Agios Pharmaceuticals, Inc.
AGIO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001439222
In the last 90 days, Agios Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 2 sales; 238 institutions reported holding it in 13F filings for Q2 2026, worth $2.45B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Agios Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 238
- +21 vs. Q3 2025
- Shares held
- 61.3M
- −2.05M (−3.2%) vs. Q3 2025
- Total value
- $1.67B
- −$870.9M (−34.3%) vs. Q3 2025
- New holders
- 65
- 79 more added
- Sold out
- 44
- 70 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AGIO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 238 | $2.45B |
| Q1 2026 | 234 | $2.12B |
| Q4 2025 | 238 | $1.67B |
| Q3 2025 | 221 | $2.55B |
| Q2 2025 | 216 | $2.05B |
| Q1 2025 | 221 | $1.76B |
| Q4 2024 | 225 | $1.97B |
| Q3 2024 | 208 | $2.58B |
| Q2 2024 | 206 | $2.51B |
| Q1 2024 | 187 | $1.81B |
| Q4 2023 | 170 | $1.33B |
| Q3 2023 | 146 | $1.46B |
| Q2 2023 | 153 | $1.68B |
| Q1 2023 | 165 | $1.36B |
| Q4 2022 | 160 | $1.67B |
| Q3 2022 | 168 | $1.64B |
| Q2 2022 | 157 | $1.31B |
| Q1 2022 | 161 | $1.74B |
| Q4 2021 | 161 | $1.95B |
| Q3 2021 | 165 | $2.81B |
| Q2 2021 | 186 | $3.63B |
| Q1 2021 | 175 | $3.37B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Agios Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Vanguard Group Inc | 5,594,353 | $152.3M | 0.00% | −10,523−0.2% | Reduced |
| BlackRock, Inc. | 5,235,429 | $142.5M | 0.00% | +689,691+15.2% | Added |
| Farallon Capital Management, L.L.C. | 5,159,505 | $140.4M | 0.73% | −621,561−10.8% | Reduced |
| State Street Corp | 3,108,145 | $84.6M | 0.00% | +845,433+37.4% | Added |
| Armistice Capital, LLC | 3,036,000 | $82.6M | 2.02% | +2,272,000+297.4% | Added |
| Erste Asset Management GmbH | 2,804,900 | $76.3M | 0.64% | +40,000+1.4% | Added |
| D. E. Shaw & Co., Inc. | 1,837,186 | $50.0M | 0.04% | +1,469,437+399.6% | Added |
| Nomura Asset Management International Inc. | 1,701,409 | $46.3M | 0.07% | +1,701,409 | New |
| Geode Capital Management, LLC | 1,413,538 | $38.5M | 0.00% | −2,777−0.2% | Reduced |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,360,730 | $37.0M | 0.04% | +373,391+37.8% | Added |
| Citadel Advisors LLC | 1,348,968 | $36.7M | 0.02% | +856,986+174.2% | Added |
| MPM Oncology Impact Management LP | 1,303,373 | $35.5M | 4.06% | +1,303,373 | New |
| Frazier Life Sciences Management, L.P. | 1,279,754 | $34.8M | 0.94% | 00.0% | Unchanged |
| GW&K Investment Management, LLC | 1,207,301 | $32.9M | 0.28% | +354,359+41.5% | Added |
| TCG Crossover Management, LLC | 1,181,841 | $32.2M | 1.06% | −248,200−17.4% | Reduced |
| Susquehanna International Group, LLP | 1,142,432 | $31.1M | 0.04% | +1,142,432 | New |
| Jane Street Group, LLC | 1,121,050 | $30.5M | 0.04% | +725,930+183.7% | Added |
| Goldman Sachs Group Inc | 1,033,974 | $28.1M | 0.00% | +229,208+28.5% | Added |
| Dimensional Fund Advisors LP | 1,004,341 | $27.3M | 0.01% | −16,860−1.7% | Reduced |
| Morgan Stanley | 894,037 | $24.3M | 0.00% | +477,039+114.4% | Added |
| Rock Springs Capital Management LP | 799,163 | $21.8M | 1.12% | −159,379−16.6% | Reduced |
