Pyxis Oncology, Inc.
PYXS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001782223
In the last 90 days, Pyxis Oncology, Inc. insiders filed 0 open-market purchases and 1 sale; 76 institutions reported holding it in 13F filings for Q2 2026, worth $101.1M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Pyxis Oncology, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 79
- +8 vs. Q3 2025
- Shares held
- 30.2M
- +3.42M (+12.8%) vs. Q3 2025
- Total value
- $34.7M
- −$24.9M (−41.8%) vs. Q3 2025
- New holders
- 22
- 25 more added
- Sold out
- 14
- 18 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PYXS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 76 | $101.1M |
| Q1 2026 | 78 | $40.5M |
| Q4 2025 | 79 | $34.7M |
| Q3 2025 | 73 | $59.7M |
| Q2 2025 | 74 | $30.2M |
| Q1 2025 | 89 | $29.6M |
| Q4 2024 | 99 | $49.2M |
| Q3 2024 | 92 | $102.3M |
| Q2 2024 | 80 | $93.1M |
| Q1 2024 | 71 | $97.7M |
| Q4 2023 | 51 | $15.8M |
| Q3 2023 | 54 | $15.4M |
| Q2 2023 | 48 | $24.6M |
| Q1 2023 | 47 | $41.5M |
| Q4 2022 | 31 | $26.5M |
| Q3 2022 | 38 | $38.3M |
| Q2 2022 | 39 | $47.7M |
| Q1 2022 | 45 | $76.1M |
| Q4 2021 | 51 | $199.9M |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Pyxis Oncology, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Pfizer Inc | 7,032,770 | $8.09M | 3.42% | 00.0% | Unchanged |
| Laurion Capital Management LP | 4,796,479 | $5.52M | 0.38% | +1,170,505+32.3% | Added |
| GordonMD Global Investments LP | 4,121,870 | $4.74M | 3.40% | +4,121,870 | New |
| Vanguard Group Inc | 2,335,768 | $2.69M | 0.00% | +171,806+7.9% | Added |
| Palo Alto Investors LP | 1,037,421 | $1.19M | 0.17% | 00.0% | Unchanged |
| 683 Capital Management, LLC | 891,910 | $1.03M | 0.09% | +366,910+69.9% | Added |
| Jane Street Group, LLC | 786,010 | $903.9K | 0.00% | +482,310+158.8% | Added |
| BlackRock, Inc. | 784,077 | $901.7K | 0.00% | +100,375+14.7% | Added |
| Millennium Management LLC | 743,107 | $854.6K | 0.00% | −72,224−8.9% | Reduced |
| Renaissance Technologies LLC | 728,380 | $837.6K | 0.00% | +152,044+26.4% | Added |
| HealthInvest Partners AB | 617,245 | $709.8K | 0.23% | +617,245 | New |
| Bank of America Corp | 587,851 | $676.0K | 0.00% | −28,071−4.6% | Reduced |
| Geode Capital Management, LLC | 577,211 | $664.2K | 0.00% | +32,703+6.0% | Added |
| Longaeva Partners L.P. | 503,214 | $578.7K | 0.07% | 00.0% | Unchanged |
| UBS Group AG | 392,766 | $451.7K | 0.00% | +19,039+5.1% | Added |
| Marshall Wace, LLP | 389,764 | $448.2K | 0.00% | +389,764 | New |
| Decheng Capital LLC | 326,810 | $375.8K | 0.05% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 317,769 | $365.4K | 0.00% | +317,769 | New |
| XTX Topco Ltd | 289,033 | $332.4K | 0.01% | +271,334+1,533.0% | Added |
| Citadel Advisors LLC | 243,589 | $280.1K | 0.00% | −93,770−27.8% | Reduced |
| State Street Corp | 241,637 | $277.9K | 0.00% | +39,582+19.6% | Added |
| Point72 Asset Management, L.P. | 188,136 | $216.4K | 0.00% | +188,136 | New |
| Graham Capital Management, L.P. | 183,942 | $211.5K | 0.01% | +183,942 | New |
| Bank of New York Mellon Corp | 165,044 | $189.8K | 0.00% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 145,813 | $167.7K | 0.00% | +115,005+373.3% | Added |
| NewEdge Wealth, LLC | 116,006 | $133.4K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 108,414 | $124.7K | 0.00% | −29,117−21.2% | Reduced |
| Two Sigma Investments, LP | 105,528 | $121.4K | 0.00% | +59,027+126.9% | Added |
| Northern Trust Corp | 101,948 | $117.2K | 0.00% | +1,175+1.2% | Added |
| Quadrature Capital Ltd | 100,536 | $115.6K | 0.00% | +100,536 | New |
| Morgan Stanley | 89,222 | $102.6K | 0.00% | −17,385−16.3% | Reduced |
| Goldman Sachs Group Inc | 86,145 | $99.1K | 0.00% | −39,309−31.3% | Reduced |
| Toronto Dominion Bank | 75,000 | $86.3K | 0.00% | +75,000 | New |
| Bridgeway Capital Management, LLC | 72,700 | $83.6K | 0.00% | −4,000−5.2% | Reduced |
| Omers Administration Corp | 67,000 | $77.0K | 0.00% | +67,000 | New |
| Cable Car Capital LLC | 61,606 | $70.8K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 60,385 | $69.4K | 0.00% | +57,424+1,939.3% | Added |
| Royal Bank of Canada | 55,551 | $64.0K | 0.00% | −22,429−28.8% | Reduced |
