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Vertex Pharmaceuticals Inc

VRTX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0000875320

In the last 90 days, Vertex Pharmaceuticals Inc insiders filed 0 open-market purchases and 3 sales; 1,763 institutions reported holding it in 13F filings for Q2 2026, worth $119.7B in total; no superinvestor holds it.

13F holders, Q3 2025

Institutional positions in Vertex Pharmaceuticals Inc as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
1,523
−13 vs. Q2 2025
Shares held
232.3M
−4.81M (−2.0%) vs. Q2 2025
Total value
$90.8B
−$14.7B (−14.0%) vs. Q2 2025
New holders
143
553 more added
Sold out
156
617 more reduced

28 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting VRTX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 1,523 institutions
Q1 2021: 1,000 institutionsQ2 2021: 979 institutionsQ3 2021: 936 institutionsQ4 2021: 1,034 institutionsQ1 2022: 1,073 institutionsQ2 2022: 1,110 institutionsQ3 2022: 1,128 institutionsQ4 2022: 1,225 institutionsQ1 2023: 1,213 institutionsQ2 2023: 1,288 institutionsQ3 2023: 1,280 institutionsQ4 2023: 1,442 institutionsQ1 2024: 1,497 institutionsQ2 2024: 1,551 institutionsQ3 2024: 1,551 institutionsQ4 2024: 1,563 institutionsQ1 2025: 1,618 institutionsQ2 2025: 1,564 institutionsQ3 2025: 1,523 institutionsQ4 2025: 1,671 institutionsQ1 2026: 1,698 institutionsQ2 2026: 1,763 institutions
Value heldQ3 2025: $90.8B
Q1 2021: $50.6BQ2 2021: $46.8BQ3 2021: $41.9BQ4 2021: $50.4BQ1 2022: $60.9BQ2 2022: $66.1BQ3 2022: $68.5BQ4 2022: $68.3BQ1 2023: $75.0BQ2 2023: $83.3BQ3 2023: $81.9BQ4 2023: $95.7BQ1 2024: $98.0BQ2 2024: $109.9BQ3 2024: $109.1BQ4 2024: $95.2BQ1 2025: $116.3BQ2 2025: $107.2BQ3 2025: $90.8BQ4 2025: $109.5BQ1 2026: $106.1BQ2 2026: $119.7B
Institutions holding VRTX and their total value by quarter
QuarterHoldersValue
Q2 20261,763$119.7B
Q1 20261,698$106.1B
Q4 20251,671$109.5B
Q3 20251,523$90.8B
Q2 20251,564$107.2B
Q1 20251,618$116.3B
Q4 20241,563$95.2B
Q3 20241,551$109.1B
Q2 20241,551$109.9B
Q1 20241,497$98.0B
Q4 20231,442$95.7B
Q3 20231,280$81.9B
Q2 20231,288$83.3B
Q1 20231,213$75.0B
Q4 20221,225$68.3B
Q3 20221,128$68.5B
Q2 20221,110$66.1B
Q1 20221,073$60.9B
Q4 20211,034$50.4B
Q3 2021936$41.9B
Q2 2021979$46.8B
Q1 20211,000$50.6B

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Vertex Pharmaceuticals Inc; share changes are against Q2 2025.

