Pyxis Oncology, Inc.
PYXS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001782223
In the last 90 days, Pyxis Oncology, Inc. insiders filed 0 open-market purchases and 1 sale; 76 institutions reported holding it in 13F filings for Q2 2026, worth $101.1M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Pyxis Oncology, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 78
- 0 vs. Q4 2025
- Shares held
- 27.6M
- −290.4K (−1.0%) vs. Q4 2025
- Total value
- $40.5M
- +$8.48M (+26.5%) vs. Q4 2025
- New holders
- 14
- 11 more added
- Sold out
- 14
- 36 more reduced
1 institution that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PYXS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 76 | $101.1M |
| Q1 2026 | 78 | $40.5M |
| Q4 2025 | 79 | $34.7M |
| Q3 2025 | 73 | $59.7M |
| Q2 2025 | 74 | $30.2M |
| Q1 2025 | 89 | $29.6M |
| Q4 2024 | 99 | $49.2M |
| Q3 2024 | 92 | $102.3M |
| Q2 2024 | 80 | $93.1M |
| Q1 2024 | 71 | $97.7M |
| Q4 2023 | 51 | $15.8M |
| Q3 2023 | 54 | $15.4M |
| Q2 2023 | 48 | $24.6M |
| Q1 2023 | 47 | $41.5M |
| Q4 2022 | 31 | $26.5M |
| Q3 2022 | 38 | $38.3M |
| Q2 2022 | 39 | $47.7M |
| Q1 2022 | 45 | $76.1M |
| Q4 2021 | 51 | $199.9M |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Pyxis Oncology, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Pfizer Inc | 7,032,770 | $9.21M | 3.86% | 00.0% | Unchanged |
| Laurion Capital Management LP | 4,997,333 | $7.30M | 0.68% | +200,854+4.2% | Added |
| GordonMD Global Investments LP | 4,121,870 | $6.02M | 4.96% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 2,033,510 | $2.97M | 0.00% | +2,033,510 | New |
| HealthInvest Partners AB | 197,036 | $1.62M | 0.52% | −420,209−68.1% | Reduced |
| Palo Alto Investors LP | 1,010,510 | $1.48M | 0.23% | −26,911−2.6% | Reduced |
| 683 Capital Management, LLC | 896,263 | $1.31M | 0.12% | +4,353+0.5% | Added |
| Renaissance Technologies LLC | 888,680 | $1.30M | 0.00% | +160,300+22.0% | Added |
| BlackRock, Inc. | 788,839 | $1.15M | 0.00% | +4,762+0.6% | Added |
| Geode Capital Management, LLC | 598,121 | $873.8K | 0.00% | +20,910+3.6% | Added |
| Longaeva Partners L.P. | 503,214 | $734.7K | 0.04% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 460,997 | $673.1K | 0.00% | +460,997 | New |
| Millennium Management LLC | 397,625 | $580.5K | 0.00% | −345,482−46.5% | Reduced |
| Marshall Wace, LLP | 354,417 | $517.4K | 0.00% | −35,347−9.1% | Reduced |
| Decheng Capital LLC | 326,810 | $477.1K | 0.07% | 00.0% | Unchanged |
| Jane Street Group, LLC | 304,459 | $444.5K | 0.00% | −481,551−61.3% | Reduced |
| Vanguard Fiduciary Trust Co | 300,897 | $439.3K | 0.00% | +300,897 | New |
| UBS Group AG | 254,124 | $371.0K | 0.00% | −138,642−35.3% | Reduced |
| State Street Corp | 248,837 | $363.3K | 0.00% | +7,200+3.0% | Added |
| XTX Topco Ltd | 200,096 | $292.1K | 0.01% | −88,937−30.8% | Reduced |
| Acadian Asset Management LLC | 144,256 | $209.0K | 0.00% | +144,256 | New |
| Bank of New York Mellon Corp | 133,996 | $195.6K | 0.00% | −31,048−18.8% | Reduced |
| NewEdge Wealth, LLC | 116,006 | $169.4K | 0.00% | 00.0% | Unchanged |
| Northern Trust Corp | 101,948 | $148.8K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 81,260 | $118.6K | 0.00% | +8,560+11.8% | Added |
| Two Sigma Investments, LP | 73,300 | $107.0K | 0.00% | −32,228−30.5% | Reduced |
| Morgan Stanley | 69,688 | $101.7K | 0.00% | −19,534−21.9% | Reduced |
| Panagora Asset Management Inc | 69,424 | $101.4K | 0.00% | +69,424 | New |
| Cable Car Capital LLC | 61,606 | $89.9K | 0.03% | 00.0% | Unchanged |
| Citadel Advisors LLC | 61,249 | $89.4K | 0.00% | −182,340−74.9% | Reduced |
| Stifel Financial Corp | 50,537 | $73.8K | 0.00% | +50,537 | New |
| Toronto Dominion Bank | 50,000 | $73.0K | 0.00% | −25,000−33.3% | Reduced |
| Barclays PLC | 49,825 | $72.7K | 0.00% | −10,560−17.5% | Reduced |
| University of Chicago | 48,731 | $71.1K | 0.02% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 46,920 | $68.5K | 0.00% | −39,225−45.5% | Reduced |
| J. Derek Lewis & Associates Inc. | 43,000 | $62.8K | 0.01% | −10,000−18.9% | Reduced |
| Susquehanna International Group, LLP | 41,201 | $60.2K | 0.00% | −67,213−62.0% | Reduced |
