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Puma Biotechnology, Inc.

PBYI
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001401667

In the last 90 days, Puma Biotechnology, Inc. insiders filed 0 open-market purchases and 5 sales; 160 institutions reported holding it in 13F filings for Q2 2026, worth $313.6M in total; no superinvestor holds it.

13F holders, Q3 2025

Institutional positions in Puma Biotechnology, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
132
+11 vs. Q2 2025
Shares held
34.4M
+1.51M (+4.6%) vs. Q2 2025
Total value
$182.6M
+$69.8M (+61.9%) vs. Q2 2025
New holders
23
44 more added
Sold out
12
35 more reduced

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PBYI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 132 institutions
Q1 2021: 118 institutionsQ2 2021: 120 institutionsQ3 2021: 116 institutionsQ4 2021: 102 institutionsQ1 2022: 104 institutionsQ2 2022: 89 institutionsQ3 2022: 83 institutionsQ4 2022: 89 institutionsQ1 2023: 78 institutionsQ2 2023: 68 institutionsQ3 2023: 69 institutionsQ4 2023: 82 institutionsQ1 2024: 93 institutionsQ2 2024: 99 institutionsQ3 2024: 100 institutionsQ4 2024: 112 institutionsQ1 2025: 116 institutionsQ2 2025: 121 institutionsQ3 2025: 132 institutionsQ4 2025: 151 institutionsQ1 2026: 157 institutionsQ2 2026: 160 institutions
Value heldQ3 2025: $182.6M
Q1 2021: $355.9MQ2 2021: $319.3MQ3 2021: $226.0MQ4 2021: $93.1MQ1 2022: $86.1MQ2 2022: $79.5MQ3 2022: $65.5MQ4 2022: $116.3MQ1 2023: $86.3MQ2 2023: $93.8MQ3 2023: $67.6MQ4 2023: $117.0MQ1 2024: $164.4MQ2 2024: $101.0MQ3 2024: $76.0MQ4 2024: $90.1MQ1 2025: $90.1MQ2 2025: $112.8MQ3 2025: $182.6MQ4 2025: $210.2MQ1 2026: $241.8MQ2 2026: $313.6M
Institutions holding PBYI and their total value by quarter
QuarterHoldersValue
Q2 2026160$313.6M
Q1 2026157$241.8M
Q4 2025151$210.2M
Q3 2025132$182.6M
Q2 2025121$112.8M
Q1 2025116$90.1M
Q4 2024112$90.1M
Q3 2024100$76.0M
Q2 202499$101.0M
Q1 202493$164.4M
Q4 202382$117.0M
Q3 202369$67.6M
Q2 202368$93.8M
Q1 202378$86.3M
Q4 202289$116.3M
Q3 202283$65.5M
Q2 202289$79.5M
Q1 2022104$86.1M
Q4 2021102$93.1M
Q3 2021116$226.0M
Q2 2021120$319.3M
Q1 2021118$355.9M

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Puma Biotechnology, Inc.; share changes are against Q2 2025.

