Alnylam Pharmaceuticals, Inc.
ALNY- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001178670
No open-market purchases or sales by Alnylam Pharmaceuticals, Inc. insiders were filed in the last 90 days; 794 institutions reported holding it in 13F filings for Q2 2026, worth $40.1B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Alnylam Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 852
- +55 vs. Q3 2025
- Shares held
- 132.8M
- +3.06M (+2.4%) vs. Q3 2025
- Total value
- $52.7B
- −$6.43B (−10.9%) vs. Q3 2025
- New holders
- 172
- 290 more added
- Sold out
- 117
- 291 more reduced
26 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting ALNY on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 794 | $40.1B |
| Q1 2026 | 793 | $43.4B |
| Q4 2025 | 852 | $52.7B |
| Q3 2025 | 823 | $59.2B |
| Q2 2025 | 653 | $43.1B |
| Q1 2025 | 625 | $34.8B |
| Q4 2024 | 594 | $30.1B |
| Q3 2024 | 569 | $34.1B |
| Q2 2024 | 525 | $29.1B |
| Q1 2024 | 499 | $17.2B |
| Q4 2023 | 501 | $22.4B |
| Q3 2023 | 454 | $20.9B |
| Q2 2023 | 477 | $22.5B |
| Q1 2023 | 478 | $24.0B |
| Q4 2022 | 489 | $28.4B |
| Q3 2022 | 497 | $26.7B |
| Q2 2022 | 424 | $16.6B |
| Q1 2022 | 443 | $18.6B |
| Q4 2021 | 435 | $19.0B |
| Q3 2021 | 407 | $21.1B |
| Q2 2021 | 401 | $19.0B |
| Q1 2021 | 391 | $15.4B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Alnylam Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Sumitomo Mitsui Trust Holdings, Inc. | 327,763 | $130.3M | 0.08% | +13,311+4.2% | Added |
| Worldquant Millennium Advisors LLC | 343,431 | $136.6M | 0.53% | +122,797+55.7% | Added |
| KBC Group NV | 348,194 | $138.5M | 0.32% | +74,842+27.4% | Added |
| Squarepoint Ops LLC | 350,969 | $139.6M | 0.28% | +205,404+141.1% | Added |
| Swiss National Bank | 359,200 | $142.8M | 0.09% | −16,600−4.4% | Reduced |
| Goldman Sachs Group Inc | 375,323 | $149.2M | 0.02% | −163,023−30.3% | Reduced |
| Raymond James Financial Inc | 388,705 | $154.4M | 0.05% | +11,411+3.0% | Added |
| BNP Paribas Arbitrage, SA | 389,435 | $154.9M | 0.10% | +236,396+154.5% | Added |
| Jacobs Levy Equity Management, Inc | 401,371 | $159.6M | 0.62% | −8,971−2.2% | Reduced |
| 1832 Asset Management L.P. | 440,145 | $175.0M | 0.22% | −19,200−4.2% | Reduced |
| D. E. Shaw & Co., Inc. | 444,493 | $176.8M | 0.13% | +245,076+122.9% | Added |
| Bellevue Group AG | 445,903 | $177.3M | 3.36% | −621−0.1% | Reduced |
| Loomis Sayles & Co L P | 488,897 | $194.4M | 0.23% | −11,775−2.4% | Reduced |
| Massachusetts Financial Services Co | 495,307 | $197.0M | 0.06% | +138,778+38.9% | Added |
| Bank of New York Mellon Corp | 504,133 | $200.5M | 0.04% | +84,350+20.1% | Added |
| Marshall Wace, LLP | 549,922 | $218.7M | 0.21% | +41,551+8.2% | Added |
| Nuveen, LLC | 565,789 | $225.0M | 0.06% | −22,032−3.7% | Reduced |
| Royal Bank of Canada | 591,495 | $235.2M | 0.04% | +154,737+35.4% | Added |
| Clearbridge Investments, LLC | 597,013 | $237.4M | 0.19% | −25,422−4.1% | Reduced |
| Amundi | 608,879 | $242.1M | 0.07% | +224,607+58.5% | Added |
| Two Sigma Investments, LP | 616,120 | $245.0M | 0.37% | +20,194+3.4% | Added |