| Capital International Investors | 703,865 | $19.2M | 0.00% | +703,865 | New |
| Price T Rowe Associates Inc | 637,886 | $17.4M | 0.00% | −1,019,052−61.5% | Reduced |
| Balyasny Asset Management LLC | 635,069 | $17.3M | 0.03% | +139,578+28.2% | Added |
| SCS Capital Management LLC | 598,765 | $16.3M | 0.17% | 00.0% | Unchanged |
| Wellington Management Group LLP | 597,826 | $16.3M | 0.00% | −1,873,590−75.8% | Reduced |
| Connor, Clark & Lunn Investment Management Ltd. | 562,642 | $15.3M | 0.04% | +32,544+6.1% | Added |
| Bank of America Corp | 539,341 | $14.7M | 0.00% | −590,659−52.3% | Reduced |
| Foresite Capital Management VI LLC | 530,000 | $14.4M | 4.36% | +530,000 | New |
| Northern Trust Corp | 511,901 | $13.9M | 0.00% | −43,509−7.8% | Reduced |
| Artisan Partners Limited Partnership | 504,485 | $13.7M | 0.02% | +101,542+25.2% | Added |
| Charles Schwab Investment Management Inc | 482,622 | $13.1M | 0.00% | +436+0.1% | Added |
| ArrowMark Colorado Holdings LLC | 466,151 | $12.7M | 0.28% | −213,771−31.4% | Reduced |
| Algert Global LLC | 414,218 | $11.3M | 0.18% | +378,448+1,058.0% | Added |
| Millennium Management LLC | 398,267 | $10.8M | 0.01% | +393,218+7,788.0% | Added |
| Qube Research & Technologies Ltd | 378,373 | $10.3M | 0.01% | +378,373 | New |
| Marshall Wace, LLP | 353,639 | $9.63M | 0.01% | +126,815+55.9% | Added |
| Legal & General Group Plc | 328,211 | $8.93M | 0.00% | +5,277+1.6% | Added |
| Vestal Point Capital, LP | 325,000 | $8.85M | 0.32% | +198,000+155.9% | Added |
| Barclays PLC | 320,352 | $8.72M | 0.00% | +104,312+48.3% | Added |
| Two Sigma Investments, LP | 300,156 | $8.17M | 0.01% | +240,527+403.4% | Added |
| Nuveen, LLC | 297,908 | $8.11M | 0.00% | +178,328+149.1% | Added |
| JPMorgan Chase & Co | 251,777 | $6.85M | 0.00% | +68,677+37.5% | Added |
| BNP Paribas Arbitrage, SA | 242,670 | $6.61M | 0.00% | +227,972+1,551.0% | Added |
| Trexquant Investment LP | 226,600 | $6.17M | 0.05% | +226,600 | New |
| Palo Alto Investors LP | 212,499 | $5.78M | 0.81% | −52,998−20.0% | Reduced |
| Pictet Asset Management Holding SA | 205,019 | $5.57M | 0.01% | −67,142−24.7% | Reduced |
| Point72 Asset Management, L.P. | 200,000 | $5.44M | 0.01% | +193,493+2,973.6% | Added |
| Bank of New York Mellon Corp | 196,893 | $5.36M | 0.00% | −73,203−27.1% | Reduced |
| ADAR1 Capital Management, LLC | 188,000 | $5.12M | 0.38% | +151,000+408.1% | Added |
| Edgestream Partners, L.P. | 167,998 | $4.57M | 0.13% | +167,998 | New |
| Group One Trading, L.P. | 166,614 | $4.54M | 0.13% | +166,614 | New |
| Polygon Management Ltd. | 162,018 | $4.41M | 0.93% | +162,018 | New |
| American Century Companies Inc | 151,486 | $4.12M | 0.00% | +6,365+4.4% | Added |
| Moore Capital Management, LP | 150,000 | $4.08M | 0.08% | +95,000+172.7% | Added |
| Allianz Asset Management GmbH | 147,950 | $4.03M | 0.00% | +1,307+0.9% | Added |
| HighVista Strategies LLC | 147,662 | $4.02M | 1.04% | −47,636−24.4% | Reduced |
| HRT Financial LP | 146,469 | $3.99M | 0.01% | +146,469 | New |
| Invesco Ltd. | 142,580 | $3.88M | 0.00% | +15,604+12.3% | Added |
| Exome Asset Management LLC | 136,942 | $3.73M | 1.84% | +136,942 | New |
