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Protalix BioTherapeutics, Inc.

PLX
Exchange
NYSE
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001006281

No open-market purchases or sales by Protalix BioTherapeutics, Inc. insiders were filed in the last 90 days; 101 institutions reported holding it in 13F filings for Q2 2026, worth $33.7M in total; no superinvestor holds it.

13F holders, Q1 2025

Institutional positions in Protalix BioTherapeutics, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
63
+17 vs. Q4 2024
Shares held
8.19M
+3.79M (+86.2%) vs. Q4 2024
Total value
$21.0M
+$12.6M (+149.5%) vs. Q4 2024
New holders
22
19 more added
Sold out
5
10 more reduced

Compare with Q4 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2025: 63 institutions
Q1 2021: 38 institutionsQ2 2021: 33 institutionsQ3 2021: 35 institutionsQ4 2021: 31 institutionsQ1 2022: 32 institutionsQ2 2022: 30 institutionsQ3 2022: 27 institutionsQ4 2022: 26 institutionsQ1 2023: 34 institutionsQ2 2023: 66 institutionsQ3 2023: 61 institutionsQ4 2023: 66 institutionsQ1 2024: 64 institutionsQ2 2024: 66 institutionsQ3 2024: 45 institutionsQ4 2024: 46 institutionsQ1 2025: 63 institutionsQ2 2025: 63 institutionsQ3 2025: 77 institutionsQ4 2025: 83 institutionsQ1 2026: 100 institutionsQ2 2026: 101 institutions
Value heldQ1 2025: $21.0M
Q1 2021: $39.4MQ2 2021: $8.71MQ3 2021: $5.91MQ4 2021: $2.52MQ1 2022: $1.29MQ2 2022: $1.30MQ3 2022: $3.70MQ4 2022: $4.87MQ1 2023: $6.15MQ2 2023: $17.9MQ3 2023: $15.2MQ4 2023: $18.1MQ1 2024: $12.4MQ2 2024: $6.60MQ3 2024: $3.53MQ4 2024: $8.40MQ1 2025: $21.0MQ2 2025: $17.6MQ3 2025: $31.0MQ4 2025: $26.8MQ1 2026: $36.6MQ2 2026: $33.7M
Institutions holding PLX and their total value by quarter
QuarterHoldersValue
Q2 2026101$33.7M
Q1 2026100$36.6M
Q4 202583$26.8M
Q3 202577$31.0M
Q2 202563$17.6M
Q1 202563$21.0M
Q4 202446$8.40M
Q3 202445$3.53M
Q2 202466$6.60M
Q1 202464$12.4M
Q4 202366$18.1M
Q3 202361$15.2M
Q2 202366$17.9M
Q1 202334$6.15M
Q4 202226$4.87M
Q3 202227$3.70M
Q2 202230$1.30M
Q1 202232$1.29M
Q4 202131$2.52M
Q3 202135$5.91M
Q2 202133$8.71M
Q1 202138$39.4M

Institutions, Q1 2025

Shares, value and share of portfolio for each institution holding Protalix BioTherapeutics, Inc.; share changes are against Q4 2024.

