Vertex Pharmaceuticals Inc
VRTX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0000875320
No open-market purchases or sales by Vertex Pharmaceuticals Inc insiders were filed in the last 90 days; 1,762 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Vertex Pharmaceuticals Inc as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 1,671
- +174 vs. Q3 2025
- Shares held
- 241.6M
- +9.62M (+4.1%) vs. Q3 2025
- Total value
- $109.5B
- +$18.8B (+20.7%) vs. Q3 2025
- New holders
- 274
- 620 more added
- Sold out
- 100
- 566 more reduced
26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 1,762 | $119.7B |
| Q1 2026 | 1,698 | $106.1B |
| Q4 2025 | 1,671 | $109.5B |
| Q3 2025 | 1,523 | $90.8B |
| Q2 2025 | 1,563 | $107.2B |
| Q1 2025 | 1,617 | $116.3B |
| Q4 2024 | 1,563 | $95.2B |
| Q3 2024 | 1,551 | $109.1B |
| Q2 2024 | 1,551 | $109.9B |
| Q1 2024 | 1,497 | $98.0B |
| Q4 2023 | 1,442 | $95.7B |
| Q3 2023 | 1,280 | $81.9B |
| Q2 2023 | 1,287 | $83.3B |
| Q1 2023 | 1,212 | $75.0B |
| Q4 2022 | 1,224 | $68.3B |
| Q3 2022 | 1,127 | $68.5B |
| Q2 2022 | 1,109 | $66.1B |
| Q1 2022 | 1,072 | $60.9B |
| Q4 2021 | 1,034 | $50.4B |
| Q3 2021 | 936 | $41.9B |
| Q2 2021 | 979 | $46.8B |
| Q1 2021 | 1,000 | $50.6B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Principal Financial Group Inc | 415,100 | $188.2M | 0.10% | +8,600+2.1% | Added |
| Raymond James Financial Inc | 418,131 | $189.6M | 0.06% | −117,554−21.9% | Reduced |
| Citadel Advisors LLC | 427,060 | $193.6M | 0.13% | +253,558+146.1% | Added |
| Bank of Montreal | 427,480 | $193.8M | 0.08% | +8,022+1.9% | Added |
| Manning & Napier Advisors LLC | 427,603 | $194.0M | 2.52% | −47,219−9.9% | Reduced |
| Rhumbline Advisers | 431,262 | $195.5M | 0.16% | −16,666−3.7% | Reduced |
| Nordea Investment Management AB | 447,169 | $202.6M | 0.17% | +86,084+23.8% | Added |
| ProShare Advisors LLC | 457,046 | $207.2M | 0.37% | +123,314+37.0% | Added |
| Envestnet Asset Management Inc | 471,643 | $213.8M | 0.06% | +888+0.2% | Added |
| DekaBank Deutsche Girozentrale | 506,457 | $219.8M | 0.41% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 505,048 | $229.0M | 0.36% | −230,840−31.4% | Reduced |
| B. Metzler seel. Sohn & Co. AG | 515,269 | $233.6M | 2.04% | +199,847+63.4% | Added |
| Natixis Advisors, L.P. | 527,864 | $239.3M | 0.34% | −9,330−1.7% | Reduced |
| National Pension Service | 530,841 | $240.7M | 0.18% | +18,728+3.7% | Added |
| Citigroup Inc | 539,930 | $244.8M | 0.17% | −650.0% | Reduced |
| Neuberger Berman Group LLC | 545,897 | $247.5M | 0.18% | +18,406+3.5% | Added |
| Franklin Resources Inc | 550,600 | $249.6M | 0.06% | +87,646+18.9% | Added |
| UBS Group AG | 555,982 | $252.1M | 0.05% | −217,066−28.1% | Reduced |
| California Public Employees Retirement System | 556,064 | $252.1M | 0.14% | −56,443−9.2% | Reduced |
| Manufacturers Life Insurance Company, The | 557,713 | $252.9M | 0.21% | +47,548+9.3% | Added |
| BNP Paribas Arbitrage, SA | 559,543 | $253.7M | 0.16% | +305,200+120.0% | Added |
