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Puma Biotechnology, Inc.

PBYI
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001401667

In the last 90 days, Puma Biotechnology, Inc. insiders filed 0 open-market purchases and 5 sales; 160 institutions reported holding it in 13F filings for Q2 2026, worth $313.6M in total; no superinvestor holds it.

13F holders, Q1 2026

Institutional positions in Puma Biotechnology, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
157
+11 vs. Q4 2025
Shares held
37.9M
+6.34M (+20.1%) vs. Q4 2025
Total value
$241.8M
+$54.4M (+29.0%) vs. Q4 2025
New holders
29
61 more added
Sold out
18
38 more reduced

5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PBYI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2026: 157 institutions
Q1 2021: 118 institutionsQ2 2021: 120 institutionsQ3 2021: 116 institutionsQ4 2021: 102 institutionsQ1 2022: 104 institutionsQ2 2022: 89 institutionsQ3 2022: 83 institutionsQ4 2022: 89 institutionsQ1 2023: 78 institutionsQ2 2023: 68 institutionsQ3 2023: 69 institutionsQ4 2023: 82 institutionsQ1 2024: 93 institutionsQ2 2024: 99 institutionsQ3 2024: 100 institutionsQ4 2024: 112 institutionsQ1 2025: 116 institutionsQ2 2025: 121 institutionsQ3 2025: 132 institutionsQ4 2025: 151 institutionsQ1 2026: 157 institutionsQ2 2026: 160 institutions
Value heldQ1 2026: $241.8M
Q1 2021: $355.9MQ2 2021: $319.3MQ3 2021: $226.0MQ4 2021: $93.1MQ1 2022: $86.1MQ2 2022: $79.5MQ3 2022: $65.5MQ4 2022: $116.3MQ1 2023: $86.3MQ2 2023: $93.8MQ3 2023: $67.6MQ4 2023: $117.0MQ1 2024: $164.4MQ2 2024: $101.0MQ3 2024: $76.0MQ4 2024: $90.1MQ1 2025: $90.1MQ2 2025: $112.8MQ3 2025: $182.6MQ4 2025: $210.2MQ1 2026: $241.8MQ2 2026: $313.6M
Institutions holding PBYI and their total value by quarter
QuarterHoldersValue
Q2 2026160$313.6M
Q1 2026157$241.8M
Q4 2025151$210.2M
Q3 2025132$182.6M
Q2 2025121$112.8M
Q1 2025116$90.1M
Q4 2024112$90.1M
Q3 2024100$76.0M
Q2 202499$101.0M
Q1 202493$164.4M
Q4 202382$117.0M
Q3 202369$67.6M
Q2 202368$93.8M
Q1 202378$86.3M
Q4 202289$116.3M
Q3 202283$65.5M
Q2 202289$79.5M
Q1 2022104$86.1M
Q4 2021102$93.1M
Q3 2021116$226.0M
Q2 2021120$319.3M
Q1 2021118$355.9M

Institutions, Q1 2026

Shares, value and share of portfolio for each institution holding Puma Biotechnology, Inc.; share changes are against Q4 2025.