Institutions holding PLX in Q1 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Renaissance Technologies LLC1,188,953$3.04M0.00%+70,953+6.3%Added
Millennium Management LLC963,011$2.47M0.00%+575,090+148.2%Added
Susquehanna International Group, LLP858,650$2.20M0.00%+858,650New
Northern Trust Corp684,758$1.75M0.00%−46,984−6.4%Reduced
Marshall Wace, LLP615,085$1.57M0.00%+513,186+503.6%Added
Connor, Clark & Lunn Investment Management Ltd.482,875$1.24M0.01%+482,875New
Stratos Wealth Partners, LTD.346,400$886.8K0.01%+76,400+28.3%Added
Jane Street Group, LLC294,318$753.5K0.00%+180,702+159.0%Added
Goldman Sachs Group Inc289,461$741.0K0.00%+239,751+482.3%Added
BlackRock, Inc.254,535$651.6K0.00%+29,878+13.3%Added
Gsa Capital Partners LLP209,292$536.0K0.05%−96,457−31.5%Reduced
Bridgeway Capital Management, LLC189,100$484.1K0.01%+7,700+4.2%Added
Omers Administration Corp179,300$459.0K0.00%+179,300New
Schonfeld Strategic Advisors LLC163,058$417.4K0.00%+163,058New
Squarepoint Ops LLC120,786$309.2K0.00%+46,846+63.4%Added
Qube Research & Technologies Ltd118,808$304.1K0.00%+93,941+377.8%Added
Hillsdale Investment Management Inc.116,100$297.2K0.02%+116,100New
Two Sigma Investments, LP86,354$221.1K0.00%+86,354New
Morgan Stanley83,558$213.9K0.00%−86,658−50.9%Reduced
Jain Global LLC81,963$209.8K0.00%+81,963New
Balyasny Asset Management LLC76,063$194.7K0.00%+76,063New
Point72 Asia (Singapore) Pte. Ltd.54,174$138.7K0.04%+667+1.2%Added
Cubist Systematic Strategies, LLC53,380$136.7K0.00%+24,073+82.1%Added
Quantessence Capital LLC51,243$131.2K0.03%+51,243New
Commonwealth Equity Services, LLC50,025$128.0K0.00%+25+0.1%Added
Orin Green Financial, LLC50,000$127.5K0.06%––
LMR Partners LLP49,025$125.5K0.00%+49,025New
Kestra Advisory Services, LLC44,500$113.9K0.00%+30,500+217.9%Added
XTX Topco Ltd41,826$107.1K0.01%+41,826New
Prudential Financial Inc36,400$93.2K0.00%00.0%Unchanged
Two Sigma Advisers, LP33,015$84.5K0.00%+33,015New
Creative Planning32,740$83.8K0.00%+32,740New
Catalyst Funds Management Pty Ltd27,139$69.5K0.02%+16,939+166.1%Added
Capital Performance Advisors LLP25,976$66.5K0.01%00.0%Unchanged
HSBC Holdings PLC25,535$64.3K0.00%−14,488−36.2%Reduced
Barclays PLC24,310$62.2K0.00%−10,013−29.2%Reduced
Aptus Capital Advisors, LLC23,938$61.3K0.00%+575+2.5%Added
Capula Management Ltd15,690$40.2K0.00%+15,690New
Lido Advisors, LLC15,554$39.8K0.00%00.0%Unchanged
Capstone Investment Advisors, LLC15,336$39.3K0.00%+15,336New
Raymond James Financial Inc15,174$38.8K0.00%+15,174New
GWM Advisors LLC15,080$38.6K0.00%+15,080New
Brevan Howard Capital Management LP13,474$34.5K0.00%+13,474New
Altshuler Shaham Ltd12,142$31.1K0.00%00.0%Unchanged
Hudson Bay Capital Management LP12,000$30.7K0.00%+12,000New
Harbour Investment Management LLC10,100$25.9K0.01%00.0%Unchanged
Acadian Asset Management LLC9,691$24.0K0.00%+9,691New
TD Waterhouse Canada Inc.6,000$15.2K0.00%00.0%Unchanged
Point72 (DIFC) Ltd5,623$14.4K0.00%+4,722+524.1%Added
Citadel Advisors LLC2,818$7.21K0.00%−142,969−98.1%Reduced
Truvestments Capital LLC2,458$6.29K0.00%00.0%Unchanged
Citigroup Inc2,292$5.87K0.00%+1,660+262.7%Added
UBS Group AG2,087$5.34K0.00%−16,091−88.5%Reduced
JPMorgan Chase & Co1,595$4.08K0.00%00.0%Unchanged
Lazard Asset Management LLC797$2.00K0.00%−458−36.5%Reduced
BNP Paribas Arbitrage, SA701$1.79K0.00%−15−2.1%Reduced
Investment Research & Advisory Group, Inc.600$1.54K0.00%+600New
Advisor Group Holdings, Inc.400$1.02K0.00%+200+100.0%Added
Activest Wealth Management300$7680.00%00.0%Unchanged
Federation des caisses Desjardins du Quebec250$6400.00%00.0%Unchanged
Y.D. More Investments Ltd220$5630.00%00.0%Unchanged
SBI Securities Co., Ltd.50$1280.00%+50New
Bank of America Corp6$160.00%−33,708−100.0%Reduced
Virtu Financial LLC0$00.00%−34,276−100.0%Sold out
PFG Investments, LLC0$00.00%−20,730−100.0%Sold out
Y-Intercept (Hong Kong) Ltd0$00.00%−18,818−100.0%Sold out
Group One Trading, L.P.0$00.00%−656−100.0%Sold out
SRS Capital Advisors, Inc.0$00.00%−39−100.0%Sold out