C4 Therapeutics, Inc.
CCCC- Exchange
- Nasdaq
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001662579
No open-market purchases or sales by C4 Therapeutics, Inc. insiders were filed in the last 90 days; 147 institutions reported holding it in 13F filings for Q2 2026, worth $547.6M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in C4 Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 101
- +8 vs. Q3 2025
- Shares held
- 79.8M
- +27.5M (+52.4%) vs. Q3 2025
- Total value
- $152.5M
- +$36.2M (+31.2%) vs. Q3 2025
- New holders
- 24
- 43 more added
- Sold out
- 16
- 20 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting CCCC on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 147 | $547.6M |
| Q1 2026 | 123 | $221.3M |
| Q4 2025 | 101 | $152.5M |
| Q3 2025 | 97 | $116.6M |
| Q2 2025 | 102 | $78.2M |
| Q1 2025 | 115 | $102.6M |
| Q4 2024 | 113 | $231.8M |
| Q3 2024 | 118 | $365.9M |
| Q2 2024 | 115 | $281.3M |
| Q1 2024 | 106 | $475.6M |
| Q4 2023 | 92 | $265.6M |
| Q3 2023 | 84 | $64.5M |
| Q2 2023 | 100 | $94.1M |
| Q1 2023 | 121 | $117.5M |
| Q4 2022 | 117 | $231.4M |
| Q3 2022 | 114 | $345.9M |
| Q2 2022 | 113 | $297.2M |
| Q1 2022 | 125 | $904.8M |
| Q4 2021 | 119 | $1.15B |
| Q3 2021 | 113 | $1.54B |
| Q2 2021 | 107 | $1.21B |
| Q1 2021 | 83 | $926.8M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding C4 Therapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| SRS Capital Advisors, Inc. | 19 | $36 | 0.00% | −36−65.5% | Reduced |
| SBI Securities Co., Ltd. | 100 | $191 | 0.00% | −52−34.2% | Reduced |
| Nisa Investment Advisors, LLC | 156 | $298 | 0.00% | 00.0% | Unchanged |
| Optima Capital LLC | 226 | $432 | 0.00% | +226 | New |
| Royal Bank of Canada | 671 | $1.00K | 0.00% | −181,969−99.6% | Reduced |
| Federation des caisses Desjardins du Quebec | 1,000 | $1.91K | 0.00% | +1,000 | New |
| GF Fund Management Co. Ltd. | 1,903 | $3.63K | 0.00% | +440+30.1% | Added |
| BNP Paribas Arbitrage, SA | 2,161 | $4.13K | 0.00% | −78,645−97.3% | Reduced |
| Rhumbline Advisers | 2,716 | $5.19K | 0.00% | 00.0% | Unchanged |
| NBC Securities, Inc. | 4,000 | $7.64K | 0.00% | +4,000 | New |
| Advisor Group Holdings, Inc. | 4,544 | $8.68K | 0.00% | +14+0.3% | Added |
| Mirae Asset Global Investments Co., Ltd. | 4,709 | $8.99K | 0.00% | +1,958+71.2% | Added |
| JPMorgan Chase & Co | 5,945 | $11.4K | 0.00% | +1,516+34.2% | Added |
| Blackston Financial Advisory Group, LLC | 10,000 | $19.1K | 0.01% | +10,000 | New |
| Bronte Capital Management Pty Ltd. | 10,033 | $19.2K | 0.00% | +10,033 | New |
| Abel Hall, LLC | 10,140 | $19.4K | 0.00% | 00.0% | Unchanged |
| Simplicity Wealth,LLC | 10,202 | $19.5K | 0.00% | −11−0.1% | Reduced |
| Ethic Inc. | 10,278 | $19.6K | 0.00% | −230−2.2% | Reduced |
| Nine Masts Capital Ltd | 11,472 | $21.9K | 0.00% | +11,472 | New |
| Price T Rowe Associates Inc | 12,400 | $24.0K | 0.00% | 00.0% | Unchanged |
| Jain Global LLC | 12,762 | $24.4K | 0.00% | +12,762 | New |
| Northern Lights Advisors, Inc. | 12,930 | $24.7K | 0.02% | +12,930 | New |
| R Squared Ltd | 13,674 | $26.1K | 0.01% | −4,206−23.5% | Reduced |
