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Sionna Therapeutics, Inc.

SION
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0002036042

In the last 90 days, Sionna Therapeutics, Inc. insiders filed 0 open-market purchases and 4 sales; 146 institutions reported holding it in 13F filings for Q2 2026, worth $2.11B in total; Viking Global Investors is the only superinvestor holding it.

13F holders, Q1 2026

Institutional positions in Sionna Therapeutics, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
122
+23 vs. Q4 2025
Shares held
45.4M
+2.65M (+6.2%) vs. Q4 2025
Total value
$1.82B
+$56.2M (+3.2%) vs. Q4 2025
New holders
32
40 more added
Sold out
9
30 more reduced

2 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q4 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SION on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2026: 122 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 0 institutionsQ2 2022: 0 institutionsQ3 2022: 0 institutionsQ4 2022: 0 institutionsQ1 2023: 0 institutionsQ2 2023: 0 institutionsQ3 2023: 0 institutionsQ4 2023: 0 institutionsQ1 2024: 0 institutionsQ2 2024: 0 institutionsQ3 2024: 0 institutionsQ4 2024: 0 institutionsQ1 2025: 47 institutionsQ2 2025: 65 institutionsQ3 2025: 78 institutionsQ4 2025: 101 institutionsQ1 2026: 122 institutionsQ2 2026: 146 institutions
Value heldQ1 2026: $1.82B
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $0Q2 2022: $0Q3 2022: $0Q4 2022: $0Q1 2023: $0Q2 2023: $0Q3 2023: $0Q4 2023: $0Q1 2024: $0Q2 2024: $0Q3 2024: $0Q4 2024: $0Q1 2025: $434.1MQ2 2025: $753.8MQ3 2025: $1.26BQ4 2025: $1.81BQ1 2026: $1.82BQ2 2026: $2.11B
Institutions holding SION and their total value by quarter
QuarterHoldersValue
Q2 2026146$2.11B
Q1 2026122$1.82B
Q4 2025101$1.81B
Q3 202578$1.26B
Q2 202565$753.8M
Q1 202547$434.1M
Q4 20240$0
Q3 20240$0
Q2 20240$0
Q1 20240$0
Q4 20230$0
Q3 20230$0
Q2 20230$0
Q1 20230$0
Q4 20220$0
Q3 20220$0
Q2 20220$0
Q1 20220$0
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q1 2026

Shares, value and share of portfolio for each institution holding Sionna Therapeutics, Inc.; share changes are against Q4 2025.

