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Puma Biotechnology, Inc.

PBYI
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001401667

In the last 90 days, Puma Biotechnology, Inc. insiders filed 0 open-market purchases and 5 sales; 160 institutions reported holding it in 13F filings for Q2 2026, worth $313.6M in total; no superinvestor holds it.

13F holders, Q3 2025

Institutional positions in Puma Biotechnology, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
132
+11 vs. Q2 2025
Shares held
34.4M
+1.51M (+4.6%) vs. Q2 2025
Total value
$182.6M
+$69.8M (+61.9%) vs. Q2 2025
New holders
23
44 more added
Sold out
12
35 more reduced

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PBYI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 132 institutions
Q1 2021: 118 institutionsQ2 2021: 120 institutionsQ3 2021: 116 institutionsQ4 2021: 102 institutionsQ1 2022: 104 institutionsQ2 2022: 89 institutionsQ3 2022: 83 institutionsQ4 2022: 89 institutionsQ1 2023: 78 institutionsQ2 2023: 68 institutionsQ3 2023: 69 institutionsQ4 2023: 82 institutionsQ1 2024: 93 institutionsQ2 2024: 99 institutionsQ3 2024: 100 institutionsQ4 2024: 112 institutionsQ1 2025: 116 institutionsQ2 2025: 121 institutionsQ3 2025: 132 institutionsQ4 2025: 151 institutionsQ1 2026: 157 institutionsQ2 2026: 160 institutions
Value heldQ3 2025: $182.6M
Q1 2021: $355.9MQ2 2021: $319.3MQ3 2021: $226.0MQ4 2021: $93.1MQ1 2022: $86.1MQ2 2022: $79.5MQ3 2022: $65.5MQ4 2022: $116.3MQ1 2023: $86.3MQ2 2023: $93.8MQ3 2023: $67.6MQ4 2023: $117.0MQ1 2024: $164.4MQ2 2024: $101.0MQ3 2024: $76.0MQ4 2024: $90.1MQ1 2025: $90.1MQ2 2025: $112.8MQ3 2025: $182.6MQ4 2025: $210.2MQ1 2026: $241.8MQ2 2026: $313.6M
Institutions holding PBYI and their total value by quarter
QuarterHoldersValue
Q2 2026160$313.6M
Q1 2026157$241.8M
Q4 2025151$210.2M
Q3 2025132$182.6M
Q2 2025121$112.8M
Q1 2025116$90.1M
Q4 2024112$90.1M
Q3 2024100$76.0M
Q2 202499$101.0M
Q1 202493$164.4M
Q4 202382$117.0M
Q3 202369$67.6M
Q2 202368$93.8M
Q1 202378$86.3M
Q4 202289$116.3M
Q3 202283$65.5M
Q2 202289$79.5M
Q1 2022104$86.1M
Q4 2021102$93.1M
Q3 2021116$226.0M
Q2 2021120$319.3M
Q1 2021118$355.9M

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Puma Biotechnology, Inc.; share changes are against Q2 2025.

Institutions holding PBYI in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Prospera Financial Services Inc189,619$1.01M0.02%−1,625−0.8%Reduced
Federated Hermes, Inc.197,981$1.05M0.00%−4,354−2.2%Reduced
Universal- Beteiligungs- und Servicegesellschaft mbH198,508$1.05M0.00%+159,200+405.0%Added
Tang Capital Management LLC200,000$1.06M0.04%00.0%Unchanged
Prudential Financial Inc220,944$1.17M0.00%−60,300−21.4%Reduced
Goldman Sachs Group Inc234,617$1.25M0.00%+32,588+16.1%Added
Los Angeles Capital Management LLC274,050$1.46M0.00%−171,427−38.5%Reduced
SEI Investments Co347,234$1.84M0.00%00.0%Unchanged
Bank of New York Mellon Corp355,368$1.89M0.00%+11,285+3.3%Added
UBS Group AG376,091$2.00M0.00%+101,991+37.2%Added
Morgan Stanley378,082$2.01M0.00%+55,620+17.2%Added
Bridgeway Capital Management, LLC433,561$2.30M0.05%+230,771+113.8%Added
Globeflex Capital L P452,606$2.40M0.37%00.0%Unchanged
Arrowstreet Capital, Limited Partnership464,734$2.47M0.00%+13,101+2.9%Added
Ritholtz Wealth Management470,767$2.50M0.05%+273,782+139.0%Added
D. E. Shaw & Co., Inc.498,598$2.65M0.00%−142,182−22.2%Reduced
Northern Trust Corp526,736$2.80M0.00%+224,721+74.4%Added
Marshall Wace, LLP557,548$2.96M0.00%+484,133+659.4%Added
LSV Asset Management559,921$2.97M0.01%+24,181+4.5%Added
State Street Corp748,658$3.98M0.00%+14,052+1.9%Added
O'Shaughnessy Asset Management, LLC828,221$4.40M0.03%+390,561+89.2%Added
Kennedy Capital Management, Inc.867,630$4.61M0.10%−119,371−12.1%Reduced
Connor, Clark & Lunn Investment Management Ltd.943,472$5.01M0.02%+43,216+4.8%Added
Russell Investments Group, Ltd.964,693$5.12M0.01%+964,673+4,823,365.0%Added
Geode Capital Management, LLC983,522$5.22M0.00%+11,848+1.2%Added
Dimensional Fund Advisors LP1,271,878$6.75M0.00%+121,838+10.6%Added
American Century Companies Inc1,483,188$7.88M0.00%+140,913+10.5%Added
Acadian Asset Management LLC2,053,305$10.9M0.02%+45,159+2.2%Added
Renaissance Technologies LLC2,151,213$11.4M0.02%+276,500+14.7%Added
BlackRock, Inc.3,577,877$19.0M0.00%−257,838−6.7%Reduced
Vanguard Group Inc3,691,720$19.6M0.00%−14,732−0.4%Reduced
Acorn Capital Advisors, LLC4,131,299$21.9M11.14%00.0%Unchanged
Janus Henderson Group PLC0$00.00%−745,541−100.0%Sold out
Citadel Advisors LLC0$00.00%−507,818−100.0%Sold out
Eversept Partners, LP0$00.00%−240,688−100.0%Sold out
State Board of Administration of Florida Retirement System0$00.00%−71,727−100.0%Sold out
Kapitalo Investimentos Ltda0$00.00%−70,269−100.0%Sold out
Susquehanna International Group, LLP0$00.00%−57,724−100.0%Sold out
HSBC Holdings PLC0$00.00%−19,751−100.0%Sold out
Ieq Capital, LLC0$00.00%−14,305−100.0%Sold out
Voya Investment Management LLC0$00.00%−12,976−100.0%Sold out
Williams & Novak, LLC0$00.00%−12,520−100.0%Sold out
Fourth Dimension Wealth, LLC0$00.00%−500−100.0%Sold out
South State Corp.0$00.00%−111−100.0%Sold out