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Milestone Pharmaceuticals Inc.

MIST
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001408443

No open-market purchases or sales by Milestone Pharmaceuticals Inc. insiders were filed in the last 90 days; 78 institutions reported holding it in 13F filings for Q2 2026, worth $66.4M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Milestone Pharmaceuticals Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
80
+20 vs. Q3 2025
Shares held
35.0M
+1.09M (+3.2%) vs. Q3 2025
Total value
$70.7M
+$2.92M (+4.3%) vs. Q3 2025
New holders
29
21 more added
Sold out
9
9 more reduced

1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting MIST on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 80 institutions
Q1 2021: 34 institutionsQ2 2021: 28 institutionsQ3 2021: 27 institutionsQ4 2021: 28 institutionsQ1 2022: 28 institutionsQ2 2022: 29 institutionsQ3 2022: 47 institutionsQ4 2022: 56 institutionsQ1 2023: 50 institutionsQ2 2023: 48 institutionsQ3 2023: 39 institutionsQ4 2023: 40 institutionsQ1 2024: 43 institutionsQ2 2024: 40 institutionsQ3 2024: 43 institutionsQ4 2024: 47 institutionsQ1 2025: 43 institutionsQ2 2025: 43 institutionsQ3 2025: 61 institutionsQ4 2025: 80 institutionsQ1 2026: 87 institutionsQ2 2026: 78 institutions
Value heldQ4 2025: $70.7M
Q1 2021: $117.4MQ2 2021: $110.8MQ3 2021: $113.9MQ4 2021: $132.6MQ1 2022: $135.1MQ2 2022: $127.2MQ3 2022: $198.7MQ4 2022: $96.9MQ1 2023: $85.5MQ2 2023: $59.0MQ3 2023: $60.7MQ4 2023: $29.7MQ1 2024: $56.4MQ2 2024: $39.9MQ3 2024: $43.6MQ4 2024: $57.9MQ1 2025: $9.46MQ2 2025: $22.9MQ3 2025: $68.3MQ4 2025: $70.7MQ1 2026: $47.2MQ2 2026: $66.4M
Institutions holding MIST and their total value by quarter
QuarterHoldersValue
Q2 202678$66.4M
Q1 202687$47.2M
Q4 202580$70.7M
Q3 202561$68.3M
Q2 202543$22.9M
Q1 202543$9.46M
Q4 202447$57.9M
Q3 202443$43.6M
Q2 202440$39.9M
Q1 202443$56.4M
Q4 202340$29.7M
Q3 202339$60.7M
Q2 202348$59.0M
Q1 202350$85.5M
Q4 202256$96.9M
Q3 202247$198.7M
Q2 202229$127.2M
Q1 202228$135.1M
Q4 202128$132.6M
Q3 202127$113.9M
Q2 202128$110.8M
Q1 202134$117.4M

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Milestone Pharmaceuticals Inc.; share changes are against Q3 2025.