| Federated Hermes, Inc. | 628,063 | $249.7M | 0.42% | +77,959+14.2% | Added |
| Charles Schwab Investment Management Inc | 647,839 | $257.6M | 0.04% | +29,069+4.7% | Added |
| UBS Asset Management Americas Inc | 652,366 | $259.4M | 0.05% | −56,198−7.9% | Reduced |
| Bank of America Corp | 685,177 | $272.5M | 0.02% | −813,314−54.3% | Reduced |
| Deutsche Bank AG | 711,975 | $283.1M | 0.09% | +105,655+17.4% | Added |
| Qube Research & Technologies Ltd | 774,676 | $308.0M | 0.44% | −36,602−4.5% | Reduced |
| Franklin Resources Inc | 787,623 | $313.2M | 0.08% | +73,611+10.3% | Added |
| UBS Group AG | 825,840 | $328.4M | 0.07% | +337,636+69.2% | Added |
| Northern Trust Corp | 857,742 | $341.1M | 0.04% | +24,591+3.0% | Added |
| AQR Capital Management LLC | 919,959 | $365.8M | 0.19% | +175,951+23.6% | Added |
| Legal & General Group Plc | 961,496 | $382.3M | 0.08% | +73,716+8.3% | Added |
| Morgan Stanley | 970,157 | $385.8M | 0.02% | +244,096+33.6% | Added |
| Arrowstreet Capital, Limited Partnership | 1,127,162 | $448.2M | 0.26% | −228,447−16.9% | Reduced |
| Two Sigma Advisers, LP | 1,132,560 | $450.4M | 0.88% | +240,060+26.9% | Added |
| American Century Companies Inc | 1,485,161 | $590.6M | 0.30% | −156,280−9.5% | Reduced |
| Orbis Allan Gray Ltd | 1,618,219 | $643.5M | 2.70% | −332,743−17.1% | Reduced |
| Wellington Management Group LLP | 1,628,931 | $647.7M | 0.11% | −197,390−10.8% | Reduced |
| Price T Rowe Associates Inc | 1,702,831 | $677.1M | 0.07% | −97,463−5.4% | Reduced |
| T. Rowe Price Investment Management, Inc. | 1,753,640 | $697.3M | 0.44% | −420,344−19.3% | Reduced |
| Dodge & Cox | 1,964,415 | $781.1M | 0.42% | −356,815−15.4% | Reduced |
| Norges Bank | 2,252,775 | $895.8M | 0.10% | +2,252,775 | New |
| Baillie Gifford & Co | 2,600,979 | $1.03B | 0.86% | −188,377−6.8% | Reduced |
| Geode Capital Management, LLC | 2,650,722 | $1.06B | 0.07% | +151,480+6.1% | Added |
| State Street Corp | 3,228,956 | $1.28B | 0.04% | +147,481+4.8% | Added |
| JPMorgan Chase & Co | 4,719,999 | $1.88B | 0.13% | +176,229+3.9% | Added |
| Invesco Ltd. | 5,133,983 | $2.04B | 0.19% | +3,652,141+246.5% | Added |
| Capital Research Global Investors | 6,779,708 | $2.70B | 0.50% | −443,132−6.1% | Reduced |
| BlackRock, Inc. | 10,400,874 | $4.14B | 0.07% | +497,273+5.0% | Added |
| Vanguard Group Inc | 13,553,932 | $5.39B | 0.08% | −11,520−0.1% | Reduced |
| FMR LLC | 15,902,149 | $6.32B | 0.32% | −865,476−5.2% | Reduced |
| Capital World Investors | 16,301,772 | $6.48B | 0.88% | −132,481−0.8% | Reduced |
| Regeneron Pharmaceuticals, Inc. | 0 | $0 | 0.00% | −1,392,303−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −291,449−100.0% | Sold out |
| Susquehanna Advisors Group, Inc. | 0 | $0 | 0.00% | −286,100−100.0% | Sold out |
| Aquatic Capital Management LLC | 0 | $0 | 0.00% | −84,059−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −78,046−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −48,920−100.0% | Sold out |
