Protalix BioTherapeutics, Inc.
PLX- Exchange
- NYSE
- Industry
- Biological Products, (No Diagnostic Substances)
- SEC CIK
- 0001006281
No open-market purchases or sales by Protalix BioTherapeutics, Inc. insiders were filed in the last 90 days; 101 institutions reported holding it in 13F filings for Q2 2026, worth $33.7M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Protalix BioTherapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 83
- +7 vs. Q3 2025
- Shares held
- 14.9M
- +1.05M (+7.6%) vs. Q3 2025
- Total value
- $26.8M
- −$3.93M (−12.8%) vs. Q3 2025
- New holders
- 12
- 29 more added
- Sold out
- 5
- 22 more reduced
1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 101 | $33.7M |
| Q1 2026 | 100 | $36.6M |
| Q4 2025 | 83 | $26.8M |
| Q3 2025 | 77 | $30.9M |
| Q2 2025 | 63 | $17.6M |
| Q1 2025 | 63 | $21.0M |
| Q4 2024 | 46 | $8.40M |
| Q3 2024 | 45 | $3.53M |
| Q2 2024 | 66 | $6.60M |
| Q1 2024 | 64 | $11.9M |
| Q4 2023 | 66 | $17.6M |
| Q3 2023 | 61 | $15.2M |
| Q2 2023 | 66 | $17.9M |
| Q1 2023 | 34 | $6.15M |
| Q4 2022 | 26 | $4.87M |
| Q3 2022 | 27 | $3.70M |
| Q2 2022 | 30 | $1.30M |
| Q1 2022 | 32 | $1.29M |
| Q4 2021 | 31 | $2.45M |
| Q3 2021 | 35 | $5.91M |
| Q2 2021 | 33 | $8.24M |
| Q1 2021 | 38 | $39.4M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Protalix BioTherapeutics, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| CWM, LLC | 203 | $0 | 0.00% | +40+24.5% | Added |
| SBI Securities Co., Ltd. | 1 | $2 | 0.00% | −200−99.5% | Reduced |
| The PNC Financial Services Group, Inc. | 20 | $36 | 0.00% | −15−42.9% | Reduced |
| SRS Capital Advisors, Inc. | 39 | $71 | 0.00% | −257−86.8% | Reduced |
| Y.D. More Investments Ltd | 220 | $383 | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 250 | $450 | 0.00% | 00.0% | Unchanged |
| Activest Wealth Management | 300 | $540 | 0.00% | 00.0% | Unchanged |
| GAMMA Investing LLC | 355 | $639 | 0.00% | +355 | New |
| Sterling Capital Management LLC | 453 | $815 | 0.00% | +284+168.0% | Added |
| Deutsche Bank AG | 846 | $1.52K | 0.00% | −64,771−98.7% | Reduced |
| Investment Research & Advisory Group, Inc. | 1,000 | $1.80K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 1,200 | $2.16K | 0.00% | +500+71.4% | Added |
| Citigroup Inc | 1,634 | $2.94K | 0.00% | −4,980−75.3% | Reduced |
| Amalgamated Bank | 2,269 | $4.00K | 0.00% | −112−4.7% | Reduced |
| FMR LLC | 2,315 | $4.17K | 0.00% | +1,877+428.5% | Added |
| Royal Bank of Canada | 3,404 | $6.00K | 0.00% | +2,331+217.2% | Added |
| California State Teachers Retirement System | 4,443 | $8.00K | 0.00% | +90+2.1% | Added |
| TD Waterhouse Canada Inc. | 6,000 | $10.7K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 6,233 | $11.2K | 0.00% | +720+13.1% | Added |
| Ameritas Investment Partners, Inc. | 7,119 | $12.8K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 7,201 | $13.0K | 0.00% | −556−7.2% | Reduced |
| Russell Investments Group, Ltd. | 7,267 | $13.1K | 0.00% | −198−2.7% | Reduced |
| Kestra Advisory Services, LLC | 10,000 | $18.0K | 0.00% | −1,000−9.1% | Reduced |
| Harbour Investment Management LLC | 10,100 | $18.2K | 0.01% | 00.0% | Unchanged |
| LPL Financial LLC | 10,291 | $18.5K | 0.00% | 00.0% | Unchanged |
| Equitable Holdings, Inc. | 11,150 | $20.1K | 0.00% | +11,150 | New |
| Alliancebernstein L.P. | 11,720 | $21.1K | 0.00% | 00.0% | Unchanged |
| Cascade Financial Partners, LLC | 12,000 | $21.6K | 0.00% | −5,000−29.4% | Reduced |
| Altshuler Shaham Ltd | 12,142 | $21.9K | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 12,900 | $23.2K | 0.00% | +2,600+25.2% | Added |
| ProShare Advisors LLC | 13,137 | $23.6K | 0.00% | +1,215+10.2% | Added |
| R Squared Ltd | 14,632 | $26.3K | 0.01% | +14,632 | New |
| BNP Paribas Arbitrage, SA | 17,021 | $30.6K | 0.00% | +1,806+11.9% | Added |
| SG Americas Securities, LLC | 17,155 | $31.0K | 0.00% | +17,155 | New |
| Manufacturers Life Insurance Company, The | 18,498 | $33.3K | 0.00% | −5,556−23.1% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 18,554 | $33.4K | 0.00% | 00.0% | Unchanged |