| HSBC Holdings PLC | 13,629 | $26.2K | 0.00% | 00.0% | Unchanged |
| Prudential Financial Inc | 15,050 | $28.7K | 0.00% | +750+5.2% | Added |
| JustInvest LLC | 15,224 | $29.1K | 0.00% | +650+4.5% | Added |
| China Universal Asset Management Co., Ltd. | 15,792 | $30.2K | 0.00% | +3,317+26.6% | Added |
| Ewa, LLC | 16,889 | $32.3K | 0.01% | −2,621−13.4% | Reduced |
| Delta Investment Management, LLC | 20,000 | $38.2K | 0.01% | +20,000 | New |
| Virtu Financial LLC | 20,655 | $39.0K | 0.00% | +20,655 | New |
| CI Private Wealth, LLC | 21,387 | $40.9K | 0.00% | −1,315−5.8% | Reduced |
| Engineers Gate Manager LP | 24,416 | $46.6K | 0.00% | +8,130+49.9% | Added |
| Cresset Asset Management, LLC | 25,000 | $47.8K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 25,980 | $49.6K | 0.00% | +17,566+208.8% | Added |
| Farallon Capital Management, L.L.C. | 28,000 | $53.5K | 0.00% | 00.0% | Unchanged |
| Canada Pension Plan Investment Board | 29,500 | $56.3K | 0.00% | +29,500 | New |
| Simplex Trading, LLC | 30,658 | $58.6K | 0.00% | +22,822+291.2% | Added |
| Callan Family Office, LLC | 31,743 | $60.6K | 0.00% | +31,743 | New |
| Lighthouse Investment Partners, LLC | 33,660 | $64.3K | 0.00% | +33,660 | New |
| Jefferies Financial Group Inc. | 35,340 | $67.5K | 0.00% | −2,860−7.5% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 37,721 | $72.0K | 0.00% | +37,721 | New |
| Colony Group, LLC | 38,187 | $72.9K | 0.00% | +38,187 | New |
| Group One Trading, L.P. | 38,994 | $74.5K | 0.00% | +26,562+213.7% | Added |
| Catalyst Funds Management Pty Ltd | 42,500 | $81.2K | 0.02% | 00.0% | Unchanged |
| Citigroup Inc | 49,840 | $95.2K | 0.00% | +46,576+1,427.0% | Added |
| UBS Group AG | 52,752 | $100.8K | 0.00% | −8,898−14.4% | Reduced |
| D. E. Shaw & Co., Inc. | 52,879 | $101.0K | 0.00% | +41,016+345.7% | Added |
| Intrepid Family Office LLC | 55,000 | $105.0K | 0.10% | −15,000−21.4% | Reduced |
| ExodusPoint Capital Management, LP | 62,165 | $118.7K | 0.00% | +62,165 | New |
| Crestwood Advisors Group LLC | 66,536 | $127.1K | 0.00% | 00.0% | Unchanged |
| Susquehanna Fundamental Investments, LLC | 67,617 | $129.1K | 0.00% | 00.0% | Unchanged |
| American Century Companies Inc | 68,245 | $130.3K | 0.00% | +43,997+181.4% | Added |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | $162.3K | 0.08% | 00.0% | Unchanged |
| Graham Capital Management, L.P. | 102,198 | $195.2K | 0.01% | +61,570+151.5% | Added |
| XTX Topco Ltd | 104,458 | $199.5K | 0.01% | −45,504−30.3% | Reduced |
| Atom Investors LP | 104,964 | $200.5K | 0.02% | +104,964 | New |
| Hudson Bay Capital Management LP | 111,551 | $213.1K | 0.00% | +111,551 | New |
| Omers Administration Corp | 117,700 | $224.8K | 0.00% | +117,700 | New |
| Mariner, LLC | 128,050 | $244.8K | 0.00% | −187−0.1% | Reduced |
| Bridgeway Capital Management, LLC | 131,100 | $250.4K | 0.01% | +51,200+64.1% | Added |
| Quadrature Capital Ltd | 133,112 | $254.2K | 0.00% | +133,112 | New |
| Squarepoint Ops LLC | 136,054 | $259.9K | 0.00% | +125,955+1,247.2% | Added |
