Pyxis Oncology, Inc.
PYXS- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001782223
In the last 90 days, Pyxis Oncology, Inc. insiders filed 0 open-market purchases and 1 sale; 76 institutions reported holding it in 13F filings for Q2 2026, worth $101.1M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Pyxis Oncology, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 79
- +8 vs. Q3 2025
- Shares held
- 30.2M
- +3.42M (+12.8%) vs. Q3 2025
- Total value
- $34.7M
- −$24.9M (−41.8%) vs. Q3 2025
- New holders
- 22
- 25 more added
- Sold out
- 14
- 18 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PYXS on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 76 | $101.1M |
| Q1 2026 | 78 | $40.5M |
| Q4 2025 | 79 | $34.7M |
| Q3 2025 | 73 | $59.7M |
| Q2 2025 | 74 | $30.2M |
| Q1 2025 | 89 | $29.6M |
| Q4 2024 | 99 | $49.2M |
| Q3 2024 | 92 | $102.3M |
| Q2 2024 | 80 | $93.1M |
| Q1 2024 | 71 | $97.7M |
| Q4 2023 | 51 | $15.8M |
| Q3 2023 | 54 | $15.4M |
| Q2 2023 | 48 | $24.6M |
| Q1 2023 | 47 | $41.5M |
| Q4 2022 | 31 | $26.5M |
| Q3 2022 | 38 | $38.3M |
| Q2 2022 | 39 | $47.7M |
| Q1 2022 | 45 | $76.1M |
| Q4 2021 | 51 | $199.9M |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Pyxis Oncology, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| CWM, LLC | 70 | $0 | 0.00% | −344−83.1% | Reduced |
| SBI Securities Co., Ltd. | 1 | $1 | 0.00% | −1−50.0% | Reduced |
| Northwestern Mutual Wealth Management Co | 12 | $14 | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 14 | $16 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 94 | $108 | 0.00% | +94 | New |
| Cornerstone Financial Management LLC | 172 | $198 | 0.00% | +172 | New |
| Jones Financial Companies LLLP | 500 | $575 | 0.00% | 00.0% | Unchanged |
| UMA Financial Services, Inc. | 943 | $1.08K | 0.00% | 00.0% | Unchanged |
| Nisa Investment Advisors, LLC | 961 | $1.10K | 0.00% | 00.0% | Unchanged |
| GF Fund Management Co. Ltd. | 1,277 | $1.47K | 0.00% | −57−4.3% | Reduced |
| Federated Hermes, Inc. | 1,894 | $2.18K | 0.00% | +1,894 | New |
| Wells Fargo & Company | 2,285 | $2.63K | 0.00% | +2,000+701.8% | Added |
| Citigroup Inc | 2,902 | $3.34K | 0.00% | +1,621+126.5% | Added |
| Mirae Asset Global Investments Co., Ltd. | 3,026 | $3.48K | 0.00% | +628+26.2% | Added |
| JPMorgan Chase & Co | 5,514 | $6.34K | 0.00% | +1,001+22.2% | Added |
| Winthrop Capital Management, LLC | 6,000 | $7.00K | 0.00% | 00.0% | Unchanged |
| Balyasny Asset Management LLC | 8,227 | $9.46K | 0.00% | +8,227 | New |
| Simplex Trading, LLC | 9,790 | $11.3K | 0.00% | +2,357+31.7% | Added |
| China Universal Asset Management Co., Ltd. | 10,146 | $11.7K | 0.00% | −725−6.7% | Reduced |
| GWM Advisors LLC | 10,250 | $11.8K | 0.00% | +10,000+4,000.0% | Added |
| Tower Research Capital LLC (TRC) | 10,810 | $12.4K | 0.00% | −2,172−16.7% | Reduced |
| Paces Ferry Wealth Advisors, LLC | 11,440 | $13.2K | 0.01% | +11,440 | New |
| FMR LLC | 12,858 | $14.8K | 0.00% | −2,597−16.8% | Reduced |
| Jefferies Financial Group Inc. | 16,000 | $18.4K | 0.00% | +16,000 | New |
| Advisor Group Holdings, Inc. | 17,224 | $19.8K | 0.00% | +2,003+13.2% | Added |
| Fox Run Management, L.L.C. | 22,566 | $26.0K | 0.00% | +22,566 | New |
| Two Sigma Advisers, LP | 22,624 | $26.0K | 0.00% | −29,900−56.9% | Reduced |
| Engineers Gate Manager LP | 22,816 | $26.2K | 0.00% | +22,816 | New |
| BNP Paribas Arbitrage, SA | 24,279 | $27.9K | 0.00% | +22,562+1,314.0% | Added |
| Maia Wealth LLC | 21,959 | $29.6K | 0.01% | +21,959 | New |
| Cetera Investment Advisers | 27,260 | $31.3K | 0.00% | −500−1.8% | Reduced |
| Avanza Fonder AB | 27,345 | $31.4K | 0.00% | +27,345 | New |
| Lighthouse Investment Partners, LLC | 28,860 | $33.2K | 0.00% | +28,860 | New |
| American Century Companies Inc | 31,936 | $36.7K | 0.00% | +31,936 | New |
| LPL Financial LLC | 35,102 | $40.4K | 0.00% | +21,100+150.7% | Added |
| HRT Financial LP | 39,649 | $45.0K | 0.00% | +24,251+157.5% | Added |
| Commonwealth Equity Services, LLC | 39,755 | $45.7K | 0.00% | −21,400−35.0% | Reduced |
| Velan Capital Investment Management LP | 40,000 | $46.0K | 0.03% | −15,000−27.3% | Reduced |