| Marshall Wace, LLP | 19,079 | $34.3K | 0.00% | +19,079 | New |
| Lido Advisors, LLC | 15,554 | $34.5K | 0.00% | 00.0% | Unchanged |
| State of Alaska, Department of Revenue | 21,831 | $39.0K | 0.00% | +21,831 | New |
| Prelude Capital Management, LLC | 22,243 | $40.0K | 0.00% | −27,548−55.3% | Reduced |
| Smartleaf Asset Management LLC | 25,975 | $45.2K | 0.00% | +25,975 | New |
| Capital Performance Advisors LLP | 25,975 | $46.8K | 0.00% | 00.0% | Unchanged |
| Aptus Capital Advisors, LLC | 26,610 | $47.9K | 0.00% | +883+3.4% | Added |
| Dimensional Fund Advisors LP | 28,744 | $51.5K | 0.00% | +11,716+68.8% | Added |
| JPMorgan Chase & Co | 30,874 | $55.6K | 0.00% | +883+2.9% | Added |
| New York State Common Retirement Fund | 31,100 | $56.0K | 0.00% | −10,200−24.7% | Reduced |
| Intech Investment Management LLC | 31,133 | $56.0K | 0.00% | −115−0.4% | Reduced |
| Mirae Asset Global ETFs Holdings Ltd. | 33,246 | $59.8K | 0.00% | +993+3.1% | Added |
| XTX Topco Ltd | 34,296 | $61.7K | 0.00% | −51,545−60.0% | Reduced |
| Price T Rowe Associates Inc | 35,278 | $64.0K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 38,518 | $69.3K | 0.00% | −34,404−47.2% | Reduced |
| Two Sigma Securities, LLC | 39,811 | $71.7K | 0.01% | +39,811 | New |
| Rhumbline Advisers | 44,369 | $79.9K | 0.00% | −20,825−31.9% | Reduced |
| Bank of America Corp | 46,352 | $83.4K | 0.00% | +26,233+130.4% | Added |
| Invesco Ltd. | 50,563 | $91.0K | 0.00% | +5,560+12.4% | Added |
| Orin Green Financial, LLC | 61,433 | $110.6K | 0.04% | +233+0.4% | Added |
| HRT Financial LP | 64,610 | $116.0K | 0.00% | +64,610 | New |
| Lazard Asset Management LLC | 71,393 | $128.5K | 0.00% | +71,393 | New |
| Wells Fargo & Company | 79,002 | $142.2K | 0.00% | +36,171+84.5% | Added |
| Nuveen, LLC | 90,188 | $162.3K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 112,849 | $203.1K | 0.00% | +11,051+10.9% | Added |
| Morgan Stanley | 131,987 | $237.6K | 0.00% | +60,950+85.8% | Added |
| Diametric Capital, LP | 138,929 | $250.1K | 0.07% | −41,055−22.8% | Reduced |
| Round Rock Advisors, LLC | 155,102 | $279.2K | 0.04% | +155,102 | New |
| Evergreen Capital Management LLC | 171,338 | $308.4K | 0.01% | 00.0% | Unchanged |
| Commonwealth Equity Services, LLC | 171,772 | $309.2K | 0.00% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 175,070 | $315.1K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 189,100 | $340.4K | 0.01% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 210,867 | $379.6K | 0.00% | +72,319+52.2% | Added |
| Main Street Financial Solutions, LLC | 214,100 | $385.4K | 0.03% | +85,000+65.8% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 232,093 | $417.8K | 0.00% | −168,305−42.0% | Reduced |
| UBS Group AG | 262,520 | $472.5K | 0.00% | +72,244+38.0% | Added |
| Goldman Sachs Group Inc | 262,809 | $473.1K | 0.00% | +111,980+74.2% | Added |
| Jane Street Group, LLC | 289,917 | $521.9K | 0.00% | +289,917 | New |
| Citadel Advisors LLC | 317,628 | $571.7K | 0.00% | +280,322+751.4% | Added |
| Vanguard Group Inc | 488,552 | $879.4K | 0.00% | +24,131+5.2% | Added |
| Stratos Wealth Partners, LTD. | 500,000 | $900.0K | 0.01% | 00.0% | Unchanged |
| State Street Corp | 585,261 | $1.05M | 0.00% | +86,714+17.4% | Added |
| Geode Capital Management, LLC | 830,054 | $1.49M | 0.00% | +10,277+1.3% | Added |
| Northern Trust Corp | 865,708 | $1.56M | 0.00% | −36,751−4.1% | Reduced |
| Renaissance Technologies LLC | 1,263,300 | $2.27M | 0.00% | −52,100−4.0% | Reduced |
| Opaleye Management Inc. | 2,478,176 | $4.46M | 0.59% | −102,380−4.0% | Reduced |
| BlackRock, Inc. | 3,647,106 | $6.56M | 0.00% | +96,078+2.7% | Added |
| State of Wyoming | 0 | $0 | 0.00% | −39,018−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −16,530−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −2,942−100.0% | Sold out |
| Truvestments Capital LLC | 0 | $0 | 0.00% | −2,458−100.0% | Sold out |
| Steward Partners Investment Advisory, LLC | 0 | $0 | 0.00% | −25−100.0% | Sold out |
| Wolverine Trading, LLC | – | – | – | – | Not filed |