Institutions holding SION in Q1 2026
InstitutionSharesValue% of portfolioChange in sharesAction
Ra Capital Management, L.P.9,905,045$397.1M4.21%00.0%Unchanged
TPG GP A, LLC6,494,962$260.4M7.08%−250,000−3.7%Reduced
OrbiMed Advisors LLC3,530,702$141.5M3.22%−30,953−0.9%Reduced
Viking Global Investors LPSuperinvestorViking Global Investors3,195,181$128.1M0.36%00.0%Unchanged
Atlas Venture Life Science Advisors, LLC2,995,602$120.1M15.20%00.0%Unchanged
Enavate Sciences GP, LLC2,478,030$99.3M28.26%00.0%Unchanged
Jennison Associates LLC1,451,220$58.2M0.04%+335,942+30.1%Added
JPMorgan Chase & Co1,465,014$53.7M0.00%+233,195+18.9%Added
BlackRock, Inc.1,295,867$52.0M0.00%+4,268+0.3%Added
Citadel Advisors LLC1,166,931$46.8M0.03%+79,606+7.3%Added
Vanguard Capital Management LLC1,029,497$41.3M0.00%+1,029,497New
Deerfield Management Company, L.P. (Series C)970,590$38.9M0.46%00.0%Unchanged
Price T Rowe Associates Inc756,376$30.3M0.00%−74,997−9.0%Reduced
State Street Corp756,227$30.3M0.00%+62,832+9.1%Added
Perceptive Advisors LLC658,439$26.4M0.52%−520,659−44.2%Reduced
Eventide Asset Management, LLC645,530$25.9M0.43%+6,485+1.0%Added
Standard Life Aberdeen plc564,175$22.6M0.04%−275,785−32.8%Reduced
Baker Bros. Advisors LP400,000$16.0M0.09%00.0%Unchanged
Geode Capital Management, LLC389,872$15.6M0.00%+9,830+2.6%Added
Siren, L.L.C.300,000$12.0M0.33%00.0%Unchanged
Sio Capital Management, LLC294,340$11.8M1.70%+294,340New
Soleus Capital Management, L.P.293,500$11.8M0.48%+25,000+9.3%Added
Goldman Sachs Group Inc263,174$10.6M0.00%+226,905+625.6%Added
Ensign Peak Advisors, Inc255,636$10.2M0.02%+175,774+220.1%Added
Candriam Luxembourg S.C.A.236,813$9.49M0.05%+236,813New
Kalehua Capital Management LLC197,072$7.90M5.59%00.0%Unchanged
Franklin Resources Inc175,483$7.04M0.00%00.0%Unchanged
Adage Capital Partners GP, L.L.C.150,000$6.01M0.01%+150,000New
UBS Group AG147,641$5.92M0.00%+58,464+65.6%Added
Vanguard Portfolio Management LLC142,081$5.70M0.00%+142,081New
Superstring Capital Management LP141,024$5.65M4.04%−39,569−21.9%Reduced
Millennium Management LLC140,641$5.64M0.00%+60,095+74.6%Added
Point72 Asset Management, L.P.136,549$5.47M0.01%+136,549New
Alyeska Investment Group, L.P.136,222$5.46M0.02%00.0%Unchanged
GordonMD Global Investments LP136,000$5.45M4.49%+136,000New
Morgan Stanley133,023$5.33M0.00%+83,147+166.7%Added
Charles Schwab Investment Management Inc120,253$4.82M0.00%−3,433−2.8%Reduced
Artia Global Partners LP119,741$4.80M1.08%00.0%Unchanged
Northern Trust Corp116,776$4.68M0.00%+4,660+4.2%Added
Vanguard Fiduciary Trust Co112,175$4.50M0.00%+112,175New
Rock Springs Capital Management LP99,429$3.99M0.23%00.0%Unchanged
Rhenman & Partners Asset Management AB87,500$3.51M0.43%+87,500New
TD Asset Management Inc82,996$3.33M0.00%−30,356−26.8%Reduced
Ameriprise Financial Inc81,974$3.29M0.00%−19,669−19.4%Reduced
FMR LLC81,395$3.26M0.00%+81,011+21,096.6%Added
Driehaus Capital Management LLC76,633$3.07M0.02%−7,217−8.6%Reduced
Manufacturers Life Insurance Company, The64,458$2.58M0.00%−4,966−7.2%Reduced
Bank of America Corp50,870$2.04M0.00%+7,303+16.8%Added
Seven Grand Managers, LLC50,000$2.00M0.13%00.0%Unchanged
Integral Health Asset Management, LLC50,000$2.00M0.11%+50,000New
Ishara Investments LP49,200$1.97M1.99%+49,200New
Russell Investments Group, Ltd.48,419$1.94M0.00%+26,478+120.7%Added
Wellington Management Group LLP46,079$1.85M0.00%+7,732+20.2%Added
Qube Research & Technologies Ltd42,242$1.69M0.00%+42,242New
BNP Paribas Arbitrage, SA40,570$1.63M0.00%+38,306+1,692.0%Added
Silverarc Capital Management, LLC39,417$1.58M0.19%−2,043−4.9%Reduced
Alps Advisors Inc36,628$1.47M0.01%−20−0.1%Reduced
StemPoint Capital LP36,540$1.46M0.28%+36,540New
Bank of New York Mellon Corp33,778$1.35M0.00%−1,356−3.9%Reduced
Polen Capital Management LLC26,775$1.07M0.01%−4,483−14.3%Reduced
Maven Securities LTD25,000$1.00M0.06%+25,000New
Nuveen, LLC23,734$951.5K0.00%00.0%Unchanged
XTX Topco Ltd23,551$944.2K0.02%+18,625+378.1%Added
Rafferty Asset Management, LLC22,137$887.5K0.00%−2,553−10.3%Reduced
Barclays PLC18,385$737.1K0.00%−29,787−61.8%Reduced
Rhumbline Advisers18,308$734.0K0.00%+614+3.5%Added
Citigroup Inc18,058$723.9K0.00%+12,873+248.3%Added
Alliancebernstein L.P.16,410$675.1K0.00%+790+5.1%Added
Squarepoint Ops LLC15,217$610.0K0.00%−1,143−7.0%Reduced
Walleye Capital LLC15,097$605.2K0.00%+15,097New
Deutsche Bank AG13,249$531.2K0.00%+3,220+32.1%Added
Longaeva Partners L.P.12,693$508.9K0.02%−67,036−84.1%Reduced
Kennedy Capital Management, Inc.12,284$492.5K0.01%+5,532+81.9%Added
Vanguard Global Advisers, LLC11,191$448.6K0.00%+11,191New
Invesco Ltd.10,787$432.5K0.00%−100,375−90.3%Reduced
Profund Advisors LLC9,939$398.5K0.01%+726+7.9%Added
Mirae Asset Global ETFs Holdings Ltd.9,185$362.9K0.00%+270+3.0%Added
MetLife Investment Management8,565$343.4K0.00%00.0%Unchanged
China Universal Asset Management Co., Ltd.7,920$317.5K0.02%−2,352−22.9%Reduced
Susquehanna International Group, LLP7,310$293.1K0.00%+7,310New
ExodusPoint Capital Management, LP7,190$288.2K0.00%+7,190New
VARCOV Co.6,571$263.4K0.10%+6,571New
Virtus Investment Advisers, Inc.6,374$255.5K0.07%+154+2.5%Added
Quarry LP6,304$252.7K0.05%+6,304New
Hudson Bay Capital Management LP6,180$247.8K0.00%+6,180New
Wells Fargo & Company5,894$236.3K0.00%−11,657−66.4%Reduced
Two Sigma Investments, LP5,500$220.5K0.00%−900−14.1%Reduced
Intech Investment Management LLC5,489$220.1K0.00%−2,100−27.7%Reduced
New York State Common Retirement Fund5,300$212.5K0.00%00.0%Unchanged
AlphaCentric Advisors LLC4,818$193.2K0.19%+2,098+77.1%Added
Police & Firemen's Retirement System of New Jersey4,232$169.7K0.00%00.0%Unchanged
Los Angeles Capital Management LLC4,116$165.0K0.00%−1,073−20.7%Reduced
Cygnus Capital Advisors, LLC3,800$152.0K0.10%+1,400+58.3%Added
STRS Ohio2,900$116.3K0.00%+2,900New
Tower Research Capital LLC (TRC)2,352$94.3K0.00%+1,223+108.3%Added
Mirae Asset Global Investments Co., Ltd.2,328$93.3K0.00%+159+7.3%Added
Legal & General Group Plc1,432$57.4K0.00%−250−14.9%Reduced
Ameritas Investment Partners, Inc.1,302$52.2K0.00%00.0%Unchanged
GF Fund Management Co. Ltd.1,003$40.2K0.00%+127+14.5%Added
California State Teachers Retirement System868$34.8K0.00%−120−12.1%Reduced