| J. Derek Lewis & Associates Inc. | 53,000 | $61.0K | 0.01% | +53,000 | New |
| Dimensional Fund Advisors LP | 50,066 | $57.6K | 0.00% | +13,550+37.1% | Added |
| University of Chicago | 48,731 | $56.0K | 0.03% | 00.0% | Unchanged |
| Velan Capital Investment Management LP | 40,000 | $46.0K | 0.03% | −15,000−27.3% | Reduced |
| Commonwealth Equity Services, LLC | 39,755 | $45.7K | 0.00% | −21,400−35.0% | Reduced |
| HRT Financial LP | 39,649 | $45.0K | 0.00% | +24,251+157.5% | Added |
| LPL Financial LLC | 35,102 | $40.4K | 0.00% | +21,100+150.7% | Added |
| American Century Companies Inc | 31,936 | $36.7K | 0.00% | +31,936 | New |
| Lighthouse Investment Partners, LLC | 28,860 | $33.2K | 0.00% | +28,860 | New |
| Avanza Fonder AB | 27,345 | $31.4K | 0.00% | +27,345 | New |
| Cetera Investment Advisers | 27,260 | $31.3K | 0.00% | −500−1.8% | Reduced |
| Maia Wealth LLC | 21,959 | $29.6K | 0.01% | +21,959 | New |
| BNP Paribas Arbitrage, SA | 24,279 | $27.9K | 0.00% | +22,562+1,314.0% | Added |
| Engineers Gate Manager LP | 22,816 | $26.2K | 0.00% | +22,816 | New |
| Two Sigma Advisers, LP | 22,624 | $26.0K | 0.00% | −29,900−56.9% | Reduced |
| Fox Run Management, L.L.C. | 22,566 | $26.0K | 0.00% | +22,566 | New |
| Advisor Group Holdings, Inc. | 17,224 | $19.8K | 0.00% | +2,003+13.2% | Added |
| Jefferies Financial Group Inc. | 16,000 | $18.4K | 0.00% | +16,000 | New |
| FMR LLC | 12,858 | $14.8K | 0.00% | −2,597−16.8% | Reduced |
| Paces Ferry Wealth Advisors, LLC | 11,440 | $13.2K | 0.01% | +11,440 | New |
| Tower Research Capital LLC (TRC) | 10,810 | $12.4K | 0.00% | −2,172−16.7% | Reduced |
| GWM Advisors LLC | 10,250 | $11.8K | 0.00% | +10,000+4,000.0% | Added |
| China Universal Asset Management Co., Ltd. | 10,146 | $11.7K | 0.00% | −725−6.7% | Reduced |
| Simplex Trading, LLC | 9,790 | $11.3K | 0.00% | +2,357+31.7% | Added |
| Balyasny Asset Management LLC | 8,227 | $9.46K | 0.00% | +8,227 | New |
| Winthrop Capital Management, LLC | 6,000 | $7.00K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 5,514 | $6.34K | 0.00% | +1,001+22.2% | Added |
| Mirae Asset Global Investments Co., Ltd. | 3,026 | $3.48K | 0.00% | +628+26.2% | Added |
| Citigroup Inc | 2,902 | $3.34K | 0.00% | +1,621+126.5% | Added |
| Wells Fargo & Company | 2,285 | $2.63K | 0.00% | +2,000+701.8% | Added |
| Federated Hermes, Inc. | 1,894 | $2.18K | 0.00% | +1,894 | New |
| GF Fund Management Co. Ltd. | 1,277 | $1.47K | 0.00% | −57−4.3% | Reduced |
| Nisa Investment Advisors, LLC | 961 | $1.10K | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 943 | $1.08K | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 500 | $575 | 0.00% | 00.0% | Unchanged |
| Cornerstone Financial Management LLC | 172 | $198 | 0.00% | +172 | New |
| US Bancorp | 94 | $108 | 0.00% | +94 | New |
| SRS Capital Advisors, Inc. | 14 | $16 | 0.00% | 00.0% | Unchanged |
| Northwestern Mutual Wealth Management Co | 12 | $14 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 1 | $1 | 0.00% | −1−50.0% | Reduced |
| CWM, LLC | 70 | $0 | 0.00% | −344−83.1% | Reduced |
| Tang Capital Management LLC | 0 | $0 | 0.00% | −2,500,000−100.0% | Sold out |
| Perceptive Advisors LLC | 0 | $0 | 0.00% | −1,178,307−100.0% | Sold out |
| StemPoint Capital LP | 0 | $0 | 0.00% | −689,538−100.0% | Sold out |
| Driehaus Capital Management LLC | 0 | $0 | 0.00% | −418,632−100.0% | Sold out |
| Schulhoff & Co Inc | 0 | $0 | 0.00% | −275,000−100.0% | Sold out |
| Pier 88 Investment Partners LLC | 0 | $0 | 0.00% | −151,730−100.0% | Sold out |
| Diadema Partners LP | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −119,561−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −60,333−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −43,082−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −34,632−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −16,300−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −13,832−100.0% | Sold out |
| EverSource Wealth Advisors, LLC | 0 | $0 | 0.00% | −434−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | – | – | – | – | Not filed |
| Point72 Asia (Singapore) Pte. Ltd. | – | – | – | – | Not filed |