Institutions holding VRTX in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Raleigh Capital Management Inc.126$49.3K0.02%−5−3.8%Reduced
JPL Wealth Management, LLC128$50.2K0.01%+128New
Core Alternative Capital131$51.3K0.01%00.0%Unchanged
Atlantic Trust, LLC132$51.7K0.01%−41−23.7%Reduced
Union Bancaire Privee, UBP SA139$53.6K0.00%00.0%Unchanged
Salomon & Ludwin, LLC133$53.6K0.00%+84+171.4%Added
GW&K Investment Management, LLC143$56.0K0.00%−18−11.2%Reduced
St Germain D J Co Inc145$56.8K0.00%00.0%Unchanged
Chelsea Counsel Co150$58.7K0.03%00.0%Unchanged
REAP Financial Group, LLC153$59.9K0.01%+16+11.7%Added
PFS Partners, LLC158$61.9K0.03%00.0%Unchanged
Boreal Capital Management LLC159$62.3K0.05%00.0%Unchanged
City State Bank160$62.7K0.02%+50+45.5%Added
University of Texas/Texas Am Investment Managment Co163$63.8K0.01%+68+71.6%Added
Farmers & Merchants Investments Inc166$65.0K0.00%00.0%Unchanged
Steigerwald, Gordon & Koch Inc.167$65.4K0.01%+167New
Truvestments Capital LLC169$66.2K0.01%+33+24.3%Added
Rise Advisors, LLC170$66.6K0.02%+4+2.4%Added
Rosenberg Matthew Hamilton173$67.8K0.01%00.0%Unchanged
1620 Investment Advisors, Inc.178$69.8K0.05%−3−1.7%Reduced
Ameritas Advisory Services, LLC179$70.1K0.00%−123−40.7%Reduced
Westside Investment Management, Inc.176$71.1K0.01%+73+70.9%Added
MCF Advisors LLC183$71.7K0.00%+16+9.6%Added
Valley National Advisers Inc185$72.0K0.01%+21+12.8%Added
Abich Financial Wealth Management LLC186$72.8K0.03%+186New
MV Capital Management, Inc.186$72.8K0.01%−10−5.1%Reduced
NBC Securities, Inc.188$73.6K0.01%−172−47.8%Reduced
Edmond de Rothschild Holding S.A.191$74.8K0.00%00.0%Unchanged
Alpine Bank Wealth Management192$75.2K0.01%−130−40.4%Reduced
Ameriflex Group, Inc.192$75.2K0.03%+138+255.6%Added
TruNorth Capital Management, LLC200$78.3K0.02%00.0%Unchanged
Moisand Fitzgerald Tamayo, LLC200$78.3K0.01%00.0%Unchanged
Montag A & Associates Inc210$82.2K0.00%−300−58.8%Reduced
Crews Bank & Trust212$83.0K0.01%00.0%Unchanged
Versant Capital Management, Inc218$85.4K0.01%−456−67.7%Reduced
Plante Moran Financial Advisors, LLC219$85.8K0.01%00.0%Unchanged
Oakworth Capital, Inc.222$86.9K0.01%+58+35.4%Added
Covestor Ltd222$87.0K0.05%−76−25.5%Reduced
Colonial Trust Advisors223$87.3K0.01%+13+6.2%Added
Root Financial Partners, LLC223$87.3K0.01%+223New
Toth Financial Advisory Corp230$90.1K0.01%00.0%Unchanged
Trust Co of Vermont231$90.5K0.00%00.0%Unchanged
WPG Advisers, LLC236$92.4K0.07%−57−19.5%Reduced
Thurston, Springer, Miller, Herd & Titak, Inc.240$94.0K0.19%−2,487−91.2%Reduced
Kempen Capital Management N.V.241$94.4K0.00%−422−63.7%Reduced
Trust Co of Toledo NA244$95.6K0.01%00.0%Unchanged
E Fund Management (Hong Kong) Co., Ltd.244$95.6K0.06%+124+103.3%Added
ORG Partners LLC246$96.3K0.02%−4−1.6%Reduced
Ofi Invest Asset Management292$97.3K0.00%+78+36.4%Added
Acadian Asset Management LLC257$99.0K0.00%+257New
Manchester Capital Management LLC264$103.4K0.01%−242−47.8%Reduced
Golden State Wealth Management, LLC265$103.8K0.01%+9+3.5%Added
Arlington Trust Co LLC271$106.1K0.02%−36−11.7%Reduced
Rossby Financial, LCC263$106.3K0.04%+24+10.0%Added
Hilltop National Bank272$106.5K0.03%00.0%Unchanged
Roble, Belko & Company, Inc279$109.0K0.01%00.0%Unchanged
Ritter Daniher Financial Advisory LLC282$110.4K0.02%00.0%Unchanged
Asset Dedication, LLC294$115.1K0.01%+19+6.9%Added
Key Financial Inc290$117.2K0.02%00.0%Unchanged
Hemington Wealth Management302$118.0K0.02%−7−2.3%Reduced
TFC Financial Management308$120.6K0.02%−15−4.6%Reduced
State of Wyoming316$123.8K0.01%+316New
Tripletail Wealth Management, LLC310$125.6K0.15%+310New
Clean Yield Group322$126.1K0.04%00.0%Unchanged
Addison Advisors LLC332$130.0K0.03%−11−3.2%Reduced
Rothschild Investment LLC346$135.5K0.01%−67−16.2%Reduced
Vestor Capital, LLC346$136.0K0.01%−624−64.3%Reduced
Washington Trust Advisors, Inc.349$136.7K0.01%+26+8.0%Added
Paradigm Asset Management Co LLC350$137.1K0.03%00.0%Unchanged
Salem Investment Counselors Inc359$140.6K0.00%−135−27.3%Reduced
LRI Investments, LLC369$144.7K0.01%−193−34.3%Reduced
Deseret Mutual Benefit Administrators378$148.0K0.06%+44+13.2%Added
Goodman Advisory Group, LLC379$148.4K0.04%−21−5.3%Reduced
CVA Family Office, LLC388$152.0K0.02%+6+1.6%Added
Cary Street Partner Investment Advisory LLC392$153.5K0.06%+110+39.0%Added
Private Wealth Asset Management, LLC402$157.4K0.02%−85−17.5%Reduced
Groupe la Francaise432$169.2K0.00%−7,557−94.6%Reduced
Grove Bank & Trust439$171.9K0.02%−26−5.6%Reduced
Wealthspire Advisors, LLC443$173.4K0.00%−438−49.7%Reduced
Aster Capital Management (DIFC) Ltd445$174.3K0.09%+445New
Adirondack Trust Co457$179.0K0.06%00.0%Unchanged
Harbour Investments, Inc.464$181.7K0.00%+61+15.1%Added
CoreCap Advisors, LLC490$191.9K0.01%−952−66.0%Reduced
Quent Capital, LLC501$196.2K0.02%+26+5.5%Added
Crewe Advisors LLC501$196.2K0.02%+109+27.8%Added
Cullen/Frost Bankers, Inc.505$197.8K0.00%−177−26.0%Reduced
Smithfield Trust Co503$198.0K0.01%00.0%Unchanged
Morris Financial Concepts, Inc.511$200.1K0.07%+7+1.4%Added
Gamco Investors, Inc. Et Al512$200.5K0.00%00.0%Unchanged
MONECO Advisors, LLC514$201.2K0.02%−105−17.0%Reduced
First Foundation Advisors515$201.7K0.01%00.0%Unchanged
BLB&B Advisors, LLC521$204.0K0.01%+7+1.4%Added
Trinity Legacy Partners, LLC480$204.3K0.05%00.0%Unchanged
Elyxium Wealth, LLC522$204.4K0.07%−17−3.2%Reduced
Confluence Wealth Services, Inc.524$205.2K0.01%+524New
Vanguard Capital Wealth Advisors530$207.6K0.17%−30−5.4%Reduced
Elm Partners Management LLC530$207.6K0.01%+530New
KMG Fiduciary Partners, LLC531$208.0K0.01%00.0%Unchanged
Heartwood Wealth Advisors LLC532$208.4K0.02%−36−6.3%Reduced
SevenBridge Financial Group, LLC480$208.4K0.03%+480New