| Palo Alto Investors LP | 0 | $0 | 0.00% | −32,320−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −30,823−100.0% | Sold out |
| Eagle Health Investments LP | 0 | $0 | 0.00% | −23,686−100.0% | Sold out |
| AMF Pensionsforsakring AB | 0 | $0 | 0.00% | −22,558−100.0% | Sold out |
| Quantessence Capital LLC | 0 | $0 | 0.00% | −15,874−100.0% | Sold out |
| Linden Advisors LP | 0 | $0 | 0.00% | −14,364−100.0% | Sold out |
| Holocene Advisors, LP | 0 | $0 | 0.00% | −13,086−100.0% | Sold out |
| Fieldview Capital Management, LLC | 0 | $0 | 0.00% | −12,658−100.0% | Sold out |
| NWK Group, Inc. | 0 | $0 | 0.00% | −8,538−100.0% | Sold out |
| Catalyst Funds Management Pty Ltd | 0 | $0 | 0.00% | −8,320−100.0% | Sold out |
| Wolverine Asset Management LLC | 0 | $0 | 0.00% | −7,800−100.0% | Sold out |
| Winton Group Ltd | 0 | $0 | 0.00% | −6,800−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −6,197−100.0% | Sold out |
| Mirabella Financial Services LLP | 0 | $0 | 0.00% | −5,447−100.0% | Sold out |
| Brighton Jones LLC | 0 | $0 | 0.00% | −4,941−100.0% | Sold out |
| Donoghue Forlines LLC | 0 | $0 | 0.00% | −4,627−100.0% | Sold out |
| Highland Capital Management, LLC | 0 | $0 | 0.00% | −4,569−100.0% | Sold out |
| Aigen Investment Management, LP | 0 | $0 | 0.00% | −4,538−100.0% | Sold out |
| Soros Fund Management LLCSuperinvestorSoros Fund Management | 0 | $0 | 0.00% | −4,295−100.0% | Sold out |
| Polar Asset Management Partners Inc. | 0 | $0 | 0.00% | −4,104−100.0% | Sold out |
| Moore Capital Management, LP | 0 | $0 | 0.00% | −4,104−100.0% | Sold out |
| Shaolin Capital Management LLC | 0 | $0 | 0.00% | −4,104−100.0% | Sold out |
| Sona Asset Management (US) LLC | 0 | $0 | 0.00% | −4,104−100.0% | Sold out |
| Knollwood Investment Advisory, LLC | 0 | $0 | 0.00% | −4,059−100.0% | Sold out |
| Lighthouse Investment Partners, LLC | 0 | $0 | 0.00% | −3,500−100.0% | Sold out |
| Sanders Morris Harris LLC | 0 | $0 | 0.00% | −3,150−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −2,614−100.0% | Sold out |
| Aristeia Capital LLC | 0 | $0 | 0.00% | −2,100−100.0% | Sold out |
| Whitebox Advisors LLC | 0 | $0 | 0.00% | −2,100−100.0% | Sold out |
| Pinkerton Retirement Specialists, LLC | 0 | $0 | 0.00% | −2,049−100.0% | Sold out |
| CSS LLC | 0 | $0 | 0.00% | −2,010−100.0% | Sold out |
| Fred Alger Management, LLC | 0 | $0 | 0.00% | −1,986−100.0% | Sold out |
| Greenland Capital Management LP | 0 | $0 | 0.00% | −1,959−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −1,740−100.0% | Sold out |
| R Squared Ltd | 0 | $0 | 0.00% | −1,660−100.0% | Sold out |
| CTC Alternative Strategies, Ltd. | 0 | $0 | 0.00% | −1,496−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −1,465−100.0% | Sold out |
| Freestone Grove Partners LP | 0 | $0 | 0.00% | −1,412−100.0% | Sold out |
| Convergence Investment Partners, LLC | 0 | $0 | 0.00% | −1,307−100.0% | Sold out |
| Quantedge Capital Pte Ltd | 0 | $0 | 0.00% | −1,300−100.0% | Sold out |
| Qsemble Capital Management, LP | 0 | $0 | 0.00% | −1,255−100.0% | Sold out |
| Crowley Wealth Management, Inc. | 0 | $0 | 0.00% | −1,250−100.0% | Sold out |