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Puma Biotechnology, Inc.

PBYI
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001401667

In the last 90 days, Puma Biotechnology, Inc. insiders filed 0 open-market purchases and 5 sales; 160 institutions reported holding it in 13F filings for Q2 2026, worth $313.6M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Puma Biotechnology, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
151
+19 vs. Q3 2025
Shares held
35.3M
+964.7K (+2.8%) vs. Q3 2025
Total value
$210.2M
+$27.7M (+15.2%) vs. Q3 2025
New holders
33
52 more added
Sold out
14
38 more reduced

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PBYI on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 151 institutions
Q1 2021: 118 institutionsQ2 2021: 120 institutionsQ3 2021: 116 institutionsQ4 2021: 102 institutionsQ1 2022: 104 institutionsQ2 2022: 89 institutionsQ3 2022: 83 institutionsQ4 2022: 89 institutionsQ1 2023: 78 institutionsQ2 2023: 68 institutionsQ3 2023: 69 institutionsQ4 2023: 82 institutionsQ1 2024: 93 institutionsQ2 2024: 99 institutionsQ3 2024: 100 institutionsQ4 2024: 112 institutionsQ1 2025: 116 institutionsQ2 2025: 121 institutionsQ3 2025: 132 institutionsQ4 2025: 151 institutionsQ1 2026: 157 institutionsQ2 2026: 160 institutions
Value heldQ4 2025: $210.2M
Q1 2021: $355.9MQ2 2021: $319.3MQ3 2021: $226.0MQ4 2021: $92.2MQ1 2022: $86.1MQ2 2022: $79.5MQ3 2022: $65.5MQ4 2022: $116.3MQ1 2023: $86.1MQ2 2023: $93.8MQ3 2023: $67.6MQ4 2023: $115.2MQ1 2024: $157.7MQ2 2024: $100.9MQ3 2024: $75.9MQ4 2024: $89.7MQ1 2025: $90.0MQ2 2025: $112.5MQ3 2025: $182.5MQ4 2025: $210.2MQ1 2026: $241.8MQ2 2026: $313.6M
Institutions holding PBYI and their total value by quarter
QuarterHoldersValue
Q2 2026160$313.6M
Q1 2026157$241.8M
Q4 2025151$210.2M
Q3 2025132$182.5M
Q2 2025121$112.5M
Q1 2025116$90.0M
Q4 2024112$89.7M
Q3 2024100$75.9M
Q2 202499$100.9M
Q1 202493$157.7M
Q4 202382$115.2M
Q3 202369$67.6M
Q2 202368$93.8M
Q1 202378$86.1M
Q4 202289$116.3M
Q3 202283$65.5M
Q2 202289$79.5M
Q1 2022104$86.1M
Q4 2021102$92.2M
Q3 2021116$226.0M
Q2 2021120$319.3M
Q1 2021118$355.9M

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Puma Biotechnology, Inc.; share changes are against Q3 2025.