| Voya Investment Management LLC | 562,352 | $254.4M | 0.25% | +130,095+30.1% | Added |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 566,227 | $256.0M | 0.17% | +21,249+3.9% | Added |
| Arrowstreet Capital, Limited Partnership | 593,947 | $269.3M | 0.16% | +212,752+55.8% | Added |
| HSBC Holdings PLC | 630,289 | $285.9M | 0.16% | −7,043−1.1% | Reduced |
| Sumitomo Mitsui Trust Holdings, Inc. | 654,470 | $296.7M | 0.17% | −46,203−6.6% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 669,807 | $303.7M | 0.35% | +213,474+46.8% | Added |
| Bellevue Group AG | 681,120 | $308.8M | 5.85% | +175,315+34.7% | Added |
| Swiss National Bank | 702,600 | $318.5M | 0.19% | −37,700−5.1% | Reduced |
| Wells Fargo & Company | 741,813 | $336.3M | 0.07% | +24,487+3.4% | Added |
| Pictet Asset Management Holding SA | 752,425 | $342.2M | 0.33% | −39,033−4.9% | Reduced |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 803,773 | $364.4M | 0.32% | −537,697−40.1% | Reduced |
| Assenagon Asset Management S.A. | 832,853 | $377.6M | 0.57% | +69,150+9.1% | Added |
| Barclays PLC | 847,758 | $384.3M | 0.15% | +105,271+14.2% | Added |
| American Century Companies Inc | 848,639 | $384.7M | 0.19% | +399,446+88.9% | Added |
| Winslow Capital Management, LLC | 887,640 | $405.1M | 1.36% | +887,640 | New |
| Dimensional Fund Advisors LP | 945,660 | $428.7M | 0.09% | +162,074+20.7% | Added |
| Nuveen, LLC | 1,042,397 | $472.6M | 0.12% | −35,313−3.3% | Reduced |
| Edgewood Management LLC | 1,060,075 | $480.6M | 2.29% | −427,467−28.7% | Reduced |
| WCM Investment Management, LLC | 1,129,145 | $512.3M | 1.05% | −20,987−1.8% | Reduced |
| Royal Bank of Canada | 1,194,512 | $541.5M | 0.10% | +803+0.1% | Added |
| Amundi | 1,304,161 | $591.3M | 0.16% | +185,190+16.6% | Added |
| Bank of New York Mellon Corp | 1,527,586 | $692.5M | 0.12% | −41,579−2.6% | Reduced |
| Goldman Sachs Group Inc | 1,754,118 | $795.2M | 0.11% | +269,460+18.1% | Added |
| Deutsche Bank AG | 1,768,881 | $801.9M | 0.26% | +168,425+10.5% | Added |
| Charles Schwab Investment Management Inc | 1,859,221 | $842.9M | 0.13% | +29,290+1.6% | Added |
| Legal & General Group Plc | 1,970,105 | $893.2M | 0.20% | +17,808+0.9% | Added |
| FMR LLC | 2,212,596 | $1.00B | 0.05% | −1,091,172−33.0% | Reduced |
| Janus Henderson Group PLC | 2,221,953 | $1.01B | 0.45% | +102,846+4.9% | Added |
| Ameriprise Financial Inc | 2,263,732 | $1.03B | 0.23% | −13,195−0.6% | Reduced |
| Price T Rowe Associates Inc | 2,278,958 | $1.03B | 0.11% | −764,847−25.1% | Reduced |
| Northern Trust Corp | 2,579,457 | $1.17B | 0.15% | −48,430−1.8% | Reduced |
| Clearbridge Investments, LLC | 2,860,176 | $1.30B | 1.04% | +214,412+8.1% | Added |
| Bank of America Corp | 2,937,030 | $1.33B | 0.10% | +96,606+3.4% | Added |
| UBS Asset Management Americas Inc | 3,000,778 | $1.36B | 0.29% | +113,661+3.9% | Added |
| Morgan Stanley | 3,120,310 | $1.41B | 0.08% | +11,905+0.4% | Added |
| Norges Bank | 3,176,613 | $1.44B | 0.15% | +3,176,613 | New |
| Jennison Associates LLC | 3,249,541 | $1.47B | 0.88% | −205,406−5.9% | Reduced |
| Victory Capital Management Inc | 3,356,766 | $1.52B | 0.86% | +1,109,200+49.4% | Added |
