$00.00%−100−100.0%Sold out
Quarry LP0$00.00%−39−100.0%Sold out
North Capital, Inc.0$00.00%−38−100.0%Sold out
Main Street Group, LTD0$00.00%−25−100.0%Sold out
Y.D. More Investments Ltd0$00.00%−89−100.0%Sold out
Mendota Financial Group, LLC0$00.00%−20−100.0%Sold out
Cloud Capital Management, LLC0$00.00%−18−100.0%Sold out
CBIZ Investment Advisory Services, LLC0$00.00%−16−100.0%Sold out
Halbert Hargrove Global Advisors, LLC0$00.00%−13−100.0%Sold out
Longfellow Investment Management Co LLC0$00.00%−13−100.0%Sold out
Coston, McIsaac & Partners0$00.00%−14−100.0%Sold out
Global Wealth Strategies & Associates0$00.00%−11−100.0%Sold out
First United Bank Trust0$00.00%−10−100.0%Sold out
Tortoise Investment Management, LLC0$00.00%−10−100.0%Sold out
HighMark Wealth Management LLC0$00.00%−10−100.0%Sold out
Piscataqua Savings Bank0$00.00%−10−100.0%Sold out
Evergreen Private Wealth LLC0$00.00%−10−100.0%Sold out
Hopwood Financial Services, Inc.0$00.00%−9−100.0%Sold out
Concord Wealth Partners0$00.00%−5−100.0%Sold out
Palisade Asset Management, LLC0$00.00%−4−100.0%Sold out
Tradewinds Capital Management, LLC0$00.00%−2−100.0%Sold out
Logan Capital Management Inc0$00.00%−2−100.0%Sold out
CGC Financial Services, LLC0$00.00%−1−100.0%Sold out
Koesten, Hirschmann & Crabtree, INC.0$00.00%0Sold out
AXA Investment Managers S.A.––––Not filed
CIBC Bancorp USA Inc.––––Not filed
Wolverine Trading, LLC––––Not filed
Thematics Asset Management––––Not filed
Shorepoint Capital Partners LLC––––Not filed
Synovus Financial Corp––––Not filed
Pinnacle Financial Partners Inc––––Not filed
Shell Asset Management Co––––Not filed
Wetherby Asset Management Inc––––Not filed
Glenmede Investment Management, LP––––Not filed
1858 Wealth Management, LLC––––Not filed
EFG Asset Management (North America) Corp.––––Not filed
Eisler Capital Management Ltd.––––Not filed
Stonegate Investment Group, LLC––––Not filed
Moloney Securities Asset Management, LLC––––Not filed
First Affirmative Financial Network––––Not filed
Lion Street Advisors, LLC––––Not filed
Hemington Wealth Management––––Not filed
Abich Financial Wealth Management LLC––––Not filed
West Oak Capital, LLC––––Not filed
Optimum Investment Advisors––––Not filed
Binnacle Investments Inc––––Not filed
AllSquare Wealth Management LLC––––Not filed
FSA Wealth Management LLC––––Not filed
Guerra Advisors Inc––––Not filed
Texas Capital Bancshares Inc––––Not filed