C4 Therapeutics, Inc.
CCCC- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001662579
No open-market purchases or sales by C4 Therapeutics, Inc. insiders were filed in the last 90 days; 147 institutions reported holding it in 13F filings for Q2 2026, worth $547.6M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in C4 Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 101
- +8 vs. Q3 2025
- Shares held
- 79.8M
- +27.5M (+52.4%) vs. Q3 2025
- Total value
- $152.5M
- +$36.2M (+31.2%) vs. Q3 2025
- New holders
- 24
- 43 more added
- Sold out
- 16
- 20 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting CCCC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 147 | $547.6M |
| Q1 2026 | 123 | $221.3M |
| Q4 2025 | 101 | $152.5M |
| Q3 2025 | 97 | $116.6M |
| Q2 2025 | 102 | $78.2M |
| Q1 2025 | 115 | $102.6M |
| Q4 2024 | 113 | $231.8M |
| Q3 2024 | 118 | $365.9M |
| Q2 2024 | 115 | $281.3M |
| Q1 2024 | 106 | $475.6M |
| Q4 2023 | 92 | $265.6M |
| Q3 2023 | 84 | $64.5M |
| Q2 2023 | 100 | $94.1M |
| Q1 2023 | 121 | $117.5M |
| Q4 2022 | 117 | $231.4M |
| Q3 2022 | 114 | $345.9M |
| Q2 2022 | 113 | $297.2M |
| Q1 2022 | 125 | $904.8M |
| Q4 2021 | 119 | $1.15B |
| Q3 2021 | 113 | $1.54B |
| Q2 2021 | 107 | $1.21B |
| Q1 2021 | 83 | $926.8M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding C4 Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 9,439,328 | $18.0M | 0.03% | +9,439,328 | New |
| Morgan Stanley | 8,981,662 | $17.2M | 0.00% | +4,009,630+80.6% | Added |
| Ra Capital Management, L.P. | 8,000,000 | $15.3M | 0.16% | +8,000,000 | New |
| Bain Capital Life Sciences Investors, LLC | 7,171,910 | $13.7M | 1.05% | +6,060,000+545.0% | Added |
| Lynx1 Capital Management LP | 7,098,133 | $13.6M | 2.74% | 00.0% | Unchanged |
| Vanguard Group Inc | 4,379,815 | $8.37M | 0.00% | +1,188,258+37.2% | Added |
| Wasatch Advisors Inc | 4,344,918 | $8.30M | 0.05% | −507,823−10.5% | Reduced |
| Soleus Capital Management, L.P. | 3,803,942 | $7.27M | 0.31% | −3,250,000−46.1% | Reduced |
| Bank of America Corp | 2,387,586 | $4.56M | 0.00% | +334,424+16.3% | Added |
| Silverarc Capital Management, LLC | 1,994,224 | $3.81M | 0.55% | +96,841+5.1% | Added |
| BlackRock, Inc. | 1,969,814 | $3.76M | 0.00% | +374,175+23.4% | Added |
| Susquehanna International Group, LLP | 1,775,783 | $3.39M | 0.00% | +1,260,346+244.5% | Added |
| Renaissance Technologies LLC | 1,602,580 | $3.06M | 0.00% | +665,630+71.0% | Added |
| Two Sigma Investments, LP | 1,509,603 | $2.88M | 0.00% | +674,877+80.9% | Added |
| OrbiMed Advisors LLC | 1,404,902 | $2.68M | 0.05% | −3,830,244−73.2% | Reduced |
| Millennium Management LLC | 1,188,969 | $2.27M | 0.00% | −745,256−38.5% | Reduced |
| Goldman Sachs Group Inc | 1,089,020 | $2.08M | 0.00% | +629,127+136.8% | Added |
| Two Sigma Advisers, LP | 1,068,200 | $2.04M | 0.00% | +305,100+40.0% | Added |
| Geode Capital Management, LLC | 988,878 | $1.89M | 0.00% | +263,574+36.3% | Added |
| Jane Street Group, LLC | 874,794 | $1.67M | 0.00% | +671,226+329.7% | Added |