| UBS Group AG | 126,665 | $3.45M | 0.00% | −116,148−47.8% | Reduced |
| Deutsche Bank AG | 122,875 | $3.34M | 0.00% | −803,859−86.7% | Reduced |
| Squarepoint Ops LLC | 121,763 | $3.31M | 0.01% | +121,763 | New |
| Ikarian Capital, LLC | 115,489 | $3.14M | 0.41% | −11,490−9.0% | Reduced |
| Jacobs Levy Equity Management, Inc | 111,150 | $3.03M | 0.01% | +111,150 | New |
| Assenagon Asset Management S.A. | 110,440 | $3.01M | 0.00% | +43,287+64.5% | Added |
| Swiss National Bank | 108,860 | $2.96M | 0.00% | +2,200+2.1% | Added |
| Rafferty Asset Management, LLC | 107,490 | $2.93M | 0.01% | +39,270+57.6% | Added |
| UBS Asset Management Americas Inc | 106,996 | $2.91M | 0.00% | +121+0.1% | Added |
| Hudson Bay Capital Management LP | 100,000 | $2.72M | 0.02% | −22,500−18.4% | Reduced |
| Parkman Healthcare Partners LLC | 99,604 | $2.71M | 0.26% | −776−0.8% | Reduced |
| Caption Management, LLC | 93,486 | $2.54M | 0.11% | +75,992+434.4% | Added |
| Citigroup Inc | 88,238 | $2.40M | 0.00% | +44,618+102.3% | Added |
| Two Sigma Advisers, LP | 85,200 | $2.32M | 0.00% | +71,600+526.5% | Added |
| Prudential Financial Inc | 81,055 | $2.21M | 0.00% | −17,184−17.5% | Reduced |
| Panagora Asset Management Inc | 79,840 | $2.17M | 0.01% | +79,840 | New |
| Y-Intercept (Hong Kong) Ltd | 79,831 | $2.17M | 0.05% | +71,899+906.4% | Added |
| Lynx1 Capital Management LP | 79,624 | $2.17M | 0.44% | +79,624 | New |
| First Trust Advisors LP | 78,656 | $2.14M | 0.00% | +4,227+5.7% | Added |
| Woodline Partners LP | 74,423 | $2.03M | 0.01% | +427+0.6% | Added |
| Rhumbline Advisers | 74,153 | $2.02M | 0.00% | −13,549−15.4% | Reduced |
| ExodusPoint Capital Management, LP | 71,146 | $1.94M | 0.02% | +71,146 | New |
| Manufacturers Life Insurance Company, The | 70,256 | $1.92M | 0.00% | −25,756−26.8% | Reduced |
| Kennedy Capital Management, Inc. | 65,655 | $1.79M | 0.04% | +41,014+166.4% | Added |
| Wells Fargo & Company | 64,772 | $1.76M | 0.00% | +20,018+44.7% | Added |
| Alliancebernstein L.P. | 61,494 | $1.67M | 0.00% | −90.0% | Reduced |
| Tudor Investment Corp Et Al | 61,345 | $1.67M | 0.01% | +61,345 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 60,560 | $1.65M | 0.00% | −10,653−15.0% | Reduced |
| TD Asset Management Inc | 57,292 | $1.56M | 0.00% | −71,002−55.3% | Reduced |
| California State Teachers Retirement System | 53,239 | $1.45M | 0.00% | −8,057−13.1% | Reduced |
| Headlands Technologies LLC | 52,739 | $1.44M | 0.12% | +52,739 | New |
| New York State Common Retirement Fund | 51,707 | $1.41M | 0.00% | +1,917+3.9% | Added |
| Engineers Gate Manager LP | 49,128 | $1.34M | 0.02% | +49,128 | New |
| Alps Advisors Inc | 47,881 | $1.30M | 0.01% | +20,327+73.8% | Added |
| State of New Jersey Common Pension Fund D | 47,414 | $1.29M | 0.00% | +47,414 | New |
| DekaBank Deutsche Girozentrale | 40,000 | $1.27M | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 46,451 | $1.26M | 0.00% | +18,801+68.0% | Added |
| Schroder Investment Management Group | 46,242 | $1.26M | 0.00% | +46,242 | New |
| XTX Topco Ltd | 46,039 | $1.25M | 0.03% | +46,039 | New |
| Virginia Retirement Systems Et Al | 41,361 | $1.13M | 0.01% | +300+0.7% | Added |