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Puma Biotechnology, Inc.

PBYI
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001401667

In the last 90 days, Puma Biotechnology, Inc. insiders filed 0 open-market purchases and 5 sales; 160 institutions reported holding it in 13F filings for Q2 2026, worth $313.6M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Puma Biotechnology, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
151
+19 vs. Q3 2025
Shares held
35.3M
+964.7K (+2.8%) vs. Q3 2025
Total value
$210.2M
+$27.7M (+15.2%) vs. Q3 2025
New holders
33
52 more added
Sold out
14
38 more reduced

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PBYI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 151 institutions
Q1 2021: 118 institutionsQ2 2021: 120 institutionsQ3 2021: 116 institutionsQ4 2021: 102 institutionsQ1 2022: 104 institutionsQ2 2022: 89 institutionsQ3 2022: 83 institutionsQ4 2022: 89 institutionsQ1 2023: 78 institutionsQ2 2023: 68 institutionsQ3 2023: 69 institutionsQ4 2023: 82 institutionsQ1 2024: 93 institutionsQ2 2024: 99 institutionsQ3 2024: 100 institutionsQ4 2024: 112 institutionsQ1 2025: 116 institutionsQ2 2025: 121 institutionsQ3 2025: 132 institutionsQ4 2025: 151 institutionsQ1 2026: 157 institutionsQ2 2026: 160 institutions
Value heldQ4 2025: $210.2M
Q1 2021: $355.9MQ2 2021: $319.3MQ3 2021: $226.0MQ4 2021: $93.1MQ1 2022: $86.1MQ2 2022: $79.5MQ3 2022: $65.5MQ4 2022: $116.3MQ1 2023: $86.3MQ2 2023: $93.8MQ3 2023: $67.6MQ4 2023: $117.0MQ1 2024: $164.4MQ2 2024: $101.0MQ3 2024: $76.0MQ4 2024: $90.1MQ1 2025: $90.1MQ2 2025: $112.8MQ3 2025: $182.6MQ4 2025: $210.2MQ1 2026: $241.8MQ2 2026: $313.6M
Institutions holding PBYI and their total value by quarter
QuarterHoldersValue
Q2 2026160$313.6M
Q1 2026157$241.8M
Q4 2025151$210.2M
Q3 2025132$182.6M
Q2 2025121$112.8M
Q1 2025116$90.1M
Q4 2024112$90.1M
Q3 2024100$76.0M
Q2 202499$101.0M
Q1 202493$164.4M
Q4 202382$117.0M
Q3 202369$67.6M
Q2 202368$93.8M
Q1 202378$86.3M
Q4 202289$116.3M
Q3 202283$65.5M
Q2 202289$79.5M
Q1 2022104$86.1M
Q4 2021102$93.1M
Q3 2021116$226.0M
Q2 2021120$319.3M
Q1 2021118$355.9M

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Puma Biotechnology, Inc.; share changes are against Q3 2025.