| Wellington Management Group LLP | 3,821,731 | $1.73B | 0.30% | −950,311−19.9% | Reduced |
| Loomis Sayles & Co L P | 4,033,525 | $1.83B | 2.20% | −88,603−2.1% | Reduced |
| Alliancebernstein L.P. | 4,496,482 | $2.04B | 0.64% | −26,104−0.6% | Reduced |
| Capital International Investors | 4,733,596 | $2.15B | 0.34% | +44,537+0.9% | Added |
| Geode Capital Management, LLC | 5,981,905 | $2.70B | 0.17% | +8,160+0.1% | Added |
| JPMorgan Chase & Co | 6,039,481 | $2.74B | 0.18% | −395,297−6.1% | Reduced |
| Invesco Ltd. | 7,852,733 | $3.56B | 0.34% | +5,755,936+274.5% | Added |
| State Street Corp | 11,689,539 | $5.30B | 0.18% | +83,539+0.7% | Added |
| Capital Research Global Investors | 17,316,344 | $7.85B | 1.45% | +763,063+4.6% | Added |
| BlackRock, Inc. | 23,751,989 | $10.8B | 0.18% | +1,498,942+6.7% | Added |
| Vanguard Group Inc | 24,105,823 | $10.9B | 0.16% | −111,042−0.5% | Reduced |
| Capital World Investors | 25,510,182 | $11.6B | 1.57% | −400,405−1.5% | Reduced |
| Parnassus Investments | 0 | $0 | 0.00% | −1,648,433−100.0% | Sold out |
| Freestone Grove Partners LP | 0 | $0 | 0.00% | −110,283−100.0% | Sold out |
| Voloridge Investment Management, LLC | 0 | $0 | 0.00% | −105,502−100.0% | Sold out |
| Migdal Insurance & Financial Holdings Ltd. | 0 | $0 | 0.00% | −75,000−100.0% | Sold out |
| Artia Global Partners LP | 0 | $0 | 0.00% | −55,100−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −51,382−100.0% | Sold out |
| Armistice Capital, LLC | 0 | $0 | 0.00% | −40,239−100.0% | Sold out |
| Adams Diversified Equity Fund, Inc. | 0 | $0 | 0.00% | −35,100−100.0% | Sold out |
| Headlands Technologies LLC | 0 | $0 | 0.00% | −29,864−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −29,596−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −27,770−100.0% | Sold out |
| Prosight Management, LP | 0 | $0 | 0.00% | −20,500−100.0% | Sold out |
| Bridger Management, LLC | 0 | $0 | 0.00% | −18,778−100.0% | Sold out |
| Morningstar Investment Management LLC | 0 | $0 | 0.00% | −12,305−100.0% | Sold out |
| Voleon Capital Management LP | 0 | $0 | 0.00% | −10,830−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −9,690−100.0% | Sold out |
| Bulltick Wealth Management, LLC | 0 | $0 | 0.00% | −9,102−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −8,889−100.0% | Sold out |
| Entropy Technologies, LP | 0 | $0 | 0.00% | −7,693−100.0% | Sold out |
| Neo Ivy Capital Management | 0 | $0 | 0.00% | −7,256−100.0% | Sold out |
| Cavalier Investments, LLC | 0 | $0 | 0.00% | −7,807−100.0% | Sold out |
| Atom Investors LP | 0 | $0 | 0.00% | −7,109−100.0% | Sold out |
| APG Asset Management US Inc. | 0 | $0 | 0.00% | −5,334−100.0% | Sold out |
| Mirabella Financial Services LLP | 0 | $0 | 0.00% | −5,377−100.0% | Sold out |
| Brighton Jones LLC | 0 | $0 | 0.00% | −4,693−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −3,343−100.0% | Sold out |
| FORA Capital, LLC | 0 | $0 | 0.00% | −3,168−100.0% | Sold out |
| Altshuler Shaham Ltd | 0 | $0 | 0.00% | −3,020−100.0% | Sold out |
| Arjuna Capital | 0 | $0 | 0.00% | −2,978−100.0% | Sold out |