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Sionna Therapeutics, Inc.

SION
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0002036042

In the last 90 days, Sionna Therapeutics, Inc. insiders filed 0 open-market purchases and 4 sales; 146 institutions reported holding it in 13F filings for Q2 2026, worth $2.11B in total; Viking Global Investors is the only superinvestor holding it.

13F holders, Q4 2025

Institutional positions in Sionna Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
101
+23 vs. Q3 2025
Shares held
44.0M
+1.11M (+2.6%) vs. Q3 2025
Total value
$1.81B
+$548.2M (+43.5%) vs. Q3 2025
New holders
30
39 more added
Sold out
7
20 more reduced

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SION on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 101 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 0 institutionsQ4 2021: 0 institutionsQ1 2022: 0 institutionsQ2 2022: 0 institutionsQ3 2022: 0 institutionsQ4 2022: 0 institutionsQ1 2023: 0 institutionsQ2 2023: 0 institutionsQ3 2023: 0 institutionsQ4 2023: 0 institutionsQ1 2024: 0 institutionsQ2 2024: 0 institutionsQ3 2024: 0 institutionsQ4 2024: 0 institutionsQ1 2025: 47 institutionsQ2 2025: 65 institutionsQ3 2025: 78 institutionsQ4 2025: 101 institutionsQ1 2026: 122 institutionsQ2 2026: 146 institutions
Value heldQ4 2025: $1.81B
Q1 2021: $0Q2 2021: $0Q3 2021: $0Q4 2021: $0Q1 2022: $0Q2 2022: $0Q3 2022: $0Q4 2022: $0Q1 2023: $0Q2 2023: $0Q3 2023: $0Q4 2023: $0Q1 2024: $0Q2 2024: $0Q3 2024: $0Q4 2024: $0Q1 2025: $434.1MQ2 2025: $753.8MQ3 2025: $1.26BQ4 2025: $1.81BQ1 2026: $1.82BQ2 2026: $2.11B
Institutions holding SION and their total value by quarter
QuarterHoldersValue
Q2 2026146$2.11B
Q1 2026122$1.82B
Q4 2025101$1.81B
Q3 202578$1.26B
Q2 202565$753.8M
Q1 202547$434.1M
Q4 20240$0
Q3 20240$0
Q2 20240$0
Q1 20240$0
Q4 20230$0
Q3 20230$0
Q2 20230$0
Q1 20230$0
Q4 20220$0
Q3 20220$0
Q2 20220$0
Q1 20220$0
Q4 20210$0
Q3 20210$0
Q2 20210$0
Q1 20210$0

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Sionna Therapeutics, Inc.; share changes are against Q3 2025.

