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Sionna Therapeutics, Inc.

SION
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0002036042

In the last 90 days, Sionna Therapeutics, Inc. insiders filed 0 open-market purchases and 4 sales; 146 institutions reported holding it in 13F filings for Q2 2026, worth $2.11B in total; Viking Global Investors is the only superinvestor holding it.

13F holders, Q4 2025

Institutional positions in Sionna Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
101
+23 vs. Q3 2025
Shares held
44.0M
+1.11M (+2.6%) vs. Q3 2025
Total value
$1.81B
+$548.2M (+43.5%) vs. Q3 2025
New holders
30
39 more added
Sold out
7
20 more reduced

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SION on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 101 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 0 institutionsQ2 2022: 0 institutionsQ3 2022: 0 institutionsQ4 2022: 0 institutionsQ1 2023: 0 institutionsQ2 2023: 0 institutionsQ3 2023: 0 institutionsQ4 2023: 0 institutionsQ1 2024: 0 institutionsQ2 2024: 0 institutionsQ3 2024: 0 institutionsQ4 2024: 0 institutionsQ1 2025: 47 institutionsQ2 2025: 65 institutionsQ3 2025: 78 institutionsQ4 2025: 101 institutionsQ1 2026: 122 institutionsQ2 2026: 146 institutions
Value heldQ4 2025: $1.81B
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $0Q2 2022: $0Q3 2022: $0Q4 2022: $0Q1 2023: $0Q2 2023: $0Q3 2023: $0Q4 2023: $0Q1 2024: $0Q2 2024: $0Q3 2024: $0Q4 2024: $0Q1 2025: $434.1MQ2 2025: $753.8MQ3 2025: $1.26BQ4 2025: $1.81BQ1 2026: $1.82BQ2 2026: $2.11B
Institutions holding SION and their total value by quarter
QuarterHoldersValue
Q2 2026146$2.11B
Q1 2026122$1.82B
Q4 2025101$1.81B
Q3 202578$1.26B
Q2 202565$753.8M
Q1 202547$434.1M
Q4 20240$0
Q3 20240$0
Q2 20240$0
Q1 20240$0
Q4 20230$0
Q3 20230$0
Q2 20230$0
Q1 20230$0
Q4 20220$0
Q3 20220$0
Q2 20220$0
Q1 20220$0
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Sionna Therapeutics, Inc.; share changes are against Q3 2025.

Institutions holding SION in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Ra Capital Management, L.P.9,905,045$407.5M4.17%−540,277−5.2%Reduced
Braidwell LP0$00.00%−314,013−100.0%Sold out
Holocene Advisors, LP0$00.00%−50,000−100.0%Sold out
Marshall Wace, LLP0$00.00%−30,103−100.0%Sold out
Renaissance Technologies LLC0$00.00%−14,600−100.0%Sold out
Jain Global LLC0$00.00%−8,513−100.0%Sold out
Federated Hermes, Inc.0$00.00%−113−100.0%Sold out
SRS Capital Advisors, Inc.0$00.00%−92−100.0%Sold out