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Sionna Therapeutics, Inc.

SION
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0002036042

In the last 90 days, Sionna Therapeutics, Inc. insiders filed 0 open-market purchases and 4 sales; 146 institutions reported holding it in 13F filings for Q2 2026, worth $2.11B in total; Viking Global Investors is the only superinvestor holding it.

13F holders, Q3 2025

Institutional positions in Sionna Therapeutics, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
78
+13 vs. Q2 2025
Shares held
42.8M
−607.8K (−1.4%) vs. Q2 2025
Total value
$1.26B
+$506.1M (+67.1%) vs. Q2 2025
New holders
19
20 more added
Sold out
6
19 more reduced

Compare with Q2 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SION on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2025: 78 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 0 institutionsQ2 2022: 0 institutionsQ3 2022: 0 institutionsQ4 2022: 0 institutionsQ1 2023: 0 institutionsQ2 2023: 0 institutionsQ3 2023: 0 institutionsQ4 2023: 0 institutionsQ1 2024: 0 institutionsQ2 2024: 0 institutionsQ3 2024: 0 institutionsQ4 2024: 0 institutionsQ1 2025: 47 institutionsQ2 2025: 65 institutionsQ3 2025: 78 institutionsQ4 2025: 101 institutionsQ1 2026: 122 institutionsQ2 2026: 146 institutions
Value heldQ3 2025: $1.26B
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $0Q2 2022: $0Q3 2022: $0Q4 2022: $0Q1 2023: $0Q2 2023: $0Q3 2023: $0Q4 2023: $0Q1 2024: $0Q2 2024: $0Q3 2024: $0Q4 2024: $0Q1 2025: $434.1MQ2 2025: $753.8MQ3 2025: $1.26BQ4 2025: $1.81BQ1 2026: $1.82BQ2 2026: $2.11B
Institutions holding SION and their total value by quarter
QuarterHoldersValue
Q2 2026146$2.11B
Q1 2026122$1.82B
Q4 2025101$1.81B
Q3 202578$1.26B
Q2 202565$753.8M
Q1 202547$434.1M
Q4 20240$0
Q3 20240$0
Q2 20240$0
Q1 20240$0
Q4 20230$0
Q3 20230$0
Q2 20230$0
Q1 20230$0
Q4 20220$0
Q3 20220$0
Q2 20220$0
Q1 20220$0
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q3 2025

Shares, value and share of portfolio for each institution holding Sionna Therapeutics, Inc.; share changes are against Q2 2025.