Institutions holding MIST in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
SBI Securities Co., Ltd.6$120.00%00.0%Unchanged
Key Capital Management, INC212$4280.00%+212New
Rialto Wealth Management, LLC300$6060.00%+300New
Medallion Wealth Advisors, LLC340$6870.00%+340New
Bank of America Corp841$1.70K0.00%−15,211−94.8%Reduced
SRS Capital Advisors, Inc.1,591$3.21K0.00%+514+47.7%Added
Rockefeller Capital Management L.P.1,700$3.43K0.00%+1,700New
US Bancorp3,200$6.46K0.00%00.0%Unchanged
Royal Bank of Canada6,698$13.0K0.00%−136,702−95.3%Reduced
Tower Research Capital LLC (TRC)8,980$18.1K0.00%+8,980New
Secure Asset Management, LLC10,000$20.2K0.00%00.0%Unchanged
AQR Capital Management LLC10,000$20.2K0.00%00.0%Unchanged
Ancora Advisors, LLC10,000$20.2K0.00%00.0%Unchanged
Taylor Financial Group, Inc.10,000$20.2K0.01%00.0%Unchanged
Integral Investment Advisors, Inc.10,000$20.2K0.01%+10,000New
Bronte Capital Management Pty Ltd.10,414$21.0K0.00%+10,414New
Strategic Family Wealth Counselors, L.L.C.12,675$25.5K0.01%+12,675New
Eaton Financial Holdings Company, LLC12,750$25.8K0.01%+12,750New
Beta Wealth Group, Inc.14,127$28.5K0.01%00.0%Unchanged
SJS Investment Consulting Inc.15,000$30.3K0.00%+15,000New
Jones Financial Companies LLLP16,000$32.3K0.00%+5,000+45.5%Added
Bayesian Capital Management, LP17,215$34.8K0.08%+17,215New
National Bank of Canada18,700$37.8K0.00%00.0%Unchanged
Quantbot Technologies LP18,990$38.4K0.00%+18,990New
Stephenson & Company, Inc.20,000$40.4K0.02%00.0%Unchanged
Journey Strategic Wealth LLC20,000$40.4K0.00%+10,000+100.0%Added
Cetera Investment Advisers20,722$41.9K0.00%+20,722New
State Street Corp21,875$44.2K0.00%−345−1.6%Reduced
Invesco Ltd.21,893$44.2K0.00%+21,893New
Creative Planning23,410$47.3K0.00%00.0%Unchanged
Mariner, LLC25,000$50.5K0.00%00.0%Unchanged
Safeguard Investment Advisory Group, LLC25,044$50.6K0.01%00.0%Unchanged
Raymond James Financial Inc26,600$53.7K0.00%00.0%Unchanged
Bay Rivers Group28,861$58.3K0.02%+12,170+72.9%Added
Federation des caisses Desjardins du Quebec29,781$60.2K0.00%00.0%Unchanged
Scientech Research LLC30,124$60.9K0.04%+30,124New
Citigroup Inc33,858$68.4K0.00%+26,046+333.4%Added
Qube Research & Technologies Ltd34,596$69.9K0.00%+34,596New
Colony Group, LLC36,000$72.7K0.00%00.0%Unchanged
Northern Trust Corp39,258$79.3K0.00%00.0%Unchanged
Cambridge Investment Research Advisors, Inc.47,140$95.0K0.00%+34,442+271.2%Added
October Effect Ltd52,100$105.2K0.12%+52,100New
Engineers Gate Manager LP59,053$119.3K0.00%+59,053New
Geode Capital Management, LLC74,022$149.5K0.00%00.0%Unchanged
Cascades Capital Asset Management, LLC77,510$156.6K0.07%+175+0.2%Added
SG Americas Securities, LLC97,375$197.0K0.00%+97,375New
Tru Independence Asset Management 2, LLC100,000$202.0K0.13%+100,000New
ADAR1 Capital Management, LLC100,100$202.2K0.02%+100,100New
Valeo Financial Advisors, LLC130,699$264.0K0.01%00.0%Unchanged
Graham Capital Management, L.P.133,620$269.9K0.01%+133,620New
LPL Financial LLC142,463$287.8K0.00%+47,163+49.5%Added
XTX Topco Ltd171,960$347.4K0.01%−15,341−8.2%Reduced
Acadian Asset Management LLC176,200$353.0K0.00%+176,200New
Group One Trading, L.P.195,099$394.1K0.01%+188,077+2,678.4%Added
BNP Paribas Arbitrage, SA221,951$448.3K0.00%+221,951New
Nomura Holdings Inc225,000$454.5K0.00%+225,000New
Gsa Capital Partners LLP236,138$477.0K0.04%+157,391+199.9%Added
Squarepoint Ops LLC249,344$503.7K0.00%+249,344New
Aptus Capital Advisors, LLC263,200$531.7K0.00%+53,000+25.2%Added
Guardian Wealth Advisors, LLC263,200$531.7K0.03%+53,000+25.2%Added
Citadel Advisors LLC353,232$713.5K0.00%−158,835−31.0%Reduced
Millennium Management LLC402,635$813.3K0.00%+1,076+0.3%Added
Point72 Asset Management, L.P.482,355$974.4K0.00%+482,355New
UBS Group AG491,868$993.6K0.00%+94,334+23.7%Added
Two Sigma Advisers, LP619,592$1.25M0.00%+385,551+164.7%Added
Susquehanna International Group, LLP643,300$1.30M0.00%+386,528+150.5%Added
Stonepine Capital Management, LLC662,666$1.34M1.06%+662,666New
Boxer Capital Management, LLC666,666$1.35M0.29%00.0%Unchanged
Toronto Dominion Bank750,000$1.51M0.00%00.0%Unchanged
Lion Point Capital, LP755,000$1.53M7.89%+96,447+14.6%Added
Morgan Stanley781,875$1.58M0.00%−2,187,192−73.7%Reduced
Pathstone Holdings, LLC1,017,040$2.10M0.01%+17,040+1.7%Added
Jane Street Group, LLC1,093,230$2.21M0.00%+684,738+167.6%Added
Simplify Asset Management Inc.1,506,405$3.04M0.05%−1,326,569−46.8%Reduced
Two Sigma Investments, LP1,514,461$3.06M0.00%+847,910+127.2%Added
Marshall Wace, LLP1,656,821$3.35M0.00%+1,231,793+289.8%Added
RTW Investments, LP2,506,102$5.06M0.05%00.0%Unchanged
Adage Capital Partners GP, L.L.C.2,810,037$5.68M0.01%−4,165,963−59.7%Reduced
Propel Bio Management, LLC4,118,321$8.32M7.10%−1,006,569−19.6%Reduced
Pavaki Capital Management LLC8,498,915$17.2M11.99%+8,498,915New
OrbiMed Advisors LLC0$00.00%−3,221,828−100.0%Sold out
Sphera Funds Management Ltd.0$00.00%−820,000−100.0%Sold out
Affinity Asset Advisors, LLC0$00.00%−666,666−100.0%Sold out
Goldman Sachs Group Inc0$00.00%−356,567−100.0%Sold out
Quadrature Capital Ltd0$00.00%−223,470−100.0%Sold out
HRT Financial LP0$00.00%−138,812−100.0%Sold out
Simplex Trading, LLC0$00.00%−66,920−100.0%Sold out
Sapient Capital LLC0$00.00%−12,200−100.0%Sold out
Wealthspire Advisors, LLC0$00.00%−1,129−100.0%Sold out
AMH Equity Ltd––––Not filed