Institutions holding PBYI in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
ZRC Wealth Management, LLC3$180.00%00.0%Unchanged
CWM Advisors, LLC5$310.00%+5New
National Bank of Canada10$590.00%+10New
SRS Capital Advisors, Inc.10$600.00%−1,262−99.2%Reduced
Clearstead Advisors, LLC17$1020.00%−318−94.9%Reduced
Sunbelt Securities, Inc.30$1780.00%00.0%Unchanged
SJS Investment Consulting Inc.36$2150.00%+36New
MAI Capital Management37$2210.00%+37New
Allworth Financial LP50$2980.00%+45+900.0%Added
SBI Securities Co., Ltd.56$3330.00%00.0%Unchanged
Jones Financial Companies LLLP68$4050.00%00.0%Unchanged
DecisionPoint Financial, LLC100$5950.00%+100New
True Wealth Design, LLC123$7320.00%00.0%Unchanged
GAMMA Investing LLC139$8270.00%+61+78.2%Added
Rockefeller Capital Management L.P.159$9460.00%+159New
US Bancorp200$1.19K0.00%00.0%Unchanged
IFP Advisors, Inc204$1.21K0.00%+155+316.3%Added
EverSource Wealth Advisors, LLC237$1.41K0.00%+70+41.9%Added
Rothschild Investment LLC293$1.74K0.00%+43+17.2%Added
Nisa Investment Advisors, LLC342$2.04K0.00%00.0%Unchanged
Essential Partners LLC441$2.62K0.00%+2+0.5%Added
The PNC Financial Services Group, Inc.513$3.05K0.00%+396+338.5%Added
Farther Finance Advisors, LLC529$3.15K0.00%+529New
Optiver Holding B.V.768$4.57K0.00%00.0%Unchanged
CIBC Private Wealth Group, LLC775$4.61K0.00%00.0%Unchanged
GF Fund Management Co. Ltd.989$5.88K0.00%+989New
GPS Wealth Strategies Group, LLC1,000$5.95K0.01%00.0%Unchanged
WealthCollab, LLC1,156$6.88K0.00%00.0%Unchanged
GHP Investment Advisors, Inc.1,170$6.96K0.00%00.0%Unchanged
Royal Bank of Canada1,254$7.00K0.00%−454−26.6%Reduced
Amalgamated Bank1,353$8.00K0.00%−79−5.5%Reduced
Rialto Wealth Management, LLC1,450$8.63K0.00%00.0%Unchanged
Global Retirement Partners, LLC1,492$8.88K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)2,239$13.3K0.00%−1,640−42.3%Reduced
Citigroup Inc2,380$14.2K0.00%+1,521+177.1%Added
Mirae Asset Global Investments Co., Ltd.2,449$14.6K0.00%+2,449New
Sterling Capital Management LLC2,482$14.8K0.00%−445−15.2%Reduced
California State Teachers Retirement System2,650$15.8K0.00%−351−11.7%Reduced
Ball & Co Wealth Management Inc.3,066$18.0K0.01%00.0%Unchanged
Private Wealth Asset Management, LLC3,500$20.8K0.00%00.0%Unchanged
Legal & General Group Plc3,564$21.2K0.00%00.0%Unchanged
New York State Common Retirement Fund3,600$21.4K0.00%00.0%Unchanged
Ameritas Investment Partners, Inc.4,055$24.1K0.00%00.0%Unchanged
China Universal Asset Management Co., Ltd.8,211$48.9K0.00%+8,211New
State of Alaska, Department of Revenue8,445$50.0K0.00%+8,445New
Group One Trading, L.P.9,233$54.9K0.00%+9,233New
BNP Paribas Arbitrage, SA9,758$58.1K0.00%+1,702+21.1%Added
Wealth Enhancement Advisory Services, LLC10,144$59.4K0.00%+10,144New
ProShare Advisors LLC10,062$59.9K0.00%+10,062New
Ethic Inc.10,548$62.8K0.00%+195+1.9%Added
Williams & Novak, LLC10,560$62.8K0.05%+10,560New
Abel Hall, LLC10,793$64.2K0.01%+10,793New
Ieq Capital, LLC11,495$68.4K0.00%+11,495New
Royce & Associates LP11,914$70.9K0.00%−6,811−36.4%Reduced
PFG Investments, LLC12,000$71.4K0.00%−3,000−20.0%Reduced
Cerity Partners LLC12,072$71.8K0.00%+1,862+18.2%Added
Advisor Group Holdings, Inc.12,169$72.4K0.00%−6,094−33.4%Reduced
Perkins Capital Management Inc12,500$74.4K0.06%+300+2.5%Added
CWM, LLC12,813$76.0K0.00%+3,893+43.6%Added
Causeway Capital Management LLC13,310$79.2K0.00%−785−5.6%Reduced
Manufacturers Life Insurance Company, The13,427$79.9K0.00%−1,730−11.4%Reduced
Alliancebernstein L.P.13,800$82.1K0.00%00.0%Unchanged
Police & Firemen's Retirement System of New Jersey15,719$93.5K0.00%+7,397+88.9%Added
Headlands Technologies LLC15,976$95.1K0.01%−13,198−45.2%Reduced
CAPROCK Group, Inc.16,448$97.9K0.00%+4,680+39.8%Added
Axq Capital, LP16,592$98.7K0.02%+16,592New
Millennium Management LLC16,614$98.9K0.00%−89,019−84.3%Reduced
Engineers Gate Manager LP18,786$111.8K0.00%+18,786New
Intech Investment Management LLC18,900$112.5K0.00%00.0%Unchanged
One Wealth Advisors, LLC19,389$115.4K0.01%+19,389New
Heron Bay Capital Management20,056$119.3K0.02%+20,056New
Mirae Asset Global ETFs Holdings Ltd.20,159$119.9K0.00%−64−0.3%Reduced
JPMorgan Chase & Co21,108$125.6K0.00%+3,823+22.1%Added
Brandywine Global Investment Management, LLC21,800$129.7K0.00%+21,800New
C2C Wealth Management, LLC23,020$137.0K0.12%00.0%Unchanged
MetLife Investment Management24,412$145.3K0.00%+9,867+67.8%Added
Price T Rowe Associates Inc25,936$155.0K0.00%+4,311+19.9%Added
Kathmere Capital Management, LLC27,131$161.4K0.01%−822−2.9%Reduced
State Board of Administration of Florida Retirement System27,335$162.6K0.00%+27,335New
Stokes Family Office, LLC28,091$167.1K0.02%+28,091New
Prelude Capital Management, LLC32,148$191.3K0.01%−6,274−16.3%Reduced
EntryPoint Capital, LLC35,389$210.6K0.08%+35,389New
Baron Wealth Management LLC35,392$210.6K0.06%+13,625+62.6%Added
Jane Street Group, LLC36,362$216.4K0.00%−102,180−73.8%Reduced
Universal- Beteiligungs- und Servicegesellschaft mbH39,308$233.9K0.00%−159,200−80.2%Reduced
Vise Technologies, Inc.40,298$239.8K0.00%+40,298New
LPL Financial LLC40,442$240.6K0.00%−10,861−21.2%Reduced
Metis Global Partners, LLC42,586$253.4K0.01%−13,212−23.7%Reduced
Virtus ETF Advisers LLC47,172$280.7K0.13%00.0%Unchanged
Man Group plc47,324$281.6K0.00%+47,324New
Wells Fargo & Company48,281$287.3K0.00%+15,750+48.4%Added
D'Orazio & Associates, Inc.49,807$296.4K0.04%+17,874+56.0%Added
Bank of America Corp52,385$311.7K0.00%+7,418+16.5%Added
State of Wyoming53,155$316.3K0.03%+40,418+317.3%Added
Rhumbline Advisers53,895$320.7K0.00%−6,106−10.2%Reduced
Verdad Advisers, LP55,542$330.5K0.38%+55,542New
Cambridge Investment Research Advisors, Inc.59,317$353.0K0.00%+8,494+16.7%Added
Lazard Asset Management LLC59,575$354.5K0.00%−3,572−5.7%Reduced
Nomura Asset Management International Inc.61,255$364.0K0.00%+61,255New
Two Sigma Advisers, LP71,100$423.0K0.00%−2,100−2.9%Reduced