Institutions holding SION in Q3 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Ra Capital Management, L.P.10,445,322$307.2M3.79%00.0%Unchanged
TPG GP A, LLC6,744,962$198.4M10.80%00.0%Unchanged
OrbiMed Advisors LLC3,704,959$109.0M2.61%00.0%Unchanged
Atlas Venture Life Science Advisors, LLC3,615,527$106.3M14.13%−78,493−2.1%Reduced
Viking Global Investors LPSuperinvestorViking Global Investors3,195,181$94.0M0.24%00.0%Unchanged
Enavate Sciences GP, LLC2,478,030$72.9M22.25%00.0%Unchanged
JPMorgan Chase & Co1,978,626$58.2M0.00%−242,562−10.9%Reduced
Perceptive Advisors LLC1,179,098$34.7M1.00%−36,947−3.0%Reduced
Vanguard Group Inc1,143,154$33.6M0.00%+512,803+81.4%Added
Jennison Associates LLC997,375$29.3M0.02%+244,575+32.5%Added
Deerfield Management Company, L.P. (Series C)970,590$28.5M0.44%00.0%Unchanged
Standard Life Aberdeen plc950,547$28.0M0.04%00.0%Unchanged
BlackRock, Inc.844,605$24.8M0.00%+207,501+32.6%Added
Price T Rowe Associates Inc637,760$18.8M0.00%−223,478−25.9%Reduced
Soleus Capital Management, L.P.413,500$12.2M0.65%+37,500+10.0%Added
Baker Bros. Advisors LP400,000$11.8M0.09%00.0%Unchanged
Siren, L.L.C.325,000$9.56M0.37%00.0%Unchanged
Geode Capital Management, LLC316,564$9.31M0.00%+27,289+9.4%Added
Braidwell LP314,013$9.24M0.27%−767,842−71.0%Reduced
Franklin Resources Inc242,147$7.12M0.00%−257,876−51.6%Reduced
State Street Corp240,199$7.06M0.00%+115,681+92.9%Added
Millennium Management LLC214,085$6.30M0.00%+200,051+1,425.5%Added
Alyeska Investment Group, L.P.186,222$5.48M0.02%00.0%Unchanged
Ameriprise Financial Inc153,151$4.50M0.00%−83,662−35.3%Reduced
Charles Schwab Investment Management Inc111,496$3.28M0.00%+18,664+20.1%Added
Silverarc Capital Management, LLC108,801$3.20M0.46%−77,214−41.5%Reduced
Rock Springs Capital Management LP99,429$2.92M0.17%00.0%Unchanged
Northern Trust Corp97,711$2.87M0.00%+5,821+6.3%Added
TD Asset Management Inc87,082$2.56M0.00%+37,116+74.3%Added
Driehaus Capital Management LLC83,850$2.47M0.02%00.0%Unchanged
Longaeva Partners L.P.61,457$1.81M0.38%+61,457New
Holocene Advisors, LP50,000$1.47M0.00%00.0%Unchanged
UBS Group AG46,666$1.37M0.00%−4,701−9.2%Reduced
Wellington Management Group LLP42,234$1.24M0.00%+42,234New
Citadel Advisors LLC35,923$1.06M0.00%−93,989−72.3%Reduced
Manufacturers Life Insurance Company, The32,080$943.5K0.00%−5,958−15.7%Reduced
Polen Capital Management LLC31,258$919.3K0.00%+14,283+84.1%Added
Marshall Wace, LLP30,103$885.3K0.00%+30,103New
Bank of New York Mellon Corp27,463$807.7K0.00%+3,332+13.8%Added
Morgan Stanley22,837$671.6K0.00%−21,181−48.1%Reduced
Barclays PLC17,643$518.9K0.00%−5,379−23.4%Reduced
Rhumbline Advisers17,240$507.0K0.00%−430−2.4%Reduced
Nuveen, LLC16,040$471.7K0.00%00.0%Unchanged
Renaissance Technologies LLC14,600$429.4K0.00%−11,400−43.8%Reduced
Goldman Sachs Group Inc12,178$358.2K0.00%−33,870−73.6%Reduced
Squarepoint Ops LLC10,162$298.9K0.00%+10,162New
Deutsche Bank AG9,596$282.2K0.00%00.0%Unchanged
Jain Global LLC8,513$250.4K0.00%+8,513New
MetLife Investment Management8,033$236.3K0.00%00.0%Unchanged
Wells Fargo & Company7,576$222.8K0.00%+1,202+18.9%Added
Intech Investment Management LLC7,486$220.2K0.00%+7,486New
Legal & General Group Plc7,374$217.2K0.00%+6,000+436.7%Added
Virtus Investment Advisers, Inc.6,698$197.0K0.06%+1,163+21.0%Added
Bank of America Corp6,541$192.4K0.00%+529+8.8%Added
Mirae Asset Global ETFs Holdings Ltd.5,643$166.0K0.00%−1,104−16.4%Reduced
New York State Common Retirement Fund5,300$155.9K0.00%−1,500−22.1%Reduced
China Universal Asset Management Co., Ltd.5,000$147.1K0.01%+5,000New
Tower Research Capital LLC (TRC)4,490$132.1K0.00%+4,490New
Police & Firemen's Retirement System of New Jersey3,234$95.1K0.00%+626+24.0%Added
BNP Paribas Arbitrage, SA2,380$70.0K0.00%+619+35.2%Added
Ameritas Investment Partners, Inc.1,259$37.0K0.00%00.0%Unchanged
Russell Investments Group, Ltd.1,022$30.1K0.00%+1,022New
California State Teachers Retirement System771$22.7K0.00%+1+0.1%Added
Citigroup Inc687$20.2K0.00%−3,693−84.3%Reduced
Aster Capital Management (DIFC) Ltd409$12.0K0.01%+409New
Amalgamated Bank421$12.0K0.00%00.0%Unchanged
Royal Bank of Canada378$11.0K0.00%+318+530.0%Added
FMR LLC234$6.88K0.00%+234New
GAMMA Investing LLC153$4.50K0.00%+153New
Federated Hermes, Inc.113$3.32K0.00%+113New
US Bancorp111$3.27K0.00%+111New
SRS Capital Advisors, Inc.92$2.71K0.00%+92New
CWM, LLC60$2.00K0.00%+60New
Hughes Financial Services, LLC44$1.57K0.00%00.0%Unchanged
Sterling Capital Management LLC30$8820.00%00.0%Unchanged
Allworth Financial LP22$6480.00%+22New
EverSource Wealth Advisors, LLC20$5880.00%+20New
The PNC Financial Services Group, Inc.5$1470.00%+5New
Prudential Financial Inc0$00.00%−135,185−100.0%Sold out
Woodline Partners LP0$00.00%−80,000−100.0%Sold out
Options Solutions, LLC0$00.00%−16,975−100.0%Sold out
Susquehanna International Group, LLP0$00.00%−14,834−100.0%Sold out
Commonwealth Equity Services, LLC0$00.00%−14,017−100.0%Sold out
STRS Ohio0$00.00%−2,300−100.0%Sold out