Pyxis Oncology, Inc.
PYXS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001782223
In the last 90 days, Pyxis Oncology, Inc. insiders filed 0 open-market purchases and 1 sale; 76 institutions reported holding it in 13F filings for Q2 2026, worth $101.1M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Pyxis Oncology, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 73
- −1 vs. Q2 2025
- Shares held
- 26.8M
- −628.2K (−2.3%) vs. Q2 2025
- Total value
- $59.7M
- +$29.5M (+97.8%) vs. Q2 2025
- New holders
- 14
- 11 more added
- Sold out
- 15
- 31 more reduced
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PYXS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 76 | $101.1M |
| Q1 2026 | 78 | $40.5M |
| Q4 2025 | 79 | $34.7M |
| Q3 2025 | 73 | $59.7M |
| Q2 2025 | 74 | $30.2M |
| Q1 2025 | 89 | $29.6M |
| Q4 2024 | 99 | $49.2M |
| Q3 2024 | 92 | $102.3M |
| Q2 2024 | 80 | $93.1M |
| Q1 2024 | 71 | $97.7M |
| Q4 2023 | 51 | $15.8M |
| Q3 2023 | 54 | $15.4M |
| Q2 2023 | 48 | $24.6M |
| Q1 2023 | 47 | $41.5M |
| Q4 2022 | 31 | $26.5M |
| Q3 2022 | 38 | $38.3M |
| Q2 2022 | 39 | $47.7M |
| Q1 2022 | 45 | $76.1M |
| Q4 2021 | 51 | $199.9M |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Pyxis Oncology, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Pfizer Inc | 7,032,770 | $15.6M | 3.57% | 00.0% | Unchanged |
| Laurion Capital Management LP | 3,625,974 | $8.05M | 1.10% | 00.0% | Unchanged |
| Tang Capital Management LLC | 2,500,000 | $5.55M | 0.21% | 00.0% | Unchanged |
| Vanguard Group Inc | 2,163,962 | $4.80M | 0.00% | +14,566+0.7% | Added |
| Perceptive Advisors LLC | 1,178,307 | $2.62M | 0.08% | +1,178,307 | New |
| Palo Alto Investors LP | 1,037,421 | $2.30M | 0.43% | 00.0% | Unchanged |
| Millennium Management LLC | 815,331 | $1.81M | 0.00% | −2,724,529−77.0% | Reduced |
| StemPoint Capital LP | 689,538 | $1.53M | 0.31% | +689,538 | New |
| BlackRock, Inc. | 683,702 | $1.52M | 0.00% | −243,103−26.2% | Reduced |
| Bank of America Corp | 615,922 | $1.37M | 0.00% | +593,853+2,690.9% | Added |
| Renaissance Technologies LLC | 576,336 | $1.28M | 0.00% | +158,514+37.9% | Added |
| Geode Capital Management, LLC | 544,508 | $1.21M | 0.00% | +33,545+6.6% | Added |
| 683 Capital Management, LLC | 525,000 | $1.17M | 0.11% | −20,000−3.7% | Reduced |
| Longaeva Partners L.P. | 503,214 | $1.12M | 0.24% | +503,214 | New |
| Driehaus Capital Management LLC | 418,632 | $929.4K | 0.01% | +418,632 | New |
| UBS Group AG | 373,727 | $829.7K | 0.00% | −22,369−5.6% | Reduced |
| Citadel Advisors LLC | 337,359 | $748.9K | 0.00% | +337,359 | New |
| Decheng Capital LLC | 326,810 | $725.5K | 0.13% | 00.0% | Unchanged |
| Jane Street Group, LLC | 303,700 | $674.2K | 0.00% | −32,384−9.6% | Reduced |
| Schulhoff & Co Inc | 275,000 | $610.5K | 0.26% | 00.0% | Unchanged |
| NewEdge Wealth, LLC | 116,006 | $453.6K | 0.01% | 00.0% | Unchanged |
| State Street Corp | 202,055 | $448.6K | 0.00% | +16,000+8.6% | Added |
| Bank of New York Mellon Corp | 165,044 | $366.4K | 0.00% | 00.0% | Unchanged |
| Pier 88 Investment Partners LLC | 151,730 | $336.8K | 0.06% | −215,440−58.7% | Reduced |
| Diadema Partners LP | 150,000 | $333.0K | 0.23% | +150,000 | New |
| Susquehanna International Group, LLP | 137,531 | $305.3K | 0.00% | +23,172+20.3% | Added |
| Goldman Sachs Group Inc | 125,454 | $278.5K | 0.00% | −98,820−44.1% | Reduced |
| Walleye Capital LLC | 119,561 | $265.4K | 0.00% | +119,561 | New |
| Morgan Stanley | 106,607 | $236.7K | 0.00% | −53,567−33.4% | Reduced |
| Northern Trust Corp | 100,773 | $223.7K | 0.00% | −1,443−1.4% | Reduced |
| Royal Bank of Canada | 77,980 | $173.0K | 0.00% | −8,385−9.7% | Reduced |
| Bridgeway Capital Management, LLC | 76,700 | $170.3K | 0.00% | −65,595−46.1% | Reduced |
| Cable Car Capital LLC | 61,606 | $136.8K | 0.06% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 61,155 | $136.0K | 0.00% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 60,333 | $133.9K | 0.00% | +60,333 | New |