| University of Chicago | 48,731 | $56.0K | 0.03% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 50,066 | $57.6K | 0.00% | +13,550+37.1% | Added |
| J. Derek Lewis & Associates Inc. | 53,000 | $61.0K | 0.01% | +53,000 | New |
| Royal Bank of Canada | 55,551 | $64.0K | 0.00% | −22,429−28.8% | Reduced |
| Barclays PLC | 60,385 | $69.4K | 0.00% | +57,424+1,939.3% | Added |
| Cable Car Capital LLC | 61,606 | $70.8K | 0.00% | 00.0% | Unchanged |
| Omers Administration Corp | 67,000 | $77.0K | 0.00% | +67,000 | New |
| Bridgeway Capital Management, LLC | 72,700 | $83.6K | 0.00% | −4,000−5.2% | Reduced |
| Toronto Dominion Bank | 75,000 | $86.3K | 0.00% | +75,000 | New |
| Goldman Sachs Group Inc | 86,145 | $99.1K | 0.00% | −39,309−31.3% | Reduced |
| Morgan Stanley | 89,222 | $102.6K | 0.00% | −17,385−16.3% | Reduced |
| Quadrature Capital Ltd | 100,536 | $115.6K | 0.00% | +100,536 | New |
| Northern Trust Corp | 101,948 | $117.2K | 0.00% | +1,175+1.2% | Added |
| Two Sigma Investments, LP | 105,528 | $121.4K | 0.00% | +59,027+126.9% | Added |
| Susquehanna International Group, LLP | 108,414 | $124.7K | 0.00% | −29,117−21.2% | Reduced |
| NewEdge Wealth, LLC | 116,006 | $133.4K | 0.00% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 145,813 | $167.7K | 0.00% | +115,005+373.3% | Added |
| Bank of New York Mellon Corp | 165,044 | $189.8K | 0.00% | 00.0% | Unchanged |
| Graham Capital Management, L.P. | 183,942 | $211.5K | 0.01% | +183,942 | New |
| Point72 Asset Management, L.P. | 188,136 | $216.4K | 0.00% | +188,136 | New |
| State Street Corp | 241,637 | $277.9K | 0.00% | +39,582+19.6% | Added |
| Citadel Advisors LLC | 243,589 | $280.1K | 0.00% | −93,770−27.8% | Reduced |
| XTX Topco Ltd | 289,033 | $332.4K | 0.01% | +271,334+1,533.0% | Added |
| ExodusPoint Capital Management, LP | 317,769 | $365.4K | 0.00% | +317,769 | New |
| Decheng Capital LLC | 326,810 | $375.8K | 0.05% | 00.0% | Unchanged |
| Marshall Wace, LLP | 389,764 | $448.2K | 0.00% | +389,764 | New |
| UBS Group AG | 392,766 | $451.7K | 0.00% | +19,039+5.1% | Added |
| Longaeva Partners L.P. | 503,214 | $578.7K | 0.07% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 577,211 | $664.2K | 0.00% | +32,703+6.0% | Added |
| Bank of America Corp | 587,851 | $676.0K | 0.00% | −28,071−4.6% | Reduced |
| HealthInvest Partners AB | 617,245 | $709.8K | 0.23% | +617,245 | New |
| Renaissance Technologies LLC | 728,380 | $837.6K | 0.00% | +152,044+26.4% | Added |
| Millennium Management LLC | 743,107 | $854.6K | 0.00% | −72,224−8.9% | Reduced |
| BlackRock, Inc. | 784,077 | $901.7K | 0.00% | +100,375+14.7% | Added |
| Jane Street Group, LLC | 786,010 | $903.9K | 0.00% | +482,310+158.8% | Added |
| 683 Capital Management, LLC | 891,910 | $1.03M | 0.09% | +366,910+69.9% | Added |
| Palo Alto Investors LP | 1,037,421 | $1.19M | 0.17% | 00.0% | Unchanged |
| Vanguard Group Inc | 2,335,768 | $2.69M | 0.00% | +171,806+7.9% | Added |
| GordonMD Global Investments LP | 4,121,870 | $4.74M | 3.40% | +4,121,870 | New |
| Laurion Capital Management LP | 4,796,479 | $5.52M | 0.38% | +1,170,505+32.3% | Added |
| Pfizer Inc | 7,032,770 | $8.09M | 3.42% | 00.0% | Unchanged |
| Tang Capital Management LLC | 0 | $0 | 0.00% | −2,500,000−100.0% | Sold out |
| Perceptive Advisors LLC | 0 | $0 | 0.00% | −1,178,307−100.0% | Sold out |
| StemPoint Capital LP | 0 | $0 | 0.00% | −689,538−100.0% | Sold out |
| Driehaus Capital Management LLC | 0 | $0 | 0.00% | −418,632−100.0% | Sold out |
| Schulhoff & Co Inc | 0 | $0 | 0.00% | −275,000−100.0% | Sold out |
| Pier 88 Investment Partners LLC | 0 | $0 | 0.00% | −151,730−100.0% | Sold out |
| Diadema Partners LP | 0 | $0 | 0.00% | −150,000−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −119,561−100.0% | Sold out |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −60,333−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −43,082−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −34,632−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −16,300−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −13,832−100.0% | Sold out |
| EverSource Wealth Advisors, LLC | 0 | $0 | 0.00% | −434−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | – | – | – | – | Not filed |
| Point72 Asia (Singapore) Pte. Ltd. | – | – | – | – | Not filed |