Institutions holding PBYI in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Williams & Novak, LLC10,560$62.8K0.05%+10,560New
Ethic Inc.10,548$62.8K0.00%+195+1.9%Added
ProShare Advisors LLC10,062$59.9K0.00%+10,062New
Wealth Enhancement Advisory Services, LLC10,144$59.4K0.00%+10,144New
BNP Paribas Arbitrage, SA9,758$58.1K0.00%+1,702+21.1%Added
Group One Trading, L.P.9,233$54.9K0.00%+9,233New
State of Alaska, Department of Revenue8,445$50.0K0.00%+8,445New
China Universal Asset Management Co., Ltd.8,211$48.9K0.00%+8,211New
Ameritas Investment Partners, Inc.4,055$24.1K0.00%00.0%Unchanged
New York State Common Retirement Fund3,600$21.4K0.00%00.0%Unchanged
Legal & General Group Plc3,564$21.2K0.00%00.0%Unchanged
Private Wealth Asset Management, LLC3,500$20.8K0.00%00.0%Unchanged
Ball & Co Wealth Management Inc.3,066$18.0K0.01%00.0%Unchanged
California State Teachers Retirement System2,650$15.8K0.00%−351−11.7%Reduced
Sterling Capital Management LLC2,482$14.8K0.00%−445−15.2%Reduced
Mirae Asset Global Investments Co., Ltd.2,449$14.6K0.00%+2,449New
Citigroup Inc2,380$14.2K0.00%+1,521+177.1%Added
Tower Research Capital LLC (TRC)2,239$13.3K0.00%−1,640−42.3%Reduced
Global Retirement Partners, LLC1,492$8.88K0.00%00.0%Unchanged
Rialto Wealth Management, LLC1,450$8.63K0.00%00.0%Unchanged
Amalgamated Bank1,353$8.00K0.00%−79−5.5%Reduced
Royal Bank of Canada1,254$7.00K0.00%−454−26.6%Reduced
GHP Investment Advisors, Inc.1,170$6.96K0.00%00.0%Unchanged
WealthCollab, LLC1,156$6.88K0.00%00.0%Unchanged
GPS Wealth Strategies Group, LLC1,000$5.95K0.01%00.0%Unchanged
GF Fund Management Co. Ltd.989$5.88K0.00%+989New
CIBC Private Wealth Group, LLC775$4.61K0.00%00.0%Unchanged
Optiver Holding B.V.768$4.57K0.00%00.0%Unchanged
Farther Finance Advisors, LLC529$3.15K0.00%+529New
The PNC Financial Services Group, Inc.513$3.05K0.00%+396+338.5%Added
Essential Partners LLC441$2.62K0.00%+2+0.5%Added
Nisa Investment Advisors, LLC342$2.04K0.00%00.0%Unchanged
Rothschild Investment LLC293$1.74K0.00%+43+17.2%Added
EverSource Wealth Advisors, LLC237$1.41K0.00%+70+41.9%Added
IFP Advisors, Inc204$1.21K0.00%+155+316.3%Added
US Bancorp200$1.19K0.00%00.0%Unchanged
Rockefeller Capital Management L.P.159$9460.00%+159New
GAMMA Investing LLC139$8270.00%+61+78.2%Added
True Wealth Design, LLC123$7320.00%00.0%Unchanged
DecisionPoint Financial, LLC100$5950.00%+100New
Jones Financial Companies LLLP68$4050.00%00.0%Unchanged
SBI Securities Co., Ltd.56$3330.00%00.0%Unchanged
Allworth Financial LP50$2980.00%+45+900.0%Added
MAI Capital Management37$2210.00%+37New
SJS Investment Consulting Inc.36$2150.00%+36New
Sunbelt Securities, Inc.30$1780.00%00.0%Unchanged
Clearstead Advisors, LLC17$1020.00%−318−94.9%Reduced
SRS Capital Advisors, Inc.10$600.00%−1,262−99.2%Reduced
National Bank of Canada10$590.00%+10New
CWM Advisors, LLC5$310.00%+5New
ZRC Wealth Management, LLC3$180.00%00.0%Unchanged
Marshall Wace, LLP0$00.00%−557,548−100.0%Sold out
Tang Capital Management LLC0$00.00%−200,000−100.0%Sold out
Wellington Management Group LLP0$00.00%−149,552−100.0%Sold out
Hillsdale Investment Management Inc.0$00.00%−77,800−100.0%Sold out
Assenagon Asset Management S.A.0$00.00%−72,979−100.0%Sold out
Macquarie Group Ltd0$00.00%−61,255−100.0%Sold out
Graham Capital Management, L.P.0$00.00%−52,708−100.0%Sold out
Deutsche Bank AG0$00.00%−30,743−100.0%Sold out
Sherbrooke Park Advisers LLC0$00.00%−30,527−100.0%Sold out
XTX Topco Ltd0$00.00%−25,524−100.0%Sold out
Sanctuary Advisors, LLC0$00.00%−23,866−100.0%Sold out
Squarepoint Ops LLC0$00.00%−21,334−100.0%Sold out
Luminist Capital LLC0$00.00%−250−100.0%Sold out
Atlantic Union Bankshares Corp0$00.00%−150−100.0%Sold out