| Velan Capital Investment Management LP | 55,000 | $122.1K | 0.11% | +15,000+37.5% | Added |
| Two Sigma Advisers, LP | 52,524 | $116.6K | 0.00% | +52,524 | New |
| University of Chicago | 48,731 | $108.2K | 0.05% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 46,501 | $103.2K | 0.00% | +46,501 | New |
| Acadian Asset Management LLC | 43,082 | $94.0K | 0.00% | +24,140+127.4% | Added |
| Dimensional Fund Advisors LP | 36,516 | $81.1K | 0.00% | 00.0% | Unchanged |
| Persistent Asset Partners Ltd | 34,632 | $76.9K | 0.06% | +34,632 | New |
| Cubist Systematic Strategies, LLC | 33,061 | $73.4K | 0.00% | +33,061 | New |
| Qube Research & Technologies Ltd | 30,808 | $68.4K | 0.00% | −72,255−70.1% | Reduced |
| Cetera Investment Advisers | 27,760 | $61.6K | 0.00% | −1,000−3.5% | Reduced |
| Point72 Asia (Singapore) Pte. Ltd. | 18,057 | $40.1K | 0.01% | −1,171−6.1% | Reduced |
| XTX Topco Ltd | 17,699 | $39.3K | 0.00% | −18,681−51.3% | Reduced |
| Prudential Financial Inc | 16,300 | $36.2K | 0.00% | +16,300 | New |
| FMR LLC | 15,455 | $34.3K | 0.00% | −79,391−83.7% | Reduced |
| HRT Financial LP | 15,398 | $34.0K | 0.00% | −35,270−69.6% | Reduced |
| LPL Financial LLC | 14,002 | $31.1K | 0.00% | −197−1.4% | Reduced |
| AQR Capital Management LLC | 13,832 | $30.7K | 0.00% | −72,931−84.1% | Reduced |
| Tower Research Capital LLC (TRC) | 12,982 | $28.8K | 0.00% | −1,675−11.4% | Reduced |
| China Universal Asset Management Co., Ltd. | 10,871 | $24.1K | 0.00% | −1,571−12.6% | Reduced |
| Advisor Group Holdings, Inc. | 15,221 | $19.5K | 0.00% | −2,500−14.1% | Reduced |
| Simplex Trading, LLC | 7,433 | $16.0K | 0.00% | −5,182−41.1% | Reduced |
| Winthrop Capital Management, LLC | 6,000 | $13.0K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 4,513 | $10.0K | 0.00% | +2,445+118.2% | Added |
| Barclays PLC | 2,961 | $6.57K | 0.00% | −1,893−39.0% | Reduced |
| Mirae Asset Global Investments Co., Ltd. | 2,398 | $5.32K | 0.00% | +5+0.2% | Added |
| BNP Paribas Arbitrage, SA | 1,717 | $3.81K | 0.00% | −116−6.3% | Reduced |
| GF Fund Management Co. Ltd. | 1,334 | $2.96K | 0.00% | −95−6.6% | Reduced |
| Citigroup Inc | 1,281 | $2.84K | 0.00% | −7,646−85.7% | Reduced |
| Nisa Investment Advisors, LLC | 961 | $2.13K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 943 | $2.09K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 500 | $1.07K | 0.00% | −1,000−66.7% | Reduced |
| CWM, LLC | 414 | $1.00K | 0.00% | −6,122−93.7% | Reduced |
| EverSource Wealth Advisors, LLC | 434 | $964 | 0.00% | −157−26.6% | Reduced |
| Wells Fargo & Company | 285 | $633 | 0.00% | −414−59.2% | Reduced |
| GWM Advisors LLC | 250 | $555 | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 14 | $31 | 0.00% | +14 | New |
| Northwestern Mutual Wealth Management Co | 12 | $27 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 2 | $4 | 0.00% | +1+100.0% | Added |
| Standard Life Aberdeen plc | 0 | $0 | 0.00% | −913,045−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −147,771−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −133,047−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −48,649−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −35,428−100.0% | Sold out |
| Catalyst Funds Management Pty Ltd | 0 | $0 | 0.00% | −23,200−100.0% | Sold out |
| Hudson Bay Capital Management LP | 0 | $0 | 0.00% | −13,790−100.0% | Sold out |
| DRW Securities, LLC | 0 | $0 | 0.00% | −13,042−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −12,334−100.0% | Sold out |
| Mercer Global Advisors Inc | 0 | $0 | 0.00% | −10,004−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −3,231−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −602−100.0% | Sold out |
| True Wealth Design, LLC | 0 | $0 | 0.00% | −276−100.0% | Sold out |
| Russell Investments Group, Ltd. | 0 | $0 | 0.00% | −64−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −1−100.0% | Sold out |