| Wells Fargo & Company | 809,260 | $1.55M | 0.00% | +790,600+4,236.9% | Added |
| Acadian Asset Management LLC | 657,173 | $1.25M | 0.00% | +529,065+413.0% | Added |
| Charles Schwab Investment Management Inc | 449,432 | $858.4K | 0.00% | +98,826+28.2% | Added |
| Citadel Advisors LLC | 447,808 | $855.3K | 0.00% | −33,641−7.0% | Reduced |
| Walleye Capital LLC | 443,341 | $846.8K | 0.00% | +443,341 | New |
| 683 Capital Management, LLC | 400,000 | $764.0K | 0.06% | +400,000 | New |
| State Street Corp | 342,773 | $654.7K | 0.00% | +55,400+19.3% | Added |
| Dimensional Fund Advisors LP | 296,480 | $566.5K | 0.00% | −52,809−15.1% | Reduced |
| Qube Research & Technologies Ltd | 290,234 | $554.3K | 0.00% | +174,261+150.3% | Added |
| Susquehanna Portfolio Strategies, LLC | 272,053 | $519.6K | 0.01% | 00.0% | Unchanged |
| Invesco Ltd. | 268,350 | $512.5K | 0.00% | +76,530+39.9% | Added |
| Marshall Wace, LLP | 265,027 | $506.2K | 0.00% | +158,752+149.4% | Added |
| FMR LLC | 254,406 | $485.9K | 0.00% | +43,058+20.4% | Added |
| LPL Financial LLC | 243,305 | $464.7K | 0.00% | +42,375+21.1% | Added |
| Hennion & Walsh Asset Management, Inc. | 237,137 | $452.9K | 0.02% | +32,104+15.7% | Added |
| Barclays PLC | 219,204 | $418.7K | 0.00% | +176,142+409.0% | Added |
| ArrowMark Colorado Holdings LLC | 204,505 | $390.6K | 0.01% | 00.0% | Unchanged |
| Northern Trust Corp | 166,207 | $317.5K | 0.00% | +27,888+20.2% | Added |
| Man Group plc | 156,098 | $298.1K | 0.00% | +65,820+72.9% | Added |
| Squarepoint Ops LLC | 136,054 | $259.9K | 0.00% | +125,955+1,247.2% | Added |
| Quadrature Capital Ltd | 133,112 | $254.2K | 0.00% | +133,112 | New |
| Bridgeway Capital Management, LLC | 131,100 | $250.4K | 0.01% | +51,200+64.1% | Added |
| Mariner, LLC | 128,050 | $244.8K | 0.00% | −187−0.1% | Reduced |
| Omers Administration Corp | 117,700 | $224.8K | 0.00% | +117,700 | New |
| Hudson Bay Capital Management LP | 111,551 | $213.1K | 0.00% | +111,551 | New |
| Atom Investors LP | 104,964 | $200.5K | 0.02% | +104,964 | New |
| XTX Topco Ltd | 104,458 | $199.5K | 0.01% | −45,504−30.3% | Reduced |
| Graham Capital Management, L.P. | 102,198 | $195.2K | 0.01% | +61,570+151.5% | Added |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | $162.3K | 0.08% | 00.0% | Unchanged |
| American Century Companies Inc | 68,245 | $130.3K | 0.00% | +43,997+181.4% | Added |
| Susquehanna Fundamental Investments, LLC | 67,617 | $129.1K | 0.00% | 00.0% | Unchanged |
| Crestwood Advisors Group LLC | 66,536 | $127.1K | 0.00% | 00.0% | Unchanged |
| ExodusPoint Capital Management, LP | 62,165 | $118.7K | 0.00% | +62,165 | New |
| Intrepid Family Office LLC | 55,000 | $105.0K | 0.10% | −15,000−21.4% | Reduced |
| D. E. Shaw & Co., Inc. | 52,879 | $101.0K | 0.00% | +41,016+345.7% | Added |
| UBS Group AG | 52,752 | $100.8K | 0.00% | −8,898−14.4% | Reduced |
| Citigroup Inc | 49,840 | $95.2K | 0.00% | +46,576+1,427.0% | Added |
| Catalyst Funds Management Pty Ltd | 42,500 | $81.2K | 0.02% | 00.0% | Unchanged |
| Group One Trading, L.P. | 38,994 | $74.5K | 0.00% | +26,562+213.7% | Added |
| Colony Group, LLC | 38,187 | $72.9K | 0.00% | +38,187 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 37,721 | $72.0K | 0.00% | +37,721 | New |
| Jefferies Financial Group Inc. | 35,340 | $67.5K | 0.00% | −2,860−7.5% | Reduced |
| Lighthouse Investment Partners, LLC | 33,660 | $64.3K | 0.00% | +33,660 | New |
| Callan Family Office, LLC | 31,743 | $60.6K | 0.00% | +31,743 | New |
| Simplex Trading, LLC | 30,658 | $58.6K | 0.00% | +22,822+291.2% | Added |
| Canada Pension Plan Investment Board | 29,500 | $56.3K | 0.00% | +29,500 | New |
| Farallon Capital Management, L.L.C. | 28,000 | $53.5K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 25,980 | $49.6K | 0.00% | +17,566+208.8% | Added |
| Cresset Asset Management, LLC | 25,000 | $47.8K | 0.00% | 00.0% | Unchanged |
| Engineers Gate Manager LP | 24,416 | $46.6K | 0.00% | +8,130+49.9% | Added |
| CI Private Wealth, LLC | 21,387 | $40.9K | 0.00% | −1,315−5.8% | Reduced |
| Virtu Financial LLC | 20,655 | $39.0K | 0.00% | +20,655 | New |
| Delta Investment Management, LLC | 20,000 | $38.2K | 0.01% | +20,000 | New |
| Ewa, LLC | 16,889 | $32.3K | 0.01% | −2,621−13.4% | Reduced |
| China Universal Asset Management Co., Ltd. | 15,792 | $30.2K | 0.00% | +3,317+26.6% | Added |
| JustInvest LLC | 15,224 | $29.1K | 0.00% | +650+4.5% | Added |
| Prudential Financial Inc | 15,050 | $28.7K | 0.00% | +750+5.2% | Added |
| HSBC Holdings PLC | 13,629 | $26.2K | 0.00% | 00.0% | Unchanged |
| R Squared Ltd | 13,674 | $26.1K | 0.01% | −4,206−23.5% | Reduced |
| Northern Lights Advisors, Inc. | 12,930 | $24.7K | 0.02% | +12,930 | New |
| Jain Global LLC | 12,762 | $24.4K | 0.00% | +12,762 | New |
| Price T Rowe Associates Inc | 12,400 | $24.0K | 0.00% | 00.0% | Unchanged |
| Nine Masts Capital Ltd | 11,472 | $21.9K | 0.00% | +11,472 | New |
| Ethic Inc. | 10,278 | $19.6K | 0.00% | −230−2.2% | Reduced |
| Simplicity Wealth,LLC | 10,202 | $19.5K | 0.00% | −11−0.1% | Reduced |
| Abel Hall, LLC | 10,140 | $19.4K | 0.00% | 00.0% | Unchanged |
| Bronte Capital Management Pty Ltd. | 10,033 | $19.2K | 0.00% | +10,033 | New |
| Blackston Financial Advisory Group, LLC | 10,000 | $19.1K | 0.01% | +10,000 | New |
| JPMorgan Chase & Co | 5,945 | $11.4K | 0.00% | +1,516+34.2% | Added |
| Mirae Asset Global Investments Co., Ltd. | 4,709 | $8.99K | 0.00% | +1,958+71.2% | Added |
| Advisor Group Holdings, Inc. | 4,544 | $8.68K | 0.00% | +14+0.3% | Added |
| NBC Securities, Inc. | 4,000 | $7.64K | 0.00% | +4,000 | New |
| Rhumbline Advisers | 2,716 | $5.19K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 2,161 | $4.13K | 0.00% | −78,645−97.3% | Reduced |
| GF Fund Management Co. Ltd. | 1,903 | $3.63K | 0.00% | +440+30.1% | Added |
| Federation des caisses Desjardins du Quebec | 1,000 | $1.91K | 0.00% | +1,000 | New |
| Royal Bank of Canada | 671 | $1.00K | 0.00% | −181,969−99.6% | Reduced |
| Optima Capital LLC | 226 | $432 | 0.00% | +226 | New |
| Nisa Investment Advisors, LLC | 156 | $298 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 100 | $191 | 0.00% | −52−34.2% | Reduced |