Institutions holding PBYI in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
ZRC Wealth Management, LLC3$160.00%00.0%Unchanged
Allworth Financial LP5$270.00%+4+400.0%Added
Sunbelt Securities, Inc.30$1590.00%+30New
IFP Advisors, Inc49$2600.00%+9+22.5%Added
SBI Securities Co., Ltd.56$2970.00%00.0%Unchanged
Jones Financial Companies LLLP68$3290.00%+68New
GAMMA Investing LLC78$4140.00%+78New
The PNC Financial Services Group, Inc.117$6210.00%+117New
True Wealth Design, LLC123$6540.00%−4−3.1%Reduced
Atlantic Union Bankshares Corp150$7970.00%+150New
EverSource Wealth Advisors, LLC167$8870.00%+6+3.7%Added
US Bancorp200$1.06K0.00%00.0%Unchanged
Luminist Capital LLC250$1.32K0.00%00.0%Unchanged
Rothschild Investment LLC250$1.33K0.00%+250New
Clearstead Advisors, LLC335$1.78K0.00%00.0%Unchanged
Nisa Investment Advisors, LLC342$1.82K0.00%00.0%Unchanged
Essential Partners LLC439$2.33K0.00%00.0%Unchanged
Optiver Holding B.V.768$4.08K0.00%+768New
CIBC Private Wealth Group, LLC775$4.12K0.00%00.0%Unchanged
Citigroup Inc859$4.56K0.00%−13,461−94.0%Reduced
GPS Wealth Strategies Group, LLC1,000$5.31K0.00%00.0%Unchanged
WealthCollab, LLC1,156$6.14K0.00%00.0%Unchanged
GHP Investment Advisors, Inc.1,170$6.21K0.00%00.0%Unchanged
SRS Capital Advisors, Inc.1,272$6.75K0.00%+1,272New
Rialto Wealth Management, LLC1,450$7.70K0.00%00.0%Unchanged
Global Retirement Partners, LLC1,492$7.92K0.00%00.0%Unchanged
Amalgamated Bank1,432$8.00K0.00%00.0%Unchanged
Royal Bank of Canada1,708$9.00K0.00%−151,562−98.9%Reduced
Sterling Capital Management LLC2,927$15.5K0.00%+1,782+155.6%Added
California State Teachers Retirement System3,001$15.9K0.00%+2+0.1%Added
Ball & Co Wealth Management Inc.3,066$16.0K0.01%−440−12.5%Reduced
Private Wealth Asset Management, LLC3,500$18.6K0.00%00.0%Unchanged
Legal & General Group Plc3,564$18.9K0.00%00.0%Unchanged
New York State Common Retirement Fund3,600$19.1K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)3,879$20.6K0.00%−4,590−54.2%Reduced
Ameritas Investment Partners, Inc.4,055$21.5K0.00%00.0%Unchanged
BNP Paribas Arbitrage, SA8,056$42.8K0.00%+2,290+39.7%Added
Police & Firemen's Retirement System of New Jersey8,322$44.2K0.00%00.0%Unchanged
CWM, LLC8,920$47.0K0.00%−542−5.7%Reduced
Cerity Partners LLC10,210$54.2K0.00%−318−3.0%Reduced
Ethic Inc.10,353$55.0K0.00%−4,815−31.7%Reduced
CAPROCK Group, Inc.11,768$59.3K0.00%+11,768New
Perkins Capital Management Inc12,200$64.8K0.06%+12,200New
State of Wyoming12,737$67.6K0.01%+12,737New
Alliancebernstein L.P.13,800$73.3K0.00%00.0%Unchanged
Causeway Capital Management LLC14,095$74.8K0.00%00.0%Unchanged
MetLife Investment Management14,545$77.2K0.00%−12,613−46.4%Reduced
PFG Investments, LLC15,000$79.7K0.00%−5,000−25.0%Reduced
Manufacturers Life Insurance Company, The15,157$80.5K0.00%−419−2.7%Reduced
Advisor Group Holdings, Inc.18,263$96.0K0.00%+319+1.8%Added
Royce & Associates LP18,725$99.4K0.00%+1,440+8.3%Added
Intech Investment Management LLC18,900$100.4K0.00%−1,923−9.2%Reduced
Mirae Asset Global ETFs Holdings Ltd.20,223$107.4K0.00%−3,542−14.9%Reduced
Squarepoint Ops LLC21,334$113.3K0.00%+3,540+19.9%Added
Price T Rowe Associates Inc21,625$115.0K0.00%+2,059+10.5%Added
Baron Wealth Management LLC21,767$115.6K0.04%+21,767New
C2C Wealth Management, LLC23,020$122.2K0.10%+2,400+11.6%Added
Sanctuary Advisors, LLC23,866$126.7K0.00%+23,866New
XTX Topco Ltd25,524$135.5K0.01%−78,900−75.6%Reduced
Kathmere Capital Management, LLC27,953$148.4K0.01%+7,749+38.4%Added
Headlands Technologies LLC29,174$154.9K0.01%+27,636+1,796.9%Added
Sherbrooke Park Advisers LLC30,527$162.1K0.08%+30,527New
Deutsche Bank AG30,743$163.2K0.00%00.0%Unchanged
D'Orazio & Associates, Inc.31,933$169.6K0.02%+16,906+112.5%Added
Wells Fargo & Company32,531$172.7K0.00%+4,505+16.1%Added
JPMorgan Chase & Co34,570$183.6K0.00%+14,325+70.8%Added
Prelude Capital Management, LLC38,422$204.0K0.02%+5,000+15.0%Added
Bank of America Corp44,967$238.8K0.00%−22,275−33.1%Reduced
Virtus ETF Advisers LLC47,172$250.5K0.14%−8,259−14.9%Reduced
Cambridge Investment Research Advisors, Inc.50,823$270.0K0.00%+50,823New
LPL Financial LLC51,303$272.4K0.00%−1,990−3.7%Reduced
Graham Capital Management, L.P.52,708$279.9K0.01%+52,708New
State of Wisconsin Investment Board54,318$288.4K0.00%+54,318New
Metis Global Partners, LLC55,798$296.3K0.01%00.0%Unchanged
Two Sigma Investments, LP56,126$298.0K0.00%−134,495−70.6%Reduced
Rhumbline Advisers60,001$318.6K0.00%−610−1.0%Reduced
Macquarie Group Ltd61,255$325.0K0.00%00.0%Unchanged
Winton Group Ltd61,324$325.6K0.01%+61,324New
Round Rock Advisors, LLC65,396$329.6K0.05%+65,396New
Lazard Asset Management LLC63,147$335.3K0.00%+63,147New
Invesco Ltd.63,817$338.9K0.00%+13,835+27.7%Added
Assenagon Asset Management S.A.72,979$387.5K0.00%+72,979New
Two Sigma Advisers, LP73,200$388.7K0.00%−172,500−70.2%Reduced
Hillsdale Investment Management Inc.77,800$413.1K0.01%−7,000−8.3%Reduced
Nuveen, LLC79,101$420.0K0.00%00.0%Unchanged
Barclays PLC79,881$424.2K0.00%−28,772−26.5%Reduced
Evergreen Capital Management LLC96,000$509.8K0.01%00.0%Unchanged
Millennium Management LLC105,633$560.9K0.00%−228,976−68.4%Reduced
Empowered Funds, LLC119,561$634.9K0.01%+81,269+212.2%Added
First Trust Advisors LP119,779$636.0K0.00%+119,779New
STRS Ohio124,900$663.2K0.00%−22,400−15.2%Reduced
Charles Schwab Investment Management Inc125,372$665.7K0.00%−2,071−1.6%Reduced
AQR Capital Management LLC130,672$693.9K0.00%−11,101−7.8%Reduced
Jane Street Group, LLC138,542$735.7K0.00%+99,094+251.2%Added
FMR LLC145,285$771.5K0.00%+12,921+9.8%Added
Wellington Management Group LLP149,552$794.1K0.00%+149,552New
Qube Research & Technologies Ltd155,516$825.8K0.00%+18,437+13.4%Added
Panagora Asset Management Inc165,921$881.0K0.00%+89,237+116.4%Added
Franklin Resources Inc173,698$922.3K0.00%+156,007+881.8%Added
Mackenzie Financial Corp175,210$930.4K0.00%−32,381−15.6%Reduced