| Man Group plc | 156,098 | $298.1K | 0.00% | +65,820+72.9% | Added |
| Northern Trust Corp | 166,207 | $317.5K | 0.00% | +27,888+20.2% | Added |
| ArrowMark Colorado Holdings LLC | 204,505 | $390.6K | 0.01% | 00.0% | Unchanged |
| Barclays PLC | 219,204 | $418.7K | 0.00% | +176,142+409.0% | Added |
| Hennion & Walsh Asset Management, Inc. | 237,137 | $452.9K | 0.02% | +32,104+15.7% | Added |
| LPL Financial LLC | 243,305 | $464.7K | 0.00% | +42,375+21.1% | Added |
| FMR LLC | 254,406 | $485.9K | 0.00% | +43,058+20.4% | Added |
| Marshall Wace, LLP | 265,027 | $506.2K | 0.00% | +158,752+149.4% | Added |
| Invesco Ltd. | 268,350 | $512.5K | 0.00% | +76,530+39.9% | Added |
| Susquehanna Portfolio Strategies, LLC | 272,053 | $519.6K | 0.01% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 290,234 | $554.3K | 0.00% | +174,261+150.3% | Added |
| Dimensional Fund Advisors LP | 296,480 | $566.5K | 0.00% | −52,809−15.1% | Reduced |
| State Street Corp | 342,773 | $654.7K | 0.00% | +55,400+19.3% | Added |
| 683 Capital Management, LLC | 400,000 | $764.0K | 0.06% | +400,000 | New |
| Walleye Capital LLC | 443,341 | $846.8K | 0.00% | +443,341 | New |
| Citadel Advisors LLC | 447,808 | $855.3K | 0.00% | −33,641−7.0% | Reduced |
| Charles Schwab Investment Management Inc | 449,432 | $858.4K | 0.00% | +98,826+28.2% | Added |
| Acadian Asset Management LLC | 657,173 | $1.25M | 0.00% | +529,065+413.0% | Added |
| Wells Fargo & Company | 809,260 | $1.55M | 0.00% | +790,600+4,236.9% | Added |
| Jane Street Group, LLC | 874,794 | $1.67M | 0.00% | +671,226+329.7% | Added |
| Geode Capital Management, LLC | 988,878 | $1.89M | 0.00% | +263,574+36.3% | Added |
| Two Sigma Advisers, LP | 1,068,200 | $2.04M | 0.00% | +305,100+40.0% | Added |
| Goldman Sachs Group Inc | 1,089,020 | $2.08M | 0.00% | +629,127+136.8% | Added |
| Millennium Management LLC | 1,188,969 | $2.27M | 0.00% | −745,256−38.5% | Reduced |
| OrbiMed Advisors LLC | 1,404,902 | $2.68M | 0.05% | −3,830,244−73.2% | Reduced |
| Two Sigma Investments, LP | 1,509,603 | $2.88M | 0.00% | +674,877+80.9% | Added |
| Renaissance Technologies LLC | 1,602,580 | $3.06M | 0.00% | +665,630+71.0% | Added |
| Susquehanna International Group, LLP | 1,775,783 | $3.39M | 0.00% | +1,260,346+244.5% | Added |
| BlackRock, Inc. | 1,969,814 | $3.76M | 0.00% | +374,175+23.4% | Added |
| Silverarc Capital Management, LLC | 1,994,224 | $3.81M | 0.55% | +96,841+5.1% | Added |
| Bank of America Corp | 2,387,586 | $4.56M | 0.00% | +334,424+16.3% | Added |
| Soleus Capital Management, L.P. | 3,803,942 | $7.27M | 0.31% | −3,250,000−46.1% | Reduced |
| Wasatch Advisors Inc | 4,344,918 | $8.30M | 0.05% | −507,823−10.5% | Reduced |
| Vanguard Group Inc | 4,379,815 | $8.37M | 0.00% | +1,188,258+37.2% | Added |
| Lynx1 Capital Management LP | 7,098,133 | $13.6M | 2.74% | 00.0% | Unchanged |
| Bain Capital Life Sciences Investors, LLC | 7,171,910 | $13.7M | 1.05% | +6,060,000+545.0% | Added |
| Ra Capital Management, L.P. | 8,000,000 | $15.3M | 0.16% | +8,000,000 | New |
| Morgan Stanley | 8,981,662 | $17.2M | 0.00% | +4,009,630+80.6% | Added |