| Commonwealth Equity Services, LLC | 34,755 | $50.7K | 0.00% | −5,000−12.6% | Reduced |
| LPL Financial LLC | 33,554 | $49.0K | 0.00% | −1,548−4.4% | Reduced |
| Point72 Asset Management, L.P. | 32,006 | $46.7K | 0.00% | −156,130−83.0% | Reduced |
| Cetera Investment Advisers | 27,260 | $39.8K | 0.00% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 25,912 | $37.8K | 0.00% | −24,154−48.2% | Reduced |
| Graham Capital Management, L.P. | 22,748 | $33.2K | 0.00% | −161,194−87.6% | Reduced |
| Maia Wealth LLC | 21,277 | $31.1K | 0.01% | −682−3.1% | Reduced |
| Vanguard Global Advisers, LLC | 21,242 | $31.0K | 0.00% | +21,242 | New |
| Catalyst Funds Management Pty Ltd | 20,400 | $29.8K | 0.01% | +20,400 | New |
| Squarepoint Ops LLC | 17,537 | $25.6K | 0.00% | +17,537 | New |
| Bank of America Corp | 16,807 | $24.5K | 0.00% | −571,044−97.1% | Reduced |
| Advisor Group Holdings, Inc. | 13,721 | $20.0K | 0.00% | −3,503−20.3% | Reduced |
| Two Sigma Securities, LLC | 13,474 | $19.7K | 0.00% | +13,474 | New |
| FMR LLC | 11,912 | $17.4K | 0.00% | −946−7.4% | Reduced |
| Paces Ferry Wealth Advisors, LLC | 11,440 | $16.7K | 0.01% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 11,286 | $16.5K | 0.00% | −134,527−92.3% | Reduced |
| China Universal Asset Management Co., Ltd. | 11,049 | $16.1K | 0.00% | +903+8.9% | Added |
| Tower Research Capital LLC (TRC) | 10,332 | $15.1K | 0.00% | −478−4.4% | Reduced |
| GWM Advisors LLC | 10,250 | $15.0K | 0.00% | 00.0% | Unchanged |
| The PNC Financial Services Group, Inc. | 6,500 | $9.49K | 0.00% | +6,500 | New |
| Royal Bank of Canada | 5,839 | $9.00K | 0.00% | −49,712−89.5% | Reduced |
| Winthrop Capital Management, LLC | 6,000 | $9.00K | 0.00% | 00.0% | Unchanged |
| Hager Investment Management Services, LLC | 5,000 | $7.30K | 0.00% | +5,000 | New |
| JPMorgan Chase & Co | 5,173 | $6.57K | 0.00% | −341−6.2% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 3,248 | $4.74K | 0.00% | +222+7.3% | Added |
| Federated Hermes, Inc. | 3,181 | $4.64K | 0.00% | +1,287+68.0% | Added |
| Citigroup Inc | 1,740 | $2.54K | 0.00% | −1,162−40.0% | Reduced |
| BNP Paribas Arbitrage, SA | 1,654 | $2.42K | 0.00% | −22,625−93.2% | Reduced |
| GF Fund Management Co. Ltd. | 1,316 | $1.92K | 0.00% | +39+3.1% | Added |
| Nisa Investment Advisors, LLC | 961 | $1.40K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 943 | $1.38K | 0.00% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 743 | $1.08K | 0.00% | −7,484−91.0% | Reduced |
| Jones Financial Companies LLLP | 500 | $655 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 285 | $416 | 0.00% | −2,000−87.5% | Reduced |
| Simplex Trading, LLC | 253 | $369 | 0.00% | −9,537−97.4% | Reduced |
| Cornerstone Financial Management LLC | 172 | $251 | 0.00% | 00.0% | Unchanged |
| CWM, LLC | 34 | $50 | 0.00% | −36−51.4% | Reduced |
| SRS Capital Advisors, Inc. | 1 | $20 | 0.00% | −13−92.9% | Reduced |
| Golden State Equity Partners | 10 | $14 | 0.00% | +10 | New |
| Caitong International Asset Management Co., Ltd | 4 | $6 | 0.00% | +4 | New |
| SBI Securities Co., Ltd. | 1 | $1 | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −317,769−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −100,536−100.0% | Sold out |
| Omers Administration Corp | 0 | $0 | 0.00% | −67,000−100.0% | Sold out |
| Velan Capital Investment Management LP | 0 | $0 | 0.00% | −40,000−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −39,649−100.0% | Sold out |
| American Century Companies Inc | 0 | $0 | 0.00% | −31,936−100.0% | Sold out |
| Lighthouse Investment Partners, LLC | 0 | $0 | 0.00% | −28,860−100.0% | Sold out |
| Avanza Fonder AB | 0 | $0 | 0.00% | −27,345−100.0% | Sold out |
| Engineers Gate Manager LP | 0 | $0 | 0.00% | −22,816−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −22,624−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −22,566−100.0% | Sold out |
| Jefferies Financial Group Inc. | 0 | $0 | 0.00% | −16,000−100.0% | Sold out |
| US Bancorp | 0 | $0 | 0.00% | −94−100.0% | Sold out |
| Northwestern Mutual Wealth Management Co | 0 | $0 | 0.00% | −12−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |