Milestone Pharmaceuticals Inc.
MIST- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001408443
No open-market purchases or sales by Milestone Pharmaceuticals Inc. insiders were filed in the last 90 days; 78 institutions reported holding it in 13F filings for Q2 2026, worth $66.4M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Milestone Pharmaceuticals Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 61
- +19 vs. Q2 2025
- Shares held
- 34.1M
- +22.3M (+188.9%) vs. Q2 2025
- Total value
- $68.3M
- +$45.4M (+197.8%) vs. Q2 2025
- New holders
- 26
- 18 more added
- Sold out
- 7
- 4 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting MIST on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 78 | $66.4M |
| Q1 2026 | 87 | $47.2M |
| Q4 2025 | 80 | $70.7M |
| Q3 2025 | 61 | $68.3M |
| Q2 2025 | 43 | $22.9M |
| Q1 2025 | 43 | $9.46M |
| Q4 2024 | 47 | $57.9M |
| Q3 2024 | 43 | $43.6M |
| Q2 2024 | 40 | $39.9M |
| Q1 2024 | 43 | $56.4M |
| Q4 2023 | 40 | $29.7M |
| Q3 2023 | 39 | $60.7M |
| Q2 2023 | 48 | $59.0M |
| Q1 2023 | 50 | $85.5M |
| Q4 2022 | 56 | $96.9M |
| Q3 2022 | 47 | $198.7M |
| Q2 2022 | 29 | $127.2M |
| Q1 2022 | 28 | $135.1M |
| Q4 2021 | 28 | $132.6M |
| Q3 2021 | 27 | $113.9M |
| Q2 2021 | 28 | $110.8M |
| Q1 2021 | 34 | $117.4M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Milestone Pharmaceuticals Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Adage Capital Partners GP, L.L.C. | 6,976,000 | $14.0M | 0.02% | +6,976,000 | New |
| Propel Bio Management, LLC | 5,124,890 | $10.2M | 10.26% | +3,333,333+186.1% | Added |
| OrbiMed Advisors LLC | 3,221,828 | $6.44M | 0.15% | +3,221,828 | New |
| Morgan Stanley | 2,969,067 | $5.94M | 0.00% | +2,148,646+261.9% | Added |
| Simplify Asset Management Inc. | 2,832,974 | $5.67M | 0.11% | +1,842,974+186.2% | Added |
| RTW Investments, LP | 2,506,102 | $5.01M | 0.06% | 00.0% | Unchanged |
| Pathstone Holdings, LLC | 1,000,000 | $2.00M | 0.01% | +1,000,000 | New |
| Sphera Funds Management Ltd. | 820,000 | $1.64M | 0.39% | +820,000 | New |
| Toronto Dominion Bank | 750,000 | $1.50M | 0.00% | 00.0% | Unchanged |
| Affinity Asset Advisors, LLC | 666,666 | $1.33M | 0.12% | +666,666 | New |
| Boxer Capital Management, LLC | 666,666 | $1.33M | 0.42% | +666,666 | New |
| Two Sigma Investments, LP | 666,551 | $1.33M | 0.00% | +666,551 | New |
| Lion Point Capital, LP | 658,553 | $1.32M | 7.48% | +109,747+20.0% | Added |
| Citadel Advisors LLC | 512,067 | $1.02M | 0.00% | +512,067 | New |
| Marshall Wace, LLP | 425,028 | $850.1K | 0.00% | +425,028 | New |
| Jane Street Group, LLC | 408,492 | $817.0K | 0.00% | +376,559+1,179.2% | Added |
| Millennium Management LLC | 401,559 | $803.1K | 0.00% | +401,559 | New |
| UBS Group AG | 397,534 | $795.1K | 0.00% | +74,886+23.2% | Added |
| Goldman Sachs Group Inc | 356,567 | $713.1K | 0.00% | +237,118+198.5% | Added |
| Susquehanna International Group, LLP | 256,772 | $513.5K | 0.00% | +193,403+305.2% | Added |
| Two Sigma Advisers, LP | 234,041 | $468.1K | 0.00% | +234,041 | New |
| AMH Equity Ltd | 231,671 | $463.3K | 0.58% | +231,671 | New |
| Quadrature Capital Ltd | 223,470 | $448.1K | 0.01% | +223,470 | New |
| Aptus Capital Advisors, LLC | 210,200 | $420.4K | 0.00% | +210,200 | New |
| Guardian Wealth Advisors, LLC | 210,200 | $420.4K | 0.03% | +210,200 | New |
| XTX Topco Ltd | 187,301 | $374.6K | 0.02% | +26,338+16.4% | Added |
| Royal Bank of Canada | 143,400 | $287.0K | 0.00% | +107,800+302.8% | Added |
| HRT Financial LP | 138,812 | $277.0K | 0.00% | +138,812 | New |
| Valeo Financial Advisors, LLC | 130,699 | $261.4K | 0.01% | 00.0% | Unchanged |
| LPL Financial LLC | 95,300 | $190.6K | 0.00% | +84,250+762.4% | Added |
| Gsa Capital Partners LLP | 78,747 | $157.0K | 0.01% | +78,747 | New |
| Cascades Capital Asset Management, LLC | 77,335 | $154.7K | 0.07% | +10,200+15.2% | Added |
| Geode Capital Management, LLC | 74,022 | $148.0K | 0.00% | +56,064+312.2% | Added |
| Simplex Trading, LLC | 66,920 | $133.0K | 0.00% | +66,920 | New |
| Northern Trust Corp | 39,258 | $78.5K | 0.00% | −13,743−25.9% | Reduced |
| Colony Group, LLC | 36,000 | $72.0K | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 29,781 | $59.6K | 0.00% | +16,781+129.1% | Added |
| Raymond James Financial Inc | 26,600 | $53.2K | 0.00% | −16,635−38.5% | Reduced |
| Safeguard Investment Advisory Group, LLC | 25,044 | $50.1K | 0.01% | 00.0% | Unchanged |
| Mariner, LLC | 25,000 | $50.0K | 0.00% | +14,000+127.3% | Added |
| Creative Planning | 23,410 | $46.8K | 0.00% | 00.0% | Unchanged |
| State Street Corp | 22,220 | $44.4K | 0.00% | +3,974+21.8% | Added |
| Stephenson & Company, Inc. | 20,000 | $40.0K | 0.02% | +20,000 | New |
| National Bank of Canada | 18,700 | $37.4K | 0.00% | 00.0% | Unchanged |
| Bay Rivers Group | 16,691 | $33.4K | 0.01% | +2,370+16.5% | Added |
| Bank of America Corp | 16,052 | $32.1K | 0.00% | +16,044+200,550.0% | Added |
| Beta Wealth Group, Inc. | 14,127 | $28.3K | 0.01% | 00.0% | Unchanged |
| Cambridge Investment Research Advisors, Inc. | 12,698 | $25.0K | 0.00% | +12,698 | New |
| Sapient Capital LLC | 12,200 | $24.8K | 0.00% | +12,200 | New |
| Jones Financial Companies LLLP | 11,000 | $22.0K | 0.00% | 00.0% | Unchanged |
| Secure Asset Management, LLC | 10,000 | $20.5K | 0.00% | +10,000 | New |
| Journey Strategic Wealth LLC | 10,000 | $20.0K | 0.00% | −5,000−33.3% | Reduced |
| Ancora Advisors, LLC | 10,000 | $20.0K | 0.00% | 00.0% | Unchanged |
| Taylor Financial Group, Inc. | 10,000 | $20.0K | 0.01% | 00.0% | Unchanged |
| AQR Capital Management LLC | 10,000 | $20.0K | 0.00% | +10,000 | New |
| Citigroup Inc | 7,812 | $15.6K | 0.00% | +7,812 | New |
| Group One Trading, L.P. | 7,022 | $14.0K | 0.00% | −24,594−77.8% | Reduced |
| US Bancorp | 3,200 | $6.40K | 0.00% | 00.0% | Unchanged |
| Wealthspire Advisors, LLC | 1,129 | $2.26K | 0.00% | +1,129 | New |
| SRS Capital Advisors, Inc. | 1,077 | $2.15K | 0.00% | +1,077 | New |
| SBI Securities Co., Ltd. | 6 | $12 | 0.00% | 00.0% | Unchanged |
| Alta Fundamental Advisers LLC | 0 | $0 | 0.00% | −1,398,977−100.0% | Sold out |
| BML Capital Management, LLC | 0 | $0 | 0.00% | −1,136,091−100.0% | Sold out |
| Bleichroeder LP | 0 | $0 | 0.00% | −500,000−100.0% | Sold out |
| Scientech Research LLC | 0 | $0 | 0.00% | −19,064−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −15,109−100.0% | Sold out |
| Mercer Global Advisors Inc | 0 | $0 | 0.00% | −15,100−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −14,761−100.0% | Sold out |
| Oliver Lagore Vanvalin Investment Group | – | – | – | – | Not filed |