Institutions holding SION in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Ra Capital Management, L.P.9,905,045$407.5M4.17%−540,277−5.2%Reduced
TPG GP A, LLC6,744,962$277.5M10.33%00.0%Unchanged
OrbiMed Advisors LLC3,561,655$146.5M3.00%−143,304−3.9%Reduced
Viking Global Investors LPSuperinvestorViking Global Investors3,195,181$131.4M0.35%00.0%Unchanged
Atlas Venture Life Science Advisors, LLC2,995,602$123.2M14.24%−619,925−17.1%Reduced
Enavate Sciences GP, LLC2,478,030$101.9M20.12%00.0%Unchanged
BlackRock, Inc.1,291,599$53.1M0.00%+446,994+52.9%Added
JPMorgan Chase & Co1,231,819$50.7M0.00%−746,807−37.7%Reduced
Vanguard Group Inc1,184,951$48.7M0.00%+41,797+3.7%Added
Perceptive Advisors LLC1,179,098$48.5M0.89%00.0%Unchanged
Jennison Associates LLC1,115,278$45.9M0.03%+117,903+11.8%Added
Citadel Advisors LLC1,087,325$44.7M0.03%+1,051,402+2,926.8%Added
Deerfield Management Company, L.P. (Series C)970,590$39.9M0.51%00.0%Unchanged
Standard Life Aberdeen plc839,960$34.6M0.05%−110,587−11.6%Reduced
Price T Rowe Associates Inc831,373$34.2M0.00%+193,613+30.4%Added
State Street Corp693,395$28.5M0.00%+453,196+188.7%Added
Eventide Asset Management, LLC639,045$26.3M0.41%+639,045New
Baker Bros. Advisors LP400,000$16.5M0.10%00.0%Unchanged
Geode Capital Management, LLC380,042$15.6M0.00%+63,478+20.1%Added
Siren, L.L.C.300,000$12.3M0.37%−25,000−7.7%Reduced
Soleus Capital Management, L.P.268,500$11.0M0.47%−145,000−35.1%Reduced
Kalehua Capital Management LLC197,072$8.11M8.02%+197,072New
Superstring Capital Management LP180,593$7.43M3.98%+180,593New
Franklin Resources Inc175,483$7.22M0.00%−66,664−27.5%Reduced
Alyeska Investment Group, L.P.136,222$5.60M0.02%−50,000−26.8%Reduced
Charles Schwab Investment Management Inc123,686$5.09M0.00%+12,190+10.9%Added
Artia Global Partners LP119,741$4.93M0.79%+119,741New
TD Asset Management Inc113,352$4.66M0.00%+26,270+30.2%Added
Northern Trust Corp112,116$4.61M0.00%+14,405+14.7%Added
Invesco Ltd.111,162$4.57M0.00%+111,162New
Ameriprise Financial Inc101,643$4.18M0.00%−51,508−33.6%Reduced
Rock Springs Capital Management LP99,429$4.09M0.21%00.0%Unchanged
UBS Group AG89,177$3.67M0.00%+42,511+91.1%Added
Driehaus Capital Management LLC83,850$3.45M0.02%00.0%Unchanged
Millennium Management LLC80,546$3.31M0.00%−133,539−62.4%Reduced
Ensign Peak Advisors, Inc79,862$3.29M0.01%+79,862New
Longaeva Partners L.P.79,729$3.28M0.39%+18,272+29.7%Added
Manufacturers Life Insurance Company, The69,424$2.87M0.00%+37,344+116.4%Added
Seven Grand Managers, LLC50,000$2.06M0.16%+50,000New
Morgan Stanley49,876$2.05M0.00%+27,039+118.4%Added
Barclays PLC48,172$1.98M0.00%+30,529+173.0%Added
Bank of America Corp43,567$1.79M0.00%+37,026+566.1%Added
Silverarc Capital Management, LLC41,460$1.71M0.25%−67,341−61.9%Reduced
Wellington Management Group LLP38,347$1.58M0.00%−3,887−9.2%Reduced
Alps Advisors Inc36,648$1.51M0.01%+36,648New
Goldman Sachs Group Inc36,269$1.49M0.00%+24,091+197.8%Added
Bank of New York Mellon Corp35,134$1.45M0.00%+7,671+27.9%Added
Polen Capital Management LLC31,258$1.29M0.01%00.0%Unchanged
Rafferty Asset Management, LLC24,690$1.02M0.00%+24,690New
Nuveen, LLC23,734$976.4K0.00%+7,694+48.0%Added
Russell Investments Group, Ltd.21,941$902.7K0.00%+20,919+2,046.9%Added
Rhumbline Advisers17,694$727.9K0.00%+454+2.6%Added
Wells Fargo & Company17,551$722.0K0.00%+9,975+131.7%Added
Squarepoint Ops LLC16,360$673.0K0.00%+6,198+61.0%Added
Alliancebernstein L.P.15,620$642.6K0.00%+15,620New
SG Americas Securities, LLC10,691$440.0K0.00%+10,691New
China Universal Asset Management Co., Ltd.10,272$422.6K0.03%+5,272+105.4%Added
Deutsche Bank AG10,029$412.6K0.00%+433+4.5%Added
Profund Advisors LLC9,213$379.0K0.01%+9,213New
Mirae Asset Global ETFs Holdings Ltd.8,915$367.1K0.00%+3,272+58.0%Added
MetLife Investment Management8,565$352.4K0.00%+532+6.6%Added
Intech Investment Management LLC7,589$312.2K0.00%+103+1.4%Added
Kennedy Capital Management, Inc.6,752$277.8K0.01%+6,752New
Two Sigma Investments, LP6,400$263.3K0.00%+6,400New
Virtus Investment Advisers, Inc.6,220$255.9K0.07%−478−7.1%Reduced
American Century Companies Inc6,180$254.2K0.00%+6,180New
Dark Forest Capital Management LP5,991$246.5K0.01%+5,991New
D. E. Shaw & Co., Inc.5,742$236.2K0.00%+5,742New
New York State Common Retirement Fund5,300$218.0K0.00%00.0%Unchanged
Citigroup Inc5,185$213.3K0.00%+4,498+654.7%Added
XTX Topco Ltd4,926$202.7K0.01%+4,926New
ProShare Advisors LLC4,903$201.7K0.00%+4,903New
Los Angeles Capital Management LLC5,189$197.2K0.00%+5,189New
CIBC Private Wealth Group, LLC4,500$185.1K0.00%+4,500New
Police & Firemen's Retirement System of New Jersey4,232$174.1K0.00%+998+30.9%Added
AlphaCentric Advisors LLC2,720$111.9K0.11%+2,720New
Cygnus Capital Advisors, LLC2,400$99.0K0.07%+2,400New
BNP Paribas Arbitrage, SA2,264$93.1K0.00%−116−4.9%Reduced
Mirae Asset Global Investments Co., Ltd.2,169$89.2K0.00%+2,169New
Legal & General Group Plc1,682$69.2K0.00%−5,692−77.2%Reduced
Balyasny Asset Management LLC1,406$57.8K0.00%+1,406New
Ameritas Investment Partners, Inc.1,302$53.6K0.00%+43+3.4%Added
Tower Research Capital LLC (TRC)1,129$46.4K0.00%−3,361−74.9%Reduced
California State Teachers Retirement System988$40.6K0.00%+217+28.1%Added
GF Fund Management Co. Ltd.876$36.0K0.00%+876New
Amalgamated Bank504$21.0K0.00%+83+19.7%Added
Royal Bank of Canada489$21.0K0.00%+111+29.4%Added
FMR LLC384$15.8K0.00%+150+64.1%Added
Farther Finance Advisors, LLC190$7.82K0.00%+190New
GAMMA Investing LLC177$7.28K0.00%+24+15.7%Added
Daiwa Securities Group Inc.149$6.00K0.00%+149New
Sterling Capital Management LLC105$4.32K0.00%+75+250.0%Added
CWM, LLC80$3.00K0.00%+20+33.3%Added
US Bancorp65$2.67K0.00%−46−41.4%Reduced
Rockefeller Capital Management L.P.48$1.98K0.00%+48New
Aster Capital Management (DIFC) Ltd37$1.52K0.00%−372−91.0%Reduced
Allworth Financial LP28$1.15K0.00%+6+27.3%Added
Hughes Financial Services, LLC25$1.03K0.00%−19−43.2%Reduced
EverSource Wealth Advisors, LLC20$8230.00%00.0%Unchanged
The PNC Financial Services Group, Inc.5$2060.00%00.0%Unchanged