Protalix BioTherapeutics, Inc.
PLX- Exchange
- NYSE
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001006281
No open-market purchases or sales by Protalix BioTherapeutics, Inc. insiders were filed in the last 90 days; 101 institutions reported holding it in 13F filings for Q2 2026, worth $33.7M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Protalix BioTherapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 83
- +7 vs. Q3 2025
- Shares held
- 14.9M
- +1.02M (+7.3%) vs. Q3 2025
- Total value
- $26.8M
- −$4.00M (−13.0%) vs. Q3 2025
- New holders
- 12
- 28 more added
- Sold out
- 5
- 23 more reduced
1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 101 | $33.7M |
| Q1 2026 | 100 | $36.6M |
| Q4 2025 | 83 | $26.8M |
| Q3 2025 | 77 | $31.0M |
| Q2 2025 | 63 | $17.6M |
| Q1 2025 | 63 | $21.0M |
| Q4 2024 | 46 | $8.40M |
| Q3 2024 | 45 | $3.53M |
| Q2 2024 | 66 | $6.60M |
| Q1 2024 | 64 | $12.4M |
| Q4 2023 | 66 | $18.1M |
| Q3 2023 | 61 | $15.2M |
| Q2 2023 | 66 | $17.9M |
| Q1 2023 | 34 | $6.15M |
| Q4 2022 | 26 | $4.87M |
| Q3 2022 | 27 | $3.70M |
| Q2 2022 | 30 | $1.30M |
| Q1 2022 | 32 | $1.29M |
| Q4 2021 | 31 | $2.52M |
| Q3 2021 | 35 | $5.91M |
| Q2 2021 | 33 | $8.71M |
| Q1 2021 | 38 | $39.4M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Protalix BioTherapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| BlackRock, Inc. | 3,647,106 | $6.56M | 0.00% | +96,078+2.7% | Added |
| Opaleye Management Inc. | 2,478,176 | $4.46M | 0.59% | −102,380−4.0% | Reduced |
| Renaissance Technologies LLC | 1,263,300 | $2.27M | 0.00% | −52,100−4.0% | Reduced |
| Northern Trust Corp | 865,708 | $1.56M | 0.00% | −36,751−4.1% | Reduced |
| Geode Capital Management, LLC | 830,054 | $1.49M | 0.00% | +10,277+1.3% | Added |
| State Street Corp | 585,261 | $1.05M | 0.00% | +86,714+17.4% | Added |
| Stratos Wealth Partners, LTD. | 500,000 | $900.0K | 0.01% | 00.0% | Unchanged |
| Vanguard Group Inc | 488,552 | $879.4K | 0.00% | +24,131+5.2% | Added |
| Citadel Advisors LLC | 317,628 | $571.7K | 0.00% | +280,322+751.4% | Added |
| Jane Street Group, LLC | 289,917 | $521.9K | 0.00% | +289,917 | New |
| Goldman Sachs Group Inc | 262,809 | $473.1K | 0.00% | +111,980+74.2% | Added |
| UBS Group AG | 262,520 | $472.5K | 0.00% | +72,244+38.0% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 232,093 | $417.8K | 0.00% | −168,305−42.0% | Reduced |
| Main Street Financial Solutions, LLC | 214,100 | $385.4K | 0.03% | +85,000+65.8% | Added |
| Bank of New York Mellon Corp | 210,867 | $379.6K | 0.00% | +72,319+52.2% | Added |
| Bridgeway Capital Management, LLC | 189,100 | $340.4K | 0.01% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 175,070 | $315.1K | 0.00% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 171,772 | $309.2K | 0.00% | 00.0% | Unchanged |
| Evergreen Capital Management LLC | 171,338 | $308.4K | 0.01% | 00.0% | Unchanged |
| Round Rock Advisors, LLC | 155,102 | $279.2K | 0.04% | +155,102 | New |
| Diametric Capital, LP | 138,929 | $250.1K | 0.07% | −41,055−22.8% | Reduced |
| Morgan Stanley | 131,987 | $237.6K | 0.00% | +60,950+85.8% | Added |
| Barclays PLC | 112,849 | $203.1K | 0.00% | +11,051+10.9% | Added |
| Nuveen, LLC | 90,188 | $162.3K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 79,002 | $142.2K | 0.00% | +36,171+84.5% | Added |
| Lazard Asset Management LLC | 71,393 | $128.5K | 0.00% | +71,393 | New |
| HRT Financial LP | 64,610 | $116.0K | 0.00% | +64,610 | New |
| Orin Green Financial, LLC | 61,433 | $110.6K | 0.04% | +233+0.4% | Added |
| Invesco Ltd. | 50,563 | $91.0K | 0.00% | +5,560+12.4% | Added |
| Bank of America Corp | 46,352 | $83.4K | 0.00% | +26,233+130.4% | Added |
| Rhumbline Advisers | 44,369 | $79.9K | 0.00% | −20,825−31.9% | Reduced |
| Two Sigma Securities, LLC | 39,811 | $71.7K | 0.01% | +39,811 | New |
| Susquehanna International Group, LLP | 38,518 | $69.3K | 0.00% | −34,404−47.2% | Reduced |
| Price T Rowe Associates Inc | 35,278 | $64.0K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 34,296 | $61.7K | 0.00% | −51,545−60.0% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 33,246 | $59.8K | 0.00% | +993+3.1% | Added |