Institutions holding PBYI in Q1 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Acorn Capital Advisors, LLC4,131,299$26.4M7.50%00.0%Unchanged
BlackRock, Inc.3,598,952$23.0M0.00%−43,636−1.2%Reduced
Acadian Asset Management LLC2,041,759$13.0M0.02%+16,936+0.8%Added
Renaissance Technologies LLC1,942,413$12.4M0.02%−181,400−8.5%Reduced
American Century Companies Inc1,916,346$12.2M0.01%+266,209+16.1%Added
Vanguard Capital Management LLC1,817,681$11.6M0.00%+1,817,681New
Vanguard Portfolio Management LLC1,734,649$11.1M0.00%+1,734,649New
Millennium Management LLC1,477,519$9.44M0.01%+1,460,905+8,793.2%Added
Dimensional Fund Advisors LP1,436,106$9.17M0.00%+96,503+7.2%Added
LSV Asset Management1,182,868$7.56M0.02%+778,066+192.2%Added
O'Shaughnessy Asset Management, LLC1,138,169$7.27M0.04%+17,840+1.6%Added
Geode Capital Management, LLC1,017,342$6.50M0.00%+22,997+2.3%Added
State Street Corp917,590$5.86M0.00%+40,513+4.6%Added
Kennedy Capital Management, Inc.889,601$5.68M0.12%+21,286+2.5%Added
AQR Capital Management LLC800,194$5.11M0.00%+133,589+20.0%Added
Connor, Clark & Lunn Investment Management Ltd.782,798$5.00M0.01%−92,503−10.6%Reduced
Bridgeway Capital Management, LLC775,341$4.95M0.10%+1,856+0.2%Added
Ritholtz Wealth Management774,308$4.95M0.09%+80,307+11.6%Added
Goldman Sachs Group Inc669,719$4.28M0.00%−124,243−15.6%Reduced
Northern Trust Corp641,753$4.10M0.00%+25,556+4.1%Added
Arrowstreet Capital, Limited Partnership538,155$3.44M0.00%−9,698−1.8%Reduced
UBS Group AG534,227$3.41M0.00%+406,915+319.6%Added
SEI Investments Co508,182$3.25M0.00%+78,257+18.2%Added
Morgan Stanley359,742$2.30M0.00%+32,968+10.1%Added
D. E. Shaw & Co., Inc.351,235$2.24M0.00%−27,061−7.2%Reduced
Globeflex Capital L P349,651$2.23M0.34%−102,955−22.7%Reduced
Bank of New York Mellon Corp347,881$2.22M0.00%−4,000−1.1%Reduced
State Board of Administration of Florida Retirement System272,890$1.74M0.00%+245,555+898.3%Added
Prudential Financial Inc253,039$1.62M0.00%−33,470−11.7%Reduced
Vanguard Fiduciary Trust Co251,683$1.61M0.00%+251,683New
Russell Investments Group, Ltd.251,653$1.61M0.00%00.0%Unchanged
Federated Hermes, Inc.237,715$1.52M0.00%−142−0.1%Reduced
Franklin Resources Inc215,391$1.38M0.00%+32,685+17.9%Added
JPMorgan Chase & Co220,724$1.35M0.00%+199,616+945.7%Added
State of Wisconsin Investment Board208,618$1.33M0.00%+74,844+55.9%Added
Empowered Funds, LLC204,041$1.30M0.01%+17,856+9.6%Added
Panagora Asset Management Inc194,887$1.25M0.00%00.0%Unchanged
FMR LLC191,833$1.23M0.00%+27,963+17.1%Added
Prospera Financial Services Inc173,051$1.11M0.02%−12,445−6.7%Reduced
Haven Private, LLC155,260$992.1K0.43%+63,177+68.6%Added
Round Rock Advisors, LLC128,912$823.7K0.13%+23,870+22.7%Added
First Trust Advisors LP123,513$789.2K0.00%+713+0.6%Added
Charles Schwab Investment Management Inc115,915$740.7K0.00%−9,457−7.5%Reduced
Evergreen Capital Management LLC96,000$613.4K0.01%00.0%Unchanged
Invesco Ltd.95,044$607.3K0.00%−13,257−12.2%Reduced
STRS Ohio91,500$584.7K0.00%−7,900−7.9%Reduced
OpenArc Corporate Advisory, LLC89,491$571.8K0.01%+130+0.1%Added
Nuveen, LLC79,101$505.5K0.00%00.0%Unchanged