| Intech Investment Management LLC | 31,133 | $56.0K | 0.00% | −115−0.4% | Reduced |
| New York State Common Retirement Fund | 31,100 | $56.0K | 0.00% | −10,200−24.7% | Reduced |
| JPMorgan Chase & Co | 30,874 | $55.6K | 0.00% | −29,108−48.5% | Reduced |
| Dimensional Fund Advisors LP | 28,744 | $51.5K | 0.00% | +11,716+68.8% | Added |
| Aptus Capital Advisors, LLC | 26,610 | $47.9K | 0.00% | +883+3.4% | Added |
| Capital Performance Advisors LLP | 25,975 | $46.8K | 0.00% | 00.0% | Unchanged |
| Smartleaf Asset Management LLC | 25,975 | $45.2K | 0.00% | +25,975 | New |
| Prelude Capital Management, LLC | 22,243 | $40.0K | 0.00% | −27,548−55.3% | Reduced |
| State of Alaska, Department of Revenue | 21,831 | $39.0K | 0.00% | +21,831 | New |
| Lido Advisors, LLC | 15,554 | $34.5K | 0.00% | 00.0% | Unchanged |
| Marshall Wace, LLP | 19,079 | $34.3K | 0.00% | +19,079 | New |
| Police & Firemen's Retirement System of New Jersey | 18,554 | $33.4K | 0.00% | 00.0% | Unchanged |
| Manufacturers Life Insurance Company, The | 18,498 | $33.3K | 0.00% | −5,556−23.1% | Reduced |
| SG Americas Securities, LLC | 17,155 | $31.0K | 0.00% | +17,155 | New |
| BNP Paribas Arbitrage, SA | 17,021 | $30.6K | 0.00% | +1,806+11.9% | Added |
| R Squared Ltd | 14,632 | $26.3K | 0.01% | +14,632 | New |
| ProShare Advisors LLC | 13,137 | $23.6K | 0.00% | +1,215+10.2% | Added |
| Two Sigma Advisers, LP | 12,900 | $23.2K | 0.00% | +2,600+25.2% | Added |
| Altshuler Shaham Ltd | 12,142 | $21.9K | 0.00% | 00.0% | Unchanged |
| Cascade Financial Partners, LLC | 12,000 | $21.6K | 0.00% | −5,000−29.4% | Reduced |
| Alliancebernstein L.P. | 11,720 | $21.1K | 0.00% | 00.0% | Unchanged |
| Equitable Holdings, Inc. | 11,150 | $20.1K | 0.00% | +11,150 | New |
| LPL Financial LLC | 10,291 | $18.5K | 0.00% | 00.0% | Unchanged |
| Harbour Investment Management LLC | 10,100 | $18.2K | 0.01% | 00.0% | Unchanged |
| Kestra Advisory Services, LLC | 10,000 | $18.0K | 0.00% | −1,000−9.1% | Reduced |
| Russell Investments Group, Ltd. | 7,267 | $13.1K | 0.00% | −198−2.7% | Reduced |
| Legal & General Group Plc | 7,201 | $13.0K | 0.00% | −556−7.2% | Reduced |
| Ameritas Investment Partners, Inc. | 7,119 | $12.8K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 6,233 | $11.2K | 0.00% | +720+13.1% | Added |
| TD Waterhouse Canada Inc. | 6,000 | $10.7K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 4,443 | $8.00K | 0.00% | +90+2.1% | Added |
| Royal Bank of Canada | 3,404 | $6.00K | 0.00% | +2,331+217.2% | Added |
| FMR LLC | 2,315 | $4.17K | 0.00% | +1,877+428.5% | Added |
| Amalgamated Bank | 2,269 | $4.00K | 0.00% | −112−4.7% | Reduced |
| Citigroup Inc | 1,634 | $2.94K | 0.00% | −4,980−75.3% | Reduced |
| Advisor Group Holdings, Inc. | 1,200 | $2.16K | 0.00% | +500+71.4% | Added |
| Investment Research & Advisory Group, Inc. | 1,000 | $1.80K | 0.00% | 00.0% | Unchanged |
| Deutsche Bank AG | 846 | $1.52K | 0.00% | −64,771−98.7% | Reduced |
| Sterling Capital Management LLC | 453 | $815 | 0.00% | +284+168.0% | Added |
| GAMMA Investing LLC | 355 | $639 | 0.00% | +355 | New |
| Activest Wealth Management | 300 | $540 | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 250 | $450 | 0.00% | 00.0% | Unchanged |
| Y.D. More Investments Ltd | 220 | $383 | 0.00% | 00.0% | Unchanged |
| SRS Capital Advisors, Inc. | 39 | $71 | 0.00% | −257−86.8% | Reduced |
| The PNC Financial Services Group, Inc. | 20 | $36 | 0.00% | −15−42.9% | Reduced |
| SBI Securities Co., Ltd. | 1 | $2 | 0.00% | −200−99.5% | Reduced |
| CWM, LLC | 203 | $0 | 0.00% | +40+24.5% | Added |
| State of Wyoming | 0 | $0 | 0.00% | −39,018−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −16,530−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −2,942−100.0% | Sold out |
| Truvestments Capital LLC | 0 | $0 | 0.00% | −2,458−100.0% | Sold out |
| Steward Partners Investment Advisory, LLC | 0 | $0 | 0.00% | −25−100.0% | Sold out |
| Wolverine Trading, LLC | – | – | – | – | Not filed |