State of Wyoming75,808$484.4K0.06%+22,653+42.6%Added
Winton Group Ltd66,333$423.9K0.01%−30,826−31.7%Reduced
Nomura Asset Management International Inc.61,255$391.0K0.00%00.0%Unchanged
EntryPoint Capital, LLC53,464$341.6K0.10%+18,075+51.1%Added
Rhumbline Advisers53,036$338.9K0.00%−859−1.6%Reduced
D'Orazio & Associates, Inc.49,915$319.0K0.04%+108+0.2%Added
Man Group plc47,375$302.7K0.00%+51+0.1%Added
Bank of America Corp40,364$257.9K0.00%−12,021−22.9%Reduced
Universal- Beteiligungs- und Servicegesellschaft mbH39,308$251.2K0.00%00.0%Unchanged
Baron Wealth Management LLC38,278$244.6K0.07%+2,886+8.2%Added
Vise Technologies, Inc.40,298$239.8K0.00%00.0%Unchanged
LPL Financial LLC36,618$234.0K0.00%−3,824−9.5%Reduced
Deutsche Bank AG33,145$211.8K0.00%+33,145New
Price T Rowe Associates Inc31,306$201.0K0.00%+5,370+20.7%Added
Citadel Advisors LLC29,959$191.4K0.00%−132,711−81.6%Reduced
Kathmere Capital Management, LLC29,779$190.3K0.01%+2,648+9.8%Added
Virtus ETF Advisers LLC29,347$187.5K0.09%−17,825−37.8%Reduced
Vanguard Global Advisers, LLC29,173$186.4K0.00%+29,173New
Engineers Gate Manager LP28,600$182.8K0.00%+9,814+52.2%Added
Envestnet Asset Management Inc26,558$169.7K0.00%+26,558New
CAPROCK Group, Inc.25,989$166.1K0.00%+9,541+58.0%Added
Metis Global Partners, LLC25,264$161.4K0.00%−17,322−40.7%Reduced
C2C Wealth Management, LLC23,620$150.9K0.13%+600+2.6%Added
Creative Planning23,113$147.7K0.00%+23,113New
Canada Pension Plan Investment Board22,800$145.7K0.00%−52,400−69.7%Reduced
One Wealth Advisors, LLC21,079$134.7K0.02%+1,690+8.7%Added
Mirae Asset Global ETFs Holdings Ltd.20,635$131.9K0.00%+476+2.4%Added
Prelude Capital Management, LLC18,448$117.9K0.01%−13,700−42.6%Reduced
Bailard, Inc.18,100$115.7K0.00%+18,100New
Lazard Asset Management LLC17,970$114.8K0.00%−41,605−69.8%Reduced
Allspring Global Investments Holdings, LLC17,066$109.1K0.00%+17,066New
Quadrature Capital Ltd16,745$107.0K0.00%+16,745New
Wells Fargo & Company16,273$104.0K0.00%−32,008−66.3%Reduced
Susquehanna International Group, LLP16,089$102.8K0.00%+16,089New
MetLife Investment Management15,842$101.2K0.00%−8,570−35.1%Reduced
Police & Firemen's Retirement System of New Jersey15,719$100.4K0.00%00.0%Unchanged
CWM, LLC15,263$97.5K0.00%+2,450+19.1%Added
XTX Topco Ltd15,116$96.6K0.00%+15,116New
Ieq Capital, LLC14,901$95.2K0.00%+3,406+29.6%Added
Mariner, LLC14,649$93.6K0.00%+14,649New
Barclays PLC13,988$89.4K0.00%−67,446−82.8%Reduced
Ashton Thomas Private Wealth, LLC13,500$86.3K0.00%+13,500New
Cerity Partners LLC13,013$83.2K0.00%+941+7.8%Added
Two Sigma Investments, LP13,000$83.1K0.00%−149,351−92.0%Reduced
HRT Financial LP13,073$83.0K0.00%+13,073New
Tocqueville Asset Management L.P.12,960$82.8K0.00%+12,960New
Alliancebernstein L.P.13,800$82.1K0.00%00.0%Unchanged
Wealth Enhancement Advisory Services, LLC11,635$80.3K0.00%+1,491+14.7%Added
Cambridge Investment Research Advisors, Inc.12,563$80.0K0.00%−46,754−78.8%Reduced
Perkins Capital Management Inc12,500$79.9K0.07%00.0%Unchanged
Manufacturers Life Insurance Company, The11,765$75.2K0.00%−1,662−12.4%Reduced
Advisor Group Holdings, Inc.11,669$74.6K0.00%−500−4.1%Reduced